Medicinal Plants of District Kupwara Used in the Treatment of Human Diseases and Their Associated Biological Functions

2020 ◽  
pp. 325-347
Author(s):  
Mudasir Nazir Bhat ◽  
Bikarma Singh ◽  
Mohammed Asif Chowdhary ◽  
Sumit Singh ◽  
Opender Surmal ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Human Diseases ◽  
Biological Functions

Extraction of Essential Oils from Medicinal Plants and their Utilization as Food Antioxidants

2020 ◽  
Vol 26 (5) ◽  
pp. 519-541 ◽  
Author(s):  
Giovanna Ferrentino ◽  
Ksenia Morozova ◽  
Christine Horn ◽  
Matteo Scampicchio
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Beneficial Effect ◽  
Essential Oils ◽  
Bioactive Compounds ◽  
Antimicrobial Properties ◽  
Food Products ◽  
Human Diseases ◽  
Present Review ◽  
Green Technologies

Background: The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of essential oils extracted from medicinal plants to cure human diseases such as hypertension, diabetes, or obesity. However, to preserve their bioactivity, the use of appropriate extraction technologies is required. Method: The present review aims to describe the studies published so far on the essential oils focusing on their sources and chemical composition, the technologies used for their recovery and their application as antioxidants in food products. Results: The review has been structured in three parts. In the first part, the main compounds present in essential oils extracted from medicinal plants have been listed and described. In the second part, the most important technologies used for extraction and distillation, have been presented. In detail, conventional methods have been described and compared with innovative and green technologies. Finally, in the last part, the studies related to the application of essential oils as antioxidants in food products have been reviewed and the main findings discussed in detail. Conclusions: In summary, an overview of the aforementioned subjects is presented by discussing the results of the most recent published studies.

scholarly journals Ethnobotanical and ethnoecological study of the most important edible, medicinal and industrial species in the grasslands of Khalil Abad region, Zarrin Dasht, Fars province, Iran

2019 ◽  
Vol 6 (2) ◽  
pp. 275-280
Author(s):  
Kourosh Kord ◽  
Fatemeh Abedi ◽  
Hamidreza Kazemeini ◽  
Somayeh Shahsavari ◽  
Kamal Solati
Keyword(s):  
Medicinal Plants ◽  
Indigenous Knowledge ◽  
New Drugs ◽  
Human Diseases ◽  
Fars Province ◽  
Herbal Drugs ◽  
Peganum Harmala ◽  
Zataria Multiflora ◽  
First Report

It is vital to record and preserve indigenous knowledge on plants to prevent loss of this valuable information. The indigenous knowledge about herbal drugs can provide us with useful information, such as their phytotherapeutic activities for the treatment of various diseases. This study investigated the indigenous knowledge regarding the use of medicinal plants for the treatment of human diseases and disorders in Khalil Abad region, Zarrin Dasht County, Fars province (Iran) from January to May 2017. Questionnaires were distributed among the subjects and traditional herbal information were recorded. The medicinal plants in this region are predominantly bush, including Zataria multiflora Boiss, Peganum harmala L., Alhagi persarum Boiss. & Buhse and Astragalus sp. The results of this study indicate that the residents of Khalil Abad village use various medicinal plants for nutritional and medicinal purposes. This is the first report of the ethnobotany of the region and the medicinal plants of indigenous knowledge of this region could be used as a source for new drugs.

scholarly journals HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

2018 ◽  
Vol 47 (3) ◽  
pp. 893-913 ◽  
Author(s):  
Qing Tang ◽  
Swei Sunny Hann
Keyword(s):  
Drug Resistance ◽  
Human Cancer ◽  
Critical Role ◽  
Stem Cell Differentiation ◽  
Human Diseases ◽  
Biological Functions ◽  
Protein Coding ◽  
Non Coding Rna ◽  
And Function ◽  
Long Non Coding Rna

Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

Modern Molecular Biology Technologies and Higher Usability of Ancient Knowledge of Medicinal Plants for Treatment of Human Diseases

2019 ◽  
pp. 173-205 ◽  
Author(s):  
Venkatesh Vaidyanathan ◽  
Vijay Naidu ◽  
Anower Jabed ◽  
Khanh Tran ◽  
Prasanna Kallingappa ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Molecular Biology ◽  
Human Diseases ◽  
Modern Molecular Biology

scholarly journals LncTarD: a manually-curated database of experimentally-supported functional lncRNA–target regulations in human diseases

2019 ◽  
Author(s):  
Hongying Zhao ◽  
Jian Shi ◽  
Yunpeng Zhang ◽  
Aimin Xie ◽  
Lei Yu ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Sequence Data ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Biological Functions ◽  
Functional Dynamics ◽  
Disease Associations ◽  
Non Coding Rnas ◽  
User Friendly ◽  
Pan Cancer

Abstract Long non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA–disease associations have received significant attention, no online repository is available to collect lncRNA-mediated regulatory mechanisms, key downstream targets, and important biological functions driven by disease-related lncRNAs in human diseases. We thus developed LncTarD (http://biocc.hrbmu.edu.cn/LncTarD/ or http://bio-bigdata.hrbmu.edu.cn/LncTarD), a manually-curated database that provides a comprehensive resource of key lncRNA–target regulations, lncRNA-influenced functions, and lncRNA-mediated regulatory mechanisms in human diseases. LncTarD offers (i) 2822 key lncRNA–target regulations involving 475 lncRNAs and 1039 targets associated with 177 human diseases; (ii) 1613 experimentally-supported functional regulations and 1209 expression associations in human diseases; (iii) important biological functions driven by disease-related lncRNAs in human diseases; (iv) lncRNA–target regulations responsible for drug resistance or sensitivity in human diseases and (v) lncRNA microarray, lncRNA sequence data and transcriptome data of an 11 373 pan-cancer patient cohort from TCGA to help characterize the functional dynamics of these lncRNA–target regulations. LncTarD also provides a user-friendly interface to conveniently browse, search, and download data. LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.

scholarly journals The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

2020 ◽  
Author(s):  
Guoxia Wen ◽  
Tong Zhou ◽  
Wanjun Gu
Keyword(s):  
Liquid Biopsy ◽  
Developmental Stages ◽  
Current Knowledge ◽  
Cell Types ◽  
Circular Rna ◽  
Disease Diagnosis ◽  
Human Diseases ◽  
Biological Functions ◽  
Aberrant Expression ◽  
Physiological Processes

Abstract Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing. Their expression is dynamically regulated and shows spatiotemporal patterns among cell types, tissues and developmental stages. CircRNAs have important biological functions in many physiological processes, and their aberrant expression is implicated in many human diseases. Due to their high stability, circRNAs are becoming promising biomarkers in many human diseases, such as cardiovascular diseases, autoimmune diseases and human cancers. In this review, we focus on the translational potential of using human blood circRNAs as liquid biopsy biomarkers for human diseases. We highlight their abundant expression, essential biological functions and significant correlations to human diseases in various components of peripheral blood, including whole blood, blood cells and extracellular vesicles. In addition, we summarize the current knowledge of blood circRNA biomarkers for disease diagnosis or prognosis.

scholarly journals MPDB 2.0: A Large Scale and Integrated Medicinal Plant Database of Bangladesh

2021 ◽  
Author(s):  
Nazmul Hussain ◽  
Rony Chando ◽  
Ruhshan Ahmed Abir ◽  
Mohsina Akter Mou ◽  
Md. Kamrul Hasan ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Large Scale ◽  
East Asian ◽  
Folk Medicine ◽  
Human Diseases ◽  
Health Practitioners ◽  
The World ◽  
Medicine History ◽  
User Friendly

Medicinal plants are generally defined as rare herbals with potent medicinal activities that can be used as an alternative treatment for diseases. Recent studies exploring novel medicine developments, originating from folk-medicinal practices challenges this notion and suggests that both the circumference of the term medicinal plant and their potential application covers a substantially extensive verse than previously suggested. While medicinal plants are not limited to the borders of any country, Bangladesh and its south-east Asian neighbors do boast a huge collection of potent medicinal plants with considerable folk-medicine history compared to most other countries of the world. MPDB 2.0 is the continuation of MPDB 1.0, it serves as both a data repertoire for medicinal of Bangladesh and a user-friendly interface for researchers, health practitioners, drug developers, and students who wish to study the various medicinal & nutritive plants scattered around Bangladesh and the underlying phytochemicals contributing to their efficacy in folk medicine. While in developing MPDB 2.0 human diseases have been highly focused upon, the information in this database is not limited in its application for human diseases or diseases only, as many of the plants indexed here can serve in developing biofuel or bioremediation technologies or nutritive diets or cosmetics, etc. MPDB 2.0 comprises a collection of more than five hundred medicinal plants from Bangladesh along with a record of their corresponding scientific, family, and local names together with their utilized parts, information regarding ailments, active compounds, and PubMed ID of related publications.

scholarly journals Study on Usage of Medicinal plants for human diseases by the Traditional Healers of Pachamalai Hills, Tamil Nadu, India

2016 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
M. Manoranjitham ◽  
M. Kamaraj
Keyword(s):  
Medicinal Plants ◽  
Medical Practice ◽  
Tamil Nadu ◽  
Traditional Healers ◽  
Human Diseases ◽  
Future Generations

The traditional healers of Pachamalai hills were studied for the use of medicinal plants for treating various human diseases.  For the present study, the medicinal usage of 40 plants have reported.   Migrations of younger generations  and not willing to practice have resultant in declining the medical practice by the healers. There is a danger the knowledge of the usage of medicinal plants also die with them.  This made us in realising the urgent desire both in documenting the plants and taking efficient steps to conserve them both for present and future generations

Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives

2020 ◽  
Vol 21 (5) ◽  
pp. 443-487
Author(s):  
Snober Shabeer Wani ◽  
Parvaiz A. Dar ◽  
Sajad M. Zargar ◽  
Tanveer A. Dar
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Human Diseases ◽  
Current Status ◽  
Mistletoe Lectin ◽  
Plant Proteins ◽  
Drug Candidates

Biologically active molecules obtained from plant sources, mostly including secondary metabolites, have been considered to be of immense value with respect to the treatment of various human diseases. However, some inevitable limitations associated with these secondary metabolites like high cytotoxicity, low bioavailability, poor absorption, low abundance, improper metabolism, etc., have forced the scientific community to explore medicinal plants for alternate biologically active molecules. In this context, therapeutically active proteins/peptides from medicinal plants have been promoted as a promising therapeutic intervention for various human diseases. A large number of proteins isolated from the medicinal plants have been shown to exhibit anti-microbial, anti-oxidant, anti-HIV, anticancerous, ribosome-inactivating and neuro-modulatory activities. Moreover, with advanced technological developments in the medicinal plant research, medicinal plant proteins such as Bowman-Birk protease inhibitor and Mistletoe Lectin-I are presently under clinical trials against prostate cancer, oral carcinomas and malignant melanoma. Despite these developments and proteins being potential drug candidates, to date, not a single systematic review article has documented the therapeutical potential of the available biologically active medicinal plant proteome. The present article was therefore designed to describe the current status of the therapeutically active medicinal plant proteins/peptides vis-à-vis their potential as future protein-based drugs for various human diseases. Future insights in this direction have also been highlighted.

Stress Proteins: Biological Functions, Human Diseases, and Virus Infections

2021 ◽  
pp. 77-102
Author(s):  
Ming-Liang He ◽  
Qianya Wan ◽  
Dan Song ◽  
Betsy He
Keyword(s):  
Stress Proteins ◽  
Human Diseases ◽  
Biological Functions ◽  
Virus Infections
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