scholarly journals Mindfulness in Treatment Approaches for Addiction — Underlying Mechanisms and Future Directions

2021 ◽  
Author(s):  
Annika Rosenthal ◽  
Michael E. Levin ◽  
Eric L. Garland ◽  
Nina Romanczuk-Seiferth
Keyword(s):  
Physiological Stress ◽  
Future Directions ◽  
Addictive Disorders ◽  
Treatment Approaches ◽  
Natural Rewards ◽  
New Treatment ◽  
Underlying Mechanisms ◽  
Meta Analyses ◽  
Mechanisms Of Mindfulness ◽  
Study Designs

Abstract Purpose of Review While the treatment of addictive disorders proves to be challenging, new treatment approaches that evolved around the concepts of mindfulness and acceptance have been utilized and investigated in recent years. Our goal is to summarize the efficacy and possible underlying mechanisms of mindfulness-based interventions (MBI) in addictive disorders. Recent Findings Various meta-analyses have suggested that MBIs show clinical efficacy in the treatment of addictive disorders. Considering the factors that impact addictive disorders, MBIs have been indicated to augment responsiveness to natural rewards in contrast to addiction-related cues as well as to increase top-down cognitive control, decrease subjective and physiological stress perception, and enhance positive affect. Summary In summary, MBIs hold promise in treating addictive disorders while larger randomized controlled trials with longitudinal study designs are needed to confirm their utility. Newest clinical endeavors strive to enhance the clinical utility of MBIs by augmentation or personalization.

Conclusions and Future Directions

2018 ◽  
Author(s):  
Christian Schmahl ◽  
K. Luan Phan ◽  
Robert O. Friedel
Keyword(s):  
Personality Disorder ◽  
Personality Disorders ◽  
Diagnostic Model ◽  
Future Directions ◽  
Treatment Approaches ◽  
Ongoing Controversy ◽  
Current State ◽  
New Treatment ◽  
The Many

This chapter provides an overarching review of the current state of personality disorder research, addresses some of the many gaps that currently exist in the literature where more research is needed, and provides recommendations for the field’s future directions. It incorporates a discussion on the ongoing controversy over whether personality disorders are best suited to a dimensional or categorical diagnostic model. It concludes with a review of several promising studies that examine potential new treatment approaches, which warrant further investigation. Topics covers include the neurobiology of personality disorder, research in the area, future directions for research, a dimensional diagnostic model, and new treatment approaches.

New treatment approaches for lung cancer and impact on survival

2002 ◽  
Vol 29 (3 Suppl 8) ◽  
pp. 26-29 ◽  
Author(s):  
Hern[aacute]n Cort[eacute]s-Funes
Keyword(s):  
Lung Cancer ◽  
Treatment Approaches ◽  
Impact On Survival ◽  
New Treatment

scholarly journals Biobehavioral Mechanisms of Mindfulness as a Treatment for Chronic Stress: An RDoC Perspective

2017 ◽  
Vol 1 ◽  
pp. 247054701771191 ◽  
Author(s):  
Eric L. Garland ◽  
Adam W. Hanley ◽  
Anne K. Baker ◽  
Matthew O. Howard
Keyword(s):  
Chronic Stress ◽  
Scientific Evidence ◽  
Self Regulation ◽  
Mental Health Research ◽  
Treatment Development ◽  
Attentional Function ◽  
Regulatory Strategies ◽  
The Face ◽  
Meta Analyses ◽  
Mechanisms Of Mindfulness

Mindfulness-based interventions have been heralded as promising means of alleviating chronic stress. While meta-analyses indicate that mindfulness-based interventions significantly reduce global measures of stress, how mindfulness-based interventions modulate the specific mechanisms underpinning chronic stress as operationalized by the National Institute of Mental Health research domain criteria (RDoC) of sustained threat has not yet been detailed in the literature. To address this knowledge gap, this article aims to (1) review evidence that mindfulness-based interventions ameliorate each of the 10 elements of behavioral dysregulation characterizing sustained threat via an array of mindful counter-regulatory strategies; (2) review evidence that mindfulness-based interventions modify biological domains implicated in sustained threat, such as the hypothalamic–pituitary–adrenal axis, as well as brain circuits involved in attentional function, limbic reactivity, habit behavior, and the default mode network; and (3) integrate these findings into a novel conceptual framework of mindful self-regulation in the face of stress—the Mindfulness-to-Meaning Theory. Taken together, the extant body of scientific evidence suggests that the practice of mindfulness enhances a range biobehavioral factors implicated in adaptive stress coping and induces self-referential plasticity, leading to the ability to find meaning in adversity. These mechanistic findings can inform the treatment development process to optimize the next generation of mindfulness-based interventions for greater therapeutic efficacy.

Factors Related to Positive Memory Count Among Trauma-Exposed Individuals: A Scoping Review

2021 ◽  
pp. 152483802110131
Author(s):  
Ateka A. Contractor ◽  
Stephanie V. Caldas ◽  
Megan Dolan ◽  
Nicole H. Weiss
Keyword(s):  
Scoping Review ◽  
Stress Disorder ◽  
Acute Stress ◽  
Longitudinal Research ◽  
Trauma Exposure ◽  
Memory Specificity ◽  
Scoping Reviews ◽  
Meta Analyses ◽  
Study Designs ◽  
Positive Memories

To examine the existing knowledge base on trauma experiences and positive memories, we conducted a scoping review of trauma and post-trauma factors related to positive memory count. In July 2019, we searched PubMed, Medline, PsycINFO, Web of Science, Cumulative Index of Nursing and Allied Health Literature, Embase, and PTSDpubs for a combination of words related to “positive memories/experiences,” “trauma/posttraumatic stress disorder (PTSD),” and “number/retrieval.” Twenty-one articles met inclusion criteria (adult samples, original articles in English, peer-reviewed, included trauma-exposed group or variable of trauma exposure, trauma exposure examined with a trauma measure/methodology, assessed positive memory count, empirical experimental/non-experimental study designs). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines, two authors reviewed abstracts, completed a secondary search, and independently extracted data. Our review indicated (1) that depression and PTSD were most researched; (2) no conclusive relationships of positive memory count with several psychopathology (depression, acute stress disorder, eating disorder, and anxiety), cognitive/affective, neurobiological, and demographic factors; (3) trends of potential relationships of positive memory count with PTSD and childhood interpersonal traumas (e.g., sexual and physical abuse); and (4) lower positive memory specificity as a potential counterpart to greater overgeneral positive memory bias. Given variations in sample characteristics and methodology as well as the limited longitudinal research, conclusions are tentative and worthy of further investigations.

scholarly journals YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer

Oncogene ◽  
2021 ◽  
Author(s):  
Hsiu-Chi Lee ◽  
Chien-Hui Ou ◽  
Yun-Chen Huang ◽  
Pei-Chi Hou ◽  
Chad J. Creighton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lipid Metabolism ◽  
Critical Issue ◽  
Castration Resistant Prostate Cancer ◽  
Cancer Stemness ◽  
New Treatment ◽  
Underlying Mechanisms ◽  
Transcriptional Complex

AbstractMetastatic castration-resistant prostate cancer (mCRPC) is a malignant and lethal disease caused by relapse after androgen-deprivation (ADT) therapy. Since enzalutamide is innovated and approved by US FDA as a new treatment option for mCRPC patients, drug resistance for enzalutamide is a critical issue during clinical usage. Although several underlying mechanisms causing enzalutamide resistance were previously identified, most of them revealed that drug resistant cells are still highly addicted to androgen and AR functions. Due to the numerous physical functions of AR in men, innovated AR-independent therapy might alleviate enzalutamide resistance and prevent production of adverse side effects. Here, we have identified that yes-associated protein 1 (YAP1) is overexpressed in enzalutamide-resistant (EnzaR) cells. Furthermore, enzalutamide-induced YAP1 expression is mediated through the function of chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) at the transcriptional and the post-transcriptional levels. Functional analyses reveal that YAP1 positively regulates numerous genes related to cancer stemness and lipid metabolism and interacts with COUP-TFII to form a transcriptional complex. More importantly, YAP1 inhibitor attenuates the growth and cancer stemness of EnzaR cells in vitro and in vivo. Finally, YAP1, COUP-TFII, and miR-21 are detected in the extracellular vesicles (EVs) isolated from EnzaR cells and sera of patients. In addition, treatment with EnzaR-EVs induces the abilities of cancer stemness, lipid metabolism and enzalutamide resistance in its parental cells. Taken together, these results suggest that YAP1 might be a crucial factor involved in the development of enzalutamide resistance and can be an alternative therapeutic target in prostate cancer.

scholarly journals Role of interleukins in the pathogenesis of pulmonary fibrosis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yi Xin She ◽  
Qing Yang Yu ◽  
Xiao Xiao Tang
Keyword(s):  
Pulmonary Fibrosis ◽  
Therapeutic Strategy ◽  
Future Directions ◽  
Regulation Mechanisms ◽  
Underlying Mechanisms ◽  
Multiple Cells ◽  
The Relationship

AbstractInterleukins, a group of cytokines participating in inflammation and immune response, are proved to be involved in the formation and development of pulmonary fibrosis. In this article, we reviewed the relationship between interleukins and pulmonary fibrosis from the clinical, animal, as well as cellular levels, and discussed the underlying mechanisms in vivo and in vitro. Despite the effects of interleukin-targeted treatment on experimental pulmonary fibrosis, clinical applications are lacking and unsatisfactory. We conclude that intervening in one type of interleukins with similar functions in IPF may not be enough to stop the development of fibrosis as it involves a complex network of regulation mechanisms. Intervening interleukins combined with other existing therapy or targeting interleukins affecting multiple cells/with different functions at the same time may be one of the future directions. Furthermore, the intervention time is critical as some interleukins play different roles at different stages. Further elucidation on these aspects would provide new perspectives on both the pathogenesis mechanism, as well as the therapeutic strategy and drug development.

scholarly journals A guide to do randomized controlled trials in the field of otolaryngology

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Sameh M. Zamzam ◽  
Mosaad Abdel-Aziz ◽  
Ahmed Atef ◽  
Usama Abdel-Naseer ◽  
Mostafa Hamoda ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Study Groups ◽  
Controlled Trials ◽  
Main Body ◽  
Main Research ◽  
Randomized Controlled ◽  
New Treatment ◽  
Meta Analyses ◽  
Based Medicine

Abstract Background Randomized controlled trials (RCTs) are prospective comparative studies in which study groups are allocated randomly to intervention or serve as controls. RCT is the mainstay to achieve evidence in the literature in clinical research. A RCT is the main research design to study the effect of an intervention and the only way to confirm the value of a new treatment. Main body RCT also gives the way to generate meta-analyses and systematic reviews giving a stronger evidence for clinical practice. Evidence-based medicine (EBM) is crucial for safe, effective, and standardized patient care. Although there is an agreement on the importance of performing RCT, it can be challenging to do it efficiently including different aspects like study design, funding, randomization, blinding, follow-up, data analysis, statistics, generalization of results, and reporting of quality of the studies. Conclusion In this article, we gave a comprehensive review for RCT in otolaryngology discussing their importance, advantages, and drawbacks, types, steps, challenges, reporting their quality and their prevalence in the literature.

The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies

2021 ◽  
Author(s):  
Wolfgang Marx ◽  
Nicola Veronese ◽  
Jaimon T Kelly ◽  
Lee Smith ◽  
Meghan Hockey ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Health Outcomes ◽  
Observational Studies ◽  
Dietary Inflammatory Index ◽  
Credibility Assessment ◽  
Umbrella Review ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Meta Analyses ◽  
Study Designs

ABSTRACT Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. A credibility assessment was conducted for each outcome using the following criteria: statistical heterogeneity, 95% prediction intervals, evidence for small-study effect and/or excess significance bias, as well as effect sizes and P values using calculated random effects meta-analyses. In total, 15 meta-analyses reporting on 38 chronic disease-related outcomes were included, incorporating a total population of 4,360,111 subjects. Outcomes (n = 38) were examined through various study designs including case-control (n = 8), cross-sectional (n = 5), prospective (n = 5), and combination (n = 20) study designs. Adherence to a pro-inflammatory dietary pattern had a significant positive association with 27 (71%) of the included health outcomes (P value < 0.05). Using the credibility assessment, Class I (Convincing) evidence was identified for myocardial infarction only, Class II (Highly suggestive) evidence was identified for increased risk of all-cause mortality, overall risk of incident cancer, and risk of incident site-specific cancers (colorectal, pancreatic, respiratory, and oral cancers) with increasing (more pro-inflammatory) DII score. Most outcomes (n = 31) presented Class III (Suggestive) or lower evidence (Weak or No association). Pro-inflammatory dietary patterns were nominally associated with an increased risk of many chronic disease outcomes. However, the strength of evidence for most outcomes was limited. Further prospective studies are required to improve the precision of the effect size.

Fysiologische stressmetingen in de werksituatie: nut, beperkingen en bevindingen

2009 ◽  
Vol 22 (3) ◽  
Author(s):  
Lorenz van Doornen ◽  
Jan Houtveen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Work Stress ◽  
Physiological Stress ◽  
Measurement Techniques ◽  
Stress Sensitivity ◽  
The Body ◽  
Limited Extent ◽  
Future Directions ◽  
Workplace Interventions

Physiological stress measures at work: relevance, limitations, and findings Physiological stress measures at work: relevance, limitations, and findings L. van Doornen & J. Houtveen, Gedrag & Organisatie, volume 22, September 2009, nr. 3, pp. 275-293 Physiological stress measures should only to a limited extent be considered as 'objective' indices of subjectively experienced work stress. Their contribution should mainly be sought in the quantification of the load on the body exerted by stress, the latter being the mediator of the health effects of work stress. For the most widely used physiological parameters in the field of work stress – blood pressure, heart rate, cardiac autonomic indices, adrenalin and cortisol – their physiology is described, their measurement techniques outlined, and an overall picture furnished with respect to differences observed between high- and low-work stress populations. Finally some suggestions are given with respect to future directions this field may take: focus on individual differences in physiological stress-sensitivity; quantification of recovery, and quantification of the effects of individual or workplace interventions.

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