Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles☆

2007 ◽  
Vol 59 (6) ◽  
pp. 505-521 ◽  
Author(s):  
A DATE ◽  
M JOSHI ◽  
V PATRAVALE
Keyword(s):  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Parasitic Diseases

scholarly journals Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Kovoru Krishnam Raju ◽  
Beeravelli Sudhakar ◽  
Kolapalli Venkata Ramana Murthy
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Competitive Inhibition ◽  
Polymeric Nanoparticles ◽  
Analytical Techniques ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Solid Lipid ◽  
Reductase Inhibitors ◽  
Coa Reductase

Statins are HMG-CoA reductase inhibitors, which lower the cholesterol level through reversible and competitive inhibition; they are involved in the biosynthesis of cholesterol and other sterols. Simvastatin exhibits poor oral bioavailability (<5%) and undergoes extensive microsomal metabolism by CYP enzymes. CYP3A4 is the major metabolizing enzyme that metabolizes lactone form of simvastatin and significantly lowers intestinal uptake. The hydrophobic properties of simvastatin prevent complete dissolution of the drug in the intestinal fluid which also contributes to its lower bioavailability. SLNs are alternative carrier system to polymeric nanoparticles. SLNs are in submicron size range (1–1000 nm). To overcome the hepatic first pass metabolism and to enhance the bioavailability, intestinal lymphatic transport of drugs can be exploited. In the present study, attempt has been made to prepare solid lipid nanoparticles of simvastatin to improve the bioavailability. SLNs of simvastatin were prepared with Trimyristin by hot homogenization followed by ultrasonication method. The SLNs were characterized for various physicochemical properties and analytical techniques like PXRD, DSC to study thermal nature and morphology of formulation and excipients. Promising results of the study indicated the applicability of simvastatin solid lipid nanoparticles as potential tools for improvement of bioavailability of poorly soluble drugs.

scholarly journals Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics

2017 ◽  
Vol 48 (1) ◽  
pp. 43-60 ◽  
Author(s):  
Young Hee Choi ◽  
Hyo-Kyung Han
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Current Status ◽  
Kinetic Characteristics ◽  
Future Perspectives ◽  
Pharmaceutical Ingredients ◽  
Superior Efficacy ◽  
Key Issues

Abstract Nanomedicines have evolved into various forms including dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles since their first launch in the market. Widely highlighted benefits of nanomedicines over conventional medicines include superior efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profiles of pharmaceutical ingredients. Especially, various kinetic characteristics of nanomedicines in body are further influenced by their formulations. This review provides an updated understanding of nanomedicines with respect to delivery and pharmacokinetics. It describes the process and advantages of the nanomedicines approved by FDA and EMA. New FDA and EMA guidelines will also be discussed. Based on the analysis of recent guidelines and approved nanomedicines, key issues in the future development of nanomedicines will be addressed.

scholarly journals Formulation of Nanostructured lipid particles

2020 ◽  
Vol 3 (2) ◽  
pp. 20-24
Author(s):  
Kavita Rani ◽  
Amit Kumar J. Raval ◽  
Dinesh Kaushik ◽  
Rajesh Khathuriya
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Second Generation ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Therapeutic Approaches ◽  
Solid Lipid ◽  
Lipid Particles ◽  
Lipid Nanocarriers ◽  
Lipid Formulations

Lipid nanocarriers are developed as an alternative to polymeric nanoparticles, liposomes and emulsions. NLCs are the second generation lipid carriers developed to overcome problems associated with Solid Lipid Nanoparticles and are utilized in various therapeutic approaches. NLCs were used for the delivery of lipophilic drugs .Biocompatible nature of lipids is responsible for its development as a good drug delivery. It was found to be having excellent characteristics over other lipid formulations.

scholarly journals Polysorbate 80 Coated Solid Lipid Nanoparticles for the Delivery of Temozolomide Into the Brain

2018 ◽  
Vol 8 (1) ◽  
pp. 21-28
Author(s):  
Pawan Yadav ◽  
Goutam Rath ◽  
Gazal Sharma ◽  
Ranjit Singh ◽  
Amit Kumar Goyal
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Animal Studies ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Polysorbate 80 ◽  
Angiogenic Therapy ◽  
Solid Lipid ◽  
Apoptotic Activity ◽  
The Brain ◽  
Patient Survival Rate

Introduction:Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.Methodology:To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.Results:Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.Conclusion:The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.

Budding Alliance of Nanotechnology in RNA Interference Therapeutics

2018 ◽  
Vol 24 (23) ◽  
pp. 2632-2643 ◽  
Author(s):  
Akshant Kumawat ◽  
Prachi Dapse ◽  
Narendra Kumar ◽  
Dinesh Kumar Mishra ◽  
Rahul Maheshwari ◽  
...  
Keyword(s):  
Rna Interference ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Research Topic ◽  
The Body ◽  
Great Success ◽  
Nanoscale Particles ◽  
Rna Molecules ◽  
Nucleic Acid Therapeutics ◽  
Novel Technique

RNA interference (RNAi), as a novel technique in which RNA molecules limit or silence the gene expression, is currently a hot research topic for producing novel therapeutic materials for challenging diseases. In the development of RNAi-based therapies, nanoscale particles, with a varying diameter along with facile modification methods that can mediate effective RNAi with targeting potential, are gaining wide interest. The nanotechnology itself has tremendous potential in the field of healthcare, especially for the development of better pharmaceuticals. Nano-enabled delivery has shown great success in the delivery of RNAi based therapeutics to specific locations in the body. Especially, siRNAs show great potential for use in nucleic acid therapeutics because of their potent and specific RNAi-triggering activity. This review summarizes the advanced nanocarriers such as solid lipid nanoparticles, gold nanoparticles, silver nanoparticles, iron oxide nanoparticles, polymeric nanoparticles, nanotransformers and curdlan nanoparticles with special emphasis on various aspects of siRNA-based therapeutics.

scholarly journals Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 191 ◽  
Author(s):  
Vijay Mishra ◽  
Kuldeep Bansal ◽  
Asit Verma ◽  
Nishika Yadav ◽  
Sourav Thakur ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Routes Of Administration ◽  
Size Dependent ◽  
Solid Lipid ◽  
Nano Drug Delivery

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.

scholarly journals A Review on SLN and NLC for Management of Fungal Infections

2021 ◽  
pp. 65-81
Author(s):  
B. G. Ramu ◽  
K. M. Asha Spandana ◽  
K. Divith ◽  
A. G. Nagashree ◽  
Amit B. Patel ◽  
...  
Keyword(s):  
Side Effects ◽  
Targeted Drug Delivery ◽  
Fungal Infections ◽  
Polymeric Nanoparticles ◽  
Physical Stability ◽  
Lipid Nanoparticles ◽  
Skin Permeability ◽  
Skin Infections ◽  
Skin Redness ◽  
Capacity Loading

Fungal disease is an invasive, serious, and systemic topical infection that affects the mucous membranes, tissues, and skin of humans. Oral medicines, on the other hand, have significant side effects, making topical treatments a viable alternative. Many antifungal medications applied through the skin in various conventional forms (gels or creams) may cause skin redness, erythema, stinging, and burning sensations. A promising approach to overcome the limitation of conventional form is the use of Nanocarriers for the treatment of skin infections since it allows targeted drug delivery, enhanced skin permeability, and controlled release and hence offers a lower risk of side effects. During the last few decades, lipid nanoparticles (LNPs) such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have gained a lot of attention. SLNs were designed to overcome the drawbacks of conventional colloidal carriers, such as emulsions, liposomes, and polymeric nanoparticles, by offering benefits such as a good release rate and drug targeting with high physical stability. NLCs are SLNs that have been modified (Second generation SLN) to improve stability and capacity loading. This review discusses the pathophysiology of the fungal diseases, the application of SLN and NLC, its method of preparation, Characterization, and an overview of clinical trials on SLN and NLC for the treatment of fungal infection.

scholarly journals FORMULATION AND EVALUATION OF NANOPARTICLES WITH NEURO PROTECTIVE CHEMICALS OF NATURAL AND SYNTHETIC ORIGIN.

2021 ◽  
pp. 11-14
Author(s):  
Pallav Kaushik Deshpande ◽  
Ragini Gothalwal
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Ethanolic Extract ◽  
Lipid Nanoparticles ◽  
Water Soluble ◽  
Drug Release Profile ◽  
Standard Drug ◽  
Conventional Drug ◽  
Nanoparticle Design

Most of the active phytoconstituents under development are poorly water soluble or have poor bioavailability . Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems and limitations of phytochemicals. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The main advantage is that they are prepared with physiologically well-tolerated lipids.Solid Lipid Nanoparticles (SLNs) as novel lipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems of polymeric nanoparticles.In present research formulation and evaluation of nanoparticles with ethanolic extract of two plants Celastrus paniculatus and Bacopa monnieri along with Donepezil as a standard drug was undertaken here for the production methods for preparation of SLNs, and pharmaceutical approach of SLNs in drug delivery . The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core–shell architecture using a single delivery system to combine multiple functionalities within nanoparticles which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. Solid liquid nanoparticles having plant extracts were successfully formulated and characterized for their stability.A biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. This architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, drug release profile,and good serum stability of phytochemicals

Sign in / Sign up

Export Citation Format

Share Document