Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

2009 ◽  
Vol 52 (12) ◽  
pp. 2161-2165 ◽  
Author(s):  
XiLin Xiao ◽  
LiXia Yang ◽  
ManLi Guo ◽  
ChunFeng Pan ◽  
QingYun Cai ◽  
...  
Keyword(s):  
Anodic Oxidation ◽  
Pure Titanium ◽  
Titania Nanotubes ◽  
Antineoplastic Drug

Nanosurface Modifacation of Biomedical β Titanium Alloy for Dental Implant and its Antibacterial Property

2014 ◽  
Vol 904 ◽  
pp. 142-145 ◽  
Author(s):  
Yu Min Qi ◽  
Bai Hui Ma ◽  
Yue Jiao Geng ◽  
Jia Yin Deng ◽  
Chun Xiang Cui
Keyword(s):  
Dental Implant ◽  
Anodic Oxidation ◽  
Antibacterial Property ◽  
Pure Titanium ◽  
Processing Parameters ◽  
Electrolytic Solution ◽  
Nanotube Array ◽  
Good Antibacterial Activity ◽  
Before And After

The TiO2 nanotube array film was synthesized on the surface of Ti-Nb-Zr-Mo βTitanium alloy via anodic oxidation in single electrolytic solution only containing HF. The diameter of TiO2 nanotubes was 30-50nm, and the length was 240nm. Compared with the processing parameters (including anodizing voltage, reaction time, concentration and kinds of electrolytic solution) used for pure Titanium or Ti-6Al-4V alloy, the parameters was further optimized. The surface morphology and element compositions Ti-Nb-Zr-Mo alloy before and after anodic oxidation were observed and analyzed by a scanning electron microscope (SEM) and an energy dispersive X-ray (EDX) spectrometer. The antibacterial property of TiO2 nanotube array film prepared with optimal conditions was evaluated by coculture in vitro between Actinomyces viscosus and materials tested. The results indicated that the TiO2 nanotube array film had very good antibacterial activity to resist Actinomyces viscosus. TiO2 nanotube array film/Ti-Nb-Zr-Mo βTi alloy biocomposite will be an more excellent dental implant owning good biomechanical adaptability, biocompatibility and antibacterial property.

In vitro Behaviour of Alumina-Hydroxiapatite Composites Coatings

2018 ◽  
Vol 69 (6) ◽  
pp. 1416-1418
Author(s):  
Alexandru Szabo ◽  
Ilare Bordeasu ◽  
Ion Dragos Utu ◽  
Ion Mitelea
Keyword(s):  
Pure Titanium ◽  
Titanium Substrate ◽  
High Strength ◽  
Biological Properties ◽  
Commercially Pure Titanium ◽  
Hvof Spraying ◽  
Before And After ◽  
Sbf Solution ◽  
Oxygen Fuel

Hydroxyapatite (HA) is a very common material used for biomedical applications. Usually, in order to improve its poor mechanical properties is combined or coated with other high-strength materials.The present paper reports the manufacturing and the biocompatibility behaviour of two different biocomposite coatings consisting of alumina (Al2O3) and hydroxyapatite (HA) using the high velocity oxygen fuel (HVOF) spraying method which were deposited onto the surface of a commercially pure titanium substrate. The biological properties of the Al2O3-HA materials were evaluated by in vitro studies. The morphology of the coatings before and after their immersing in the simulated body fluid (SBF) solution was characterized by scanning electron microscopy (SEM). The results showed an important germination of the biologic hydroxyapatite crystallite on the surface of both coatings.

scholarly journals Biocompatibility Characteristics of Titanium Coated with Multi Walled Carbon Nanotubes—Hydroxyapatite Nanocomposites

Materials ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 224 ◽  
Author(s):  
Jung-Eun Park ◽  
Yong-Seok Jang ◽  
Tae-Sung Bae ◽  
Min-Ho Lee
Keyword(s):  
Electron Microscopy ◽  
Carbon Nanotubes ◽  
Sol Gel ◽  
Pure Titanium ◽  
Cell Proliferation And Differentiation ◽  
Transmission Electron ◽  
Proliferation And Differentiation ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Multi walled carbon nanotubes-hydroxyapatite (MWCNTs-HA) with various contents of MWCNTs was synthesized using the sol-gel method. MWCNTs-HA composites were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). HA particles were generated on the surface of MWCNT. Produced MWCNTs-HA nanocomposites were coated on pure titanium (PT). Characteristic of the titanium coated MWCNTs-HA was evaluated by field-emission scanning electron microscopy (FE-SEM) and XRD. The results show that the titanium surface was covered with MWCNTs-HA nanoparticles and MWCNTs help form the crystalized hydroxyapatite. Furthermore, the MWCNTs-HA coated titanium was investigated for in vitro cellular responses. Cell proliferation and differentiation were improved on the surface of MWCNT-HA coated titanium.

FCVA-Synthesized Tetrahedral Amorphous Carbon Films for Biomedical Applications

2007 ◽  
Vol 336-338 ◽  
pp. 1577-1580 ◽  
Author(s):  
Chuan Lin Zheng ◽  
Wu Bao Yang ◽  
X. Chang
Keyword(s):  
Amorphous Carbon ◽  
Biomedical Applications ◽  
Pure Titanium ◽  
Carbon Films ◽  
Vacuum Arc ◽  
Negative Bias Voltage ◽  
Tetrahedral Amorphous Carbon ◽  
In Vitro Measurements ◽  
Filtered Cathodic Vacuum Arc

Tetrahedral amorphous carbon (ta-C) films were deposited onto Si(100) wafers by using filtered cathodic vacuum arc technique (FCVA). The influence of the negative bias voltage applied to substrates on film structures was studied by Raman spectroscopy, X-ray photoemission spectroscopy (XPS). The ta-C films showed maximal sp3 fractions 87%, the hardness and elastic modulus of the ta-C film is 72 and 480 GPa, respectively. In vitro measurements of contact angle and platelet adhesion were applied to evaluate the biocompatibility of the ta-C films in comparison with that of NiTi, 316L and pure titanium. The results show that the ta-C films have hydrophobicity and exhibit better hemocompatibility which are very suitable for biomedical applications.

scholarly journals Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Coatings ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 69
Author(s):  
Diana Maria Vranceanu ◽  
Elena Ungureanu ◽  
Ionut Cornel Ionescu ◽  
Anca Constantina Parau ◽  
Adrian Emil Kiss ◽  
...  
Keyword(s):  
Anatase Phase ◽  
Pure Titanium ◽  
Chemical Properties ◽  
Secondary Phase ◽  
Xrd Analysis ◽  
Electrochemical Treatment ◽  
Titania Nanotubes ◽  
Nanostructured Surface ◽  
Nanostructured Surfaces ◽  
Zn Content

The current research aim is to biofunctionalize pure titanium (Ti, grade IV) substrate with titania nanotubes and Zn doped hydroxyapatite-based coatings by applying a duplex electrochemical treatment, and to evaluate the influence of Zn content on the physico-chemical properties of hydroxyapatite (HAp). The obtained nanostructured surfaces were covered with HAp-based coatings doped with Zn in different concentrations by electrochemical deposition in pulsed galvanostatic mode. The obtained surfaces were characterized in terms of morphology, elemental and phasic composition, chemical bonds, roughness, and adhesion. The nanostructured surface consisted of titania nanotubes (NT), aligned, vertically oriented, and hollow, with an inner diameter of ~70 nm. X-Ray Diffraction (XRD) analysis showed that the nanostructured surface consists of an anatase phase and some rutile peaks as a secondary phase. The morphology of all coatings consisted of ribbon like-crystals, and by increasing the Zn content the coating became denser due to the decrement of the crystals’ dimensions. The elemental and phase compositions evidenced that HAp was successfully doped with Zn through the pulsed galvanostatic method on the Ti nanostructured surfaces. Fourier Transform Infrared spectroscopy (FTIR) and XRD analysis confirmed the presence of HAp in all coatings, while the adhesion test showed that the addition of a high quantity leads to some delamination. Based on the obtained results, it can be said that the addition of Zn enhances the properties of HAp, and through proper experimental design, the concentration of Zn can be modulated to achieve coatings with tunable features.

in vitro reactivity of the antineoplastic drug carmustin and acrolein with model peptides

2009 ◽  
Vol 49 (6) ◽  
pp. 586-595 ◽  
Author(s):  
VIRGINIA CARBONE ◽  
ANNAMARIA SALZANO ◽  
PIERO PUCCI ◽  
IMMA FIUME ◽  
GABRIELLA POCSFALVI ◽  
...  
Keyword(s):  
Antineoplastic Drug ◽  
Model Peptides

scholarly journals Enhancement of pure titanium localized corrosion resistance by anodic oxidation

2017 ◽  
Vol 69 (4) ◽  
pp. 503-509 ◽  
Author(s):  
Davide Prando ◽  
Andrea Brenna ◽  
MariaPia Pedeferri ◽  
Marco Ormellese
Keyword(s):  
Corrosion Resistance ◽  
Anodic Oxidation ◽  
Pure Titanium ◽  
Localized Corrosion

scholarly journals Platelet Adhesion on Commercially Pure Titanium Plates in Vitro II. Immunofluorescence Visualization of PDGF-B, TGFβ1, and PPARγ Released from Activated Adherent Platelets

2019 ◽  
Vol 7 (4) ◽  
pp. 109 ◽  
Author(s):  
Tetsuhiro Tsujino ◽  
Akira Takahashi ◽  
Taisuke Watanabe ◽  
Kazushige Isobe ◽  
Yutaka Kitamura ◽  
...  
Keyword(s):  
Industrial Development ◽  
Platelet Adhesion ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Commercially Pure ◽  
Titanium Surfaces ◽  
Cp Ti

Recent progress in the industrial development of dental implants has improved their surface bio-affinity, while clinical implantologists attempt to improve it through coating with various compounds, including platelet-rich plasma (PRP) in clinical settings. However, it is poorly understood how PRP acts on titanium surfaces. To validate this surface modification method and demonstrate how platelet-derived soluble biomolecules released from the activated adherent platelets act on plain, commercially pure-titanium (cp-Ti) plates, we evaluated the distribution of biomolecules by immunofluorescence. PPARγ, PDGF-B, and TGFβ1 were similarly released at immunofluorescence levels from activated adherent platelets, retained in the surrounding extra-platelet spaces for a while, and did not immediately diffuse away to distant spaces. Exogenously added CaCl2 augmented release and retention of those biomolecules along with activation and aggregation. Taken together with our previous data regarding platelet adhesion, these findings suggest that especially when treated with CaCl2, platelets immediately adhere on cp-Ti plates to release their stored biomolecules in the absence of plasma proteins and that these biomolecules do not diffuse away, but stay longer in extra-platelet spaces around the platelets by newly formed, immature fibrin fiber fragments. Consequently, these retained biomolecules are anticipated to cooperatively stabilize implants by stimulating alveolar bone regeneration and integration.

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