Large marine foundation piles are an important part of offshore structural pile foundations, and their lifting operations have always been a major problem in the construction and construction of marine structures. Based on IHC’s bilateral marine foundation pile spreader, this paper proposes a structural scheme of “internal and external clamping type variable diameter marine foundation pile spreader”. It solves the problem of poor adaptability of spreaders to foundation piles of the same specification and different pipe diameters. At the same time, this article has conducted in-depth research on the two clamping methods of friction clamping and wedge tooth embedded clamping. Through experiments, it is found that under the same lateral load, the load capacity of the wedge teeth tightening is three times that of the friction clamping. Aiming at the embedding and clamping method of the wedge teeth of the spreader, first of all, the influence of the tooth profile angle of the wedge teeth on their embedding performance was studied by the plastic mechanics slip line field theory and Abaqus simulation analysis. Subsequently, the elastic mechanics theory and Abaqus simulation analysis were used to study the stress characteristics of the wedge teeth during the lifting process, and the internal stress distribution was obtained. The article aims to provide a reference for the design of spreaders in actual projects.