Nanosurface Modifacation of Biomedical β Titanium Alloy for Dental Implant and its Antibacterial Property

2014 ◽  
Vol 904 ◽  
pp. 142-145 ◽  
Author(s):  
Yu Min Qi ◽  
Bai Hui Ma ◽  
Yue Jiao Geng ◽  
Jia Yin Deng ◽  
Chun Xiang Cui
Keyword(s):  
Dental Implant ◽  
Anodic Oxidation ◽  
Antibacterial Property ◽  
Pure Titanium ◽  
Processing Parameters ◽  
Electrolytic Solution ◽  
Nanotube Array ◽  
Good Antibacterial Activity ◽  
Before And After

The TiO2 nanotube array film was synthesized on the surface of Ti-Nb-Zr-Mo βTitanium alloy via anodic oxidation in single electrolytic solution only containing HF. The diameter of TiO2 nanotubes was 30-50nm, and the length was 240nm. Compared with the processing parameters (including anodizing voltage, reaction time, concentration and kinds of electrolytic solution) used for pure Titanium or Ti-6Al-4V alloy, the parameters was further optimized. The surface morphology and element compositions Ti-Nb-Zr-Mo alloy before and after anodic oxidation were observed and analyzed by a scanning electron microscope (SEM) and an energy dispersive X-ray (EDX) spectrometer. The antibacterial property of TiO2 nanotube array film prepared with optimal conditions was evaluated by coculture in vitro between Actinomyces viscosus and materials tested. The results indicated that the TiO2 nanotube array film had very good antibacterial activity to resist Actinomyces viscosus. TiO2 nanotube array film/Ti-Nb-Zr-Mo βTi alloy biocomposite will be an more excellent dental implant owning good biomechanical adaptability, biocompatibility and antibacterial property.

In vitro Behaviour of Alumina-Hydroxiapatite Composites Coatings

2018 ◽  
Vol 69 (6) ◽  
pp. 1416-1418
Author(s):  
Alexandru Szabo ◽  
Ilare Bordeasu ◽  
Ion Dragos Utu ◽  
Ion Mitelea
Keyword(s):  
Pure Titanium ◽  
Titanium Substrate ◽  
High Strength ◽  
Biological Properties ◽  
Commercially Pure Titanium ◽  
Hvof Spraying ◽  
Before And After ◽  
Sbf Solution ◽  
Oxygen Fuel

Hydroxyapatite (HA) is a very common material used for biomedical applications. Usually, in order to improve its poor mechanical properties is combined or coated with other high-strength materials.The present paper reports the manufacturing and the biocompatibility behaviour of two different biocomposite coatings consisting of alumina (Al2O3) and hydroxyapatite (HA) using the high velocity oxygen fuel (HVOF) spraying method which were deposited onto the surface of a commercially pure titanium substrate. The biological properties of the Al2O3-HA materials were evaluated by in vitro studies. The morphology of the coatings before and after their immersing in the simulated body fluid (SBF) solution was characterized by scanning electron microscopy (SEM). The results showed an important germination of the biologic hydroxyapatite crystallite on the surface of both coatings.

scholarly journals Lactoferrin Coating Improves the Antibacterial and Osteogenic Properties of Alkali-Treated Titanium with Nanonetwork Structures

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Derong Yin ◽  
Yonglong Hong ◽  
Luyuan Chen ◽  
Satoshi Komasa ◽  
Yuanyuan Yang ◽  
...  
Keyword(s):  
Dental Implant ◽  
Alkali Treatment ◽  
Pure Titanium ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Bacterial Attachment ◽  
Physiological Concentration ◽  
Implant Materials

Titanium and its alloys are the main dental implant materials used at present. The biological properties of pure titanium can be further improved by surface treatment methods. Alkali treatment of pure titanium at room temperature can form nanonetwork structures (TNS) on the surface, which has better osteoinductive ability than pure titanium. However, TNS does not possess antimicrobial properties, and bacterial infection is one of the main reasons for the failure of dental implant therapy. Therefore, it was the focus of our research to endow TNS with certain antimicrobial properties on the premise of maintaining its osteoinductive ability. Because of its excellent broad-spectrum antimicrobial properties and because it promotes osteoblast-like cell growth, lactoferrin (LF) was considered a promising prospect as a surface biological treatment material. In this study, bovine LF of physiological concentration was successfully coated on the surface of TNS to form the TNS-LF composite material. Results from in vitro and in vivo experiments showed that TNS-LF had better osteoinductive ability than TNS. Bacterial attachment and biofilm formation were also significantly decreased on the surface of TNS-LF. Therefore, this study has provided an experimental basis for the development of osteoinduction-antimicrobial composite implant materials for dental applications.

Different Activities of Osteoblast and Bacteria on a Nanostructured Titanium Surface for Dental Implant

2012 ◽  
Vol 586 ◽  
pp. 39-44 ◽  
Author(s):  
Yan Hua Zheng ◽  
Jin Bo Li ◽  
Xuan Yong Liu ◽  
Jiao Sun
Keyword(s):  
Dental Implant ◽  
Titanium Surface ◽  
Clinical Success ◽  
Pure Titanium ◽  
Clinical Success Rate ◽  
Antimicrobial Effect ◽  
Antibacterial Activities ◽  
Nanostructured Titanium ◽  
Good Antibacterial Activity

Insufficience of osteogenesis and antimicrobial effect have been still impacted the long term clinical success rate of dental implants. A nanostructured titanium surface prepared by hydrothermal treatment with H2O2 was evaluated on its osteoblastic viability and antibacterial effect. Samples were divided into 2 groups: untreated pure titanium surface (Ti) and a nanostructured titanium surface (NT). The antibacterial activities against S.mutans and C.albicans were measured by film applicator coating assay, as well as the live/dead bacteria stain. The osteoblastic viability was investigated by SEM and MTT assay. Results showed that the active microbia on NT was reduced at 24h (P<0.05) significantly according to the live/dead bacteria stain and film applicator coating assay, which could also enhance the osteoblast viability. Therefore, a nanostructured titanium surface exhibits good antibacterial activity on S.mutans and C.albicans, and promoting osteoblast viability, which will be a potential kind of dental implant material.

Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

2009 ◽  
Vol 52 (12) ◽  
pp. 2161-2165 ◽  
Author(s):  
XiLin Xiao ◽  
LiXia Yang ◽  
ManLi Guo ◽  
ChunFeng Pan ◽  
QingYun Cai ◽  
...  
Keyword(s):  
Anodic Oxidation ◽  
Pure Titanium ◽  
Titania Nanotubes ◽  
Antineoplastic Drug

scholarly journals Preparation of Bioactive Titanium Surfaces via Fluoride and Fibronectin Retention

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Carlos Nelson Elias ◽  
Patricia Abdo Gravina ◽  
Costa e Silva Filho ◽  
Pedro Augusto de Paula Nascente
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Osteoblastic Cells ◽  
Acid Etching ◽  
Implant Surface ◽  
Force Microscopy ◽  
Dental Implant Surface ◽  
Before And After ◽  
Titanium Surfaces

Statement of Problem. The chemical or topographic modification of the dental implant surface can affect bone healing, promote accelerated osteogenesis, and increase bone-implant contact and bonding strength.Objective. In this work, the effects of dental implant surface treatment and fibronectin adsorption on the adhesion of osteoblasts were analyzed.Materials and Methods. Two titanium dental implants (Porous-acid etching and PorousNano-acid etching followed by fluoride ion modification) were characterized by high-resolution scanning electron microscopy, atomic force microscopy, and X-ray diffraction before and after the incorporation of human plasma fibronectin (FN). The objective was to investigate the biofunctionalization of these surfaces and examine their effects on the interaction with osteoblastic cells.Results. The evaluation techniques used showed that the Porous and PorousNano implants have similar microstructural characteristics. Spectrophotometry demonstrated similar levels of fibronectin adsorption on both surfaces (80%). The association indexes of osteoblastic cells in FN-treated samples were significantly higher than those in samples without FN. The radioactivity values associated with the same samples, expressed as counts per minute (cpm), suggested that FN incorporation is an important determinant of thein vitrocytocompatibility of the surfaces.Conclusion. The preparation of bioactive titanium surfaces via fluoride and FN retention proved to be a useful treatment to optimize and to accelerate the osseointegration process for dental implants.

scholarly journals Studying Biomimetic Coated Niobium as an Alternative Dental Implant Material to Titanium (in vitro and in vivo study)

2018 ◽  
Vol 15 (3) ◽  
pp. 253-261
Author(s):  
Baghdad Science Journal
Keyword(s):  
Dental Implant ◽  
Body Fluid ◽  
Pure Titanium ◽  
Commercially Pure Titanium ◽  
Removal Torque ◽  
X Ray ◽  
Commercially Pure ◽  
Implant Material

Commercially pure titanium (cpTi) is widely used as dental implant material although it was found that titanium exhibited high modulus of elasticity and the lower corrosion tendency in oral environment. Niobium(Nb) was chosen for this study as an alternative to cpTi implant material due to its bioinert behavior and good elastic modulus and moderate cost in addition to corrosion resistance. This study was done to evaluate the effect of biomimetic coating on the surface properties of the commercially pure titanium and niobium implants by in vitro and in vivo experiments. The in vitro study was involved etching the samples of each material in HCl then soaking in 10M NaOH aqueous solution. These samples were then immersed in a 5 times concentrated simulated body fluid for 14 days. Scanning Electron Microscope, Energy Dispersive X-ray, and X-Ray Diffraction tests were done to analyze surface changes. The in vivo study was done by the implantation of screw-shaped implants (two from each material, uncoated and the other was biomimetically coated) in the tibias of New Zealand rabbits. After 2 and 4 weeks of healing period, 20 rabbits were sacrificed for each period. A removal torque was done for ten animals in each group, whereas the other ten were used for histological testing and histomorphometric analysis with optical microscope.The in vitro experiments showed that the use of 14 days immersion in a concentrated simulated body fluid produced a layer of calcium phosphate on metal surfaces. The removal torque values and new bone formation were increased significantly in Nb than Ti, in coated than uncoated screws, and in 4 weeks than 2 weeks healing periods. The Nb implants had better biomechanical and biological properties than the commercially pure titanium implants and can be used as an alternative dental implant.

Effect of Processing Parameters on the Properties of Metal Injection Moulded Titanium Dental Implants

2015 ◽  
Vol 828-829 ◽  
pp. 145-151 ◽  
Author(s):  
Alfred T. Sidambe ◽  
Iain Todd ◽  
Paul Hatton
Keyword(s):  
Dental Implants ◽  
Pure Titanium ◽  
Chemical Properties ◽  
Cost Effective ◽  
Processing Parameters ◽  
Commercially Pure Titanium ◽  
Ti Powder ◽  
Cp Ti ◽  
And Chemical Properties

Metal injection moulding (MIM) is a well-established, cost-effective method of fabricating small-to-moderate size near net-shape metal components. MIM is increasingly being employed as a process for fabricating orthopaedic and dental products with complicated shapes. In this study, commercially pure titanium (CP-Ti) powder has been used to fabricate dental implants via MIM. The CP-Ti powder was mixed with binders containing Polyethylene glycol (PEG), High Density Polyethylene (HDPE) and stearic acid (SA) to form the MIM feedstock. Commercially available feedstock was also used to fabricate MIM implants. The MIM compacts were then subjected to debinding and sintering, and then the mechanical and chemical properties of the compacts were investigated for their suitability for dental implantology. The effect of the MIM processing variables on the surface roughness of CP-Ti was also investigated and studies for biocompatibility were carried out using in-vitro cell culture. The results showed that the mechanical and chemical properties of the sintered components were within ASTM Grade MIM 2 and Grade MIM 3 (ASTM F2989 − 13) specifications for titanium. The results also showed that the implants produced by MIM appeared to meet basic biocompatibility requirements. It was concluded that dental implant prototypes may be fabricated successfully using MIM and this approach offers greater opportunities for future manufacturing.

Enhance the Biological Properties of Commercial Pure Titanium with Bioactive Glass Coating by Pulsed Laser Deposition

2021 ◽  
Vol 51 ◽  
pp. 29-37
Author(s):  
Alaa A. Mohammed
Keyword(s):  
Bioactive Glass ◽  
Pulsed Laser Deposition ◽  
Antibacterial Property ◽  
Pure Titanium ◽  
Pulsed Laser ◽  
Mouse Fibroblast ◽  
Laser Deposition ◽  
Biological Behavior ◽  
Glass Coating

Titanium is the most broadly employed implant material for the load bearing dental and the orthopedic uses due to its brilliant biological and mechanical characteristics. The aim of the present study is to assay the biological behavior of pure Titanium coated with a bioactive glass coating made by pulsed laser deposition. The coating characteristic and the biological behavior of coated specimens were assessed and compared with uncoated specimens. In vitro biological behavior including bioactivity, biocompatibility and antibacterial property was evaluated. The bioactivity of the specimens was assayed by immersion in a simulated body fluid for various times (7 and 14) days. Biocompatibility was assessed by MTT assay of L929 mouse fibroblast cells after 1, 3 and 5 days. Also, the antibacterial property was evaluated against S. aures by optical density method. The obtained results revealed that the pulsed laser deposited bioactive glass coating significantly improved the potential of Titanium for dental and orthopedic applications.

scholarly journals Influence of the Digital Mock-Up and Experience on the Ability to Determine the Prosthetically Correct Dental Implant Position during Digital Planning: An In Vitro Study

2019 ◽  
Vol 9 (1) ◽  
pp. 48
Author(s):  
Miriam O’Connor Esteban ◽  
Elena Riad Deglow ◽  
Álvaro Zubizarreta-Macho ◽  
Sofía Hernández Montero
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
In Vitro Study ◽  
Study Groups ◽  
T Test ◽  
Dental Surgery ◽  
Operator Experience ◽  
Planning Software ◽  
Before And After

The purpose of this study was to analyze the influence of the digital mock-up and operator experience on the dental implant planning position. A total of 200 dental implants were planned, which were distributed into two study groups: A. dental implant planning by dental surgeons with 5–10 years of experience (n = 80); and B. dental implant planning by dental surgery students without experience (n = 120). Operators were required to plan eight dental implants in the same maxillary edentulous case uploaded in 3D implant-planning software, before and after using the digital mock-up. Deviations between the dental implant planning positions before and after using the digital mock-up were analyzed at platform, apical and angular levels, and were analyzed using a 3D implant-planning software using Student’s t test. The paired t-test revealed statistically significant differences between the deviation levels of participants with 5–10 years’ experience and no experience at the platform, apical and angular levels. Digital mock-ups allow for more accurate dental implant planning regardless of the experience of the operator. Nevertheless, they are more useful for operators without dental surgery experience.

The Effect of Electrolyte Composition on the Fabrication of Self-Organized Titanium Oxide Nanotube Arrays by Anodic Oxidation

2005 ◽  
Vol 20 (1) ◽  
pp. 230-236 ◽  
Author(s):  
Qingyun Cai ◽  
Maggie Paulose ◽  
Oomman K. Varghese ◽  
Craig A. Grimes
Keyword(s):  
Titanium Oxide ◽  
Anodic Oxidation ◽  
Anatase Phase ◽  
Pure Titanium ◽  
Electrolyte Solutions ◽  
Electrolyte Composition ◽  
Nanotube Arrays ◽  
Solution Ph ◽  
Nanotube Array ◽  
Self Organized

We report on the fabrication of self-organized titanium oxide nanotube arrays of enhanced surface area prepared by anodic oxidation of a pure titanium sheet in electrolyte solutions containing potassium fluoride (KF) or sodium fluoride (NaF). The effects of electrolyte composition and concentration, solution pH, and the anodic potential on the formation of nanotubes and dimensions of the resulting nanotubes are detailed. Although nanotube arrays of length greater than 500 nm are not possible with hydrofluoric acid containing electrolytes [G.K. Mor, O.K. Varghese, M. Paulose,N. Mukherjee, C.A. Grimes, J. Mater. Res. 18, 2588 (2003)], by adjusting the pH of a KF containing electrolyte to 4.5 using additives such as sulfuric acid, sodium hydroxide, sodium hydrogen sulfate, and/or citric acid, we could increase the length of the nanotube-array to approximately 4.4 μm, an order of magnitude increase in length. The as-prepared nanotubes are composed of amorphous titanium oxide. Independent of the electrolyte composition, crystallization of the nanotubes to anatase phase occurred at temperatures ⩾280 °C. Rutile formation occurred at the nanotube-Ti substrate interface at temperatures near 480 °C. It appears geometry constraints imposed by the nanotube walls inhibit anatase to rutile transformation. No disintegration of the nanotube array structure is observed at temperatures as high as 580 °C. The excellent structural and crystal phase stability of these nanotubes make them promising for both low- and high-temperature applications.

Sign in / Sign up

Export Citation Format

Share Document