RF and microwave diagnostics for compact plasma traps and possible perspectives for fusion devices

Plasma diagnostics is a topic having a great impact on R&D in compact ion sources as well as in large fusion reactors. Towards this aim, non-invasive microwave diagnostics approaches, such as interferometric, polarimetric and microwave imaging profilometric techniques can allow obtaining volumetric, line-integrated or even space-resolved information about plasma electron density. Special probes can be also designed and implemented in order to characterize external and/or self-generated radio-waves in the plasmas. In particular, the design, construction and operation of a K-band microwave interferometry/polarimetry setup based on the Frequency-Modulated Continuous-Wave (FMCW) method at INFN-LNS will be described: this tool provides reliable measurements of the plasma density even in the extreme unfavorable wavelength-to-plasma scale ratio in plasma-based ion sources. A “frequency sweep” and a post-processing filtering method (for interferometry and polarimetry, respectively) were used to filter out the multipath contributions or cavity induced depolarizations in the detected signals. Besides this, the use of the aforementioned RF plasma-immersed probes will also be discussed, which allow measuring local E-fields and fast temporal response in order to characterize turbulent (through kinetic instabilities, cyclotron maser emission, etc.) vs. stable plasma regimes. An analysis based on wavelet transform applied to measurements of plasma radio self-emission in B-minimum and simple mirror traps will be presented. These tools and methods have the potential to be applied to plasma machines both in compact traps and large-size reactors with a proper scaling.

Beneficial Effects of Slow-Release Large Neutral Amino Acids after a Phenylalanine Oral Load in Patients with Phenylketonuria

The mainstay of phenylketonuria treatment is a low protein diet, supplemented with phenylalanine (Phe)-free protein substitutes and micronutrients. Adhering to this diet is challenging, and even patients with good metabolic control who follow the dietary prescriptions in everyday life ignore the recommendations occasionally. The present study explores the ability of slow-release large neutral amino acids (srLNAAs) to prevent Phe increase following a Phe dietary load. Fourteen phenylketonuric patients aged ≥13 years were enrolled in a 6-week protocol. Oral acute Phe loads of 250 and 500 mg were added to the evening meal together with srLNAAs (0.5 gr/kg). Phe and tyrosine were dosed before dinner, 2h-after dinner, and after the overnight fast. After oral Phe loads, mean plasma Phe remained stable and below 600 µmol/L. No Phe peaks were registered. Tyrosine levels significantly increased, and Phe/Tyrosine ratio decreased. No adverse events were registered. In conclusion, a single oral administration of srLNAAs at the dose of 0.5 gr/kg is effective in maintaining stable plasma Phe during acute oral loads with Phe-containing food and may be added to the dietetic scheme in situations in which patients with generally good adherence to diet foresee a higher than prescribed Phe intake due to their commitments.

Properties of toroidal magnetic fields in axial plasma flow on the PF-1000U plasma focus facility

This paper presents the results of studies of plasma flow parameters on the PF-1000U facility. A distinctive feature of this facility is the ability to create profiled initial gas distributions using gas puffs. In the experiments described, a combined system for filling the vacuum chamber with a working gas was used, in which an additional injection of various gases (deuterium, helium, neon and their mixtures) into the axial region of the chamber prefilled with deuterium was performed using a pulse valve. Thus, both the pinching processes and, accordingly, the generation of axial plasma flows and the conditions of their propagation in the background gas of the facility chamber were affected. Regimes with the generation of compact stable plasma formations propagating over long distances were found. The results obtained can be used in laboratory modelling of astrophysical jets from young stellar objects.

Stable Plasma Sample Storage in Acetonitrile for Angiotensin and Aldosterone Analysis

Background Angiotensin I, II (AI, AII) and aldosterone are unstable in plasma specimens at room temperature, making it difficult for collect samples for remote regions in centralized and collaborative studies. Here we introduce a stable storage method which do not require cold conditions.. Methods Acetonitrile was added to the plasma to 60%, and then the supernatants were kept at 4°C and room temperature for 0, 1, 2, 3, 10 and 30 days. AI, AII and aldosterone were extracted and analyzed by chemiluminescence immunoassays. Results AI, AII and aldosterone were well retained in the supernatant under this method. The intra- and inter-day CVs of this method were all below 10%. The levels of AI, AII and aldosterone by this method remained stable for 30 days at room temperature. Conclusion Addition of 60% acetonitrile in the plasma provides a stable storage method for clinical AI, AII and aldosterone.

Integration of molecular profiles in a longitudinal wellness profiling cohort

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

LOCAL MECHANICAL PROPERTIES OF ATMOSPHERIC SPRAYED MOLYBDENUM COATINGS DEPOSITED WITH CASCADED PLASMA TORCH

Increasing interest for industrial use of thermally sprayed coatings leads to development in most thermal spraying technologies, including atmospheric plasma spraying (APS). The latest cascaded torch SinplexPro from Oerlikon Metco incorporates the efficiency advantages of cascaded arc technology into a single-cathode spray gun. It leads to more stable plasma arc across a wide range of gas flows, mixtures and pressures and also highly increases powder throughput. Thermal sprayed molybdenum coatings are widely used for improving wear resistance and sliding properties in many mechanical applications. Results of pure molybdenum coatings sprayed with cascaded plasma torch are not yet fully investigated. In this paper, mechanical properties of atmospheric plasma sprayed molybdenum coatings on steel (S235) substrate are evaluated. Optimization of spraying parameters for spherical Mo powder sprayed by cascaded plasma torch SinplexPro is carried out and the influence on final microstructure, mechanical and tribological properties of molybdenum coatings is analysed.