scholarly journals Treatment of Immature Scars: Evidence-Based Techniques and Treatments

2020 ◽  
pp. 193-201
Author(s):  
Julian Poetschke ◽  
Gerd G. Gauglitz
Keyword(s):  
Side Effects ◽  
Mode Of Action ◽  
Pulsed Dye Laser ◽  
Evidence Based ◽  
Burn Scar ◽  
Long Time ◽  
Hard Evidence ◽  
Scar Prevention ◽  
Silicone Gel Sheeting ◽  
Initial Research

AbstractSevere scarring is known for causing severe functional, aesthetic, and psychosocial impairments. During the last years, treatment of mature scars has evolved significantly; however, researchers and clinicians are more and more focused on preventing excessive scarring altogether, thus avoiding long and strenuous treatment. While some forms of scar prevention have been known and used for decades, others are relatively new and have yet to prove themselves. Pressure garments have long been successfully used in widespread burn scar prevention. However, reduced compliance, large treatment costs, and little hard evidence are points that should be taken into consideration regarding this well-established form of treatment. Silicone gel sheeting has also been used for a long time, and it is well regarded for its efficacy in reducing scar height and improving pliability while boasting little side effects. Its mode of action, however, remains unclear. Recently, lasers have become a new focus in the effort to prevent pathological scarring. Here, the older pulsed dye laser, as well as newer, fractional ablative and nonablative lasers, is increasingly employed for the treatment of fresh scars, where initial research is showing significant promise.This chapter explores the currently available methods for scar prevention and examines their application and the evidence regarding their efficacy.

scholarly journals Review on Evidence Based Ayurvedic Treatment Practices for Psoriasis

2018 ◽  
Vol 9 (2) ◽  
pp. 39-41
Author(s):  
Venkateshwarlu B ◽  
Anumol K ◽  
Mithuna Mohan ◽  
Priyanka Bai ◽  
Murali Krishna C ◽  
...  
Keyword(s):  
Side Effects ◽  
Time Use ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Therapeutic Approaches ◽  
Treatment Practices ◽  
Therapeutic Regime ◽  
Modern System ◽  
Long Time ◽  
Ayurvedic Treatment

Psoriasis is characterized by sharply defined erythematous squamous lesions. It is one of the commonest chronic, non-infectuous papulo-squamous disorder of the skin. Several treatment modalities are in existence in modern system of medicine; however they have limitations due to their side effects due to long time use. Considering this, search for new safe therapeutic regime in psoriasis is going on. The present paper presents some of the promising evidence based Ayurvedic therapeutic approaches in the management of psoriasis.  

Therapeutic Aspects of Squill; An Evidence-Based Review

2020 ◽  
Vol 17 (3) ◽  
pp. 318-324 ◽  
Author(s):  
Khadije Saket ◽  
Jalil T. Afshari ◽  
Ehsan Saburi ◽  
Mahdi Yousefi ◽  
Roshanak Salari
Keyword(s):  
Side Effects ◽  
Traditional Medicine ◽  
Respiratory Diseases ◽  
Low Cost ◽  
Current Evidence ◽  
Evidence Based ◽  
Helminthic Infections ◽  
Traditional Persian Medicine ◽  
Healing Of Wounds ◽  
Bioactive Agents

From ancient times, medicinal plants have been usually utilized to treat many disorders, but today, interest in these herbs is again aroused, because of their fewer side effects and low-cost. In traditional medicine, for many diseases, various medicinal herbs have been suggested so far. Drimia maritime, also named squill, is an important medicinal plant for the treatment of many diseases, especially respiratory diseases. In the current evidence-based study, we conducted a review of the general characteristics, ingredients, administration form, and side effects of squill in traditional medicine. For this purpose, traditional Persian medicine literatures and electronic databases were examined including PubMed, Scopus, and Google Scholar. Many compounds are isolated from D.maritima, including scillaren, scillirubroside, scillarenin, and bufadienolide glycosides. Oxymel is the most commonly used form of squill for various diseases, especially respiratory diseases. Besides, squill has been used in the treatment of cardiovascular, digestive, and dermatological disorders, it is also used against various cancer cells for its antioxidant and cytotoxic properties. Moreover, there is relatively reliable evidence of its benefits for bacterial and helminthic infections, rheumatism, edema, gout, abortion induction, healing of wounds and urine induction. It seems that supplementary studies are required to explore the bioactive agents and their effective mechanisms.

33 An Evidence Based Laser Therapy Algorithm for the Treatment of Burn Scars

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S26-S27
Author(s):  
Rajiv Sood
Keyword(s):  
Laser Treatment ◽  
Laser Therapy ◽  
Co2 Laser ◽  
Statistical Significance ◽  
Evidence Based ◽  
Baseline Measurement ◽  
Burn Scar ◽  
Therapy Algorithm ◽  
Laser Treatments ◽  
The Impact

Abstract Introduction Hypertrophic scarring after burn injury can be extremely painful, cause profound itching, and affect the way patients view themselves and how the outside world perceives them. We have utilized laser therapy as a modality for scar modulation for our patients since 2013. In 2014, we initiated and completed a prospective IRB approved study to evaluate the outcome of scars treated with fractional CO2 laser therapy (FLT) utilizing objective and subjective tools. Recently, we have completed a prospective study evaluating the use of pulse dye laser (PDL) therapy and the impact on post-burn pruritis. In reviewing the outcomes from these two studies, we have developed an evidence-based laser therapy algorithm for burn scar management. Methods The FLT study entailed a series of three CO2 laser treatments minimally 4–6 weeks apart with scar measurements and POSAS form completion performed prior to each laser treatment and four weeks after the last FLT. Scar measurements that included color, pliability, and scar thickness; and completion of the POSAS form were obtained prior to each laser therapy session and four weeks after the third laser treatment. The measurements of color, pliability, and scar thickness were measured with the Colorimeter, Cutometer, and ultrasound. The PDL study utilized the 5-D Itch scale to evaluate post-burn pruritis. A baseline measurement was obtained prior to any laser treatments. Each patient underwent two PDL sessions and a 5-D itch scale was completed four to six weeks after the second PDL session. The baseline measurement was then compared to the final 5-D itch scale measurement. Results Data from the FLT study is in Table 1 and shows that there were statistically significant improvements in the Patient and Observer POSAS scores, patient rated Itch score, scar thickness, and measured skin density. Changes to patient rated scar pain, scar color, and pliability were noted but were not of statistical significance. Data from the PDL study is in Table 2 and shows a statistically significant decrease in the treated patients’ post-burn pruritis. Conclusions In reviewing the outcomes of these two studies, we have developed an algorithm based on our studies. All of our patients undergoing laser therapy receive two PDL sessions that are four to six weeks apart followed by 3 FLT sessions. The use of both PDL and FLT decreases post-burn pruritis, decreases scar thickness, decreases pain, and increases patient satisfaction as shown in our research.

Evidence-based approaches for the management of side-effects of adjuvant endocrine therapy in patients with breast cancer

2021 ◽  
Author(s):  
Maria Alice Franzoi ◽  
Elisa Agostinetto ◽  
Marta Perachino ◽  
Lucia Del Mastro ◽  
Evandro de Azambuja ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Endocrine Therapy ◽  
Adjuvant Endocrine Therapy ◽  
Evidence Based

Update on hypnotherapy for psychiatrists

2021 ◽  
pp. 1-7
Author(s):  
Natalie A. Chan ◽  
Zhisong Zhang ◽  
Guoxing Yin ◽  
Zhimeng Li ◽  
Roger C. Ho
Keyword(s):  
Psychiatric Disorders ◽  
Practice Guidelines ◽  
Review Article ◽  
Outcome Studies ◽  
Evidence Based ◽  
High Quality ◽  
Long Time ◽  
Meta Analyses ◽  
Evidence Based Therapy

SUMMARY Although hypnosis has played a part in psychotherapy for a long time, it is not yet seen as an evidence-based therapy and is absent from many practice guidelines when it comes to the treatment of psychiatric disorders. At present, the applications and methods of hypnotherapy are poorly understood and other methods of psychotherapy tend to be favoured. This review article aims to introduce the role of hypnotherapy and its application for certain common psychiatric presentations, as well as examine its efficacy by summarising recent evidence from high-quality outcome studies and meta-analyses.

scholarly journals Comparison of the Effectiveness of Nonablative Fractional Laser versus Pulsed-Dye Laser in Thyroidectomy Scar Prevention

2014 ◽  
Vol 26 (5) ◽  
pp. 615 ◽  
Author(s):  
Ji Min Ha ◽  
Han Su Kim ◽  
Eun Byul Cho ◽  
Gyeong Hun Park ◽  
Eun Joo Park ◽  
...  
Keyword(s):  
Dye Laser ◽  
Pulsed Dye Laser ◽  
Fractional Laser ◽  
Scar Prevention

scholarly journals Helping or Harming? The Effect of Trigger Warnings on Individuals with Trauma Histories

2019 ◽  
Author(s):  
Payton J. Jones ◽  
Benjamin W. Bellet ◽  
Richard J. McNally
Keyword(s):  
Side Effects ◽  
World Literature ◽  
Empirical Studies ◽  
Emotional Reactions ◽  
Trauma Survivors ◽  
Evidence Based ◽  
Substantial Evidence ◽  
Adverse Side Effects ◽  
Mixed Samples ◽  
Trigger Warnings

Objective: Trigger warnings alert trauma survivors about potentially disturbing forthcoming content. However, most empirical studies on trigger warnings indicate that they are either functionally inert or cause small adverse side effects. These evaluations have been limited to either trauma-naïve participants or mixed samples. Accordingly, we tested whether trigger warnings would be psychologically beneficial in the most relevant population: survivors of serious trauma. Method: Our experiment was a preregistered replication and extension of a previous one (Bellet, Jones, & McNally, 2018); 451 trauma survivors were randomly assigned to either receive or not receive trigger warnings prior to reading potentially distressing passages from world literature. They provided their emotional reactions to each passage; self-reported anxiety was the primary dependent variable. Results: We found no evidence that trigger warnings were helpful for trauma survivors, for those who self-reported a PTSD diagnosis, or for those who qualified for probable PTSD, even when survivors' trauma matched the passages’ content. We found substantial evidence that trigger warnings countertherapeutically reinforce survivors' view of their trauma as central to their identity. Regarding replication hypotheses, the evidence was either ambiguous or substantially favored the hypothesis that trigger warnings have no effect. Conclusions: Trigger warnings are not helpful for trauma survivors. It is less clear whether trigger warnings are explicitly harmful. However, such knowledge is unnecessary to adjudicate whether to use trigger warnings – because trigger warnings are consistently unhelpful, there is no evidence-based reason to use them.

scholarly journals REVIEW: Organosulphure compound of garlic (Allium sativum L.) and its biological activities

2003 ◽  
Vol 1 (2) ◽  
pp. 65-76 ◽  
Author(s):  
UDHI EKO HERNAWAN ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Platelet Aggregation ◽  
Side Effects ◽  
Allium Sativum ◽  
Urinary Infection ◽  
Biological Activities ◽  
Bioactive Compound ◽  
Traditional Medicines ◽  
Anti Cancer ◽  
Long Time ◽  
Anti Oxidant

Garlic has been used a long time ago as traditional medicines. The valuable bulb is used to treat hypertension, respiratory infection, headache, hemorrhoids, constipation, bruised injury or slice, insomnia, cholesterol, influenza, urinary infection, etc. Garlic bulbs can be used as anti-diabetic, anti-hypertension, anti-cholesterol, anti-atheroschlerosis, anti-oxidant, anti-cell platelet aggregation, fibrinolyse spur, anti-viral, anti-microbial, and anti-cancer. The ultimate bioactive compound of garlic is organo-sulphure components, i.e. alliin, allicin, ajoene, allyl sulphide groups, and allyl cystein. There was not any report of any side effects or toxicity of garlic.

scholarly journals Glukokortikoidi v nefrologiji I: farmakologija in stranski učinki

2015 ◽  
Vol 84 (3) ◽  
Author(s):  
Jernej Pajek ◽  
Mojca Jensterle Sever
Keyword(s):  
Side Effects ◽  
Mode Of Action ◽  
Withdrawal Syndrome ◽  
Clinical Medicine ◽  
Ongoing Research ◽  
Organ Systems ◽  
Genomic Effects ◽  
Higher Doses

Glucocorticoids have been used in clinical medicine since 1940s. Despite the time-long use they are still a subject of active ongoing research. We describe the mode of action, pharmacology and side effects to enable proper prescription of these drugs. Glucocorticoids exert genomic and non-genomic effects, the latter become important at higher doses. The nomenclature of dosage ranges and the principles of dosage adjustments are given. Glucocortioid use is associated with frequent and important side effects in numerous organ systems. Prophylactic treatments for osteoporosis and infections are described. The suppression of hypothalamic-hypophyseal hormonal axis determines the need for gradual glucocorticoid withdrawal and supplementation after discontinuation. Finally, glucocorticoid withdrawal syndrome is described.

Managing the side effects of contraception

2021 ◽  
Vol 32 (6) ◽  
pp. 226-231
Author(s):  
Katie Boog
Keyword(s):  
Side Effects ◽  
Hormonal Contraception ◽  
Oral Contraceptive Pill ◽  
Common Reason ◽  
Evidence Based ◽  
Contraceptive Methods ◽  
Mood Change ◽  
Combined Oral Contraceptive ◽  
Free Interval ◽  
Combined Hormonal Contraception

Side effects are the most common reason for the discontinuation of contraceptive methods. Dr Katie Boog summarises the available evidence on how to manage them Although often transient, side effects are the most common reason for individuals to discontinue contraception. The evidence to prove causality is limited, as is evidence-based guidance on how to manage these side effects. This article summarises the available evidence. For individuals who have new or worsening acne on progestogen-only contraception (POC), switching to combined hormonal contraception (CHC) is likely to improve their skin. Continuous or extended CHC use may be beneficial for individuals with premenstrual mood change, and for those who experience headaches in the hormone-free interval. Unpredictable bleeding patterns on POC are common. Injectable users can try reducing the interval between injections to 10 weeks. Implant, injectable or intrauterine system users can be offered a 3-month trial of a combined oral contraceptive pill (COC). CHC and POP users with unpredictable bleeding may benefit from switching to an alternative preparation.

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