Decision-Making Procedures and Their Relation to Knowledge Management and Quality Management

The environment in which managers currently operate is dynamic and turbulent. This fact affects the great complexity and dynamism of changes. Thus, decision-making becomes more complex in the context of sustainability. Decisive decision-making is becoming rare, and the challenge of globalization is increasing. Under its influence, decision-making is no longer deterministic. Decision-making processes prevail in conditions of uncertainty. In this context, there is a very intense need to be acquainted with progressive tools to support decision-making and management and to apply the acquired knowledge in practice. This paper focuses on three related areas. We are talking about knowledge management in connection with the most important contributing element—decision-making with quality management. We deal with the characteristics of the individual areas, defining their mutual relationship on a systemic basis. The paper also points to the necessary connection between theory and practice. More specifically, it points to the practical applications of management to decision-making as a managerial function and, at the same time, related to decision-making in quality management. Subsequently, we define the links to knowledge management with an emphasis on the use of procedures, methods, and knowledge in the decision-making process, which we use in theory and practice in quality management.

Decision Support for Plan Adaptation in Unforeseen Situations

Handling irregular phenomena might bring great complexity for involved teams. Variables considered for undertaking recommended procedures may yield many decision alternatives, challenging to deal with at planning time. Additionally, expectations regarding the phenomena handling may not match those observed. This means that the existing plan’s application may become inappropriate, and teams must be creative in performing actions and decision-making. An approach for on-the-fly adaptation of plans aims to assist teams in identifying and diagnosing unforeseen situations, besides adjusting previously developed plans at runtime. This approach was evaluated through experiments in the emergency management domain, and the initial results indicate its feasibility in dealing with unforeseen situations while handling irregular phenomena in complex environments.

Party-related primacy effects in proportional representation systems: evidence from a natural experiment in Polish local elections

We study the primacy effects that occur when voters cast their votes because a candidate or party is listed first on a ballot. In the elections that we analyzed, there are three potential types of such effects that might occur when voters vote for (1) the first candidate listed on the ballot in single-member district (SMD) elections (candidate primacy); (2) the first party listed on the ballot in open-list proportional representation (OLPR) elections (party primacy); or (3) the first candidate on a party list in OLPR elections (list primacy). We estimated the party primacy effect (2) and established that there was no interaction between (2) and (3). A party primacy effect is especially difficult to estimate because parties’ positions on ballots are typically fixed in all multi-member districts (MMDs) and it is impossible to separate the first-position “bonus” from a party’s normal electoral performance. A rare natural experiment allowed us to estimate the primacy party bonus between 6.02 and 8.52% of all votes cast for the 2014 Polish local elections. We attribute the large size of such bonus to the great complexity of voting in the OLPR elections, especially the much longer ballots, voting in many simultaneous elections, and ballot design as a booklet rather than a sheet.

Rapports intertextuels et (re)constructions identitaires dans le roman Bois rouge de Jean-Marie Touratier

Published in 1993, the novel Bois rouge by Jean-Marie Touratier brings to life the history of the short-lived French colony of Brazil, the Antarctic France, whose existence, reduced to only five years (1555-1560), was described in the travelogues written in the 16th century by André Thevet (Les Singularitez de la France Antarctique - The New Found World, or Antarctike) and Jean de Léry (Histoire d’un voyage faict en la terre du Brésil – History of a Voyage to the Land of Brazil). Beneath the appearance of a simple story told by an ironic voice, sometimes even satirical towards the military leader of the French colony, the Knight of Malta Nicolas Durand de Villegagnon and his chaplain, André Thevet, future cosmographer of the kings of France, the novel delves into issues of great complexity, such as (the issue of) identity and the relationship to the Other (the American “savage”).

Experimental Modeling of Large Diameter Holes Based on Materials of Bronze Age Stone Axes

In the Urals, there are more than a hundred products with large-diameter holes, some of which are made using a copper tube. Experiments on hollow drilling in the expedition of S. A. Semenov have shown great complexity of this method. In experiments on drilling it was planned to identify labor costs for the manufacture of copper tube, and also reveal various aspects of drilling techniques. The article presents the results of experiments on drilling different types of stone (soapstone, marble, serpentine and jade) with a copper tube. Experiments have shown that drilling with a brace is 1.5 times more effective than drilling with a borer. And using a copper tube as a drill increased the speed of making holes by 4–7 times. It also turned out that the abrasive used is very important for drilling efficiency. The most effective abrasive was emery, whose deposits are known in the southern Urals. The results obtained allow the authors to establish with great accuracy what drills and with application of what equipment stone axes of Bronze Age were drilled. A comparison of the experimental drills with bronze age drills shows that drilling with a copper tube was often, but not always, performed using a special machine tool. Labor-intensive making stone axes with large diameter holes especially made of strong row materials attest about high social status of their owners.

How can SHAP values help to shape metabolic stability of chemical compounds?

Background Computational methods support nowadays each stage of drug design campaigns. They assist not only in the process of identification of new active compounds towards particular biological target, but also help in the evaluation and optimization of their physicochemical and pharmacokinetic properties. Such features are not less important in terms of the possible turn of a compound into a future drug than its desired affinity profile towards considered proteins. In the study, we focus on metabolic stability, which determines the time that the compound can act in the organism and play its role as a drug. Due to great complexity of xenobiotic transformation pathways in the living organisms, evaluation and optimization of metabolic stability remains a big challenge. Results Here, we present a novel methodology for the evaluation and analysis of structural features influencing metabolic stability. To this end, we use a well-established explainability method called SHAP. We built several predictive models and analyse their predictions with the SHAP values to reveal how particular compound substructures influence the model’s prediction. The method can be widely applied by users thanks to the web service, which accompanies the article. It allows a detailed analysis of SHAP values obtained for compounds from the ChEMBL database, as well as their determination and analysis for any compound submitted by a user. Moreover, the service enables manual analysis of the possible structural modifications via the provision of analogous analysis for the most similar compound from the ChEMBL dataset. Conclusions To our knowledge, this is the first attempt to employ SHAP to reveal which substructural features are utilized by machine learning models when evaluating compound metabolic stability. The accompanying web service for metabolic stability evaluation can be of great help for medicinal chemists. Its significant usefulness is related not only to the possibility of assessing compound stability, but also to the provision of information about substructures influencing this parameter. It can assist in the design of new ligands with improved metabolic stability, helping in the detection of privileged and unfavourable chemical moieties during stability optimization. The tool is available at https://metstab-shap.matinf.uj.edu.pl/.

Learning Ethical, Environmental and Professional Responsibility at Universitat Politècnica de València. Where Are We?

This paper presents a study on the development of the cross-curricular learning outcome (CCLO) “Ethical, environmental and professional responsibility” for students of different Bachelor’s Degrees taught at Universitat Politècnica de València (Spain). The work involved in the development of this learning outcome entails great complexity, given the double dimension of responsibility that it involves. At the end of their training at the university, students are expected to show ethical, environmental, and professional responsibility towards themselves and others. Interviews have been conducted with lecturers who work and assess this outcome in their subjects, most/all of them related to science and engineering. The objective was to identify the learning approach used in the different subjects to guarantee the acquisition of this CCLO by the students. A focus group has also been carried out with students to determine the importance they give to this learning outcome, and to know their degree of satisfaction with the training received. The methodology used to obtain the data from lecturers and students and to process the information to get a precise diagnosis is fully described in the paper. Results are satisfactory to some extent: most of the lecturers carry out appropriate activities and most students achieve the expected proficiency level. Finally, recommendations are given to improve the development of this cross-curricular learning outcome.

Outcomes of women with congenital heart disease admitted to acute-care hospitals for delivery in Japan: a retrospective cohort study using nationwide Japanese diagnosis procedure combination database

Background The number of women with congenital heart disease (CHD) who are of childbearing age is increasing due to advancements in medical management. Nonetheless, data on the outcomes of delivery in women with CHD remain limited. Therefore, we conducted a retrospective cohort study using a nationwide database of deliveries by women with CHD. Methods Deliveries by women with CHD discharged from acute-care hospitals between April 2017 and March 2018 were identified based on the Diagnosis Procedure Combination database which covers almost all acute-care hospitals in Japan. By using this database, we tried to include relatively high-risk deliveries by women with CHD. Subjects were divided into three groups according to the underlying disease complexity: simple, moderate, and great complexity. The clinical characteristics and incidence of peripartum cardiovascular events were compared among the three groups. Results A total of 249 deliveries from 107 hospitals were included. The largest facility had 29 deliveries per year. Given the uncertainty of underlying cardiac anomalies, 48 women were excluded, and the remaining 201 women (median age, 32 years) were analyzed. In-hospital maternal death, use of extracorporeal membrane oxygenation, intra-aortic balloon pump, pacemaker, and direct current cardioversion were not observed. Nine patients (4.5%) required intravenous diuretic administration. However, the difference in the frequency of diuretic use was not significant among the three groups (simple, 1.9%; moderate, 7.2%; great, 6.9%; P = 0.204). One participant required valve replacement surgery at 22 days after a successful cesarean section. As the disease complexity increased, deliveries occurred more frequently at university hospitals (simple, 41.7%; moderate, 52.2%; great, 72.4%; P = 0.013) and the length of hospitalization was significantly longer, with median durations of 9.0 (interquartile range [IQR] 7.0–11.0) days, 10.0 (IQR 8.0–24.0) days, and 11.0 (IQR 8.0–36.0) days in the simple, moderate, and great complexity groups, respectively (P = 0.002). Conclusions Appropriate patient selection and management by specialized tertiary institutions may contribute to positive outcomes in pregnancies in women with CHD.

COMPUTATION OF PLATE GEOMETRY OF DRIVE CHAIN FOR VALVE TIMING GEARS OF VEHICLES

The purpose of the study is to evaluate the geometric parameters of the plates of roller chains used in the supply of gas distribution mechanisms of motor vehicles. The method used is an analytical representation of the dependencies of the plate shape. The relevance of the proposed approach is justified by the great complexity of pre-design studies for choosing the type of drive chain of various mechanisms. Main results-dependences are proposed for determining the area of plates both with the "eight" type shape of the inner link of a standard roller (bushing) chain, and plates with straight side faces, and it is reasonable to choose the design of the drive chain for the specified operating loading conditions. Dependencies have a scientific novelty and practical significance when used in the production activities of employees of technological departments and design services of machine-building and auto repair enterprises.