scholarly journals Polymeric nanoparticles as therapeutic agents against coronavirus disease

2022 ◽  
Vol 24 (1) ◽  
Author(s):  
Letícia Emiliano Charelli ◽  
Gabriela Calidone de Mattos ◽  
Ariane de Jesus Sousa-Batista ◽  
José Carlos Pinto ◽  
Tiago Albertini Balbino
Keyword(s):  
Polymeric Nanoparticles ◽  
Therapeutic Agents

scholarly journals Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1035 ◽  
Author(s):  
Jiayi Pan ◽  
Kobra Rostamizadeh ◽  
Nina Filipczak ◽  
Vladimir Torchilin
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agent ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Individual Therapy ◽  
Multiple Factors ◽  
Therapeutic Outcomes ◽  
Anti Cancer

Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles. Various polymeric nanoparticles have been applied to achieve enhanced therapeutic efficacy in cancer therapy. However, reported drug ratios used in such systems often vary widely. Thus, the same combination of drugs may result in very different therapeutic outcomes. In this review, we investigated polymeric co-delivery systems used in cancer treatment and the drug combinations used in these systems for synergistic anti-cancer effect. Development of polymeric co-delivery systems for a maximized therapeutic effect requires a deeper understanding of the optimal ratio among therapeutic agents and the natural heterogenicity of tumors.

Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

2020 ◽  
Vol 26 (11) ◽  
pp. 1128-1137 ◽  
Author(s):  
Mohammad A. Ansari ◽  
Ill-Min Chung ◽  
Govindasamy Rajakumar ◽  
Mohammad A. Alzohairy ◽  
Mohammad N. Alomary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Vital Role ◽  
Drug Molecules ◽  
Brain Drug Delivery ◽  
Anti Cancer ◽  
The Central Nervous System ◽  
The Brain

: Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease, Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted, drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in this review.

Subcellular co-delivery of two different site-oriented payloads based on multistage targeted polymeric nanoparticles for enhanced cancer therapy

2018 ◽  
Vol 6 (42) ◽  
pp. 6752-6766 ◽  
Author(s):  
Chao-Qun You ◽  
Hong-Shuai Wu ◽  
Zhi-Guo Gao ◽  
Kai Sun ◽  
Fang-Hui Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Antitumor Therapy

Smart nanoparticles which encapsulated two different site-oriented therapeutic agents for multistage targeted delivery and enhanced antitumor therapy.

scholarly journals Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Yajing Sun ◽  
Qingshan Yang ◽  
Xue Xia ◽  
Xiaozhe Li ◽  
Weimin Ruan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Nanoparticles ◽  
Membrane System ◽  
Therapeutic Agents ◽  
Treatment Efficiency ◽  
Design And Synthesis ◽  
The Past ◽  
Promising Strategy ◽  
Anticancer Treatment ◽  
Mitochondria Targeting

Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.

H 2 O 2 -responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease

2016 ◽  
Vol 511 (2) ◽  
pp. 1022-1032 ◽  
Author(s):  
Byeongsu Kwon ◽  
Changsun Kang ◽  
Jinsub Kim ◽  
Donghyuck Yoo ◽  
Byung-Ryul Cho ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Polymeric Nanoparticles ◽  
Arterial Disease ◽  
Therapeutic Agents ◽  
Peripheral Arterial

scholarly journals Sonoporation Using Nanoparticle-Loaded Microbubbles Increases Cellular Uptake of Nanoparticles Compared to Co-Incubation of Nanoparticles and Microbubbles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 640
Author(s):  
Sofie Snipstad ◽  
Sigurd Hanstad ◽  
Astrid Bjørkøy ◽  
Ýrr Mørch ◽  
Catharina de Lange Davies
Keyword(s):  
Confocal Microscopy ◽  
Sustained Release ◽  
Blood Brain Barrier ◽  
Cellular Uptake ◽  
Duty Cycle ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Brain Barrier ◽  
Ultrasound Parameters

Therapeutic agents can benefit from encapsulation in nanoparticles, due to improved pharmacokinetics and biodistribution, protection from degradation, increased cellular uptake and sustained release. Microbubbles in combination with ultrasound have been shown to improve the delivery of nanoparticles and drugs to tumors and across the blood-brain barrier. Here, we evaluate two different microbubbles for enhancing the delivery of polymeric nanoparticles to cells in vitro: a commercially available lipid microbubble (Sonazoid) and a microbubble with a shell composed of protein and nanoparticles. Various ultrasound parameters are applied and confocal microscopy is employed to image cellular uptake. Ultrasound enhanced cellular uptake depending on the pressure and duty cycle. The responsible mechanisms are probably sonoporation and sonoprinting, followed by uptake, and to a smaller degree enhanced endocytosis. The use of commercial Sonazoid microbubbles leads to significantly lower uptake than when using nanoparticle-loaded microbubbles, suggesting that proximity between cells, nanoparticles and microbubbles is important, and that mainly nanoparticles in the shell are taken up, rather than free nanoparticles in solution.

Acid Degradable and Biocompatible Polymeric Nanoparticles for the Potential Codelivery of Therapeutic Agents

2011 ◽  
Vol 44 (20) ◽  
pp. 8008-8019 ◽  
Author(s):  
Hien T. T. Duong ◽  
Christopher P. Marquis ◽  
Michael Whittaker ◽  
Thomas P. Davis ◽  
Cyrille Boyer
Keyword(s):  
Polymeric Nanoparticles ◽  
Therapeutic Agents

scholarly journals Present Scenario of Bioconjugates in Cancer Therapy: A Review

2019 ◽  
Vol 20 (21) ◽  
pp. 5243 ◽  
Author(s):  
Aishani Wadhawan ◽  
Mary Chatterjee ◽  
Gurpal Singh
Keyword(s):  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Therapeutic Effects ◽  
Chemotherapeutic Drugs ◽  
Antitumor Effects ◽  
Biological Origin ◽  
The World ◽  
Alternative Techniques ◽  
Inducing Resistance

Cancer is one of the deadliest diseases and poses a risk to people all over the world. Surgery, chemo, and radiation therapy have been the only options available until today to combat this major problem. Chemotherapeutic drugs have been used for treatment for more than 50 years. Unfortunately, these drugs have inherent cytotoxicities and tumor cells have started inducing resistance against these drugs. Other common techniques such as surgery and radiotherapy have their own drawbacks. Therefore, such techniques are incompetent tools to alleviate the disease efficiently without any adverse effects. This scenario has inspired researchers to develop alternative techniques with enhanced therapeutic effects and minimal side effects. Such techniques include targeted therapy, liposomal therapy, hormonal therapy, and immunotherapy, etc. However, these therapies are expensive and not effective enough. Furthermore, researchers have conjugated therapeutic agents or drugs with different molecules, delivery vectors, and/or imaging modalities to combat such problems and enhance the therapeutic effect. This conjugation technique has led to the development of bioconjugation therapy, in which at least one molecule is of biological origin. These bioconjugates are the new therapeutic strategies, having prospective synergistic antitumor effects and have potency to overcome the complications being produced by chemo drugs. Herein, we provide an overview of various bioconjugates developed so far, as well as their classification, characteristics, and targeting approach for cancer. Additionally, the most popular nanostructures based on their organic or inorganic origin (metallic, magnetic, polymeric nanoparticles, dendrimers, and silica nanoparticles) characterized as nanocarriers are also discussed. Moreover, we hope that this review will provide inspiration for researchers to develop better bioconjugates as therapeutic agents.

Use of Nanoparticles in Medicine

2020 ◽  
Vol 6 (1) ◽  
pp. 7-24 ◽  
Author(s):  
Puneet Utreja ◽  
Shivani Verma ◽  
Mahfoozur Rahman ◽  
Lalit Kumar
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
High Reactivity ◽  
Medical Field ◽  
Preclinical Efficacy ◽  
Reduced Toxicity ◽  
Nanoparticulate Systems ◽  
Dimensional Range

Background: Nanotechnology involves the study of materials having dimensional range 1 to 100 nm. When the concept of nanotechnology is applied in the medical field, the resulting outcome is known as ‘Nanomedicine’. Nanomedicine generally includes nanoparticles, which are explored for various therapeutic applications. Various properties of nanoparticles like high reactivity, large surface area, and ultra small size make them highly efficient compared to conventional therapeutic agents. Methods: Present review discloses applications of various nanoparticulate systems in drug delivery and therapeutics. We searched nanoparticulate systems like liposomes, polymeric nanoparticles, lipidic nanoparticles, dendrimers, carbon nanotubes, and gold nanoparticles using search engines like PubMed and Google Scholar. Results: Results of a literature review regarding the use of nanoparticulate systems revealed their high preclinical efficacy, safety, and reduced toxicity compared to various traditional systems used for the delivery of various therapeutic agents. Implementation of targeting moieties like peptides, antibodies, or aptamers in nanoparticulate systems shows a synergistic effect in their efficacy. Conclusion: Nanoparticulate systems have shown significant effects on different areas of the medical field. However, clinical exploration of various nanoparticulate systems is still a challenge and this fact should be taken into consideration by pharmaceutical scientists. Despite this, nanomedicine is expected to have a tremendous effect on various areas of the medical field in the future.

scholarly journals The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 416 ◽  
Author(s):  
Gorabi ◽  
Kiaie ◽  
Reiner ◽  
Carbone ◽  
Montecucco ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Polymeric Nanoparticles ◽  
Immunosuppressive Agents ◽  
Therapeutic Agents ◽  
Experimental Models ◽  
Atherosclerotic Lesions ◽  
Main Determinants ◽  
Drug Kinetics

Chronic inflammation is one of the main determinants of atherogenesis. The traditional medications for treatment of atherosclerosis are not very efficient in targeting atherosclerotic inflammation. Most of these drugs are non-selective, anti-inflammatory and immunosuppressive agents that have adverse effects and very limited anti-atherosclerotic effects, which limits their systemic administration. New approaches using nanoparticles have been investigated to specifically deliver therapeutic agents directly on atherosclerotic lesions. The use of drug delivery systems, such as polymeric nanoparticles, liposomes, and carbon nanotubes are attractive strategies, but some limitations exist. For instance, nanoparticles may alter the drug kinetics, based on the pathophysiological mechanisms of the diseases. In this review, we will update pathophysiological evidence for the use of nanoparticles to reduce inflammation and potentially prevent atherogenesis in different experimental models.

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