Determination of BMI and Constitution of Females Living in Ecologically Unfavorable Conditions of the Aral Sea Region

From the ontogenetic point of view, the adolescent period is considered an achievement of human biological development and a period that has accurate measurements of all morphofunctional indicators. The negative impact of environmental pollution is considered as one of the main factors of the phenotypic variability of the organism. The adaptation of the body to environmental factors contributes to the formation of the phenotype. This ensures optimal conditions for its vital activity. Somatotypes are considered as ways of adapting the body to the environment. The anthropometric survey was conducted on 84 females aged 20 years. This work is aimed at analyzing the main anthropometric indicators among females and identifying the features of physical development characteristic of the studied territory. According to the results of our study, the body weight deficit and asthenization of the body in females were revealed.

Localising the ‘Characteristic Town’: A Socio-Spatial Framework for Understanding the Everyday Rural Urbanisation of China’s Hinterlands

The shift towards an urbanised world is generating profound social, economic, and environmental complexities. Agglomerating regions require new understandings to capture the socio-spatial restructuring of this planetary urbanisation. In China, top-down rural urbanisation policies such as the Characteristic Town, or tese xiaozhen, address urban-rural polarisation through a ‘one-town-one-characteristic-industry’ model aiming to generate localised rural economic development. Characteristic Towns have been criticised as only superficially addressing local challenges, imposing tabula-rasa developments that extend urbanisation into rural areas, excluding vulnerable groups. Within the mega-urban Yangtze River Delta corridor, the Smart Moulding Town in Huangyan-Taizhou’s hinterland is leading regional industrial upgrading processes, epitomising visions of politicians, planners, and developers. The urban-rural interface is undergoing a fragmented transition towards industrialisation while villagers adapt their local economies and everyday practices, generating new socio-spatial typologies for dwelling. This inductive research reveals the role of villagers in shaping, and being shaped by, top-down rural urbanisation programs. The multi-scalar theoretical framework is structured around private, collective, and institutional layers of dwelling, interrogated through Lefebvre’s spatial production theory. Uncovering hybrid urban-rural qualities and actor networks, the empirical findings illustrate that villagers’ micro-scale tactics are deeply embedded in trans-local industrialisation processes, redefining rural identities and defying top-down spatial compartmentalisation by negotiating informality.

Trends in a natural product fucoxanthin

Fucoxanthin is a xanthophyll pigment which occurs in marine brown seaweeds (macroalgae), diatoms and several microalgae species. It forms with chlorophyll a-c and several proteins, a major fucoxanthin-chlorophyll a/c complex, which transfers light energy to the photosynthesis center and plays a major role in light harvesting. Recent studies have reported that fucoxanthin has many physiological functions and biological effects, such as anti-obesity, antidiabetic, anti-inflammatory, anticancer and cardiovascular system protection. Therefore, this pigment is highly preferred for the prevention and treatment of various chronic diseases. In addition, potential applications of high value fucoxanthin can be found in cosmetic, food and feed industries. In this review paper, the historical development, characteristic properties and possible sources of fucoxanthin are extensively described. The potential biological activities of fucoxanthin are also discussed. Finally, brief overview of common applications and market analysis of commercial fucoxanthin are also reported.

Identification and Validation of Two Lung Adenocarcinoma-Development Characteristic Gene Sets for Diagnosing Lung Adenocarcinoma and Predicting Prognosis

Background: Lung adenocarcinoma (LUAD) is one of the main types of lung cancer. Because of its low early diagnosis rate, poor late prognosis, and high mortality, it is of great significance to find biomarkers for diagnosis and prognosis.Methods: Five hundred and twelve LUADs from The Cancer Genome Atlas were used for differential expression analysis and short time-series expression miner (STEM) analysis to identify the LUAD-development characteristic genes. Survival analysis was used to identify the LUAD-unfavorable genes and LUAD-favorable genes. Gene set variation analysis (GSVA) was used to score individual samples against the two gene sets. Receiver operating characteristic (ROC) curve analysis and univariate and multivariate Cox regression analysis were used to explore the diagnostic and prognostic ability of the two GSVA score systems. Two independent data sets from Gene Expression Omnibus (GEO) were used for verifying the results. Functional enrichment analysis was used to explore the potential biological functions of LUAD-unfavorable genes.Results: With the development of LUAD, 185 differentially expressed genes (DEGs) were gradually upregulated, of which 84 genes were associated with LUAD survival and named as LUAD-unfavorable gene set. While 237 DEGs were gradually downregulated, of which 39 genes were associated with LUAD survival and named as LUAD-favorable gene set. ROC curve analysis and univariate/multivariate Cox proportional hazards analyses indicated both of LUAD-unfavorable GSVA score and LUAD-favorable GSVA score were a biomarker of LUAD. Moreover, both of these two GSVA score systems were an independent factor for LUAD prognosis. The LUAD-unfavorable genes were significantly involved in p53 signaling pathway, Oocyte meiosis, and Cell cycle.Conclusion: We identified and validated two LUAD-development characteristic gene sets that not only have diagnostic value but also prognostic value. It may provide new insight for further research on LUAD.

THE ESSENCE OF SOCIAL AND COMMUNICATIVE COMPETENCE OF THE INDIVIDUAL

Социально-коммуникативная компетентность личности является важнейшей чертой каждого индивида в современном мире. Совершенствование данного качества легло в основу развития инновационных идей, передовых технологий, современных теорий, неометодик. Социально-коммуникативная компетентность личности является неотъемлемой способностью индивида в построении правильного, рационального, эффективного, успешного контакта с другими людьми, а также входит в понятие «человеческая культура». Целью развития данной способности является не столько замена «естественного» опыта другим, более эффективным, но и организация, точнее, помощь в самоорганизации более эффективных способов освоения богатства коммуникативной культуры. Раскрываются сущность социально-коммуникативной компетентности личности, ее компоненты, уровни развития; указываются признаки людей, обладающих данным навыком коммуникации. Развитие социально-коммуникативной компетентности личности осуществляется при помощи различных методик и технологий. Представлены приемы становления данной компетентности. Теоретическая значимость исследования определяется выявлением новых проблем торможения развития социально-коммуникативной компетенции личности. Практическая значимость обусловлена возможностью использования новых методик развития данного качества. Social and communicative competence of a person is the most important feature of every individual in the modern world. The improvement of this quality formed the basis for the formation of innovative ideas, advanced technologies, modern theories, and neo-methods. Social and communicative competence of a person is an integral ability of an individual to build correct, rational, effective, successful formation of contacts with other people, and is also included in the concept of “human culture”. In the modern world, the purpose of the development of this ability is not so much the replacement of “natural” experience with another, more effective one, but also the organization, more precisely, assistance in selforganization of more effective ways of mastering the wealth of communicative culture. The article reveals the essence of the social and communicative competence of a person, its components, levels of development; characteristic features of people with this communication skill are indicated. The development of a person’s social and communicative competence is carried out using various methods and technologies; the study presents the methods of its formation. The theoretical significance of the study is determined by the identification of new problems of inhibition of the development of social and communicative competence of the individual. The practical significance of the article is due to the possibility of using new methods for the development of this quality.

Print-Based Learning Media

The purpose of this paper is to identify about the print-based media learning. The paper discusses about the development, characteristic, types and the advantages disadvantages of the print based media learning. In a teaching and learning process, two very important elements are teaching methods and learning media. These two aspects are interrelated. The choice of a particular teaching method will affect the appropriate type of learning media, although there are various other aspects that must be considered in choosing learning media, including learning objectives, types of tasks and responses expected by students and student characteristics. Even so, it can be said that one of the main functions of learning media is as a teaching aid that influences the climate, conditions, and learning environment that are organized and created by the teacher.

Deutsch als schwächere Sprache bei deutsch-polnisch bilingualen Kindern: Studie zur Negation- und Verbstellung

This article examines the acquisition of German as the weaker language in the cases of German-Polish bilingual children. Focusing on negation and verb position, phenomena that have frequently been taken as diagnostic when distinguishing between the course of language development characteristic for first (L1) and second language acquisition (L2), we analyse experimental and productive data from six simultaneously bilingual children. Due to the constrained input, German is their weaker language. The results in Forced Choice and Grammaticality Judgements tasks are compared with the results of monolingual children. We show that in the area of negation the acquisition of German as the weaker language resembles L1, and in the area of inversion and verb final position the development of the weaker language is delayed. The striking difference between bilinguals’ results in the experimental vs. productive tasks points to specific processing mechanisms in bilingual language use. In narrative contexts of the production tasks the language of the performance is activated, while the other is inhibited, which leads to a target-like performance. Structural properties of the stronger language tend to be activated, however, in the experimental tasks involving the weaker language, resulting in non-target-like responses.

Identification and validation of two LUAD-development characteristic gene sets for diagnosing lung adenocarcinoma and predicting prognosis

Purpose Lung adenocarcinoma (LUAD) is one of the main types of lung cancer, the low rates for early diagnosis and a bad prognosis for advanced stage lead to a higher mortality rate. Therefore, it is of great significance to identify the related genes that promote its development.Patients and methods 512 LUADs from The Cancer Genome Atlas were used to performed differentially expressed gene (DEG) analysis and short-term time-series expression miner to identify the LUAD-development characteristic gene sets. Survival analysis was applied to identified LUAD-unfavorable gene set and LUAD-favorable gene set. Gene set variation analysis (GSVA) was performed to score individual samples against the two gene sets. ROC curve analysis, univariate and multivariate cox regression analysis were used to evaluate the diagnostic and prognostic value of the two GSVA score systems. Two independent data sets from GEO were used for verifying the results. Functional enrichment analysis was used to explore the potential biological functions of LUAD-unfavorable gene set.Results With the development of LUAD, 185 DEGs were gradually up-graduated, including 84 genes associated with survival and classed as LUAD-unfavorable gene set; 237 DEGs were gradually down-graduated, including 39 genes associated with survival and classed as LUAD-favorable gene set. ROC curve analysis and univariate/multivariate Cox proportional hazards analyses indicated both of LUAD-unfavorable GSVA score and LUAD-favorable GSVA score were biomarkers for diagnosing LUAD and independent biomarkers for predicting prognosis. The LUAD-unfavorable genes were involved in multiple cancer-related pathways, such as p53 signaling pathway and cell cycle.ConclusionWe identified and validated two LUAD-development characteristic gene sets that not only have diagnostic value but also prognostic value. It may provide new insight for further research on LUAD.