VITAMIN D3 IN BREAST CANCER PREVENTION: MYTH OR REALITY (literature review)

Vestnik ◽  
2021 ◽  
pp. 285-290
Author(s):  
Б.К. Таракова ◽  
А.С. Култаев ◽  
С.Е. Есентаева ◽  
Ж.К. Жакенова
Keyword(s):  
Breast Cancer ◽  
Vitamin D3 ◽  
Breast Tissue ◽  
Natural Death ◽  
Breast Cells ◽  
The Republic ◽  
Relationship Of ◽  
The Relationship ◽  
Oncological Pathology

В 2018 году в Республике Казахстан было зарегистрировано 4648 новых случая рака молочной железы (РМЖ). Результаты: О взаимосвязи уровня витамина Д3 и риска развития РМЖ свидетельствуют результаты достаточного числа исследований. Женщины с высоким содержанием витамина Д в рационе питания имеют меньший риск развития РМЖ. Положительное противоопухолевое действие витамина Д3 связано с двумя основными механизмами: антипролиферативным эффектом, ингибирующим ростом клеток путем подавления сигналов, стимулирующих рост рецепторов, которые имеются в ткани молочной железы, и проапоптотическим эффектом, способствующим естественной гибели клеток молочной железы. Заключение: Накопленные к настоящему времени данные о роли витамина Д3 в организме человека, взаимосвязи его уровня с развитием и течением онкологической патологии позволяют предположить, что коррекция недостаточного уровня витамина Д3 может быть перспективным направлением в профилактике и комплексном лечении онкологических заболеваний. Introduction: In 2018, 4648 new cases of breast cancer (BC) were registered in the Republic of Kazakhstan. Results: The relationship between the level of vitamin D3 and the risk of developing breast cancer is evidenced by the results of a sufficient number of studies. Women with a high vitamin D diet have a lower risk of developing breast cancer. The positive antitumor effect of vitamin D3 is associated with two main mechanisms: the antiproliferative effect, which inhibits cell growth by suppressing signals that stimulate the growth of receptors present in the breast tissue, and the proapoptotic effect, which promotes the natural death of breast cells. Conclusion: The data accumulated to date on the role of vitamin D3 in the human body, the relationship of its level with the development and course of oncological pathology suggests that the correction of insufficient levels of vitamin D3 may be a promising direction in the prevention and complex treatment of cancer.

scholarly journals Традиции гостеприимства у кряшен в свете автоэтнографии

2021 ◽  
pp. 304-316
Author(s):  
Иван Владимирович Севастьянов
Keyword(s):  
Mutual Influence ◽  
Field Research ◽  
Self Reflection ◽  
Cultural Specificity ◽  
Original Field ◽  
The Republic ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

Статья посвящена анализу особенностей традиции гостеприимства у кряшен, самобытного этноконфессионального сообщества, характеризующегося сочетанием татароязычия и православного вероисповедания. Изыскания автора основываются как на письменных источниках, так и на оригинальных полевых материалах, касающихся преимущественно двух этнографических групп кряшенского населения Республики Татарстан, молькеевской и заказанской, каждая из которых обладает собственной этнокультурной спецификой. Этнографический материал, анализируемый в статье, относится к хронологическому отрезку от рубежа к. XIX – нач. XX вв. до настоящего дня. Ставится задача, во-первых, исследовать проявления гостеприимства в конкретной этнической среде в его функциональных разновидностях; во-вторых, проследить трансформацию этого обычая в условиях современности. Показана саморефлексия автора-исследователя по поводу проблемы взаимовлияния объекта и субъекта изучения (этнографического наблюдения) и роль субъективности в научном постижении иной этнической культуры. Отношения диалога между исследователем и информантом рассматриваются как значимый приоритетный аналитический подход. В этой связи на примере опыта полевой работы в среде кряшенского населения Республики Татарстан выявляется воздействие, которое традиция гостеприимства в ее современном бытовании оказала на полевые исследования ученых-этнологов. Важнейшим ресурсом в процессе работы, по мнению автора, оказались взаимная расположенность и доверие, во многом базирующиеся на обычае гостеприимства. The article is devoted to the analysis of the tradition of hospitality among the Kryashens, an authentic ethno-confessional community, characterized by a combination of the Tatar-speaking and Orthodox faith. The research is based on both written sources and original field materials concerning mainly two ethnographic groups of the Kryashen population of the Republic of Tatarstan – Molkeevskaya and Zakazan, each of them having its own ethno-cultural specificity. The ethnographic material analyzed in the article refers to the period from the turn of the XIX – early XX centuries to the present day. The task is, firstly, to study the manifestations of hospitality in a specific ethnic environment in its functional varieties; secondly, to trace the transformation of this custom in modern conditions. The self-reflection of the author-researcher on the problem of the mutual influence of the object and the subject of study (ethnographic observation), the role of subjectivity in the scientific comprehension of another ethnic culture is shown. Understanding the relationship of the dialogue between the researcher and the informant is considered as a significant analytical approach. In this regard, the experience of fieldwork among the Kryashen population of the Republic of Tatarstan reveals the impact that the tradition of hospitality in its contemporary form had on the field research of ethnologists. Mutual disposition and trust, largely based on the custom of hospitality, turned out to be the most important resource in the process of an ethnological study.

scholarly journals The role of the immune response mediator genes polymorphism in the predisposition to juvenile idiopathic arthritis

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Liliia Sh. Nazarova ◽  
Ksenia V. Danilko ◽  
Viktor A. Malievsky ◽  
Akhat B. Bakirov ◽  
Tatiana V. Viktorova
Keyword(s):  
Immune Response ◽  
Juvenile Idiopathic Arthritis ◽  
Control Group ◽  
Polymorphic Loci ◽  
Republic Of Bashkortostan ◽  
Clinical Variants ◽  
The Republic ◽  
Relationship Of ◽  
The Relationship

Objective ― The aim of the work was to study the contribution of the immune response mediator genes polymorphism (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) to the formation of the predisposition to juvenile idiopathic arthritis (JIA) and its clinical variants. Material and Methods ― The JIA group included 330 patients and the control group – 342 volunteers without autoimmune diseases from the Republic of Bashkortostan, Russia. Genotyping was conducted by the real-time polymerase chain reaction. Results ― Taking into account the differences by sex, it was established, that the alleles/genotypes of the TNFA rs1800629, LTA rs909253, IL2-IL21 rs6822844, PTPN22 rs2476601 polymorphic loci and the TNFA rs1800629*G – LTA rs909253*G haplotype are associated with the development of JIA as a whole (p<0.05); alleles/genotypes of the LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601 polymorphic loci and the TNFA rs1800629*G – LTA rs909253*G haplotype – with some of JIA clinical variants (p<0.05). Conclusion ― In this work, the relationship of the alleles, genotypes and haplotypes of a number of the immune response mediator genes polymorphic loci with the risk of the development of JIA and its clinical variants was established. Specific associations were observed for girls and boys, which indicates the existence of sexual dimorphism in the JIA pathogenesis.

scholarly journals Peranan Pemerintah Daerah di Era Reformasi

Wajah Hukum ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 94
Author(s):  
Mhd Ansori
Keyword(s):  
Public Policy ◽  
Conceptual Approach ◽  
Regional Autonomy ◽  
Historical Approach ◽  
Unitary State ◽  
The Republic ◽  
Relationship Of ◽  
The Relationship ◽  
Supervisory Relations

The republic of Indonesia as a unitary state embraces the principle of decentralization in the administration of goverment, by providing opportunies and freedom to the region to organize regional autonomy. Thus, regional autonomy is a policy that is in accordance with the principle of decentralization within the framework of the unitary state of the Indonesian republic. The real autonomy is the flexibility of the region to exercise the authority of the goverment in certain areas that are real and necessary and growing, living and developing in the regions. Of course this is to realize independence, autonomy is closely related to the pattern of relation between the central and regional which includes various aspects of the relationship of authority, supervisory relations, financial relations, and so forth traditional. Soewargono and Djohan stated that one of the main functions of goverment is to make public policy. The role of goverment is more as a servant of society that does not aim to gain profit rather than fulfill what the bureaucracy’s own will. The purpose of this paper to know the role of local goverment in the current era of reformasi. The type of research used is normative juridical research, using conceptual approach, legislation approach, and historical approach.

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto
Keyword(s):  
Twentieth Century ◽  
Political Crisis ◽  
The Political ◽  
Modern Poetry ◽  
Progressive Politics ◽  
The World ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.

SECTANITY IN THE CONTEXT OF MANIFESTATIONS OF MODERN RELIGIOUS EXTREMISM

2020 ◽  
Author(s):  
Pavel Agapov ◽  
Kirill Stepkin
Keyword(s):  
Russian Federation ◽  
Religious Extremism ◽  
The Russian Federation ◽  
Relationship Of ◽  
The Relationship ◽  
Theoretical Foundations

The article considers the general theoretical foundations of the relationship of sectarianism and religious extremism in the Russian Federation. Practical examples of the role of destructive sects in modern religious extremism in the Russian Federation are given.

The Meaning of the Concept of “Spiritual Energy” in the Philosophy of William James and Henry Bergson

2020 ◽  
Vol 63 (4) ◽  
pp. 115-131
Author(s):  
Maria M. Kuznetsova
Keyword(s):  
Spiritual Development ◽  
William James ◽  
Science And Religion ◽  
Western Philosophy ◽  
Creative Evolution ◽  
Spiritual Energy ◽  
Spiritual Reality ◽  
Relationship Of ◽  
The Relationship

The article examines the philosophy of Henri Bergson and William James as independent doctrines aimed at rational comprehension of spiritual reality. The doctrines imply the paramount importance of consciousness, the need for continuous spiritual development, the expansion of experience and perception. The study highlights the fundamental role of spiritual energy for individual and universal evolution, which likens these doctrines to the ancient Eastern teaching as well as to Platonism in Western philosophy. The term “spiritual energy” is used by Bergson and James all the way through their creative career, and therefore this concept should considered in the examination of their solution to the most important philosophical and scientific issues, such as the relationship of matter and spirit, consciousness and brain, cognition, free will, etc. The “radical empiricism” of William James and the “creative evolution” of Henry Bergson should be viewed as conceptions that based on peacemaking goals, because they are aimed at reconciling faith and facts, science and religion through the organic synthesis of sensory and spiritual levels of experience. Although there is a number of modern scientific discoveries that were foreseen by philosophical ideas of Bergson and James, both philosophers advocate for the artificial limitation of the sphere of experimental methods in science. They call not to limit ourselves to the usual intellectual schemes of reality comprehension, but attempt to touch the “living” reality, which presupposes an increase in the intensity of attention and will, but finally brings us closer to freedom.

The role and relationship of mindreading and social attunement in HRI – position statements of interdisciplinary researchers. Workshop HRI'20

2020 ◽  
Author(s):  
Agnieszka Wykowska ◽  
Jairo Pérez-Osorio ◽  
Stefan Kopp
Keyword(s):  
Mental States ◽  
Human Robot Interaction ◽  
Human Interaction ◽  
Artificial Agents ◽  
The Novel ◽  
Robot Interaction ◽  
Novel Coronavirus ◽  
Relationship Of ◽  
The Relationship

This booklet is a collection of the position statements accepted for the HRI’20 conference workshop “Social Cognition for HRI: Exploring the relationship between mindreading and social attunement in human-robot interaction” (Wykowska, Perez-Osorio &amp; Kopp, 2020). Unfortunately, due to the rapid unfolding of the novel coronavirus at the beginning of the present year, the conference and consequently our workshop, were canceled. On the light of these events, we decided to put together the positions statements accepted for the workshop. The contributions collected in these pages highlight the role of attribution of mental states to artificial agents in human-robot interaction, and precisely the quality and presence of social attunement mechanisms that are known to make human interaction smooth, efficient, and robust. These papers also accentuate the importance of the multidisciplinary approach to advance the understanding of the factors and the consequences of social interactions with artificial agents.

CHILD-PARENT RELATIONS AS A FACTOR IN THE FORMATION OF PROFESSIONAL PREFERENCES IN PEDAGOGICAL DYNASTIES

2020 ◽  
Vol 2 (4) ◽  
pp. 126-130
Author(s):  
N. V. SHAMANIN ◽  
Keyword(s):  
Professional Development ◽  
The Family ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship ◽  
Parent Child Relationships ◽  
Professional Preferences ◽  
Parent Child

The article raises the issue of the relationship of parent-child relationships and professional preferences in pedagogical dynasties. Particular attention is paid to the role of the family in the professional development of the individual. It has been suggested that there is a relationship between parent-child relationships and professional preferences.

scholarly journals Psychological contract breach and voluntary turnover among newcomers: the role of supervisor trustworthiness and negative affectivity

2021 ◽  
pp. 1-21
Author(s):  
Émilie Lapointe ◽  
Christian Vandenberghe
Keyword(s):  
Psychological Contract ◽  
Negative Affectivity ◽  
Voluntary Turnover ◽  
Three Dimensions ◽  
Psychological Contract Breach ◽  
Contract Breach ◽  
Indirect Relationship ◽  
Relationship Of ◽  
The Relationship

Abstract This article looks at the relationship between psychological contract breach and voluntary turnover among newcomers, using supervisor trustworthiness as a mediator and negative affectivity as a moderator. Relying on data from 243 newcomers, psychological contract breach was found to be negatively related to the three dimensions of supervisor trustworthiness, i.e., ability, benevolence, and integrity. Supervisor integrity further mediated a positive relationship between psychological contract breach and voluntary turnover measured 8 months later. Psychological contract breach interacted with negative affectivity such that it was less negatively related to dimensions of supervisor trustworthiness at high levels of negative affectivity. The indirect relationship of psychological contract breach to voluntary turnover as mediated by supervisor integrity was also weaker at high levels of negative affectivity. We discuss the implications of these findings for research and practice.

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