Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques

Despite well-documented maladaptive neuroinflammation in Alzheimer's disease (AD), the principal signal that drives memory and cognitive impairment remains elusive. Here, we reveal robust, age-dependent cellular reactions to type I interferon (IFN), an innate immune cytokine aberrantly elicited by beta-amyloid plaques, and examine their role in cognition and neuropathology relevant to AD in a murine amyloidosis model. Long-term blockade of IFN receptor rescued both memory and synaptic deficits and resulted in reduced microgliosis, inflammation, and neuritic pathology. Interestingly, microglia-specific IFN receptor ablation attenuated the loss of post-synaptic terminals, whereas IFN signaling in neural cells contributed to pre-synaptic alteration and plaque accumulation. Intriguingly, IFN pathway activation displayed a strong inverse correlation with cognitive performance, promoting selective synapse engulfment by microglia rather than amyloid plaques. Overall, IFN signaling represents a critical module within the neuroinflammatory network of AD and prompts a concerted cellular state that is detrimental to memory and cognition.

An Umbrella Review Article on A Correlation of Osborn Waves with Hypothermia Induced Left Ventricular Systolic Dysfunction

The purpose of this review article is an overall finding from published studies on hypothermic causes of the Osborn waves induced lv systolic dysfunction and related topics are discussed. A systematic literature search was performed in the PubMed and Embase databases and collected 100 articles, out of which 28 were removed after peer review. We found 100 articles, out of which a total of 72 cases were considered. When analyzing only cases with more than one reported ECG, there was a strong inverse correlation between J wave, body temperature and left ventricular dysfunction. Electrocardiographic manifestations of hypothermia may assist in timely diagnosis and management of hypothermic patients. Even though prominent J-waves are the hallmark of hypothermic patient’s ECG, they are not pathognomonic, as they have been associated with other inherited or acquired conditions, many of which are highly arrhythmogenic.

[Oral health care and periodontal disease among schoolchildren in the Syrian Arab Republic]

It has been observed that a strong inverse correlation exists between prevalence and severity of periodontal disease and the level of oral hygiene, where appropriate oral health behaviour and good knowledge in oral health have an important role in preventing such disease. A study was conducted among 360 children of 15 years of age in the Syrian Arab Republic. to assess the relation between oral health behaviour and periodontal disease. The results of the study revealed law cleanliness levels, poor knowledge and inappropriate behaviour in oral health and high prevalence of periodontal disease. Oral health education programmes and oral hygiene procedures should be oriented towards schoolchildren as early as possible

Convalescent plasma use in the United States was inversely correlated with COVID-19 mortality

Background. The US Food and Drug Administration authorized Convalescent Plasma (CCP) therapy for hospitalized COVID-19 patients via the Expanded Access Program (EAP) and the Emergency Use Authorization (EUA), leading to use in about 500,000 patients during the first year of the pandemic for the US.Methods. We tracked the number of CCP units dispensed to hospitals by blood banking organizations and correlated that usage with hospital admission and mortality data.Results. CCP usage per admission peaked in Fall 2020, with more than 40% of inpatients estimated to have received CCP between late September and early November 2020. However, after randomized controlled trials failed to show a reduction in mortality, CCP usage per admission declined steadily to a nadir of less than 10% in March 2021. We found a strong inverse correlation (r = -0.52, P = 0.002) between CCP usage per hospital admission and deaths occurring two weeks after admission, and this finding was robust to examination of deaths taking place one, two or three weeks after admission. Changes in the number of hospital admissions, SARS-CoV-2 variants, and age of patients could not explain these findings. The retreat from CCP usage might have resulted in as many as 29,000 excess deaths from mid-November 2020 to February 2021.Conclusions. A strong inverse correlation between CCP use and mortality per admission in the USA provides population level evidence consistent with the notion that CCP reduces mortality in COVID-19 and suggests that the recent decline in usage could have resulted in excess deaths.Funding. There was no specific funding for this study. AC was supported in part by RO1 HL059842 and R01 AI1520789; MJJ was supported in part by 5R35HL139854. This project has been funded in whole or in part with Federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority under Contract No. 75A50120C00096.

Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. A strong inverse correlation between miR-21-5p and KRIT1 expression levels was observed in CRC-adjacent vessels. Furthermore, miR-21-5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. Thus, our data suggest that exosomal miR-21-5p is involved in angiogenesis and vascular permeability in CRC and may be used as a potential new therapeutic target.

Empowering Compartmental Modeling With Mobility and Shelter-in-Place Analysis

A model that is capable of handling the non-linear trend of COVID-19 throughout the US and evaluate different effects of interstate/intrastate mobility measures can help decision-makers adjust guidelines and state-wide mandates to contain the pandemic's spread. The abundance of cellular-based data has made it possible to study many aspects of users' mobility, including their travel, contact, and dwell patterns. This study uses a compartmental metapopulation model to present a correlation between the contact and mobility indices and the likelihood of being susceptible to infection. We studied the effect of travel from other states on overall infections in a destination state and observed a strong inverse correlation of 0.98 between the contact index and social awareness compartment, i.e., individuals who are no longer susceptible to infection. The shelter-in-place what-if analysis for travelers from other states on the course of infection in the destination state showed a possible reduction of over 22% in the total number of infections and death if travelers sheltered in place for 5–7 days.

Convalescent Plasma Use in the United States was inversely correlated with COVID-19 Mortality: Did Plasma Hesitancy cost lives?

BackgroundThe US Food and Drug Administration authorized Convalescent Plasma (CCP) therapy for hospitalized COVID-19 patients via the Expanded Access Program (EAP) and the Emergency Use Authorization (EUA), leading to use in about 500,000 patients during the first year of the pandemic for the US.MethodsWe tracked the number of CCP units dispensed to hospitals by blood banking organizations and correlated that usage with hospital admission and mortality data.ResultsCCP usage per admission peaked in Fall 2020, with more than 40% of inpatients estimated to have received CCP between late September and early November 2020. However, after randomized controlled trials failed to show a reduction in mortality, CCP usage per admission declined steadily to a nadir of less than 10% in March 2021. We found a strong inverse correlation (r = −0.52, P = 0.002) between CCP usage per hospital admission and deaths occurring two weeks after admission, and this finding was robust to examination of deaths taking place one, two or three weeks after admission. Changes in the number of hospital admissions, SARS-CoV-2 variants, and age of patients could not explain these findings. The retreat from CCP usage might have resulted in as many as 29,000 excess deaths from mid-November 2020 to February 2021.ConclusionsA strong inverse correlation between CCP use and mortality per admission in the USA provides population level evidence consistent with the notion that CCP reduces mortality in COVID-19 and suggests that the recent decline in usage could have resulted in excess deaths.

Change on detection of vegetation cover and soil salinity using GIS technique in Diyala Governorate, Iraq

Soil salinity is one of the most important problems of land degradation, that threatening the environmental, economic and social system. The aim of this study to detect the changes in soil salinity and vegetation cover for Diyala Governorate over the period from 2005 to 2020, through the use of remote sensing techniques and geographic information system. The normalized difference vegetation index (NDVI) and salinity index (SI) were used, which were applied to four of the Landsat ETM+ and Landsat OLI satellite imagery. The results showed an increase in soil salinity from 7.27% in the period 2005–2010 to 27.03% in 2015–2020, as well as an increase in vegetation from 10% to 24% in the same period. Also the strong inverse correlation between the NDVI and the SI showed that vegetation is significantly affected and directly influenced by soil salinity changes

The Urine Anion Gap: Common Misconceptions

Two papers, one in 1986 and another one in 1988, reported a strong inverse correlation between urinary anion gap (UAG) and urine ammonia excretion (UNH4) in patients with metabolic acidosis and postulated that UAG could be used as an indirect measure of UNH4. This postulation has persisted until now and is widely accepted. In this review, we discuss factors regulating UAG and examine published evidence to uncover errors in the postulate and the design of the original studies. The essential fact is that, in the steady state, UAG reflects intake of Na, K, and Cl. Discrepancy between intake and urinary output of these electrolytes (i.e., UAG) indicates selective extrarenal loss of these electrolytes or nonsteady state. UNH4 excretion, which depends, in the absence of renal dysfunction, mainly on the daily acid load, has no consistent relationship to UAG either theoretically or in reality. Any correlation between UAG and UNH4, when observed, was a fortuitous correlation and cannot be extrapolated to other situations. Furthermore, the normal value of UAG has greatly increased over the past few decades, mainly due to increases in dietary intake of potassium and widespread use of sodium salts with anions other than chloride as food additives. The higher normal values of UAG must be taken into consideration in interpreting UAG.