Tissue Engineering in Periodontal Regeneration

2019 ◽  
pp. 301-327
Author(s):  
Aysel Iranparvar ◽  
Amin Nozariasbmarz ◽  
Sara DeGrave ◽  
Lobat Tayebi
Keyword(s):  
Tissue Engineering ◽  
Periodontal Regeneration

Regenereation in periodontics

2018 ◽  
Author(s):  
Murtaza Kaderi ◽  
Mohsin Ali ◽  
Alfiya Ali ◽  
Tasneem Kaderi
Keyword(s):  
Tissue Engineering ◽  
Clinical Practice ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Tissue Regeneration ◽  
Surgical Procedures ◽  
Periodontal Regeneration ◽  
Guided Tissue Regeneration ◽  
Periodontal Tissues ◽  
Extensive Documentation

The goals of periodontal therapy are to arrest of periodontal disease progression and to attain the regeneration of the periodontal apparatus. Osseous grafting and Guided tissue regeneration (GTR) are the two techniques with the most extensive documentation of periodontal regeneration. However, these techniques offer limited potential towards regenerating the periodontal tissues. Recent surgical procedures and application of newer materials aim at greater and more predictable regeneration with the concept of tissue engineering for enhanced periodontal regeneration and functional attachment have been developed, analyzed, and employed in clinical practice

scholarly journals A Tissue Engineering Approach for Periodontal Regeneration Based on a Biodegradable Double-Layer Scaffold and Adipose-Derived Stem Cells

2014 ◽  
Vol 20 (17-18) ◽  
pp. 2483-2492 ◽  
Author(s):  
João F. Requicha ◽  
Carlos A. Viegas ◽  
Fernando Muñoz ◽  
Jorge M. Azevedo ◽  
Isabel B. Leonor ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Double Layer ◽  
Periodontal Regeneration ◽  
Adipose Derived Stem Cells ◽  
Engineering Approach ◽  
Tissue Engineering Approach

Physiological features of periodontal regeneration and approaches for periodontal tissue engineering utilizing periodontal ligament cells

2007 ◽  
Vol 103 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Bruno Braga Benatti ◽  
Karina Gonzales Silvério ◽  
Márcio Zaffalon Casati ◽  
Enílson Antônio Sallum ◽  
Francisco Humberto Nociti
Keyword(s):  
Tissue Engineering ◽  
Periodontal Ligament ◽  
Periodontal Regeneration ◽  
Periodontal Ligament Cells ◽  
Periodontal Tissue

scholarly journals Gene Therapy in Periodontal Tissue Engineering

2016 ◽  
Vol 8 (1) ◽  
pp. 46-48
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Gene Delivery ◽  
Periodontal Regeneration ◽  
Periodontal Tissue ◽  
Delivery Method ◽  
Molecular Events ◽  
Artificial Extracellular Matrix ◽  
Periodontal Healing ◽  
Primary Strategy

ABSTRACT An elaborate system of signaling molecules regulates the cellular and molecular events of periodontal healing, the primary strategy for which is functional periodontal compartment regeneration and replication of components of the natural cellular microenvironment by providing an artificial extracellular matrix and by delivering growth factors. A new, so-called gene delivery method works by converting cells into protein- producing factories, thereby bypassing the dilemma. Gene therapy can channel the cellular signals in a controlled and very systematic manner, to provide encoded proteins at every stage of tissue regeneration. The aim of this review is to highlight the applications of gene delivery and tissue engineering in periodontal regeneration. How to cite this article Lakhani N, Vandana KL. Gene Therapy in Periodontal Tissue Engineering. CODS J Dent 2016;8(1):46-48.

scholarly journals Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Membranes ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 606
Author(s):  
Dilcele Silva Moreira Dziedzic ◽  
Bassam Felipe Mogharbel ◽  
Ana Carolina Irioda ◽  
Priscila Elias Ferreira Stricker ◽  
Maiara Carolina Perussolo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue ◽  
Amniotic Membrane ◽  
Stromal Cells ◽  
Cell Attachment ◽  
Periodontal Regeneration ◽  
Human Amniotic Membrane ◽  
Micro Computed Tomography ◽  
Adipose Derived Stromal Cells

Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, periodontal ligament, and cementum. The application of a bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) with adipose-derived stromal cells (ASCs) has shown to be convenient and valuable. This study aims to investigate the treatments of a rat periodontal furcation defect model with DAM, ASCs, and a mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on DAM, and with a bone differentiation medium for four weeks, deposited ECM on DAM. Periodontal healing for four weeks was evaluated by micro-computed tomography and histological analysis after treatments with DAM, ASCs, and ECM and compared to untreated defects on five consecutive horizontal levels, from gingival to apical. The results demonstrate that DAM preserves its structure during cultivation and healing periods, supporting cell attachment, permeation, bone deposition on DAM, and periodontal regeneration. DAM and DAM+ASCs enhance bone healing compared to the control on the gingival level. In conclusion, DAM with ASC or without cells and the ECM ensures bone tissue healing. The membrane supported neovascularization and promoted osteoconduction.

Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology

2000 ◽  
Vol 24 (1) ◽  
pp. 253-269 ◽  
Author(s):  
P. MARK BARTOLD ◽  
CHRISTOPHER A. G. MCCULLOCH ◽  
A. SAMPATH NARAYANAN ◽  
SANDU PITARU
Keyword(s):  
Tissue Engineering ◽  
Cell Biology ◽  
Periodontal Regeneration ◽  
New Paradigm

Periodontal Tissue Engineering with a Multiphasic Construct and Cell Sheets

2019 ◽  
Vol 98 (6) ◽  
pp. 673-681 ◽  
Author(s):  
C. Vaquette ◽  
S. Saifzadeh ◽  
A. Farag ◽  
D.W. Hutmacher ◽  
S. Ivanovski
Keyword(s):  
Tissue Engineering ◽  
Periodontal Ligament ◽  
Cell Sheet ◽  
Periodontal Regeneration ◽  
Surrounding Tissue ◽  
Periodontal Ligament Cells ◽  
Periodontal Tissue ◽  
Micro Computed Tomography ◽  
Cell Sheets ◽  
Tissue Integration

This study reports on scaffold-based periodontal tissue engineering in a large preclinical animal model. A biphasic scaffold consisting of bone and periodontal ligament compartments manufactured by melt and solution electrospinning, respectively, was used for the delivery of in vitro matured cell sheets from 3 sources: gingival cells (GCs), bone marrow–derived mesenchymal stromal cells (Bm-MSCs), and periodontal ligament cells (PDLCs). The construct featured a 3-dimensional fibrous bone compartment with macroscopic pore size, while the periodontal compartment consisted of a flexible porous membrane for cell sheet delivery. The regenerative performance of the constructs was radiographically and histologically assessed in surgically created periodontal defects in sheep following 5 and 10 wk of healing. Histologic observation demonstrated that the constructs maintained their shape and volume throughout the entirety of the in vivo study and were well integrated with the surrounding tissue. There was also excellent tissue integration between the bone and periodontal ligament compartments as well as the tooth root interface, enabling the attachment of periodontal ligament fibers into newly formed cementum and bone. Bone coverage along the root surface increased between weeks 5 and 10 in the Bm-MSC and PDLC groups. At week 10, the micro–computed tomography results showed that the PDLC group had greater bone fill as compared with the empty scaffold, while the GC group had less bone than the 3 other groups (control, Bm-MSC, and PDLC). Periodontal regeneration, as measured by histologically verified new bone and cementum formation with obliquely inserted periodontal ligament fibers, increased between 5 and 10 wk for the empty, Bm-MSC, and PDLC groups, while the GC group was inferior to the Bm-MSC and PDLC groups at 10 wk. This study demonstrates that periodontal regeneration can be achieved via the utilization of a multiphasic construct, with Bm-MSCs and PDLCs obtaining superior results as compared with GC-derived cell sheets.

scholarly journals Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4802
Author(s):  
Min Guk Kim ◽  
Chan Ho Park
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Critical Role ◽  
Periodontal Regeneration ◽  
Tissue Formation ◽  
Hard Tissue ◽  
Periodontal Tissues ◽  
Mineralized Tissues ◽  
Biomechanical Forces

The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.

scholarly journals Current Status of Low Intensity Pulsed Ultrasound for Dental Purposes

2012 ◽  
Vol 6 (1) ◽  
pp. 220-225 ◽  
Author(s):  
Emanuel Braga Rego ◽  
Takashi Takata ◽  
Kazuo Tanne ◽  
Eiji Tanaka
Keyword(s):  
Tissue Engineering ◽  
Present Article ◽  
Cell Metabolism ◽  
Periodontal Regeneration ◽  
Current Status ◽  
Biological Functions ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
The Past

Over the past few years, tissue engineering applied to the dental field has achieved relevant results. Tissue engineering can be described by actions taken to improve biological functions. Several methods have been described to enhance cellular performance and low intensity pulsed ultrasound (LIPUS) has shown to play an important role in cell metabolism. The present article provides an overview about the current status of LIPUS as a tissue engineering tool to be used to enhance tooth and periodontal regeneration.

scholarly journals Stem cells, tissue engineering and periodontal regeneration

2013 ◽  
Vol 59 ◽  
pp. 117-130 ◽  
Author(s):  
J Han ◽  
D Menicanin ◽  
S Gronthos ◽  
PM Bartold
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Periodontal Regeneration
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