scholarly journals Adhesion Behavior of Ti–PMMA–Ti Sandwiches for Biomedical Applications

JOM ◽  
2021 ◽  
Author(s):  
Gargi Shankar Nayak ◽  
Flavien Mouillard ◽  
Patrick Masson ◽  
Geneviève Pourroy ◽  
Heinz Palkowski ◽  
...  
Keyword(s):  
Adhesion Strength ◽  
Biomedical Applications ◽  
Large Scale ◽  
Stress Shielding ◽  
Time Dependent ◽  
Pmma Sheet ◽  
Metallic Implants ◽  
Process Route ◽  
Adhesion Behavior ◽  
Grafting From

AbstractThe “stress-shielding” problem, common with metallic implants, may be solved by using biocompatible sandwiches with a polymeric core between two metallic skin sheets. To achieve such sandwiches, a process route has been developed, beginning with the grafting of poly-(methyl-methacrylate) (PMMA) on titanium (Ti) sheets via the “grafting from” technique. Grafting resulted in variable thicknesses of PMMA on the Ti sheets. Hot-pressing was used to prepare semi-finished Ti–PMMA–Ti sandwiches. The adhesion was achieved by the interpenetration between PMMA sheet and the grafted PMMA chains. Investigation was carried out to understand the influence of the grafted PMMA thickness on the adhesion strength. Similar adhesion strengths were found for the sandwiches despite variable grafted PMMA thicknesses, indicating a successful grafting of PMMA on large-scale Ti sheets. The adhesion followed the autohesion theory, where a time-dependent increase in adhesion strength was found for the sandwiches.

Benchmark of Simplified Time-Dependent Density Functional Theory for UV-Vis Spectral Properties of Porphyrinoids

2019 ◽  
Author(s):  
Kamal Batra ◽  
Stefan Zahn ◽  
Thomas Heine
Keyword(s):  
Density Functional Theory ◽  
Density Functional ◽  
Large Scale ◽  
Absolute Error ◽  
Time Dependent ◽  
Basis Set ◽  
Basis Sets ◽  
Functional Theory ◽  
Framework Materials ◽  
Dependent Density

<p>We thoroughly benchmark time-dependent density- functional theory for the predictive calculation of UV/Vis spectra of porphyrin derivatives. With the aim to provide an approach that is computationally feasible for large-scale applications such as biological systems or molecular framework materials, albeit performing with high accuracy for the Q-bands, we compare the results given by various computational protocols, including basis sets, density-functionals (including gradient corrected local functionals, hybrids, double hybrids and range-separated functionals), and various variants of time-dependent density-functional theory, including the simplified Tamm-Dancoff approximation. An excellent choice for these calculations is the range-separated functional CAM-B3LYP in combination with the simplified Tamm-Dancoff approximation and a basis set of double-ζ quality def2-SVP (mean absolute error [MAE] of ~0.05 eV). This is not surpassed by more expensive approaches, not even by double hybrid functionals, and solely systematic excitation energy scaling slightly improves the results (MAE ~0.04 eV). </p>

Alban Berg

2017 ◽  
Author(s):  
Helen Abbott
Keyword(s):  
Adhesion Strength ◽  
String Quartet ◽  
Large Scale ◽  
Statistical Data ◽  
Alban Berg ◽  
German Translation ◽  
Stefan George ◽  
Strength Tests ◽  
Parallel Texts

When Austrian composer Alban Berg was working on his opera Lulu, he wrote three Baudelaire songs as a Konzertaria entitled Der Wein. Premiered in 1930, Der Wein is a large-scale work for voice and orchestra. Berg uses a German translation by Stefan George, but the published score is in parallel texts, accommodating the French verse line. The chapter also considers a ‘hidden’ Baudelaire setting from Berg’s 1926 Lyric Suite for string quartet. The analysis covers: (a) the context of composition; (b) the connections established between selected poems; (c) the statistical data generated from the adhesion strength tests; and (d) how the data shape an evaluation of Berg’s settings of Baudelaire. Evidence suggests that Berg’s settings of Baudelaire are loosely entangled; the highly prescriptive score affects syntax, semantics, and prosody. Yet, because Der Wein has stood the test of time, the settings are deemed loosely accretive.

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

In Situ Tests on Creep Behavior of Rock Mass with Joint or Shearing Zone in Foundation of Large-Scale Hydroelectric Projects

2004 ◽  
Vol 261-263 ◽  
pp. 1097-1102 ◽  
Author(s):  
Jian Liu ◽  
Xia Ting Feng ◽  
Xiu Li Ding ◽  
Huo Ming Zhou
Keyword(s):  
Rock Mass ◽  
Creep Behavior ◽  
Large Scale ◽  
Time Dependent ◽  
Three Gorges Project ◽  
Three Gorges ◽  
The Three Gorges ◽  
The Three Gorges Project

The time-dependent behavior of rock mass, which is generally governed by joints and shearing zones, is of great significance for engineering design and prediction of long-term deformation and stability. In situ creep test is a more effective method than laboratory test in characterizing the creep behavior of rock mass with joint or shearing zone due to the complexity of field conditions. A series of in situ creep tests on granite with joint at the shiplock area of the Three-Gorges Project and basalt with shearing zone at the right abutment of the Xiluodu Project were performed in this study. Based on the test results, the stress-displacement-time responses of the joints and basalt are analyzed, and their time-dependent constitutive model and model coefficients are given, which is crucial for the design to prevent the creep deformations of rock masses from causing the failure of the operation of the shiplock gate at the Three-Gorges Project and long-term stability of the Xiluodu arc dam.

scholarly journals GAKTpore: Stereological Characterisation Methods for Porous Foams in Biomedical Applications

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1269
Author(s):  
Gareth Sheppard ◽  
Karl Tassenberg ◽  
Bogdan Nenchev ◽  
Joel Strickland ◽  
Ramy Mesalam ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Large Scale ◽  
Collagen Scaffold ◽  
Porous Structures ◽  
Tissue Engineering Scaffolds ◽  
Biological Responses ◽  
Sem Micrograph ◽  
Cell Adhesion And Proliferation ◽  
Characterisation Methods

In tissue engineering, scaffolds are a key component that possess a highly elaborate pore structure. Careful characterisation of such porous structures enables the prediction of a variety of large-scale biological responses. In this work, a rapid, efficient, and accurate methodology for 2D bulk porous structure analysis is proposed. The algorithm, “GAKTpore”, creates a morphology map allowing quantification and visualisation of spatial feature variation. The software achieves 99.6% and 99.1% mean accuracy for pore diameter and shape factor identification, respectively. There are two main algorithm novelties within this work: (1) feature-dependant homogeneity map; (2) a new waviness function providing insights into the convexity/concavity of pores, important for understanding the influence on cell adhesion and proliferation. The algorithm is applied to foam structures, providing a full characterisation of a 10 mm diameter SEM micrograph (14,784 × 14,915 px) with 190,249 pores in ~9 min and has elucidated new insights into collagen scaffold formation by relating microstructural formation to the bulk formation environment. This novel porosity characterisation algorithm demonstrates its versatility, where accuracy, repeatability, and time are paramount. Thus, GAKTpore offers enormous potential to optimise and enhance scaffolds within tissue engineering.

scholarly journals Recent Developments in Coatings for Orthopedic Metallic Implants

Coatings ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 791
Author(s):  
Muzamil Hussain ◽  
Syed Hasan Askari Rizvi ◽  
Naseem Abbas ◽  
Uzair Sajjad ◽  
Muhammad Rizwan Shad ◽  
...  
Keyword(s):  
Stress Shielding ◽  
Orthopedic Implant ◽  
Coating Materials ◽  
Implant Materials ◽  
Metallic Implants ◽  
Common Causes ◽  
Recent Developments ◽  
Orthopedic Applications ◽  
The Impact ◽  
Cocrmo Alloys

Titanium, stainless steel, and CoCrMo alloys are the most widely used biomaterials for orthopedic applications. The most common causes of orthopedic implant failure after implantation are infections, inflammatory response, least corrosion resistance, mismatch in elastic modulus, stress shielding, and excessive wear. To address the problems associated with implant materials, different modifications related to design, materials, and surface have been developed. Among the different methods, coating is an effective method to improve the performance of implant materials. In this article, a comprehensive review of recent studies has been carried out to summarize the impact of coating materials on metallic implants. The antibacterial characteristics, biodegradability, biocompatibility, corrosion behavior, and mechanical properties for performance evaluation are briefly summarized. Different effective coating techniques, coating materials, and additives have been summarized. The results are useful to produce the coating with optimized properties.

Time-Dependent Intermodal A* Algorithm: Methodology and Implementation on a Large-Scale Network

2018 ◽  
Vol 2672 (47) ◽  
pp. 219-230 ◽  
Author(s):  
Ömer Verbas ◽  
Joshua Auld ◽  
Hubert Ley ◽  
Randy Weimer ◽  
Shon Driscoll
Keyword(s):  
Large Scale ◽  
Vehicular Network ◽  
Upper Bounds ◽  
Time Dependent ◽  
Regional Network ◽  
A Algorithm ◽  
Transit Network ◽  
Park And Ride ◽  
Large Scale Network ◽  
Scale Network

This paper proposes a time-dependent intermodal A* (TDIMA*) algorithm. The algorithm works on a multimodal network with transit, walking, and vehicular network links, and finds paths for the three major modes (transit, walking, driving) and any feasible combination thereof (e.g., park-and-ride). Turn penalties on the vehicular network and progressive transfer penalties on the transit network are considered for improved realism. Moreover, upper bounds to prevent excessive waiting and walking are introduced, as well as an upper bound on driving for the park-and-ride (PNR) mode. The algorithm is validated on the large-scale Chicago Regional network using real-world trips against the Google Directions API and the Regional Transit Authority router.

The structure of weakly compressible grid-generated turbulence

2001 ◽  
Vol 432 ◽  
pp. 219-283 ◽  
Author(s):  
G. BRIASSULIS ◽  
J. H. AGUI ◽  
Y. ANDREOPOULOS
Keyword(s):  
Mach Number ◽  
Large Scale ◽  
Isotropic Turbulence ◽  
Three Dimensional ◽  
High Amplitude ◽  
Time Dependent ◽  
Wide Range ◽  
Dynamical Flow ◽  
Set Up ◽  
Decay Exponent

A decaying compressible nearly homogeneous and nearly isotropic grid-generated turbulent flow has been set up in a large scale shock tube research facility. Experiments have been performed using instrumentation with spatial resolution of the order of 7 to 26 Kolmogorov viscous length scales. A variety of turbulence-generating grids provided a wide range of turbulence scales with bulk flow Mach numbers ranging from 0.3 to 0.6 and turbulent Reynolds numbers up to 700. The decay of Mach number fluctuations was found to follow a power law similar to that describing the decay of incompressible isotropic turbulence. It was also found that the decay coefficient and the decay exponent decrease with increasing Mach number while the virtual origin increases with increasing Mach number. A possible mechanism responsible for these effects appears to be the inherently low growth rate of compressible shear layers emanating from the cylindrical rods of the grid. Measurements of the time-dependent, three dimensional vorticity vectors were attempted for the first time with a 12-wire miniature probe. This also allowed estimates of dilatation, compressible dissipation and dilatational stretching to be obtained. It was found that the fluctuations of these quantities increase with increasing mean Mach number of the flow. The time-dependent signals of enstrophy, vortex stretching/tilting vector and dilatational stretching vector were found to exhibit a rather strong intermittent behaviour which is characterized by high-amplitude bursts with values up to 8 times their r.m.s. within periods of less violent and longer lived events. Several of these bursts are evident in all the signals, suggesting the existence of a dynamical flow phenomenon as a common cause.

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