scholarly journals Actively revealing card attack on card-based protocols

2021 ◽  
Author(s):  
Ken Takashima ◽  
Daiki Miyahara ◽  
Takaaki Mizuki ◽  
Hideaki Sone
Keyword(s):  
Secure Computation ◽  
Malicious Attack ◽  
Formal Framework ◽  
Almost All ◽  
And Function

AbstractIn 1989, den Boer presented the first card-based protocol, called the “five-card trick,” that securely computes the AND function using a deck of physical cards via a series of actions such as shuffling and turning over cards. This protocol enables a couple to confirm their mutual love without revealing their individual feelings. During such a secure computation protocol, it is important to keep any information about the inputs secret. Almost all existing card-based protocols are secure under the assumption that all players participating in a protocol are semi-honest or covert, i.e., they do not deviate from the protocol if there is a chance that they will be caught when cheating. In this paper, we consider a more malicious attack in which a player as an active adversary can reveal cards illegally without any hesitation. Against such an actively revealing card attack, we define the t-secureness, meaning that no information about the inputs leaks even if at most t cards are revealed illegally. We then actually design t-secure AND protocols. Thus, our contribution is the construction of the first formal framework to handle actively revealing card attacks as well as their countermeasures.

scholarly journals Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 350
Author(s):  
Julianty Frost ◽  
Mark Frost ◽  
Michael Batie ◽  
Hao Jiang ◽  
Sonia Rocha
Keyword(s):  
Gene Expression ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Regulator ◽  
Hydroxylase Activity ◽  
Control Of Gene Expression ◽  
Prolyl Hydroxylases ◽  
Chromatin Organisation ◽  
Sense And Respond ◽  
Almost All ◽  
And Function

Hypoxia—reduction in oxygen availability—plays key roles in both physiological and pathological processes. Given the importance of oxygen for cell and organism viability, mechanisms to sense and respond to hypoxia are in place. A variety of enzymes utilise molecular oxygen, but of particular importance to oxygen sensing are the 2-oxoglutarate (2-OG) dependent dioxygenases (2-OGDs). Of these, Prolyl-hydroxylases have long been recognised to control the levels and function of Hypoxia Inducible Factor (HIF), a master transcriptional regulator in hypoxia, via their hydroxylase activity. However, recent studies are revealing that dioxygenases are involved in almost all aspects of gene regulation, including chromatin organisation, transcription and translation. We highlight the relevance of HIF and 2-OGDs in the control of gene expression in response to hypoxia and their relevance to human biology and health.

scholarly journals The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration

2021 ◽  
Vol 22 (5) ◽  
pp. 2472
Author(s):  
Carl Randall Harrell ◽  
Valentin Djonov ◽  
Vladislav Volarevic
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Cells ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Multipotent Stem Cells ◽  
Tissue Repair And Regeneration ◽  
Almost All ◽  
And Function

Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.

scholarly journals Soil ammonia-oxidizing archaea in a paddy field with different irrigation and fertilization managements

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Limin Wang ◽  
Dongfeng Huang
Keyword(s):  
Ammonia Oxidation ◽  
Chemical Properties ◽  
Paddy Soils ◽  
Soil Nitrification ◽  
Treated Soil ◽  
Ammonia Oxidizing Archaea ◽  
Rice Yields ◽  
Traditional Irrigation ◽  
Almost All ◽  
And Function

AbstractBecause ammonia-oxidizing archaea (AOA) are ubiquitous and highly abundant in almost all terrestrial soils, they play an important role in soil nitrification. However, the changes in the structure and function of AOA communities and their edaphic drivers in paddy soils under different fertilization and irrigation regimes remain unclear. In this study, we investigated AOA abundance, diversity and activity in acid paddy soils by a field experiment. Results indicated that the highest potential ammonia oxidation (PAO) (0.011 μg NO 2 -  –N g-1 d.w.day-1) was found in T2 (optimal irrigation and fertilization)—treated soils, whereas the lowest PAO (0.004 μg NO 2 -  –N g-1 d.w.day-1) in T0 (traditional irrigation)- treated soils. Compared with the T0—treated soil, the T2 treatment significantly (P < 0.05) increased AOA abundances. Furthermore, the abundance of AOA was significantly (P < 0.01) positively correlated with pH, soil organic carbon (SOC), and PAO. Meanwhile, pH and SOC content were significantly (P < 0.05) higher in the T2—treated soil than those in the T1 (traditional irrigation and fertilization)- treated soil. In addition, these two edaphic factors further influenced the AOA community composition. The AOA phylum Crenarchaeota was mainly found in the T2—treated soils. Phylogenetic analysis revealed that most of the identified OTUs of AOA were mainly affiliated with Crenarchaeota. Furthermore, the T2 treatment had higher rice yield than the T0 and T1 treatments. Together, our findings confirm that T2 might ameliorate soil chemical properties, regulate the AOA community structure, increase the AOA abundance, enhance PAO and consequently maintain rice yields in the present study.

scholarly journals STEM-17. NOT ALL GBM STEM CELLS ARE EQUAL: IMPLICATIONS FOR RESEARCH AND THERAPY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii199-ii200
Author(s):  
Luciano Galdieri ◽  
Arijita Jash ◽  
Olga Malkova ◽  
Diane Mao ◽  
Jian Campian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Phenotypic Diversity ◽  
Treatment Resistance ◽  
Surface Markers ◽  
Mass Cytometry ◽  
Pathway Activation ◽  
Almost All ◽  
And Function ◽  
Activation Status

Abstract Glioblastoma (GBM) kills almost all patients within 2 years. A subpopulation of cells, GBM stem cells (GSCs), contributes to treatment resistance and recurrence. A major therapeutic goal is to kill GSCs, but no targeted therapy yet exists. Since their discovery, GSCs have been isolated using single surface markers, such as CD15, CD44, CD133, and a-6 integrin. It remains unknown how these single surface marker-defined GSC populations compare to each other in terms of signal transduction and function and whether expression of different combinations of these markers is associated with distinct phenotypes. Using mass cytometry and fresh operating room specimens, we found that 15 distinct GSC subpopulations exist in vivo and they differ in their MEK/ERK, WNT, and AKT pathway activation status. In culture, some subpopulations were lost and previously undetectable ones materialized. GSCs highly expressing all four surface markers had the greatest self-renewal capacity and in vivo tumorigenicity as well as the strongest WNT pathway activation. This work highlights the signaling and phenotypic diversity in GSC subpopulations, together suggesting that not all GSCs are equivalent. These observations should be considered when studying GSCs in the laboratory, with implications for the development of treatments that target GSCs and prevent tumor recurrence in patients.

Inter-Basal and Septal Connections of Papillary Muscles - An Anatomical Rationale for Rhythmic Opening of AV Valves - A Multicentric Medical College Based Cross Sectional Study

2021 ◽  
Vol 8 (31) ◽  
pp. 2865-2869
Author(s):  
Praveen Mulki Shenoy ◽  
Amith Ramos ◽  
Narasimha Pai ◽  
Bharath Shetty ◽  
Aravind Pallipady Rao
Keyword(s):  
Left Ventricle ◽  
Papillary Muscle ◽  
Interventricular Septum ◽  
Cross Sectional Study ◽  
Papillary Muscles ◽  
Cross Sectional ◽  
Medical College ◽  
Moderator Band ◽  
Almost All ◽  
And Function

BACKGROUND The papillary muscle basal connections have significant clinical implications. Variety of studies done on its morphology and function by various specialists in different departments. A close look on these revealed the interconnections of papillary muscles to one another and to the interventricular septum of both ventricles is related to uncoordinated contractions of papillary muscles, leading to hyper or hypokinesia or prolapse or even its rupture. METHODS Our study done in 25 formalin soaked hearts revealed after the deep and meticulous dissection, reflecting the walls of ventricles laterally the numerous interconnections of papillary muscles at its bases and IVS. Ventricles are opened by inverted ‘L’ shaped incision and its reflected more laterally till all the papillary muscles is visible in one frame after incising the moderator band. The connections were noted, measured, photographed, tabulated, compared with similar studies and analysed with experts with respective fields. RESULTS Almost all the specimens did have the interconnections. Further the post mortem findings of the cardiac related deaths with involvement of papillary muscles suggest damage to such ‘bridges’. The moderator band extensions to the base of right APM, and its extension to the posterior groups is noted in all the specimens. The bridge from the IVS to bases of both the groups of papillary muscles is noted in left ventricle. In90% of specimens the one PPM is found to be loosely connected, more so in left ventricle. CONCLUSIONS We are of a conclusion that such basal interconnections and to the interventricular septum are responsible for rhythmic contractions of papillary muscles of both ventricles. Since the AV valves have to open simultaneously, interconnections becomes mandatory as the impulse has to reach it before it reaches the trabeculae carniae. One of the Posterior papillary muscles is loosely connected to other papillary muscles, may be the reason for its rupture, more so in left ventricle. KEYWORDS Papillary Muscle, Interbasal Connection, Moderator Band, Valvular Prolapse, AV Valves

scholarly journals Delineating urban functional regions by considering interaction cohesiveness and function diversity

2019 ◽  
Vol 1 ◽  
pp. 1-1
Author(s):  
Fei-Ying Kuo ◽  
Tzai-Hung Wen
Keyword(s):  
Public Transportation ◽  
Urban System ◽  
Market Area ◽  
Functional Region ◽  
Trip Purpose ◽  
Functional Regions ◽  
Human Movements ◽  
Local Labour ◽  
Almost All ◽  
And Function

<p><strong>Abstract.</strong> A functional region is usually defined as a region characterized by not only interaction cohesiveness but also function diversity. The former indicates that places within a region should share a cohesive interacting pattern of human movements, such as commute or daily travel; the latter means that the places should possess diverse functions like residence, commerce, etc. Due to these two characteristics, people living and moving in one region can acquire almost all their daily needs, and they do not need to frequently move to other regions. In other words, a functional region resembles a life circle. Based on this definition, many previous studies have developed different methods to analyse human flow data so that they can properly profile different types of functional regions like Local labour market area (LLMA) or daily urban system (DUS), which helps people better understand how functional regions compose an area. Existing methods have considered interaction cohesiveness in a functional region, but function diversity is ignored. This is because these studies only used specific-purpose-trip data, such as journey to work or to shop. These kinds of trips describe people moving from their home to their office or to shopping malls, so each trip has an inherent distinction of functions between its origin and destination; thus, a functional region consisting of these trips indirectly owns function diversity. However, this framework has some problems. First, it cannot profile a functional region shaped by composite functions, for only one trip purpose can be taken into account each time. Second, collecting the data of specific-purpose trips needs either some questionnaires or some surveys, so it is often costly and time consuming. Finally, the purpose-unrecorded-trip data provided by rapidly developed smart card systems in several countries can be collected quickly, yet it cannot properly profile functional regions through the aforementioned framework due to the lack of trip purposes. Therefore, we propose a new spatial partitioning algorithm which can simultaneously consider both interaction cohesiveness and function diversity in profiling functional regions. Compared with previous methods, the proposed algorithm can better profile functional regions from many purpose-unrecorded-trip data based on the inclusion of land-use data. Our results provide deeper insights for understanding how various functions of lands and human movements together shape the boundary of a region. It could be significant reference for developing policies for urban planning or public transportation management.</p>

scholarly journals How important risk analysis of plastic pollution in coastal area? Case study in Masohi, Central Maluku

2020 ◽  
Vol 200 ◽  
pp. 02014
Author(s):  
Bachtiar W Mutaqin ◽  
Muh Aris Marfai ◽  
Muhammad Helmi ◽  
Nurhadi Nurhadi ◽  
Muhammad Rizali Umarella ◽  
...  
Keyword(s):  
Public Awareness ◽  
Coastal Areas ◽  
Plastic Waste ◽  
Small Island ◽  
Marine Biota ◽  
Plastic Pollution ◽  
Short Period ◽  
Almost All ◽  
And Function ◽  
Interdisciplinary Study

Human pressure on the coastal and aquatic surrounding ecosystem in Indonesia, through plastic waste, is increasing, considering that 60 % of the approximately 250 million people live in the coastal areas. Plastic waste originating from human activities has become a massive problem in almost all the small island and coastal regions, especially in the eastern part of Indonesia. This condition is caused by poor waste management and a lack of public awareness in disposing of waste in its place, including in an area known as its marine biodiversities and marine tourism spots like Masohi in Central Maluku. Also, the composition of waste is dominated by plastic waste that cannot be decomposed in a short period, continue circulated on the ocean currents, and will be deposited in coastal areas. Furthermore, some plastic waste will break down into micro-plastics that pollute not only the environment but also marine biota, which are often consumed by humans. This situation profoundly affects the sustainability and function of aquaecosystem services in coastal areas. Therefore, a comprehensive policy and regulation, and interdisciplinary study for analysing vulnerable coastal ecosystem, and mitigating the potential risk of plastic pollution in Masohi, Central Maluku are essential to be conducted.

KAJIAN ORNAMEN GORGA DI RUMAH ADAT BATAK TOBA (Studi Kasus : Di Kawasan Desa Wisata Tomok, Huta Siallagan dan Huta Bolon Di Kabupaten Samosir)

2019 ◽  
Vol 2 (1) ◽  
pp. 1-14
Author(s):  
Dearma A Saragih ◽  
Yulianto Yulianto ◽  
Raimundus Pakpahan
Keyword(s):  
Comparative Research ◽  
Research Method ◽  
Toba Batak ◽  
Historical Heritage ◽  
The Many ◽  
Almost All ◽  
And Function ◽  
Meaning And Function ◽  
House Building

One of the interesting cultural potentials to be studied is traditional houses. This traditional house has its own uniqueness in every area. One of the uniqueness can be seen from the many ornaments in it. Diversity has its own meaning and function. Ornaments is one of the historical heritage of Indonesia where almost all the tribes in Indonesia can be found various kinds of ornaments that reflect the techniques of each region in Indonesia. Ornament Batak Toba is one of the many ornaments that exist in this country Indonesia. Toba Batak ornament can be found in North Sumatera Province precisely in Samosir regency which always apply Toba Batak ornament as decoration or as identity in important building for Batak Toba, for example in traditional house building in Huta Siallagan, Tomok Village and Huta Bolon.This research is classified in research using descriptive-comparative research method, doing the study by comparing the existing ornaments in these three villages with theories about Ornaments Gorga Rumah Adat Batak Toba, then do the analysis of the condition in accordance with the theory used as a reference

Molecular Paleontology and Biochemical Evolution

2008 ◽  
Author(s):  
Susan M. Gaines ◽  
Geoffrey Eglinton ◽  
Jürgen Rullkötter
Keyword(s):  
Twentieth Century ◽  
Cambrian Explosion ◽  
Microbial World ◽  
Form And Function ◽  
The Past ◽  
Unicellular Algae ◽  
Almost All ◽  
And Function ◽  
Multicellular Organisms ◽  
Molecular Paleontology

Carl Woese’s drive for a unified system of biological classification didn’t just open the microbial world to exploration: it reshuffled the entire taxonomic system and revolutionized the way that biologists study evolution, reigniting interest in preanimal evolution. Studies of evolution from the mid-nineteenth through most of the twentieth century relied on the comparison of forms in living and fossil organisms and were limited to the complex multicellular organisms that developed over the past 550 million years. In other words, much was known about the evolution of animals and land plants that left distinctive hard fossils, and very little was known about the unicellular algae and microorganisms that occupied the seas for most of the earth’s history. Woese’s Tree of Life, derived from nucleic acid sequences in ribosomal RNA, has revealed ancestral relationships that form and function don’t even hint at, allowing biologists to look beyond the rise of multicellular life and link it with less differentiated, more primal forms—which was precisely Woese’s intention. But evolution is a history, not just a family tree of relationships. If the information stored in the genes of extant organisms is to provide true insight into that history, it needs to be anchored in time, linked to extinct organisms and to past environments. Ultimately, we must look to the record in the rocks and sediments, just as paleontologists and biologists have been doing for the past two centuries. In Darwin’s time, that record comprised rocks from the past 550 million years, a span of time that geologists now call the Phanerozoic eon, based on Greek words meaning visible or evident life. The eon began with the rocks of the Cambrian period, in which nineteenth- and early-twentieth-century paleontologists discovered a fabulous assortment of fossils—traces of trilobites, anemones, shrimp, and other multicellular animals that were completely missing from any of the earlier strata. Thousands of new animals and plants, including representatives of almost all contemporary groups, as well as hundreds of now-extinct ones, appeared so suddenly between 542 and 530 million years ago that paleontologists refer to the phenomenon as the Cambrian “explosion.”

scholarly journals (MED) RESIDENT SATISFACTION IN CANADIAN PEDIATRIC RESIDENT CONTINUITY CLINICS

2018 ◽  
Vol 23 (suppl_1) ◽  
pp. e57-e57
Author(s):  
Adila El-Korazati ◽  
Erin Peebles ◽  
Michael Miller ◽  
Bojana Babic
Keyword(s):  
Residency Training ◽  
Outpatient Setting ◽  
Resident Satisfaction ◽  
Contributing Factors ◽  
Training Environment ◽  
Common Structure ◽  
Included Patient ◽  
June July ◽  
Almost All ◽  
And Function

Abstract BACKGROUND Resident continuity clinics (RCCs) provide an opportunity for residents to gain experience with longitudinal care in an outpatient setting. RCCs have become a part of almost all recognized residency training programs across specialties in North America. However, the structure, function, and effectiveness of RCCs vary widely. OBJECTIVES To determine resident perspective on the structure and function of paediatric RCCs and investigate which factors were associated with resident satisfaction with paediatric RCCs. DESIGN/METHODS A qualitative survey of Canadian paediatric resident trainees was conducted to assess their RCC experience. The survey was administered through the REDCap© database and distributed through the Canadian Pediatric Program Directors Consortium in June-July 2016. RESULTS There were 127 respondents. Approximately 40% participated in RCCs. The majority of respondents were likely to recommend RCCs to other programs. The most common structure reported was a monthly half-day clinic overseen by an academic paediatrician. Referrals were mainly from inpatient wards, emergency department or family physicians. The majority of residents were satisfied with their experience (n=33, 71.7%). Participants in resident-run RCCs had more positive views compared to participants in staff-run RCCs (all U≥25.0, p≤0.009). Contributing factors to a positive RCC experience included patient-resident continuity, being viewed as the main care provider, and learning to make independent management decisions. CONCLUSION Almost all respondents felt that RCCs should be part of paediatric residency training. Further research is needed to determine the optimal structure for paediatric RCCs. Understanding our current training environment is an important precursor for informing program leadership and national policymakers who wish to improve ambulatory care training

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