Drug Delivery Formulations of Ordered and Nonordered Mesoporous Silica: Comparison of Three Drug Loading Methods

2011 ◽  
Vol 100 (8) ◽  
pp. 3294-3306 ◽  
Author(s):  
Tarja Limnell ◽  
Hélder A. Santos ◽  
Ermei Mäkilä ◽  
Teemu Heikkilä ◽  
Jarno Salonen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Loading Methods

Mesoporous Silica Molecular Sieve based Nanocarriers: Transpiring Drug Dissolution Research

2017 ◽  
Vol 23 (3) ◽  
pp. 467-480 ◽  
Author(s):  
Satyanarayan Pattnaik ◽  
Kamla Pathak
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Molecular Sieves ◽  
Release Kinetics ◽  
Drug Loading ◽  
Scale Up ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Water Soluble Drugs ◽  
Loading Methods

Background: Improvement of oral bioavailability through enhancement of dissolution for poorly soluble drugs has been a very promising approach. Recently, mesoporous silica based molecular sieves have demonstrated excellent properties to enhance the dissolution velocity of poorly water-soluble drugs. Description: Current research in this area is focused on investigating the factors influencing the drug release from these carriers, the kinetics of drug release and manufacturing approaches to scale-up production for commercial manufacture. Conclusion: This comprehensive review provides an overview of different methods adopted for synthesis of mesoporous materials, influence of processing factors on properties of these materials and drug loading methods. The drug release kinetics from mesoporous silica systems, the manufacturability and stability of these formulations are reviewed. Finally, the safety and biocompatibility issues related to these silica based materials are discussed.

The Potential of Milk-derived Exosomes for Drug Delivery

2020 ◽  
Vol 17 ◽  
Author(s):  
Shuyuan Li ◽  
Yue Tang ◽  
Yushun Dou
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Biological Fluids ◽  
Drug Loading ◽  
Drug Carriers ◽  
Current Application ◽  
Therapeutic Benefits ◽  
Loading Methods

Background: Exosomes, one of the extracellular vesicles, are widely present in all biological fluids and play an important role in intercellular communication. Because of its hydrophobic lipid bilayer and aqueous hydrophilic core structure, it is considered a possible alternative to liposome drug delivery systems. Not only do they protect the cargo like liposomes during delivery, they are less toxic and better tolerated. However, due to the lack of sources and methods for obtaining enough exosomes, the therapeutic application of exosomes as drug carriers is limited. Methods: A literature search was performed using the ScienceDirect and PubMed electronic databases to obtain information from published literature on milk exosomes related to drug delivery. Results: Here, we briefly reviewed the current knowledge of exosomes, expounded the advantages of milk-derived exosomes over other delivery vectors, including a higher yield, the oral delivery characteristic and additional therapeutic benefits. The purification and drug loading methods of milk exosomes, and the current application of milk exosomes were also introduced. Conclusion: The emergence of milk-derived exosomes is expected to break through the limitations of exosomes as therapeutic carriers of drugs. We hope to raise awareness of the therapeutic potential of milk-derived exosomes as a new drug delivery system.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

scholarly journals Mesenchymal stem cells-derived exosomes for drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yao Sun ◽  
Guoliang Liu ◽  
Kai Zhang ◽  
Qian Cao ◽  
Tongjun Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lipid Bilayers ◽  
Drug Loading ◽  
The Body ◽  
Existing Problems ◽  
Drug Delivery Carrier ◽  
Purification Methods ◽  
Loading Methods

AbstractExosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.

scholarly journals Hybrid mesoporous silica with controlled drug release

2019 ◽  
Vol 84 (9) ◽  
pp. 1027-1039 ◽  
Author(s):  
László Almásy ◽  
Ana-Maria Putz ◽  
Qiang Tian ◽  
Gennady Kopitsa ◽  
Tamara Khamova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Nitrogen Adsorption ◽  
Controlled Drug Release ◽  
Ammonium Bromide ◽  
Structure Directing Agent ◽  
One Step

The mesoporous silica particles were prepared by the sol?gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated precursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

2019 ◽  
Vol 19 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Xiaohui Pu ◽  
Jia Li ◽  
Peng Qiao ◽  
Mengmeng Li ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Loading ◽  
Synthetic Methods ◽  
Pubmed Database ◽  
Modified Surface

Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface. Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about the advance in this field. Methods: Information has been collected from the recently published literature available mainly through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the literature available during 2008-2017. Results: In this review, the major research advances of MSNs on the drug delivery and biomedical applications were summarized. The significant advantages of MSNs have also been listed. It was found that the several significant challenges need to be addressed and investigated to further advance the applications of these structurally defined nanomaterials. Conclusion: Through approaching this review, the researchers can be aware of many new synthetic methods, smart designs proposed in the recent year and remaining questions of MSNs at present.

Comparison of fenofibrate–mesoporous silica drug-loading processes for enhanced drug delivery

2013 ◽  
Vol 50 (3-4) ◽  
pp. 400-409 ◽  
Author(s):  
Robert J. Ahern ◽  
John P. Hanrahan ◽  
Joseph M. Tobin ◽  
Katie B. Ryan ◽  
Abina M. Crean
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Loading

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

scholarly journals Mesoporous Silica Encapsulated Iron Oxide-Silver Heterodimeric Nanoparticles and Their Applications in Multi-Responsive Drug Release

2021 ◽  
Author(s):  
Xiaoting Sun ◽  
Xiaohui Zhang ◽  
Huazhe Yang ◽  
Xiaohong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Combined Therapy ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Ph Response ◽  
Growth Method

Abstract Background Metal based nanomaterials play essential roles in the fields of cancer diagnosis and therapy, drug delivery and exploration. As a novel kind of metal nanocomposites, magnetic-plasmonic nanohybrids are promising candidates in combined therapy. However, few studies have demonstrated the multi-responsive drug delivery properties of the nanohybrids. In this work, novel Fe3O4-Ag heterodimer nanoparticles coated with mesoporous SiO2 were prepared for multi-responsive drug release applications. Results Seed growth method was employed to form the heterodimer particles, and a layer of mesoporous silica was coated on the particle to improve the biocompatibility of metal nanoparticles, which also acted as drug loading and release component. Characterized via infrared spectroscopy, X-Ray diffraction and transmission electron microscopy, the particles were confirmed to appear a Janus like structure with Fe3O4 and Ag hemispheres encapsulating in silica. Doxorubicin hydrochloride (DOX) was loaded on the surface of the particles for drug delivery. The drug loading efficiency, release performance and the apoptosis action of the particles on MCF-7 cells were investigated in vitro. The results showed that DOX was successfully loaded on the particles with encapsulation efficiency of 88.3% and drug loading of 30.6%. And the release amount after 48 h increased from 10.05 ± 0.19% to 68.53 ± 8.20% as the environment was tuned to acidic, indicating an obvious pH response of the particles. Simultaneously, due to the photothermal effect of Ag hemispheres, the particles had exhibited an enhanced drug release stimulated by 808 nm near infrared (NIR) irradiation. And the results of apoptosis assay were in accord with the drug release profiles. Besides, the particles could well respond to an external magnetic field, which is beneficial to particle location or recovery. Conclusion The as-prepared particles exhibit good magnetic and photothermal properties originating from Fe3O4 and Ag hemispheres respectively, which are desired features in magnetic hyperthermia and photothermal therapy. The particles also possess pH and NIR light responsive drug release properties, enabling triggered and targeted drug delivery.

Evaluation of Potential of Uncoated Mesoporous Silica Particles for Drug Delivery Applications

2021 ◽  
Vol 875 ◽  
pp. 366-372
Author(s):  
Tayyab Ali Khan ◽  
Syed Mujtaba Ul Hassan ◽  
Hassan Waqas ◽  
Jamil Ahmad ◽  
Ahmat Khurshid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Cancer Cell Line ◽  
Silica Particles ◽  
Atomic Force ◽  
Drug Delivery Applications ◽  
Model Drug ◽  
Average Size

The drug loading capability and inherent cytotoxicity of mesoporous silica particles are two prime considerations for targeted drug delivery applications. In current study, uncoated mesoporous silica (UMS) carrier particles were synthesized by sol-gel emulsion approach. The morphology and structure of UMS was thoroughly characterized using atomic force microscope (AFM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Brunauer–Emmett–Teller (BET). The scanning electron microscopy (SEM) and dynamic light scattering (DLS) measurements reveal that mono dispersed silica particles have an average size of 250 nm with narrow size distribution. The pore size was measured as 47nm. Concentration dependent biocompatibility of UMS was evaluated using MTT assay with Hep-2c cancer cell line and cell viability of ~65% at concentrations of 7.5 nM was observed. Finally, the drug loading capability of UMS carrier was studied using ibuprofen as a model drug.

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