Mesenchymal Stem Cell Immunomodulation: A Novel Intervention Mechanism in Cardiovascular Disease

Mesenchymal stem cells (MSCs) are the member of multipotency stem cells, which possess the capacity for self-renewal and multi-directional differentiation, and have several characteristics, including multi-lineage differentiation potential and immune regulation, which make them a promising source for cell therapy in inflammation, immune diseases, and organ transplantation. In recent years, MSCs have been described as a novel therapeutic strategy for the treatment of cardiovascular diseases because they are potent modulators of immune system with the ability to modulating immune cell subsets, coordinating local and systemic innate and adaptive immune responses, thereby enabling the formation of a stable inflammatory microenvironment in damaged cardiac tissues. In this review, the immunoregulatory characteristics and potential mechanisms of MSCs are sorted out, the effect of these MSCs on immune cells is emphasized, and finally the application of this mechanism in the treatment of cardiovascular diseases is described to provide help for clinical application.

Urban collective housing: safety and hygiene on site. Contributions for the management of excavations, submurations and demolitions

In Argentina, public policies related to Safety and Hygiene started at the beginning of the 20th century, and it was not until the 1970s that the first regulations related to the subject were passed, when the current Law Nº 19587 on "Safety and Hygiene at Work" was sanctioned. In particular, the construction industry, since 1996, has had a complementary regulatory framework with Decree Nº 911. On the other hand, the demolition, excavation and submurder stages found an intervention mechanism with SRT Resolutions Nº 550/11 and SRT Nº 503/14. However, the regulatory framework does not provide specificity in relation to procedures and consequently does not guarantee efficiency/effectiveness in operational terms. This work exposes a gap, which, from a particular methodological approach, concludes with the obtaining of results, as it verifies the levels of compliance of the actions in the traceability of the work, aimed at framing the demolition, excavation and submuration tasks according to regulatory parameters of Health and Safety established by the instrument of analysis / matrix. As part of the final considerations, this work proposes to contribute with management guidelines for the aforementioned tasks in urban collective housing works.

A Systematic Literature Review of Quality Management Initiatives in Dental Clinics

By considering the recently proposed definitions and metrics, oral healthcare quality management (OHQM) emerges as a distinct field in the wider healthcare area. The goal of this paper is to systematically review quality management initiatives (QMIs) implementation by dental clinics. The research methodology approach is a review of 72 sources that have been analyzed using the Context–Intervention–Mechanism–Outcome Framework (CIMO). The analysis identifies five mechanisms that explain how quality management initiatives are implemented by dental clinics. The simplest QMIs implementations are related to (1) overall quality. The next ones, in terms of complexity, are related to (2) patient satisfaction, (3) service quality, (4) internal processes improvement, and (5) business outcomes. This paper is the first attempt to provide a critical review of this topic and represents an important advancement by providing a theoretical framework that explains how quality management is implemented by practitioners in this field. The results can be used by scholars for advancing their studies related to this emerging research area and by healthcare managers in order to better implement their quality management initiatives.

Promoting helpful attention and interpretation patterns to reduce anxiety and depression in young people: weaving scientific data with young peoples’ lived experiences

Background Anxiety and depression are common, disabling and frequently start in youth, underscoring the need for effective, accessible early interventions. Empirical data and consultations with lived experience youth representatives suggest that maladaptive cognitive patterns contribute to and maintain anxiety and depression in daily life. Promoting adaptive cognitive patterns could therefore reflect “active ingredients” in the treatment and/or prevention of youth anxiety and depression. Here, we described and compared different therapeutic techniques that equipped young people with a more flexible capacity to use attention and/or promoted a tendency to positive/benign (over threatening/negative) interpretations of uncertain situations. Methods We searched electronic databases (PubMed, PsycINFO, EMBASE, and PsycARTICLES) for studies containing words relating to: intervention; youth; anxiety and/or depression and attention and/or interpretation, and selected studies which sought to reduce self-reported anxiety/depression in youth by explicitly altering attention and/or interpretation patterns. Ten young people with lived experiences of anxiety and depression and from diverse backgrounds were consulted on the relevance of these strategies in managing emotions in their daily lives and also whether there were additional strategies that could be targeted to promote adaptive thinking styles. Results Two sets of techniques, each targeting different levels of responding with different strengths and weaknesses were identified. Cognitive bias modification training (CBM) tasks were largely able to alter attention and interpretation biases but the effects of training on clinical symptoms was more mixed. In contrast, guided instructions that teach young people to regulate their attention or to evaluate alternative explanations of personally-salient events, reduced symptoms but there was little experimental data establishing the intervention mechanism. Lived experience representatives suggested that strategies such as deliberately recalling positive past experiences or positive aspects of oneself to counteract negative thinking. Discussion CBM techniques target clear hypothesised mechanisms but require further co-design with young people to make them more engaging and augment their clinical effects. Guided instructions benefit from being embedded in clinical interventions, but lack empirical data to support their intervention mechanism, underscoring the need for more experimental work. Feedback from young people suggest that combining complimentary techniques within multi-pronged “toolboxes” to develop resilient thinking patterns in youth is empowering.

The Integration of Lean and Resilience Paradigms: A Systematic Review Identifying Current and Future Research Directions

Integration of the lean and resilience paradigms has attracted increasing attention among scientists and practitioners. In an interconnected world, the need to be resilient involves increased readiness to deal with risks from both outside and inside an enterprise, and to be lean involves maximizing value while minimizing waste. The combination of these requirements has been the catalyst for a move towards lean–resilience operations. To better understand this trend, which seeks to help firms retain a competitive position and survive disruptions, this paper provides a systematic literature review of 53 articles identified through the C-I-M-O (context-intervention-mechanism-outcome) framework and examines them using descriptive and content analysis. The results trace the growth of lean–resilience research from its infancy to its current advanced state. This paper also identifies for the first time the lack of structured research on the number and categories of implemented practices and their associated benefits. To address this deficiency, a concept map is developed to provide guidance on the topic, identify gaps and inconsistencies in the literature, understand the state of development and suggest future research directions. The results are used to identify four dominant streams: application, compatibility, integration, and impact assessment in the context of the supply chain, conceptual development and operational research of various organizational and industry sectors. Further topics for investigation are recommended in the form of research questions. The proposed concept map is intended to assist researchers and practitioners to develop knowledge about the integration of lean and resilience paradigms in new contexts and formulate more effective deployment strategies.

ASEAN Non-Intervention Principles: An Alternative Settlement towards Human Rights Violation in Rohingya

The frame of international news is colored with a series of systemic and consistent human rights violation experienced by the Rohingya ethnic group in Burma. Toward this case, it is unlikely for Burma to be willing and to be able to resolve this case internally. Hence, as a regional security and stability guard in the Southeast Asia region, ASEAN should take part in settling human rights violations that occur in its member states. However, every settlement attempted by ASEAN is constantly distracted with Non-Intervention Principles. This research aims to examine the alternative ideas for Non-Intervention Principles of ASEAN as a settlement towards human rights violation on Rohingya ethnic. This research used normative research, based on the secondary data was employed as the research method. The obtained data were analyzed by using qualitative analysis. The research found that the Non-Intervention principle has been applied in ASEAN in the most rigid form. Meanwhile, Humanitarian Assistance and Humanitarian Intervention mechanism is an alternative settlement towards human rights violations on the Rohingya ethnic group in Myanmar

Metabonomic Study on the Plasma of High-Fat Diet-Induced Dyslipidemia Rats Treated with Ge Gen Qin Lian Decoction by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Gegen Qinlian decoction (GGQLD) has a definite effect on T2DM in clinic, and it has the effect of lowering blood sugar, improving insulin resistance, and improving the blood lipid level of rats with dyslipidemia, but the intervention mechanism of GGQLD on dyslipidemia has not been clarified. The changes in endogenous metabolites in the plasma of high-fat diet-induced dyslipidemia rats treated with Ge Gen Qin Lian Decoction (GGQLD) were studied to elucidate the therapeutic effects and mechanism of action of GGQLD in dyslipidemia. Based on ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS), the metabolic profiles of rat serum samples were collected. The rat model of dyslipidemia was induced by a 60% fat-fed high-fat diet. After feeding the rats with a high-fat diet for 4 weeks, dyslipidemia appeared. After 5 weeks of GGQLD (14.85 g kg−1) administration, the metabonomics of rats’ plasma samples in the normal group, model group, and administration group were analyzed. Mass profiler professional (MPP), SIMCA-P 14.1, and Graphpad prism 6.0 software were used combined with METLIN biological database and human metabolite database HMDB to screen and identify endogenous biomarkers. Metaboanalyst 4.0 software was used by combining with HMDB and KEGG databases; the enrichment and metabolic pathway of biomarkers were analyzed to explore the metabolic mechanism of dyslipidemia rats induced by high-fat diet and the intervention mechanism of Gegen Qinlian decoction. After 5 weeks of administration of GGQLD, the levels of serum TC and TG were significantly decreased ( P < 0.05 , P < 0.01 ), while HDL-C and LDL-C were not significantly affected. After administration, the food intake of rats in the administration group decreased gradually, and the change trend of body weight gradually slowed down. The metabonomics of rat plasma samples results showed that 23 potential biomarkers including α-linolenic acid, arachidonic acid, and lysophosphatidylcholine were significantly changed in positive ion mode. Studies have shown that GGQLD has a significant lipid-lowering effect on dyslipidemia rats induced by a high-fat diet, and its preventive mechanism is related to tryptophan metabolism, fatty acid biosynthesis, α-linolenic acid metabolism, arachidonic acid, and glycerophosphatidyl metabolism pathway.

Sustainability Interventions on Agro-Ecosystems: An Experience from Yunnan Province, China

Increasing agricultural production, without having a pronounced negative impact on ecosystems, continues to be a massive challenge. Interventions in sustainability that improve agro-ecosystems are thus crucial. Current literature focuses on sustainability concepts, assessment tools, and intervention impacts, yet lacks in intervention mechanisms and implementation processes. Therefore, this study aims to present an intervention framework on agro-ecosystems that helps transform sustainability concepts into implementation actions. We first create the intervention framework on agro-ecosystems using a systematic approach, and then analyze the intervention mechanism. Next, we formulate the agro-ecological sustainability index (AESI) and its sub-indices to assess the results of interventions. We find that, by integrating interventions, we can reverse the sustainability trend from deterioration to recovery and improvement; however, with a spatial difference. We highlight that the process for a successful intervention comprises (1) utilizing an integrated intervention portfolio, (2) acting with a long-term perspective, (3) utilizing adaptive implementation, and (4) strengthening local institutions. We suggest closely monitoring the impact of interventions, diversifying farmers’ income sources, and enhancing capacity building for young generations. Additionally, we suggest conducting multidisciplinary research and strengthening local government capacity to hedge against future risks. Our intervention framework and Yunnan’s intervention experience provides a useful lesson for other policymakers and researchers to achieve the Sustainable Development Goals.