A Combinatorial Approach to Reliable Quantitative Analysis of Small Nano-Sized Precipitates: A Case Study with α′ Precipitates in Fe–20 at% Cr Alloy

The quantitative characterization of small nano-sized precipitates poses genuine challenges and is often deficient in accuracy due to the inherent limitations inevitably associated with the individual experimental techniques. A convenient solution is to utilize multiple complementary techniques. The present work demonstrates an effective way to reliably quantify nano-sized precipitates using a combination of complementary techniques of atom probe tomography (APT), small angle neutron scattering (SANS), and transmission electron microscopy (TEM). As a case study, the size (radius, r), number density (NP), volume fraction (ϕ), and chemical composition of Cr-rich α′ precipitates are determined in Fe–20 at% Cr alloy, thermally aged at 773 K for 1,000 h. This combinatorial approach utilizes the strength of each technique in such a way that the overall accuracy of quantitative precipitation analysis improves significantly. For example, the superior spatial resolution makes TEM the appropriate technique to estimate the size and size distribution of the precipitates, while APT provides the chemical composition. Similarly, SANS analysis incorporates both the size and the compositional information thus derived independently and provides statiscally averaged quantitative analysis overcoming the field-of-view limitations of both TEM and APT. This combinatorial approach improves the accuracy of quantification and provides the true representation of the microstructure.

A real-world study of wearable sensors in Parkinson’s disease

Most wearable sensor studies in Parkinson’s disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observational study, we assessed motor features using wearable sensors developed by MC10, Inc. Participants wore five sensors, one on each limb and on the trunk, during an in-person clinic visit and for two days thereafter. Using the accelerometer data from the sensors, activity states (lying, sitting, standing, walking) were determined and steps per day were also computed by aggregating over 2 s walking intervals. For non-walking periods, tremor durations were identified that had a characteristic frequency between 3 and 10 Hz. We analyzed data from 17 individuals with Parkinson’s disease and 17 age-matched controls over an average 45.4 h of sensor wear. Individuals with Parkinson’s walked significantly less (median [inter-quartile range]: 4980 [2835–7163] steps/day) than controls (7367 [5106–8928] steps/day; P = 0.04). Tremor was present for 1.6 [0.4–5.9] hours (median [range]) per day in most-affected hands (MDS-UPDRS 3.17a or 3.17b = 1–4) of individuals with Parkinson’s, which was significantly higher than the 0.5 [0.3–2.3] hours per day in less-affected hands (MDS-UPDRS 3.17a or 3.17b = 0). These results, which require replication in larger cohorts, advance our understanding of the manifestations of Parkinson’s in real-world settings.

Role of non-state organizations in strengthening social capital: case study of Mansehra district of KP province, Pakistan

The building of functional linkages between non-profit/non-state organizations and other collaborators at various levels is a necessity to benefit the welfare of the rural poor. Pakistan is also embracing its inclusion in the list of economies that are considered to have weak social capital. Strengthening of social capital has a valuable contribution by the NGOs especially in the rangelands of Pakistan. The current study is designed to examine the role of non-governmental and non-state organizations in building up social capital. Data were taken from three different localities in the Mansehra district of Hazara region in Pakistan adopting qualitative and quantitative approaches. A weak organizational infrastructure in terms of horizontal and vertical principles (transparency, viability, integrity, accountability etc.) was found in all three study areas. The access to social capital at sites I II obtained 1.98 and 1.78 respectively and residents of site III were found deprived. The study showed that rural people with low income (often referred to as poor) have lower social incomes compared to people with high- and medium-income levels (often referred as well off and better off). The limitations of time availability and social confidence results in no contact or social interaction among poor. A significant role of NGOs has been observed in bringing poor and oppressed people into mainstream social capital. The study delineates the increased involvement of registered and unregistered local groups/organizations in the development of rural community. Findings of the research also conclude that local community groups are more vital than that of the registered organizations due to their informal culture and true representation of practical needs of the community. The volunteers played an important role in creating social grants, and their inclusion in the form of a comprehensive social capital plan will result in refinement of services and overall betterment of society.

Public views of coronavirus science and scientists: findings from a cross-sectional survey

Background: Throughout the coronavirus pandemic, references to scientific findings have permeated public-facing communications. Understanding how members of the public view science, scientists and scientific uncertainty should enhance approaches to communication and individuals’ decisions to engage with public health measures, including restrictions and vaccination programmes. Methods: A survey was conducted on our behalf by YouGov in November 2020. The survey asked about: level of public trust in scientists and scientific information; changes in trust between March and November 2020; views about communication of scientific uncertainty; confidence in the accuracy of scientific findings; and views about whether public information is an accurate representation of coronavirus science. Results: The sample comprised 2,025 individuals living in England; 40.5% were ≥55 years old, 51.1% were female, and 12.3% identified as members of an ethnic minority/mixed ethnicity. Here, we present descriptive statistics across six key variables: age, gender, ethnicity, keyworker status, shielding status, and coronavirus exposure. Trust was highest among older respondents and those who identified as of white ethnicity. The concurrent (November 2020) levels of reported trust in scientific information about coronavirus were generally lower than those reported retrospectively for the start of the pandemic (March 2020). There was higher trust and positivity about science among people who had been shielding and among those who had not contracted coronavirus. Around half of respondents did not think that the uncertainty in science was conveyed much or at all, most were confident in the accuracy of coronavirus science, and around half thought that public information was a true representation of the science. Conclusions: Our study indicates that there is room to improve trust and communication in science. As well as detailed analyses to account for inter-relationships, further research could examine reasons behind change in trust over time and any persisting patterns by age, ethnicity, and shielding status.

Polyisobutylene and Silicone in Warm Edge Glazing Systems—Evaluation of Long-Term Performance

This article describes the characteristics of one type of sealing system used in warm edge glazing units and analyses the possible causes of damage. Attention was focused on the performance of the dual seal, PIB/silicone system. This type of glazing is widely used for modern curtain walls and roofs of office buildings and shopping centres. Study was focused on PIB displacement defects, which affects both the appearance and thermal performance of the curtain wall system. Wide-ranging field surveys were conducted to examine the problems identified in some office buildings. The information gathered in this way was used to identify the critical areas and causes of seal displacement in the analysed insulating glass units (IGUs). Laboratory tests were conducted on PIB and silicone seals retrieved from the removed defective units. The properties of these materials were determined and used to evaluate the applied edge sealing system and build a representative numerical model. Due to the problems encountered in deriving accurate analytical formulas, finite element (FE) approximation was used as a problem solving tool. The generated FE model and strain analysis were the key parts to obtaining a true representation of the actual behaviour of IGUs subjected to various environmental loads, taking into account the influence of the air cavity. Results of computer simulations and laboratory tests were compared for model validation. The effect of changes in ambient pressure was examined, showing the development of tensile strains in the silicone and PIB, which can lead to debonding. The greatest principal strains occur at the silicone/butyl rubber interface and this location should be considered to be the most susceptible to failure. The observations are summarised in the final conclusions. Additionally, as field study showed, after ten years in service, the percentage of damaged units is considerable. More frequent IGUs inspection should cover both appearance and thermal imaging to detect unsealed panels. From the standpoint of both durability and appearance, dual silicone/PIB should be phased out in favour of modern seal systems.

ADMINISTRATIVE FAILURE TO CURB SECTARIANISM WHILE BRINGING SOCIAL REINTEGRATION INTO WAR-TORN AREA OF DISTRICT HANGU, PAKISTAN

Purpose of the study: The present study highlights the administrative causing institutional intra-faith disintegration and its revival to social reintegration in district Hangu-Pakistan. Methodology: The study proceeded with a sound conceptual framework comprised of the independent variable, i.e., administrative failure to curb sectarianism, and dependent variable, i.e., "social reintegration," bypassing these through a sound statistical operationalization, i.e., chi-square and factor analysis, respectively. A sample size of 306 representing all leading categories of the study was chosen by stratified random sampling procedure to ensure the true representation of the masses living in the study area. Main Findings: The study disclosed that administrative failure had a strong and significant relationship with disintegration as causative factors and had been identified as a catalyst towards the social reintegration provided. Both literate and illiterate are taken into consideration for their involvement in the reintegration process while restructuring the administrative state of the area, as pointed out by the literate respondents. Applications of this study: The study recommended that the government should take initiatives by indulging all the stakeholders for greater social inclusion in the study arena, allowing both sects to participate in the common values under the ambit of Islam. A policy of non-interference by the state of Pakistan needs to be designed and communicated accordingly to all forces involving particular reference to the neighboring states. Novelty/Originality of this study: To the best of my knowledge, little empirical work in this area has been conducted in the Pakistani context. Thus, this study will be helpful in policy planning on both local and international levels.

Data Cleaning Needs and Issues: A Case Study of the National Reproductive Health Assessment (RHA) Data from Solomon Islands

Data cleaning is an essential part of any research work without which the validity and reliability of the data could come under the spotlight. Aim: to document common errors found during the cleaning of datasets and suggests ways of minimizing errors during data entry process, reducing human errors throughout data cleaning. Design and Setting: a case study based on the national Reproductive Health Assessment (RHA) data conducted in Solomon Islands in 2013. Objective: The main objective of the Solomon Islands RHA was to establish the health status of reproductive aged women between the ages of 15 – 49 for the Solomon Islands. Method: data was collected using questionnaires and entered on to the SPSS database in the country by the local Solomon Islands research assistants who were trained by the Pacific Sexual and Reproductive Health Research Center (PSRHRC). The data was brought back to Fiji where the cleaning process took place. Results: findings of this case study showed that there were issues with the standardization of databases, database familiarization and data merging. Conclusion: more training is needed for researchers who are involved in data collection, data entry and data cleaning to minimize such errors which could give results which may not be a true representation of the indented study.

Epistemic logic: All knowledge is based on our experience, and epistemic logic is the cognitive representation of our experiential confrontation in reality

Epistemic Logic is our basic universal science, the method of our cognitive confrontation in reality to prove the truth of our basic cognitions and theories. Hence, by proving their true representation of reality we can self-control ourselves in it, and thus refuting the Berkeleyian solipsism and Kantian a priorism. The conception of epistemic logic is that only by proving our true representation of reality we achieve our knowledge of it, and thus we can prove our cognitions to be either true or rather false, and otherwise they are doubtful. Therefore, truth cannot be separated from being proved and we cannot hold anymore the principle of excluded middle, as it is with formal semantics of metaphysical realism. In distinction, the intuitionistic logic is based on subjective intellectual feeling of correctness in constructing proofs, and thus it is epistemologically encapsulated in the metaphysical subject. However, epistemic logic is our basic science which enable us to prove the truth of our cognitions, including the epistemic logic itself.

Possessing reasons: why the awareness-first approach is better than the knowledge-first approach

In order for a reason to justify an action or attitude it must be one that is possessed by an agent. Knowledge-centric views of possession ground our possession of reasons, at least partially, either in our knowledge of them or in our being in a position to know them. On virtually all accounts, knowing P is some kind of non-accidental true belief that P. This entails that knowing P is a kind of non-accidental true representation that P. I outline a novel theory of the epistemic requirement on possession in terms of this more general state of non-accidental true representation. It is just as well placed to explain the motivations behind knowledge-centric views of possession, and it is also better placed to explain the extent of the reasons we possess in certain cases of deductive belief-updates and cases involving environmental luck. I conclude with three reflections. First, I indicate how my arguments generate a dilemma for Errol Lord’s (2018a) view that possessing reasons is just a matter of being in a position to manifest one’s knowledge how to use them. Second, I explain how my view can simultaneously manage cases of environmental luck without falling prey to lottery cases. Finally, I sketch the direction for a further range of counterexamples to knowledge-centric theories of possession.