Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2/HO-1 system and inflammatory response in tongue of male Wistar rats

2018 ◽  
Vol 25 (12) ◽  
pp. 12072-12082 ◽  
Author(s):  
Norhan M. El-Sayed ◽  
Amal A. M. Ahmed ◽  
Manar A. A. Selim
Keyword(s):  
Inflammatory Response ◽  
Cytotoxic Effect ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats

2019 ◽  
Vol Volume 12 ◽  
pp. 73-86 ◽  
Author(s):  
Dzhuliia Sh. Dzhalilova ◽  
Anna M Kosyreva ◽  
Mikhail E. Diatroptov ◽  
Elena A. Ponomarenko ◽  
Ivan S. Tsvetkov ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Wistar Rats ◽  
Systemic Inflammatory Response ◽  
Resistance To Hypoxia ◽  
Male Wistar Rats

Curcumin prevents inflammatory response, oxidative stress and insulin resistance in high fructose fed male Wistar rats: Potential role of serine kinases

2016 ◽  
Vol 244 ◽  
pp. 187-194 ◽  
Author(s):  
Nachimuthu Maithilikarpagaselvi ◽  
Magadi Gopalakrishna Sridhar ◽  
Rathinam Palamalai Swaminathan ◽  
Bobby Zachariah
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Inflammatory Response ◽  
Wistar Rats ◽  
Potential Role ◽  
High Fructose ◽  
Male Wistar Rats ◽  
Serine Kinases

scholarly journals EFFECT OF SINGLE INTAKE OF EXOGENOUS HEPATOCYTES GROWTH INDUCER ON THE INDICES OF NON-SPECIFIC RESISTANCE UNDER CONDITIONS OF POSTRESECTION LIVER INJURY

2016 ◽  
Vol 1 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Прокопьев ◽  
Maksim Prokopev ◽  
Коваль ◽  
Elena Koval ◽  
Курганский ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Resection ◽  
Liver Injury ◽  
Inflammatory Response ◽  
Postoperative Period ◽  
Wistar Rats ◽  
Specific Resistance ◽  
White Male ◽  
Early Postoperative Period ◽  
Male Wistar Rats

HGF is one of the factors taking part in regeneration and recovery of liver after injury. The article is dedicated to the study of influence of single HGF intake on the indices of non-specific immune response in rats after 70% liver resection in the early postoperative period. Research was conducted on 42 six-months white male Wistar rats of 250–300 g. It was revealed that level of segmentonuclear neutrophils and lymphocytes in the group with HGF intake stand at normal level on the 2nd day and normalizes to the 11th day that testifies to the decrease of inflammatory response. Increased level of leukocytes and monocytes is registered in the group with HGF intake. Also integrity of non-specific resistance in the early postoperative period on the 2nd day is registered. Suppression of phagocytosis indices with preservation of functional activity of phagocytes was registered to the 11th day.

scholarly journals Pengaruh Pemberian Ekstrak Daun Mahkota Dewa pada Gambaran Histopatologi Paru Tikus Putih yang Dipapar Asap Rokok

2019 ◽  
Vol 17 (1) ◽  
pp. 48
Author(s):  
NGURAH BAGUS RADITYA SRI DAMAR ◽  
JANTO POERNOMO HADI ◽  
EDIJONO EDIJONO ◽  
TROEF SOEMARNO
Keyword(s):  
Inflammatory Response ◽  
Cigarette Smoke ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Leaf Extract ◽  
White Male ◽  
Significant Difference ◽  
Lung Histopathology ◽  
Male Wistar Rats ◽  
Phaleria Macrocarpa

<p><strong>Background</strong>: Smoking is a bad habit for health. There are many dangerous components inside a cigarette. The smoke that comes out from the cigarette contains many harmful components. Smoking and getting exposed to cigarette smoke in a long period of time can cause inflammatory response on respiratory tract. Mahkota dewa leaf contains beneficial biological component, such as <em>flavonoid</em>, <em>alkaloid</em>, and<em>saponin </em>that have anti-inflammatory, anti-cancer, and many others.</p><p><strong>Aim :</strong>The purpose of this research was to determine the effect of administration of mahkota dewa leaf (<em>Phaleria macrocarpa</em>) extract onlung histopathology in white male Wistar rats (<em>Rattus norvegicus</em>) exposed to cigarette smoke.</p><p><strong>Methods : </strong>This research is a true laboratory experimental research using <em>Post-Test Only Control Group Design</em>. The subject in this research were 30 male Wistar Rats (<em>Rattus norvegicus</em>) which were divided into 4 groups, a group without given any treatment (K-), a group where they only getting exposed to cigarette smoke (K+), a group where they exposed to cigarette smoke and given mahkota dewa leaf extract at 1500 mg/kgBW/day dose (Eg1), and the group exposed to cigarette smoke and a mahkota dewa leaf extract at a 2500 mg/kgBW/day dose (Eg2).</p><p><strong>Result            : </strong>1.) There was a significant difference on lung histopathology between K- and K+, Eg1, and Eg2. 2.) There was no significant difference on lung histopathology between K+, Eg1 and Eg2.</p><p><strong>Conclusion : </strong>Exposure to 5 cigarette smoke in 21 days caused lung histopathology changes. However, there was no effect of the administration of mahkota dewa leaves extract at 1500 mg/kgBW/day and 2500 mg/kgBW/day on lung histopathology of white male Wistar rats exposed to 5 cigarette smoke in 21 days.</p><p><strong>Keyword : </strong><em>Phaleria macrocarpa leaf, </em>Flavonoid, Alkaloid, cigarette smoke, inflammatory response, Infiltration of Inflammatory cells.</p>

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

Augurin stimulates food intake in male Wistar rats

2013 ◽  
pp. 1-1
Author(s):  
Michael Patterson ◽  
John Tadross ◽  
Keisuke Suzuki ◽  
Kylie Beale ◽  
Charoltte Boughton ◽  
...  
Keyword(s):  
Food Intake ◽  
Wistar Rats ◽  
Male Wistar Rats

Pengaruh Profilaksis Ekstrak Ubi Jalar Ungu (Ipomoea batatas L.) terhadap Kadar Malondialdehida Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karagenan

2018 ◽  
Vol 15 (2) ◽  
pp. 146
Author(s):  
BRILIAN DINANTI ◽  
FITRI HANDAJANI
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Wistar Rats ◽  
Group Method ◽  
Control Group ◽  
Intraplantar Injection ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Potato Extract ◽  
Purple Sweet Potato

<p>Liver is an organ with complex metabolism. When the liver is inflamed, cellular immunity will defend against inflammatory agents by stimulating immune cells to produce reactive oxygen species (ROS). Excessive ROS accumulation cause oxydative stress with increased  liver malondialdehyde (MDA) level. Some researches showed that purple sweet potato contain flavonoids (anthocyanins) that functioned as antioxydants. This study aimed to show the prophylactic effect of purple sweet potato extract to the liver MDA level of male Wistar rats induced by carrageenan.</p><p>This study used post-only control group method using 18 male Wistar rats divided into 3 groups: group of rats without treatment, group of rats induced by 0,1 ml of 1% carrageenan by intraplantar injection on day-8, and group of rats given with 872 mg/kgBW of purple sweet potato extract for 7 days and induced by 0,1 ml of 1% carrageenan. In the end of the study, the liver MDA levels were measured by Thio-Barbituric Acid method on each groups.</p><p>The results of One-Way ANOVA test showed there was no significant difference (p = 0,290) between group of rats without treatment (<em>x̅</em>= 207,50) and group of rats induced by carrageenan (<em>x̅</em>=233,17). Then, there is no significant difference (p = 0.978) between group of rats induced by carrageenan and group of rats given with prophylactic purple sweet potato extract and induced by carrageenan (<em>x̅</em>= 232,50).</p><p>The conclusion of this study is giving intraplantar injection of carrageenan can increase liver MDA level insignificantly and giving prophylactic purple sweet potato extract has an effect to decrease the liver MDA level of rats induced by carragenan insignificantly because it contains anthocyanins as antioxidants.</p><p> </p><strong>Keywords: </strong>Liver, <em>Ipomoea batatas</em> L., Malondialdehyde, Anthocyanins

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