CAUSALITY IMPUTATION BETWEEN HERBAL PRODUCTS AND HILI: AN ALGORITHM EVALUATION IN A SYSTEMATIC REVIEW

As herbal medicines have become commercialized, the safety, quality and efficacy of medicinal plants and herbal products have become of great concern. In view of this a review on Plant fingerprinting was carried out using systematic review and TLC fingerprinting was also carried out on two herbal products using simple Thin Layer Chromatography. The results revealed Morphological, Chemical and genetic methods are the major types studied. The High Performance Thin Layer Chromatography (HPTLC) is the most common type to chemical method utilized and most of the studies on Plants fingerprinting were carried out in Asia. Comparing the TLC profile of the two herbal preparations reveals that the two products are basically the same

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Antibacterial Efficacy of Conventional Versus Herbal Products on Streptococcus mutans in Adult Population- a Systematic Review & Meta-analysis

Brazilian Dental Science ◽

10.14295/bds.2020.v23i4.2012 ◽

2020 ◽

Vol 23 (4) ◽

pp. 18p

Author(s):

Kavalipurapu Venkata Teja ◽

Apoorva Vasundhara Kaligotla ◽

Sriram Gummuluri

Keyword(s):

Systematic Review ◽

Natural Products ◽

Dental Caries ◽

Streptococcus Mutans ◽

Meta Analysis ◽

In Vivo Studies ◽

Antibacterial Efficacy ◽

Caries Risk ◽

Herbal Products ◽

Google Search

Background: Dental caries is challenging infectious disease, which is wide spread and difficult to control. Although it’s multifactorial, microorganisms especially cariogenic Streptococcus mutans plays a wide role in initiation and progression of dental caries. Objective: The present review mainly aimed to evaluate and assess the antibacterial efficacy of herbal versus conventional products on Streptococcus mutans. Data Sources: A search was execute in electronic database (i.e., PUBMEDCENTRAL, COCHRANE, LILAC, SCIENCEDIRECT, GOOGLE SEARCH) using following search terms alone and in combination by means of PUBMED search builder from January 1990 up to July 2019. Study Eligibility Criteria: Studies were stipulate if they met the following criteria: In vivo studies comparing herbal and conventional products on anticariogenic or antibacterial activity on Streptococcus mutans were selected. Participants and Intervention: Adult patients aged from 18-65 years with dental caries undergoing intervention of herbal products. Study Appraisal and Synthesis Material and Methods: Out of 225 studies collected from databases, only 6 studies were included and other 6 were collected by hand search. Finally 12 included studies were analyzed out of which 5 studies were considered for meta-analysis. Results: The results unveil that natural products exerted virtually homogeneous antibacterial effect against Streptococcus mutans when compared with the counterpart. Limitations: Review was assessing on patients with dental caries and studies previously assessed did not mention about the caries risk. Prevalence varies based on caries risk assessments. Study was concentrating only on single species Streptococcus mutans. But ideally caries is multifactorial. Conclusion: Although natural products were effective, the present systematic review does not furnish concrete evidence to a show increased antibacterial efficacy of natural products as compared to conventional products. Keywords Antibiotics, Chlorhexidine, Dental Caries, Herbal, Streptococcus mutans.

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The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03450-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ranil Jayawardena ◽

Tormalli V. Francis ◽

Sachith Abhayaratna ◽

Priyanga Ranasinghe

Keyword(s):

Systematic Review ◽

Weight Loss ◽

Clinical Trials ◽

Meta Analysis ◽

Obesity Prevalence ◽

Herbal Products ◽

Appetite Suppressant ◽

Physical Activity Interventions ◽

Almost All ◽

Sciverse Scopus

Abstract Background Obesity prevalence has increased during the past few decades, causing a pandemic with an influx in other co-morbidities. Many factors influence weight gain in an obesogenic environment therefore strategies for treating obesity may vary from conventional dietary and physical activity interventions to pharamacotherapy. A shift in unconventional strategies as herbal products for treating obesity have been investigated and one such plant extract is Caralluma fimbriata (C. fimbriata). Further, the studies included were systematically reviewed to gather evidence on potential effects of C. fimbriata as an appetite suppressant and weight loss supplement. Methods A systematic review of clinical trials reporting the effects of C. fimbriata as appetite suppression and anti-obesity supplement was reported according to PRISMA guidelines. Data were obtained by searching three databases: PubMed®, Web of Science® and SciVerse Scopus® for studies published until 30th April 2020. Results A total of 7 articles studying C. fimbriata satisfied the inclusion and exclusion criteria and were sourced from various countries including Australia (3), Cuba (1), India (2) and Spain (1). Almost all studies recruited adults who were overweight or obese with a BMI > 25 kg/m2 (n = 5), with the exception of two studies, one that recruited healthy adults with a BMI average of 26.5 kg/m2 and the second one utilised a population of children and adolescents with Prader-Willis Syndrome (PWS). Parameters assessing obesity, biochemical and appetite factors were analysed by carrying out a meta-analysis. Compared to placebo controlled group, C. fimbriata extract significantly reduced WC by 1.59 cm (95% CI, − 3.07 to − 0.10, p = 0.041) and WHR by 0.06 (95% CI, − 0.12 to − 0.01, p = 0.05) although no significant effects were seen on BW, BMI and HC. Biochemical and appetite parameters outcome on C. fimbriata consumption had no significant changes. Any side effects of individuals who ingested the extract were reported by few studies of which most common effects were constipation, diarrhoea, nausea and rashes. Conclusion Appetite parameters showed no significant changes and metabolic parameters did not improve with C.fimbriata supplementation therefore it is unlikely to recommend C. fimbriata as a weight loss supplement and an appetite suppressant.

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The effect of celery (Apium graveolens L.) on fertility: A systematic review

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2016-0141 ◽

2017 ◽

Vol 15 (2) ◽

Cited By ~ 3

Author(s):

Wesam Kooti ◽

Maryam Moradi ◽

Khadijeh Peyro ◽

Maedeh Sharghi ◽

Fatima Alamiri ◽

...

Keyword(s):

Systematic Review ◽

Treatment Time ◽

Apium Graveolens ◽

Protective Effects ◽

Inhibitory Effects ◽

High Concentration ◽

Herbal Products ◽

Synthetic Drugs ◽

Positive Effect ◽

Different Doses

Abstract Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were “Apium graveolens L.”, “fertility”, “reproductive system”, “sperm”, “testis”, “delivery”, “sexual hormone”, “LH”, “FSH”, “testosterone”, “semen”, “male”, and “female”. Out of 238 collected articles (published in the period 1995 to 2015), 222 were excluded due to non-relevance and lack of access to the original article. Results The notable points were the different results seen by different researchers during different treatment periods or at different doses. Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant. Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis. In this regard, the doses used and the treatment time while using the plant must be accurately investigated. Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.

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Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/898261 ◽

2013 ◽

Vol 2013 ◽

pp. 1-15 ◽

Cited By ~ 10

Author(s):

Sophia Yui Kau Fong ◽

Qiong Gao ◽

Zhong Zuo

Keyword(s):

Systematic Review ◽

Drug Interactions ◽

Dietary Supplements ◽

Dietary Supplement ◽

Plasma Concentrations ◽

Inclusion Criteria ◽

First Line ◽

Pharmacodynamic Interaction ◽

Herbal Products ◽

Therapeutic Outcomes

Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ.Method. A systematic review was conducted on six English databases and four Chinese databases.Results. 196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified. No fatal or severe interactions were documented. The majority of the interactions were pharmacokinetic-based (80%). Traditional Chinese medicine accounted for most of the interactions (n=17), followed by food (n=10), dietary supplements (n=3), and other herbs/botanicals (n=3). Coadministration of 11 and 12 of the studied herbal products/dietary supplement/food significantly decreased or increased the plasma concentrations of CBZ. Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin, and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ.Conclusion. This review provides a comprehensive summary of the documented interactions between CBZ and herbal products/food/dietary supplements which assists healthcare professionals to identify potential herb-drug and food-drug interactions, thereby preventing potential adverse events and improving patients’ therapeutic outcomes when prescribing CBZ.

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Herbal Sealers in Endodontics – A Systematic Review

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4289 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 1278-1285

Author(s):

Manoj Chandak ◽

Pradnya Nikhade ◽

Rakhi Chandak ◽

Pavan Bajaj ◽

Kajol Relan ◽

...

Keyword(s):

Systematic Review ◽

Green Tea ◽

Azadirachta Indica ◽

Root Canal ◽

Ethylenediaminetetraacetic Acid ◽

Garlic Extract ◽

Herbal Products ◽

Tea Tree ◽

Dental Profession ◽

Micro Organisms

Root canal infections usually occur due to many micro-organisms, among which most frequent are the obligatory anaerobes. One of the predominantly found microbes is Candida albicans that requires special attention. Herbs have and are being used for health ailments and avoiding diseases that include epidemics for decades. A lot of plants are used as Phytomedicines in the dental profession because they have various biological and antimicrobial effects. Various irritants are used such as NaOCl, Chlorhexidine, hydrogen peroxide, ethylenediaminetetraacetic acid (EDTA), citric acid etc. to eradicate microbes. However, these irrigants may have several disadvantages. In Endodontics, plants and their extract can be used as irrigant and intracanal medicament to prevent the potential side effects caused by conventional chemical agents. Less toxic herbal products are being used since ancient era, and they are Triphala, Morinda citrofolia, Propolis, Azadirachta indica, Carvacrol, Green tea, Orange oil, tea tree oil, Arctium lappa, Garlic extract etc. Most commonly used are Triphala, Morinda citrofolia, Propolis, Azadirachta indica, Green tea, Garlic extract. Such herbal preparations are derived from the roots, leaves, seeds, stems and flowers of medicinal plants. This systematic review aims to enlighten and focus on various herbal products that can be used in endodontics to eradicate the root canal infection and to create the environment necessary for periapical healing. This is essential for successful Root canal treatment.

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The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

Food & Function ◽

10.1039/d0fo01976c ◽

2021 ◽

Author(s):

Yali Wei ◽

Yan Meng ◽

Na Li ◽

Qian Wang ◽

Liyong Chen

Keyword(s):

Systematic Review ◽

Fatty Acid ◽

Polyunsaturated Fatty Acid ◽

Meta Analysis ◽

Chain Polyunsaturated Fatty Acid ◽

Inflammation Markers ◽

Pufa Supplementation ◽

Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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Parent Education in Studies With Nonverbal and Minimally Verbal Participants With Autism Spectrum Disorder: A Systematic Review

American Journal of Speech-Language Pathology ◽

10.1044/2019_ajslp-19-00007 ◽

2020 ◽

Vol 29 (2) ◽

pp. 890-902

Author(s):

Lynn Kern Koegel ◽

Katherine M. Bryan ◽

Pumpki Lei Su ◽

Mohini Vaidya ◽

Stephen Camarata

Keyword(s):

Systematic Review ◽

Autism Spectrum Disorder ◽

Parent Education ◽

Autism Spectrum ◽

Verbal Communication ◽

Fidelity Of Implementation ◽

Spectrum Disorder ◽

Education Programs ◽

Minimally Verbal ◽

Parent Education Programs

Purpose The purpose of this systematic review was to identify parent education procedures implemented in intervention studies focused on expressive verbal communication for nonverbal (NV) or minimally verbal (MV) children with autism spectrum disorder (ASD). Parent education has been shown to be an essential component in the habilitation of individuals with ASD. Parents of individuals with ASD who are NV or MV may particularly benefit from parent education in order to provide opportunities for communication and to support their children across the life span. Method ProQuest databases were searched between the years of 1960 and 2018 to identify articles that targeted verbal communication in MV and NV individuals with ASD. A total of 1,231 were evaluated to assess whether parent education was implemented. We found 36 studies that included a parent education component. These were reviewed with regard to (a) the number of participants and participants' ages, (b) the parent education program provided, (c) the format of the parent education, (d) the duration of the parent education, (e) the measurement of parent education, and (f) the parent fidelity of implementation scores. Results The results of this analysis showed that very few studies have included a parent education component, descriptions of the parent education programs are unclear in most studies, and few studies have scored the parents' implementation of the intervention. Conclusions Currently, there is great variability in parent education programs in regard to participant age, hours provided, fidelity of implementation, format of parent education, and type of treatment used. Suggestions are made to provide both a more comprehensive description and consistent measurement of parent education programs.

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