scholarly journals Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan

2021 ◽  
Author(s):  
Saori Mizuno-Iijima ◽  
Toshiaki Nakashiba ◽  
Shinya Ayabe ◽  
Hatsumi Nakata ◽  
Fumio Ike ◽  
...  
Keyword(s):  
Quality Control ◽  
Science Studies ◽  
Cost Effective ◽  
Added Value ◽  
Research Center ◽  
High Quality ◽  
Control Programs ◽  
International Mouse Phenotyping Consortium ◽  
The Government ◽  
Resource Networks

AbstractThe RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division, one of the BRC infrastructure divisions, has been designated as the core facility for mouse resources within the National BioResource Project (NBRP) by the Japanese government since FY2002. Our activities regarding the collection, preservation, quality control, and distribution of mouse resources have been supported by the research community, including evaluations and guidance on advancing social and research needs, as well as the operations and future direction of the BRC. Expenditure for collection, preservation, and quality-control operations of the BRC, as a national core facility, has been funded by the government, while distribution has been separately funded by users’ reimbursement fees. We have collected over 9000 strains created mainly by Japanese scientists including Nobel laureates and researchers in cutting-edge fields and distributed mice to 7000 scientists with 1500 organizations in Japan and globally. Our users have published 1000 outstanding papers and a few dozen patents. The collected mouse resources are accessible via the RIKEN BRC website, with a revised version of the searchable online catalog. In addition, to enhance the visibility of useful strains, we have launched web corners designated as the “Mouse of the Month” and “Today’s Tool and Model.” Only high-demand strains are maintained in live colonies, while other strains are cryopreserved as embryos or sperm to achieve cost-effective management. Since 2007, the RIKEN BRC has built up a back-up facility in the RIKEN Harima branch to protect the deposited strains from disasters. Our mice have been distributed with high quality through the application of strict microbial and genetic quality control programs that cover a globally accepted pathogens list and mutated alleles generated by various methods. Added value features, such as information about users’ publications, standardized phenotyping data, and genome sequences of the collected strains, are important to facilitate the use of our resources. We have added and disseminated such information in collaboration with the NBRP Information Center and the NBRP Genome Information Upgrading Program. The RIKEN BRC has participated in international mouse resource networks such as the International Mouse Strain Resource, International Mouse Phenotyping Consortium, and Asian Mouse Mutagenesis and Resource Association to facilitate the worldwide use of high-quality mouse resources, and as a consequence it contributes to reproducible life science studies and innovation around the globe.

scholarly journals Formularium Nasional (FORNAS) dan e-Catalogue Obat Sebagai Upaya Pencegahan Korupsi dalam Tata Kelola Obat Jaminan Kesehatan Nasional (JKN)

INTEGRITAS ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. 30
Author(s):  
Syahdu Winda Winda
Keyword(s):  
Quality Control ◽  
Cost Control ◽  
Drug Prescription ◽  
Cost Effective ◽  
Health Facilities ◽  
Control Cost ◽  
Drug Procurement ◽  
The Government ◽  
Facility Level ◽  
Effective Drugs

In the National Health Insurance (JKN), drug governance have to implement quality control and cost control. The Government has published the National Formulary (FORNAS) as quality control and e-catalogue as price control. FORNAS and e-catalogue are expected to minimize corruption practices in drug prescription and drug procurement. Quality and cost effective drugs have been selected in FORNAS. Use of drug and restrictions are also regulated for each level of health facilities to avoid irrational using. FORNAS is expected to reduce corruption by eliminating bribery/gratification practices to doctors/hospitals by pharmaceutical companies. On the other hand, the corruption holes in the procurement are tried to be reduced through the e-catalogue system. A number of drugs needed have been tendered and negotiated by LKPP at the best price in e-catalogue. Health facilities can carry out drug procurement quickly and transparently without auction process. But in the process of applying FORNAS and e-catalogue as quality control, cost control and to minimize corruption, there are still problems that have not yet been able to reach their goals optimally. Mismatch number of drugs and item of drugs in FORNAS and e-catalogue, differences of drug lists in FORNAS with the Clinical Practice Guidelines (PPK), the absence of rules governing the minimum percentage of FORNAS in Hospital formularies, delays in drug display processes in e-catalogs and weaknesses in e-catalogue application is a series of problems that still hamper FORNAS and e-catalogue as solutions to prevent corruption in JKN drug governance. Relevant agencies (Ministry of Health and LKPP) need to make improvements in the form of regulations that encourage FORNAS compliance at each of the health facility level, fulfillment of FORNAS drug items in e-catalogue, availability of FORNAS in e-catalogue in early year and improvement of e-catalogue application features.

scholarly journals Introduction

1986 ◽  
Vol 87 (3-4) ◽  
pp. 113-114
Author(s):  
John Atwell
Keyword(s):  
Quality Standards ◽  
Local Economy ◽  
Raw Material ◽  
Added Value ◽  
Processed Foods ◽  
High Quality ◽  
Strong Link ◽  
Food And Beverages ◽  
The Government

Excluding brewing and distilling, the food and beverages sector of the Scottish economy is estimated to employ about one in six of the manufacturing workforce and has a gross added value of just over £1000m per annum. These industries also have a strong link with suppliers of machinery and packaging equipment within the local economy, and of course with Scottish agriculture which provides an important part of the raw material used. On the conservative assumption that Scotland is responsible for about 10% of the U.K. exports of unprocessed and processed foods, which total just short of £3000m per annum and that exports depend on high quality standards in choice of raw material for processing, Scotland should be uniquely placed to contribute to the government-backed 'Food from Britain' campaign which is now getting under way.

Innovation on Quality Control: Case from Chinese Biggest E-Commerce Platform Operator

2012 ◽  
Vol 472-475 ◽  
pp. 3067-3070
Author(s):  
Hua Yao Zhang
Keyword(s):  
Quality Control ◽  
Cost Effective ◽  
Third Party ◽  
Control Case ◽  
Evaluation Design ◽  
High Quality ◽  
Analysis Problem ◽  
Specific Approach ◽  
Interaction Mode ◽  
And Control

This paper introduces the innovation on quality control from a single Tmall mode to online and offline interaction mode taken by the biggest Chinese e-commerce platform operator of Alibaba. During analysis, problem Alibaba has ever faced is followed by specific approach it applied, and then by a discussion of relative issues. What a reader can learn from this research is that the innovation is designed for the purpose of providing cost-effective, high-quality goods with perfect services. Consumer-oriented evaluation design and joint certification and control with suppliers and third-party agencies are severing for these purposes.

Predicting effects of quality-control practices on the cost-effective operation of a stable, multitest analytical system

1990 ◽  
Vol 36 (10) ◽  
pp. 1760-1764 ◽  
Author(s):  
J O Westgard ◽  
J J Oryall ◽  
D D Koch
Keyword(s):  
Quality Control ◽  
Error Detection ◽  
Predictive Models ◽  
Cost Effective ◽  
Batch Size ◽  
High Quality ◽  
Low Frequencies ◽  
Effective Operation ◽  
Analytical System ◽  
The Cost

Abstract The cost-effective operation of an analytical system depends on quality-control (QC) practices such as the QC procedure itself (control rules, number of control measurements); the batch size or the run length; and the use of bracketed, nonbracketed, or pre-control modes of operation. Predictive value models that predict the defect rate and test yield of each test, as well as of the system as a whole, have been used to study these practices and to develop strategies for improving the quality and productivity of a multitest analyzer. Quality was optimized for most tests by achieving high error detection and low false rejection by the QC procedures. For a few tests where ideal QC performance could not be achieved, predictive models indicate that high quality is achieved, predictive models indicate that high quality is achieved as long as the observed stabilities (low frequencies of errors) of the measurement procedures are maintained. In our laboratories, productivity gains of 2.9% ($17,400/year) were achieved by changing QC procedures. Predictive models indicate that further gains are possible by increasing batch size and changing from bracketed to nonbracketed control operation. In general, the common practice of bracketed control on stable analytical systems may need to be re-examined owing to its effect on the cost of operation.

scholarly journals Establishment of seed quality control programs

1998 ◽  
Vol 55 (spe) ◽  
pp. 34-38 ◽  
Author(s):  
S. M. Cicero
Keyword(s):  
Quality Control ◽  
Internal Control ◽  
Seed Quality ◽  
Control Program ◽  
Physical Structure ◽  
External Control ◽  
High Quality ◽  
Quality Control Program ◽  
Control Programs ◽  
Administrative Procedures

An efficient quality control program should lead to the production of high quality seeds. Consequently, a series of technical and administrative procedures must be adopted in a way that does not compromise this objective. Considering that, in applied terms, external control becomes less important as internal control programs advance technologically, this work emphasizes the principle factors that should be considered in the implantation of a seed quality control program, such as: work groups, physical structure and procedures to initiate the program.

Crisis Reactions and Their Consequences for the Real Sector of the Russian Economy

2011 ◽  
pp. 39-50
Author(s):  
V. Lushin
Keyword(s):  
Financial Crisis ◽  
Acute Phase ◽  
Dutch Disease ◽  
Added Value ◽  
Real Sector ◽  
The Real ◽  
Balanced Development ◽  
Russian Economy ◽  
The Government ◽  
State Modernization

The author analyzes factors that led to a deeper fall in output and profitability in the real sector of the Russian economy in comparison with other segments during the acute phase of the financial crisis. It is argued that some contradictions in the government anti-recession policy, activities of the financial sector and natural monopolies lead to pumping out added value created in manufacturing and agriculture, increase symptoms of the «Dutch disease», etc. It is shown that it may threaten the balanced development of the Russian economy, and a set of measures is suggested to minimize these tendencies and create a basis for the state modernization policy.

Analisis Rantai Nilai Komoditas Cabai Merah

2019 ◽  
Vol 2 (1) ◽  
pp. 336-346
Author(s):  
Dhamon Oridilla B
Keyword(s):  
Distribution Pattern ◽  
Distribution Patterns ◽  
Added Value ◽  
Commodity Chain ◽  
Market Prices ◽  
Data Analyst ◽  
Bargaining Position ◽  
Agricultural Business ◽  
The Government ◽  
Red Peppers

Candi Village in Bandungan District is one of the Chili Supply Sub-district for Semarang Regency and surrounding area has agro-climate suitable for the development of various agricultural commodities supported by wide market opportunity, so it is suitable for agricultural business development. The purpose of this research is to identify the distribution pattern of red pepper, to know each value of commodity chains and distribution, to design alternative distribution pattern of red pepper.Population in this research is 88 respondents from 735 of member of chilli farmer in Desa Candi with total area of 150,3 hectare consisting of rice field, moor and yard. Methods of data analyst using quantitative approach is done by using Margin Marketing Analysis. The results include: (1) The pattern of distribution of existing farming business grows naturally in accordance with the developments and needs of the perpetrators, the actors in this pattern are farmers, wholesalers, collectors, wholesalers, retailers, consumers. (2) The value of the red chili commodity chain in this naturally grown pattern often makes pricing more dominant by traders, so farmers receive prices slightly lower than market prices. (3) Some obstacles faced in distributing red peppers are the difficulty of changing the mindset of the community about advanced farming, this is best utilized by market participants (chain of distribution) who are more informed and always keep abreast of market dynamics. Conventional marketing pattern by farmer cause price level accepted by farmer in general relatively smaller compared to price received by trader. Suggestions shorten the chain of distribution patterns, increase the added value of products and improve the bargaining position of farmers and for the government always guide / accompany farmers in getting accurate market information, which can be used as farmers in bargaining, Increased market transparency can act as a trigger for the functioning of a market, improved competition and increased adaptation to meet the needs of supply and opportunity to compete with market prices. Desa Candi di Kabupaten Bandungan adalah salah satu Kecamatan Penyedia Cabai untuk Kabupaten Semarang dan sekitarnya memiliki agroklimat yang cocok untuk pengembangan berbagai komoditas pertanian yang didukung oleh peluang pasar yang luas, sehingga sangat cocok untuk pengembangan bisnis pertanian. Tujuan dari penelitian ini adalah untuk mengidentifikasi pola distribusi cabai merah, untuk mengetahui masing-masing nilai rantai komoditas dan distribusi, untuk merancang alternatif pola distribusi cabai merah. Populasi dalam penelitian ini adalah 88 responden dari 735 anggota petani cabai di Desa Candi dengan total luas 150,3 hektar yang terdiri dari sawah, tegalan dan pekarangan. Metode analis data menggunakan pendekatan kuantitatif dilakukan dengan menggunakan Analisis Pemasaran Margin. Hasil meliputi: (1) Pola distribusi usaha pertanian yang ada tumbuh secara alami sesuai dengan perkembangan dan kebutuhan pelaku, pelaku dalam pola ini adalah petani, pedagang besar, pengumpul, pedagang besar, pedagang besar, pengecer, konsumen. (2) Nilai rantai komoditas cabai merah dalam pola yang dikembangkan secara alami ini sering membuat penetapan harga lebih dominan oleh para pedagang, sehingga petani menerima harga yang sedikit lebih rendah daripada harga pasar. (3) Beberapa kendala yang dihadapi dalam mendistribusikan paprika merah adalah sulitnya mengubah pola pikir masyarakat tentang pertanian maju, hal ini paling baik digunakan oleh pelaku pasar (rantai distribusi) yang lebih banyak informasi dan selalu mengikuti perkembangan dinamika pasar. Pola pemasaran konvensional oleh petani menyebabkan tingkat harga yang diterima petani pada umumnya relatif lebih kecil dibandingkan dengan harga yang diterima pedagang. Saran mempersingkat rantai pola distribusi, meningkatkan nilai tambah produk dan meningkatkan posisi tawar petani dan bagi pemerintah selalu membimbing / menemani petani dalam mendapatkan informasi pasar yang akurat, yang dapat digunakan sebagai petani dalam tawar-menawar, Peningkatan transparansi pasar dapat bertindak sebagai pemicu berfungsinya pasar, meningkatnya kompetisi dan peningkatan adaptasi untuk memenuhi kebutuhan pasokan dan peluang untuk bersaing dengan harga pasar.

The Formability and Elongation of Aluminum Alloys AA5083 and AA3003 for Micro-Truss Sandwiches Manufacturing

2020 ◽  
Vol 38 (9A) ◽  
pp. 1396-1405
Author(s):  
Arwa F. Tawfeeq ◽  
Matthew R. Barnett
Keyword(s):  
Aluminum Alloy ◽  
Strain Rate ◽  
Cost Effective ◽  
Tensile Tests ◽  
Truss Structures ◽  
High Quality ◽  
Trade Off ◽  
Clad Layer ◽  
Higher Temperature ◽  
Different Shapes

The development in the manufacturing of micro-truss structures has demonstrated the effectiveness of brazing for assembling these sandwiches, which opens new opportunities for cost-effective and high-quality truss manufacturing. An evolving idea in micro-truss manufacturing is the possibility of forming these structures in different shapes with the aid of elevated temperature. This work investigates the formability and elongation of aluminum alloy sheets typically used for micro-truss manufacturing, namely AA5083 and AA3003. Tensile tests were performed at a temperature in the range of 25-500 ○C and strain rate in the range of 2x10-4 -10-2 s-1. The results showed that the clad layer in AA3003 exhibited an insignificant effect on the formability and elongation of AA3003. The formability of the two alloys was improved significantly with values of m as high as 0.4 and 0.13 for AA5083 and AA3003 at 500 °C. While the elongation of both AA5083 and AA3003 was improved at a higher temperature, the elongation of AA5083 was inversely related to strain rate. It was concluded that the higher the temperature is the better the formability and elongation of the two alloys but at the expense of work hardening. This suggests a trade-off situation between formability and strength. 

The cost-effectiveness of insulin analogs and regular insulin for diabetes control: a case study in Iran

2020 ◽  
Vol 33 (4/5) ◽  
pp. 323-331
Author(s):  
Mohsen pakdaman ◽  
Raheleh akbari ◽  
Hamid reza Dehghan ◽  
Asra Asgharzadeh ◽  
Mahdieh Namayandeh
Keyword(s):  
Cost Effectiveness ◽  
Cost Effective ◽  
Regular Insulin ◽  
Diabetes Control ◽  
Diabetic Patients ◽  
Insulin Analogs ◽  
Content Type ◽  
Patients With Diabetes ◽  
The Government ◽  
The Cost

PurposeFor years, traditional techniques have been used for diabetes treatment. There are two major types of insulin: insulin analogs and regular insulin. Insulin analogs are similar to regular insulin and lead to changes in pharmacokinetic and pharmacodynamic properties. The purpose of the present research was to determine the cost-effectiveness of insulin analogs versus regular insulin for diabetes control in Yazd Diabetes Center in 2017.Design/methodology/approachIn this descriptive–analytical research, the cost-effectiveness index was used to compare insulin analogs and regular insulin (pen/vial) for treatment of diabetes. Data were analyzed in the TreeAge Software and a decision tree was constructed. A 10% discount rate was used for ICER sensitivity analysis. Cost-effectiveness was examined from a provider's perspective.FindingsQALY was calculated to be 0.2 for diabetic patients using insulin analogs and 0.05 for those using regular insulin. The average cost was $3.228 for analog users and $1.826 for regular insulin users. An ICER of $0.093506/QALY was obtained. The present findings suggest that insulin analogs are more cost-effective than regular insulin.Originality/valueThis study was conducted using a cost-effectiveness analysis to evaluate insulin analogs versus regular insulin in controlling diabetes. The results of study are helpful to the government to allocate more resources to apply the cost-effective method of the treatment and to protect patients with diabetes from the high cost of treatment.

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