Myopericytoma of the Parotid and Molecular Profiling: Report of a Rare Case and Review of the Literature

Myopericytomas are uncommon tumors defined by their round to spindle shaped cells often arranged in a concentric pattern of perivascular growth. They are typically well-circumscribed, nodular, slow-growing lesions that occur in the soft tissue of the extremities. Here, we present a 30-year-old female with a 2.4 cm myopericytoma occurring in the deep lobe of the parotid gland. The diagnosis was made with detailed histopathologic and immunohistochemical findings and positive identification of the specific mutation for PDGFRβ p.Asp666Lys by next generation sequencing (NGS). This is the first case report of a parotid myopericytoma with a genetic testing that shows a particular mutation that has been linked to myopericytomatosis.

A Study on the Mechanical Properties of 3D Printed PLA Specimens According to Infilled Pattern and Printing Direction

This paper intended to measure the material's rigidity according to the orientation of the PLA specimen produced by the FDM method. To measure the change of strength and stiffness according to the direction of stacking of FDM PLA, the specimen was manufactured and tested not only in the direction of stacking but also infill using line pattern and concentric pattern. The intensity of each direction was 38.11MPa with a 0 degree tensile in the line pattern, 3.45 times higher than 11.9MPa with a 90 degree tensile, and 2.15 times higher shear strength with 28.05MPa and 13.88MPa. In concentric pattern, 0 degree tensile was 50.62MPa, 6.25 times higher than 8.46MPa, and 2.23 times higher in shear strength at 13.52MPa compared to 29.56MPa. The biggest difference in zero-degree concentric pattern tensile was the 37% difference in the 0 degree concentric pattern factor. This shows that the difference in intensity according to direction is more pronounced in concentric patterns than line patterns, and the behavior under load will be similar until the breaking point regardless of the direction.

Effect of Autoclave Pressure and Temperature on Consolidation of Layers and Mechanical Properties of Additively Manufactured (FDM) Products with PLA

In additive manufacturing technologies, fused deposition modelling (FDM) is continuing its advancement from rapid prototyping to rapid manufacturing. However, effective usage of FDM is not performed due to the poor mechanical properties of the 3D-printed components. This drawback restricts their usage in many applications. Much research, such as reinforcing 3D-printed parts with fibers, changing printing parameters (infill density, infill concentration, extrusion temperature, nozzle diameter, layer thickness, raster angle, etc.) are aimed to increase the mechanical properties of 3D-printed parts. This research paper aims to investigate the effect of pressure and temperature on the mechanical properties and consolidation of layers of 3D-printed PLA (Polylactic Acid). Post-treatment was done using a customized autoclave. Autoclave has the capability to maintain 185 °C and 135 bar pressure. Three-dimensional-printed specimens were manufactured using the FDM process with two patterns. Later, the specimens were subjected to various post-treatment processes, then followed with testing and analysis of mechanical properties. Post-treatment process carried out by placing them in an autoclave at certain pressure and temperature conditions. To investigate the repeatability and tolerances, the test series includes a minimum of four to six test specimens. The results indicate that the concentric pattern yields the most desirable tensile, impact, and flexural strength due to the alignment of deposited rasters and better consolidation of layers with the loading direction. The pressure and temperature of the autoclave has a positive effect on the PLA samples, which helped them to reorganize the structure, hence strength properties were enhanced. The test results also compared with injection-molded samples for better understating.

Cytogenetic events in the endosperm of amphiploid Avena magna × A. longiglumis

This study analysed cytogenetic events occurring in the syncytial endosperm of the Avena magna H. C. Murphy & Terrell × Avena longiglumis Durieu amphiploid, which is a product of two wild species having different genomes. Selection through the elimination of chromosomes and their fragments, including those translocated, decreased the level of ploidy in the endosperm below the expected 3n, leading to the modal number close to 2n. During intergenomic translocations, fragments of the heterochromatin-rich C-genome were transferred to the D and Al genomes. Terminal and non-reciprocal exchanges dominated, whereas other types of translocations, including microexchanges, were less common. Using two probes and by counterstaining with DAPI, the A. longiglumis and the rare exchanges between the D and Al genomes were detected by GISH. The large discontinuity in the probe labelling in the C chromosomes demonstrated inequality in the distribution of repetitive sequences along the chromosome and probable intragenomic rearrangements. In the nucleus, the spatial arrangement of genomes was non-random and showed a sectorial-concentric pattern, which can vary during the cell cycle, especially in the less stable tissue like the hybrid endosperm.

Comparative Surface Imaging Study of Multifocal Diffractive Intraocular Lenses

Purpose To analyse and compare the surface topography and roughness of three different types of diffractive multifocal IOLs. Methods Using scanning electron microscope (SEM, Inspect F, 5.0 KV, maximum magnification up to 20,000) and atomic force microscope (AFM, Park Systems, XE-100, non-contact, area profile comparison, 10 × 10 µm, 40 × 40 µm), the surface quality of the following diffractive IOLs was studied: the AcrySof IQ PanOptix (Alcon, USA), the AT LARA 829MP (Carl Zeiss Meditec, Germany), and Tecnis Symfony (Johnson&Johnson Vision, USA). The measurements were made over three representative areas (central non-diffractive optic, central diffractive optic, and diffractive step) of each IOL. Roughness profile in terms of mean arithmetic roughness (Ra) and root-mean-squared roughness (Rq) values were obtained and compared statistically. Results In SEM examination, all IOLs showed a smooth optical surface without any irregularities at low magnification. At higher magnification, Tecnis Symfony showed unique highly regular, concentric, and lineate structures in the diffractive optic area which could not be seen in the other studied diffractive IOLs. The differences in the measured Ra and Rq values of the Tecnis Symfony were statistically significant compared to the other models (p < 0.05). Conclusion Various different topographical traits were observed in three diffractive multifocal IOLs. The Ra values of all studied IOLs were within an acceptable range. Tecnis Symfony showed statistically significant higher surface Ra values at both central diffractive optic and diffractive step areas. Furthermore, compared to its counterparts, Tecnis Symfony demonstrated highly ordered, concentric pattern in its diffractive surfaces.

Cytogenetic events in the endosperm of amphiploidAvena maroccana×A. longiglumis

This study analysed cytogenetic events occurring in the syncytial endosperm of theAvena maroccanaGand. ×Avena longiglumisDur. amphiploid, which is a product of two wild species having different genomes. Selection through the elimination of chromosomes and their fragments, including those translocated, decreased the level of ploidy in the endosperm below the expected 3n, leading to the modal number close to 2n. During intergenomic translocations, fragments of the heterochromatin-rich C-genome were transferred to the A and Al genomes. Terminal and non-reciprocal exchanges dominated, whereas other types of translocations, including microexchanges, were less common. Using two probes and by counterstaining with DAPI, theA. longiglumisand the rare exchanges between the A and Al genomes were detected by GISH. The large discontinuity in the probe labelling in the C chromosomes demonstrated inequality in the distribution of repetitive sequences along the chromosome and probable intragenomic rearrangements. In the nucleus, the spatial arrangement of genomes was non-random and showed a sectorial-concentric pattern, which can vary during the cell cycle, especially in the less stable tissue like the hybrid endosperm.

Improved Climatology of Tropical Cyclone Precipitation from Satellite Passive Microwave Measurements

Accurate precipitation climatology is presented for tropical depression (TD), tropical storm (TS), and tropical cyclone (TC) over oceans using the recently-released, consistent and high quality precipitation datasets from all passive microwave sensors covering 1998-2012 along with the Automated Rotational Center Hurricane Eye Retrieval (ARCHER)-based TC center positions. Impacts with respect to the direction of both TC movement and the 200-850 hPa wind shear on the spatial distributions of TC precipitation are analyzed. The TC eyewall contraction process during its intensification is noted by a decrease in the radius of maximum rainrate with an increase in TC intensity. For global TCs, the maximum rainrate with respect to the direction of TC movement is located in the down-motion quadrants for TD, TS, and Cat 1-3 TCs, and in a concentric pattern for Cat 4-5 TCs. A consistent maximum TC precipitation with respect to the direction of the 200-850 hPa wind shear is shown in the down shear left quadrant (DSLQ). With respect to direction of TC movement, spatial patterns of TC precipitation vary with basins and show different features for weak and strong storms. The maximum rainrate is always located in DSLQ for all TC categories and basins, except the Southern Hemisphere basin where it is in the down shear right quadrant (DSRQ). This study not only confirms previously published results on TC precipitation distributions relative to vertical wind shear direction, but also provides a detailed distribution for each TC category and TS, while TD storms display an enhanced rainfall rate ahead of the down shear quadrants.

Measuring Changes in Residential Segregation in São Paulo in the 2000s

Residential segregation is known as one of the most prevalent problems of Latin American and Brazilian cities. This chapter looks into the changes in segregation levels in the Metropolitan Region of São Paulo between 2000 and 2010. This period was marked by economic growth and decreasing social inequalities in Brazil with consequent improvement to the quality of life of lower income classes. Despite those improvements, general patterns of urban segregation in Brazilian cities showed remarkable stability, albeit with important changes in the details of segregation patterns. This chapter explores the spatial relationship between socio-occupational groups using global and local segregation indices. The analysis confirmed a highly segregated distribution of social groups in the Metropolitan Region and revealed increased levels of segregation, with global indices figures for 2010 higher than for 2000. Analysis demonstrated that peripheral areas of the Metropolitan Region became more fragmented and heterogeneous in that period, and revealed that their increased heterogeneity is mainly composed of classes with close social proximity, rather than polarised ones. Results showed that while middle classes became more integrated amongst themselves and with lower classes, the separation between lower and upper classes was not only maintained but also increased during the period. All these findings suggest a reconfiguration of the concentric pattern of segregation that maintained a spatial structure of strong social isolation during the period, although with greater complexity.

TATA RUANG IBUKOTA TERAKHIR KERAJAAN GALUH (1371 - 1475 M)

Penelitian ini bertujuan untuk menguak tata ruang Galuh Pakwan sebagai ibukota terakhir Kerajaan Galuh, sejauhmana pola ruang kota tersebut berkaitan dengan nilai-nilai kelokalan sebagaimana tergambar dalam historiografi tradisional. Dalam penelitian ini metode sejarah akan dipergunakan sebagai fitur utama agar menghasilkan suatu hasil kajian yang komprehensif, dan menggunakan teori tata kota, serta metode deskriptif-kualitatif. Minimnya sumber terkait sejarah Galuh Pakwan, wawancara secara mendalam kepada para narasumber diharapkan bisa menjadi suatu bahan analisis historis. Berdasarkan fakta di lapangan, Galuh Pakwan sebagai ibukota kerajaan berawal dari sebuah kabuyutan. Pada masa pemerintahan Niskalawastu Kancana, kabuyutan tersebut dijadikan pusat politik dengan tetap menjalankan fungsi kabuyutannya. Seiring waktu, Galuh Pakwan menjelma menjadi sebuah kota yang tata ruangnya menunjukkan representasi dan implementasi konsep kosmologi Sunda. Galuh Pakwan terbentuk oleh pola radial-konsentris menerus, sebagai gambaran kosmologi Sunda sebagaimana terungkap dalam naskah-naksah Sunda kuna.The research is not only aimed at uncovering the spatial layout of Galuh Pakwan as the last capital of Galuh Kingdom, but also at exploring how well the relationship between the urban spatial patterns and the local values as depicted in the traditional historiography. Beside having the historical methods as the main feature to produce a comprehensive study result, the study also uses the urban planning theory, as well as the descriptive qualitative methods. The historical sources related to the history of the Galuh Pakuan are very limited. As a result, the in-depth interviews with the resource persons are expected to be appropriate as the observation material for historical analysis. Based on the facts found in the field, the Galuh Pakwan as the capital of the kingdom originated from a Kabuyutan. During the reign of Niskalawastu Kancana, Kabuyutan served as a political center while maintaining its original function as Kabuyutan. As the time passed, the Galuh Pakwan was transformed into a city whose spatial layout represented and implemented the Sundanese cosmological concept. The Galuh Pakwan was formed by a continuous radial-concentric pattern, as a description of Sundanese cosmology in the ancient Sundanese manuscript.

RESIDENTIAL DIFFERENTIATION AT TWO GEOGRAPHIC SCALES – THE METROPOLITAN AREA AND THE CITY: THE CASE OF TEL AVIV

The research of residential differentiation in cities is concentrated on one geographic scale such as metropolitan areas, cities, or counties. As a result, we have relatively little information regarding the extent of residential differentiation and its spatial pattern at different geographic scales. This paper examines the residential differentiation within the socio-spatial structure of the Tel Aviv metropolitan area as it was in 1995. The analysis is conducted at two geographic scales. The first analyzes the entire metropolitan area as one spatial entity; the second examines the 22 cities located within that area. We applied the method of classical factorial social ecology to investigate residential differentiation along the social dimensions of ethnicity, socio-economic status and family status (stage in the family life cycle) in their spatial expression at the metropolitan and city geographic scales. The findings indicated that residential differentiation in the metropolitan area and in cities tends to be dominated by the ethnic dimension, which is most closely associated with the socio-economic dimension. The relative independence of family status enables the formation of socially diverse residential areas which are often organized in nearly a sectoral-concentric pattern. In general, residential differentiation was more significant at the geographic scale of cities.