Vitamin E Homologues: Current Evidence

2016 ◽  
pp. 107-120
Author(s):  
Tiffany C. Yang ◽  
Helen M. Macdonald
Keyword(s):  
Vitamin E ◽  
Current Evidence

Vitamin E and Prostate Cancer: Current Evidence and Future Directions

2005 ◽  
Vol 1 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Margaret Wright ◽  
Michael Leitzmann
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Current Evidence ◽  
Future Directions

scholarly journals Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

2020 ◽  
Vol 17 (22) ◽  
pp. 8452
Author(s):  
Madalyn Riley Higgins ◽  
Azimeh Izadi ◽  
Mojtaba Kaviani
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Fruits And Vegetables ◽  
Performance Enhancement ◽  
Current Evidence ◽  
Antioxidant Supplementation ◽  
Negative Effects ◽  
Impaired Performance ◽  
Antioxidant Supplements ◽  
Vitamin E And C

Antioxidant supplementation, including vitamin E and C supplementation, has recently received recognition among athletes as a possible method for enhancing athletic performance. Increased oxidative stress during exercise results in the production of free radicals, which leads to muscle damage, fatigue, and impaired performance. Despite their negative effects on performance, free radicals may act as signaling molecules enhancing protection against greater physical stress. Current evidence suggests that antioxidant supplementation may impair these adaptations. Apart from athletes training at altitude and those looking for an immediate, short-term performance enhancement, supplementation with vitamin E does not appear to be beneficial. Moreover, the effectiveness of vitamin E and C alone and/or combined on muscle mass and strength have been inconsistent. Given that antioxidant supplements (e.g., vitamin E and C) tend to block anabolic signaling pathways, and thus, impair adaptations to resistance training, special caution should be taken with these supplements. It is recommended that athletes consume a diet rich in fruits and vegetables, which provides vitamins, minerals phytochemicals, and other bioactive compounds to meet the recommended intakes of vitamin E and C.

scholarly journals Associations of Dietary and Circulating Vitamin E Level With Metabolic Syndrome. A Meta-Analysis of Observational Studies

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi Zhang ◽  
Jun Ding ◽  
Hongbin Guo ◽  
Ze Liu ◽  
Qi Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin E ◽  
Observational Studies ◽  
Meta Analysis ◽  
The Other ◽  
Dietary Vitamin ◽  
Current Evidence ◽  
Control Subjects ◽  
Other Hand ◽  
Standard Mean Difference

Objective: The associations of dietary and circulating vitamin E level with metabolic syndrome (MetS) remains conflicting. This meta-analysis of observational study was therefore employed to investigate the issue above.Methods: The PubMed, Web of Science and Embase database were searched up to April 2021. The observational studies on the associations of dietary and circulating vitamin E level with MetS were specified. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary and circulating vitamin E level, and the standard mean difference (SMD) of dietary and circulating vitamin E level for MetS vs. control subjects, were calculated.Results: A total of 25 observational studies with 51,276 participants, were included in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary vitamin E level was inversely associated with MetS (RR = 0.92, 95%CI: 0.85–1.00; P = 0.044). In addition, the dietary vitamin E level in MetS was also lower than that in control subjects according to the overall combined SMD (SMD = −0.08, 95%CI: −0.14 to −0.02; P = 0.024). On the other hand, the overall multi-variable adjusted RR showed no significant relationship between the circulating vitamin E level and MetS (RR = 1.46, 95%CI: 0.85–2.48; P = 0.17). However, the circulating vitamin E level in MetS was lower than that in control subjects according to the overall combined SMD (SMD = −0.58, 95%CI: −1.04 to −0.13; P = 0.013).Conclusions: The results of this meta-analysis suggest that the dietary vitamin E level is inversely associated with MetS. On the other hand, current evidence is still insufficient to conclude a relationship between the circulating vitamin E level and MetS. More well-designed prospective cohort studies are needed to address the issues further.

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

2020 ◽  
Vol 76 (5) ◽  
pp. 354-360
Author(s):  
Lixia Zhang ◽  
Xiaoyan Shi ◽  
Jinran Yu ◽  
Peipei Zhang ◽  
Ping Ma ◽  
...  
Keyword(s):  
Vitamin E ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Dietary Vitamin ◽  
Current Evidence ◽  
Cross Sectional ◽  
Dietary Recall ◽  
Health And Nutrition ◽  
Daily Energy ◽  
Using Data

<b><i>Introduction:</i></b> Current evidence on the association between dietary vitamin E intake and hyperuricemia risk is limited and conflicting. <b><i>Objective:</i></b> The aim of the study was to assess the association of dietary vitamin E intake with hyperuricemia in US adults. <b><i>Methods:</i></b> We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey, 2009–2014. Dietary vitamin E intake was evaluated through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were used to examine the association between dietary vitamin E intake and hyperuricemia. <b><i>Results:</i></b> Overall, 12,869 participants were included. The prevalence of hyperuricemia was 19.35%. After adjustment for age, gender, BMI, race, educational level, smoking status, alcohol consumption, physical activity, total daily energy intake, total cholesterol, protein intake, glomerular filtration rate, serum Cr, use of uric acid drugs, and drug abuse, the odds ratio (95% confidence interval) of hyperuricemia for the highest tertile of dietary vitamin E intake was 0.77 (0.63–0.96) compared with that of the lowest tertile. In men, dietary vitamin E intake and hyperuricemia were negatively correlated. In stratified analyses by age (20–39, 40–59, and ≥60 years), dietary vitamin E intake was inversely associated with hyperuricemia only among participants aged ≥60 years. Dose-response analyses showed that dietary vitamin E intake was inversely associated with hyperuricemia in a nonlinear manner. <b><i>Conclusion:</i></b> Dietary vitamin E intake was negatively correlated with hyperuricemia in US adults, especially among males and participants aged ≥60 years.

scholarly journals Vitamin E as an Antiosteoporotic Agent via Receptor Activator of Nuclear Factor Kappa-B Ligand Signaling Disruption: Current Evidence and Other Potential Research Areas

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kok-Yong Chin ◽  
Soelaiman Ima-Nirwana
Keyword(s):  
Vitamin E ◽  
Bone Metabolism ◽  
Molecular Mechanism ◽  
Nuclear Factor Kappa B ◽  
Bone Cells ◽  
Early Stage ◽  
Current Evidence ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator

Osteoporosis is a growing healthcare burden that affects the quality of life in the aging population. Vitamin E is a potential prophylactic agent that can impede the progression of osteoporosis. Variousin vivostudies demonstrated the antiosteoporotic potential of vitamin E, but evidence on its molecular mechanism of action is limited. A fewin vitrostudies showed that various forms of vitamin E can affect the receptor activator of nuclear factor kappa-B ligand (RANKL) signaling and their molecular targets, thus preventing the formation of osteoclasts in the early stage of osteoclastogenesis. Various studies have also shown that the effects of the different isoforms of vitamin E differ. The effects of single isoforms and combinations of isoforms on bone metabolism are also different. Vitamin E may affect bone metabolism by disruption of free radical-mediated RANKL signaling, by its oestrogen-like effects, by its effects on the molecular mechanism of bone formation, by the anti-inflammatory effects of its long-chain metabolites on bone cells, and by the inhibition of 3-hydroxyl-3-methyglutaryl coenzyme A (HMG-CoA). In conclusion, the vitamin E isoforms have enormous potential to be used as prophylactic and therapeutic agents in preventing osteoporosis, but further studies should be conducted to elucidate their mechanisms of action.

scholarly journals The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence

2019 ◽  
Vol 20 (6) ◽  
pp. 1453 ◽  
Author(s):  
Sok Wong ◽  
Nur-Vaizura Mohamad ◽  
Nurul Ibrahim ◽  
Kok-Yong Chin ◽  
Ahmad Shuid ◽  
...  
Keyword(s):  
Vitamin E ◽  
Bone Resorption ◽  
Bone Formation ◽  
Molecular Mechanisms ◽  
Nuclear Factor Kappa B ◽  
Bone Remodelling ◽  
Current Evidence ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator

Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption is coupled with bone formation to maintain the bone volume and microarchitecture. This process is a result of communication between bone cells (osteoclasts, osteoblasts, and osteocytes) with paracrine and endocrine regulators, such as cytokines, reactive oxygen species, growth factors, and hormones. The essential signalling pathways responsible for osteoclastic bone resorption and osteoblastic bone formation include the receptor activator of nuclear factor kappa-B (RANK)/receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG), Wnt/β-catenin, and oxidative stress signalling. The imbalance between bone formation and degradation, in favour of resorption, leads to the occurrence of osteoporosis. Intriguingly, vitamin E has been extensively reported for its anti-osteoporotic properties using various male and female animal models. Thus, understanding the underlying cellular and molecular mechanisms contributing to the skeletal action of vitamin E is vital to promote its use as a potential bone-protecting agent. This review aims to summarize the current evidence elucidating the molecular actions of vitamin E in regulating the bone remodelling cycle.

scholarly journals The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Omid Asbaghi ◽  
Mehdi Sadeghian ◽  
Behzad Nazarian ◽  
Mehrnoosh Sarreshtedari ◽  
Hassan Mozaffari-Khosravi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Vitamin E ◽  
Beneficial Effect ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Inflammatory Biomarkers ◽  
Current Evidence ◽  
Serum Concentrations ◽  
Tnf Α ◽  
Vitamin E Supplementation

Abstract The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the effects of vitamin E supplementation on inflammatory biomarkers in adults. We searched the online databases using relevant keywords up to November 2019. Randomized clinical trials (RCTs) investigating the effect of vitamin E, compared with the placebo, on serum concentrations of inflammatory cytokines were included. Overall, we included 33 trials with a total sample size of 2102 individuals, aged from 20 to 70 years. Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (− 0.52, 95% CI − 0.80, − 0.23 mg/L, P < 0.001). Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used α-tocopherol and those trials that included patients with disorders related to insulin resistance. Moreover, we found a significant reducing effect of vitamin E supplementation on tumor necrosis factor-α (TNF-α) concentrations at high dosages of vitamin E; such that based on dose–response analysis, serum TNF-α concentrations were reduced significantly at the dosages of ≥ 700 mg/day vitamin E (Pnon-linearity = 0.001). Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults. Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting.

scholarly journals Vitamin E in Sarcopenia: Current Evidences on Its Role in Prevention and Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Shy Cian Khor ◽  
Norwahidah Abdul Karim ◽  
Wan Zurinah Wan Ngah ◽  
Yasmin Anum Mohd Yusof ◽  
Suzana Makpol
Keyword(s):  
Vitamin E ◽  
Antioxidant Properties ◽  
Current Evidence ◽  
Geriatric Syndrome ◽  
Age Related ◽  
Prevention And Treatment ◽  
Muscle Health

Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS) can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and currentin vitroandin vivostudies.

The Tempo and mode(S) of Prebiotic Evolution

1997 ◽  
Vol 161 ◽  
pp. 419-429 ◽  
Author(s):  
Antonio Lazcano
Keyword(s):  
Origin Of Life ◽  
Organic Compounds ◽  
Biological Evolution ◽  
Current Evidence ◽  
Early Diversification ◽  
Time Period ◽  
The Galaxy ◽  
History Of ◽  
Widespread Phenomenon ◽  
The Origin Of Life

AbstractDifferent current ideas on the origin of life are critically examined. Comparison of the now fashionable FeS/H2S pyrite-based autotrophic theory of the origin of life with the heterotrophic viewpoint suggest that the later is still the most fertile explanation for the emergence of life. However, the theory of chemical evolution and heterotrophic origins of life requires major updating, which should include the abandonment of the idea that the appearance of life was a slow process involving billions of years. Stability of organic compounds and the genetics of bacteria suggest that the origin and early diversification of life took place in a time period of the order of 10 million years. Current evidence suggest that the abiotic synthesis of organic compounds may be a widespread phenomenon in the Galaxy and may have a deterministic nature. However, the history of the biosphere does not exhibits any obvious trend towards greater complexity or «higher» forms of life. Therefore, the role of contingency in biological evolution should not be understimated in the discussions of the possibilities of life in the Universe.

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