scholarly journals The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease

2021 ◽  
Author(s):  
Oscar Kristiansen ◽  
Elise Sverre ◽  
Kari Peersen ◽  
Morten Wang Fagerland ◽  
Erik Gjertsen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cholesterol Levels ◽  
Statin Adherence ◽  
The Relationship

scholarly journals The influence of deficit of endogenous neuropeptides on the clinical course of coronary heart disease

2017 ◽  
Vol 95 (2) ◽  
pp. 127-131
Author(s):  
Aleksandr V. Dontsov
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Peroxidation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Cytokines ◽  
Inverse Correlation ◽  
Cholesterol Levels ◽  
Group 2 ◽  
The Relationship ◽  
Reduced Activity

The study is aimed at elucidating the relationship between the blood b-endorphin level in patients with coronary heart disease (CHD) with metabolic syndrome (MS) and cardiovascular risk factors and evaluating the possibility to correct them by dalargin therapy. The study included 123 patients (61 men and 62 women) at the mean age 57.6±5,2 years randomized into 2 groups. The patients of group 1 (n=63) were given the standard treatment, those of group 2 (n=60) additionally received 2 mg/day of dalargin for 10 days (3 courses during 3 months). The group of comparison (n=84) contained 84 CHD patients without MS. Biochemical and immunological characteristics were measured by immunoenzyme and immunochemiluminescent assays before and 3 months after treatment. The study revealed inverse correlation between b-endorphin levels and those of leptin, insulin, cortisol, TNF-a, IL-6, oxidized LDLP, triglycerides (TG), and HDLP cholesterol. Standard therapy resulted in a 6.5% reduction ofinsulin level, 9,4% , 6,1%, and 17,4% reduction of TNF-a , IL-6, TG levels respectively; it increased the HDLP cholesterol level by 10,3% (p<0,05 for all values) but did not change other parameters of interest. Dalargin therapy caused a 32,6% and 17,4%, rise in the b-endorphin and HDLP cholesterol levels but decreased leptin, insulin, cortisol, TNF-a, IL-6, LDLP, and tG levels by 36,1%, 22,4%, 23,9%, 55%, 56,3%, 14% and 27,2% respectively (p<0,001). It is concluded that the decrease of the blood b-endorphin level in the patients with coronary heart disease and metabolic syndrome is associated with enhanced blood atherogenicity, hyperinsulinemia, hypercortisolemia, activation of pro-inflammatory cytokines and lipid peroxidation. Supplementation of conventional therapy with dalargin results in the increased b-endorphin level, enhanced anti-atherogenic effect, reduced activity ofpro-inflammatory cytokines and lipid peroxidation, reduction of leptin, insulin and cortisol levels.

scholarly journals Total Cholesterol, Triglyseryda, and Coronary Hearth Disease Incidence in Hearth Polyclinic of dr. M. Yunus Hospital Bengkulu

2020 ◽  
Vol 25 (2) ◽  
pp. 1-9
Author(s):  
Nurul Khairani ◽  
Awal Isgiyanto ◽  
Lilis Sumarni
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Data Analysis ◽  
Total Cholesterol ◽  
Health Workers ◽  
Disease Incidence ◽  
Sampling Technique ◽  
Cholesterol Levels ◽  
The Impact ◽  
The Relationship

The impact of coronary heart disease (CHD) can cause heart failure and even a deadly heart attack. This study aimed to study the relationship of total cholesterol and triglyceride levels with CHD in patients visiting the Cardiac Polyclinic of        Dr. M. Yunus Bengkulu. This type of research used Analytical Survey with Case Control design. The population in this study was all patients of the Cardiac Polyclinic of RSUD dr. M. Yunus Bengkulu. Case samples in this study were 84 patients with CHD and 84 controls were taken using a Systematic Random Sampling technique. The data in this study used secondary data and data analysis techniques using univariate, bivariate, and multivariate analysis. Data analysis in this study used Chi-Square test (c2). To determine the closeness of the relationship, the Contingency Coefficient (C) test was used. To find out the risk factors used the Odds Ratio (OR) test. The results obtained from 168 people there were 84 people (50.0%) who had CHD, 87 people (51.8%) had total cholesterol levels ≥ 200 mg / dL and 100 people (59.5%) who had triglyceride levels ≥ 150 mg / dL. There was a correlation between total cholesterol levels and triglyceride levels with CHD in patients who visited the Cardiac Polyclinic of  dr. M. Yunus Bengkulu with a moderate relationship category. It is expected that health workers can increase information regarding the prevention and control of total cholesterol levels and triglyceride levels in CHD patients, and recommend to maintain a healthy lifestyle and exercise in order to improve the quality of life of patients with CHD.Keywords: coronary heart disease, total cholesterol levels, triglyceride levels,

Mortality and associated risk factors in diabetics

1985 ◽  
Vol 110 (4_Suppl) ◽  
pp. S21-S26 ◽  
Author(s):  
R. J. Jarrett ◽  
M. J. Shipley
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mortality Risk ◽  
Mortality Rates ◽  
Potential Risk Factors ◽  
Diabetic Population ◽  
Associated Risk Factors ◽  
The Relationship

Summary. In 168 male diabetics aged 40-64 years participating in the Whitehall Study, ten-year age adjusted mortality rates were significantly higher than in non-diabetics for all causes, coronary heart disease, all cardiovascular disease and, in addition, causes other than cardiovascular. Mortality rates were not significantly related to known duration of the diabetes. The predictive effects of several major mortality risk factors were similar in diabetics and non-diabetics. Excess mortality rates in the diabetics could not be attributed to differences in levels of blood pressure or any other of the major risk factors measured. Key words: diabetics; mortality rates; risk factors; coronary heart disease. There are many studies documenting higher mortality rates - particularly from cardiovascular disease -in diabetics compared with age and sex matched diabetics from the same population (see Jarrett et al. (1982) for review). However, there is sparse information relating potential risk factors to subsequent mortality within a diabetic population, information which might help to explain the increased mortality risk and also suggest preventive therapeutic approaches. In the Whitehall Study, a number of established diabetics participated in the screening programme and data on mortality rates up to ten years after screening are available. We present here a comparison of diabetics and non-diabetics in terms of relative mortality rates and the influence of conventional risk factors as well as an analysis of the relationship between duration of diabetes and mortality risk.

scholarly journals Up-Beat UK: A programme of research into the relationship between coronary heart disease and depression in primary care patients

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
André Tylee ◽  
Mark Ashworth ◽  
Elizabeth Barley ◽  
June Brown ◽  
John Chambers ◽  
...  
Keyword(s):  
Primary Care ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Primary Care Patients ◽  
The Relationship

scholarly journals Insulin Resistance and the Relationship of a Dyslipidemia to Coronary Heart Disease

2011 ◽  
Vol 31 (5) ◽  
pp. 1208-1214 ◽  
Author(s):  
Sander J. Robins ◽  
Asya Lyass ◽  
Justin P. Zachariah ◽  
Joseph M. Massaro ◽  
Ramachandran S. Vasan
Keyword(s):  
Insulin Resistance ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Relationship Of ◽  
The Relationship

Risk Factors for Coronary Artery Disease in Children: Recognition, Evaluation, and Therapy

1980 ◽  
Vol 2 (5) ◽  
pp. 131-138
Author(s):  
C. J. Glueck ◽  
M. J. Mellies ◽  
R. C. Tsang ◽  
J. A. Morrison
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Eating Habits ◽  
Plasma Cholesterol ◽  
Saturated Fat ◽  
Cholesterol Levels ◽  
Chd Risk ◽  
Artery Disease ◽  
Atherosclerosis Prevention

PEDIATRIC GENESIS OF ATHEROSCLEROSIS Atherosclerosis results from a variety of pathophysiologic disturbances, some currently recognized, and many undoubtedly not yet recognized, which in aggregate are identified as risk factors. Genetic and environmental influences conjointly affect the incidence and the severity of these risk factors and, thus, coronary heart disease (CHD) risk. Prophylaxis should be designed to prevent or retard the development of arterial plaques. This suggests that diagnostic and preventive efforts should begin in childhood. Eating habits are also probably established in childhood, allowing their early modification. The atherosclerotic plaque appears to have its genesis in childhood. The data from wartime autopsies confirm the presence of mature atherosclerotic lesions by the end of the second decade and emphasize the importance of primary atherosclerosis prevention beginning in the first and second decades. While there are clearly genetic factors in CHD, variation in rates in differing geographic areas appears less likely to be related to genetic than to environmental differences. Marked differences in plasma cholesterol levels are found in children in different geographic areas, generally paralleling pediatric cholesterol and saturated fat intake and the incidence of adult coronary heart disease. The relationships of elevated total plasma cholesterol levels to the incidence of coronary heart disease are clearly established in adults.

Antioxidant potential of diet: Association between dietary antioxidant index and odds of coronary heart disease: A case-control study

2021 ◽  
pp. 1-13
Author(s):  
Farhad Vahid ◽  
Zahra Nasiri ◽  
Amir Abbasnezhad ◽  
Ezatollah Fazeli Moghadam
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Dietary Antioxidants ◽  
Dietary Antioxidant ◽  
The Relationship ◽  
Control Study

BACKGROUND: Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE: This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS: In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS: Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION: Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.

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