Risk factors for neurological complications in children with Flavivirus infection

2021 ◽  
Author(s):  
Aline Almeida Bentes ◽  
Roberta Maia de Castro Romanelli ◽  
Paula Eillanny Silva Marinho ◽  
Ana Paula Correa Crispim ◽  
Karina Soares Loutfi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neurological Complications ◽  
Flavivirus Infection

scholarly journals The Myocardial and Neuronal Infectivity of SARS-CoV-2 and Detrimental Outcomes

2021 ◽  
Author(s):  
Ernest Herbert ◽  
Dominique Fournier ◽  
Waleed A. Al-Shaqha ◽  
Mohamed Chahine
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Severe Acute Respiratory Syndrome ◽  
Hospital Mortality ◽  
Early Stage ◽  
Neurological Complications ◽  
Insufficient Data ◽  
Neurological Manifestations ◽  
Characteristic Features ◽  
Neuronal Functions

The epidemiological outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), alias COVID-19, began in Wuhan, Hubei, China, in late December and eventually turned into a pandemic that has led to 3.71+ million deaths and 173+ million infected cases worldwide. In addition to respiratory manifestations, COVID-19 patients with neurological and myocardial dysfunctions exhibit a higher risk of in-hospital mortality. The immune function tends to be affected by cardiovascular risk factors and is thus indirectly related to the prognosis of COVID-19 patients. Many neurological symptoms and manifestations have been reported in COVID-19 patients. However, detailed descriptions of the prevalence and characteristic features of these symptoms are restricted due to insufficient data. It is thus advisable for clinicians to be vigilant for both cardiovascular and neurological manifestations in order to detect them at an early stage to avoid inappropriate management of COVID-19 and to address the manifestations adequately. Patients with severe COVID-19 are notably more susceptible to developing cardiovascular and neurological complications than non-severe COVID-19 patients. This review focuses on the consequential outcomes of COVID-19 on cardiovascular and neuronal functions, including other influencing factors.

scholarly journals Risk Factors for Non-Neurological Complications in Adult Spinal Deformity Surgery: An International, Large-Scale, Prospective Multicenter Study

2015 ◽  
Vol 5 (1_suppl) ◽  
pp. s-0035-1554345-s-0035-1554345
Author(s):  
Kenneth M. C. Cheung ◽  
Cora Bow ◽  
Dino Samartzis ◽  
Mark Dekutoski ◽  
Frank Schwab ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multicenter Study ◽  
Spinal Deformity ◽  
Large Scale ◽  
Adult Spinal Deformity ◽  
Neurological Complications ◽  
Prospective Multicenter Study ◽  
Spinal Deformity Surgery

scholarly journals Pott’s Spine with Tubercular Meningitis and Primary Optic Atrophy: An Enigma with a Rare Cautionary Tale

2019 ◽  
Vol 08 (03) ◽  
pp. 199-202
Author(s):  
Khursheed Alam Khan ◽  
Kunj Bihari Saraswat ◽  
Tushar Marbate ◽  
Ashok Gupta
Keyword(s):  
Risk Factors ◽  
Optic Atrophy ◽  
Delayed Diagnosis ◽  
Neurological Complications ◽  
Cautionary Tale ◽  
Tubercular Meningitis ◽  
Clinical Presentations ◽  
Associated Risk Factors ◽  
Tuberculosis Of Spine ◽  
Significant Health

AbstractTuberculosis of spine, known as Pott’s spine, is a significant health risk. Misdiagnosis or delayed diagnosis with lack of timely interventions lead to serious neurological complications and is associated with morbidity and mortality. We present a case of Pott’s spine who developed tubercular meningitis with decreased vision due to primary optic atrophy, to highlight the significance of thorough clinical and neuroradiological workup with instillation of prompt antitubercular therapy in patients of central nervous system tuberculosis (CNS TB). This association of Pott’s spine with decreased vision secondary to primary optic atrophy due to tubercular involvement of the second cranial nerve is very rare. Here, associated risk factors, varied clinical presentations, complications, and treatment of CNS TB are reviewed.

scholarly journals Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study

2021 ◽  
Vol 17 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Beata Sarecka-Hujar ◽  
Ilona Kopyta ◽  
Dorota Raczkiewicz
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Pediatric Patients ◽  
Age At Onset ◽  
Neurological Complications ◽  
Arterial Ischemic Stroke ◽  
Stroke Subtype ◽  
Anterior Circulation ◽  
Post Stroke ◽  
Normal Outcome

IntroductionVarious neurological complications may occur as a consequence of arterial ischemic stroke (AIS) and have an impact on daily activity of the patients, costs of their medical care and rehabilitation. The aim of this study was to analyze risk factors, stroke symptoms and post-stroke consequences in Polish pediatric patients depending on stroke subtype.Material and methodsWe retrospectively reviewed 77 children under the age of 18 years following their first AIS. Patients were white, Polish Caucasians, recruited in the Department of Pediatric Neurology at the Medical University of Silesia in Katowice (Poland). Statistical analysis was performed using Statistica 12.0.ResultsGender differed significantly between stroke subgroups (p = 0.030). The presence of focal cerebral arteriopathy (FCA) and chronic diseases was associated with type of AIS (p = 0.003 and p = 0.050, respectively). An outcome without neurological deterioration (normal outcome) was observed in 43% of children with lacunar anterior circulation infarct (LACI). Hemiparesis was present in almost all children with total anterior circulation infarct (TACI), in two thirds of children with partial anterior circulation infarct (PACI) and in almost 50% of children with LACI or posterior circulation infarct (POCI). In every child with hemiplegia the stroke symptom evolved into hemiparesis at follow-up. Additionally, patients with a normal outcome were older at the time of AIS than those with at least one neurological consequence (OR = 0.894, p = 0.034).ConclusionsThe presence and number of neurological outcomes depend on stroke subtypes. A relation between the presence of post-stroke deficits and age at onset was observed. The odds of deficit after ischemic stroke decreases by an average of 10.6% if the child is 1 year older at the time of AIS.

scholarly journals Severe neurological outcomes after very early bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kathrin Burgmaier ◽  
◽  
Gema Ariceta ◽  
Martin Bald ◽  
Anja Katrin Buescher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Recessive ◽  
Neurological Complications ◽  
Control Group ◽  
Polycystic Kidney ◽  
Neurological Outcomes ◽  
Additional Control ◽  
Independent Risk Factors

Abstract To test the association between bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD) and long-term clinical outcome and to identify risk factors for severe outcomes, a dataset comprising 504 patients from the international registry study ARegPKD was analyzed for characteristics and complications of patients with very early (≤ 3 months; VEBNE) and early (4–15 months; EBNE) bilateral nephrectomies. Patients with very early dialysis (VED, onset ≤ 3 months) without bilateral nephrectomies and patients with total kidney volumes (TKV) comparable to VEBNE infants served as additional control groups. We identified 19 children with VEBNE, 9 with EBNE, 12 with VED and 11 in the TKV control group. VEBNE patients suffered more frequently from severe neurological complications in comparison to all control patients. Very early bilateral nephrectomies and documentation of severe hypotensive episodes were independent risk factors for severe neurological complications. Bilateral nephrectomies within the first 3 months of life are associated with a risk of severe neurological complications later in life. Our data support a very cautious indication of very early bilateral nephrectomies in ARPKD, especially in patients with residual kidney function, and emphasize the importance of avoiding severe hypotensive episodes in this at-risk cohort.

Sign in / Sign up

Export Citation Format

Share Document