scholarly journals Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis

2021 ◽  
Vol 1867 (5) ◽  
pp. 166084
Author(s):  
Dong Woo Kang ◽  
Won Chan Hwang ◽  
Yu Na Noh ◽  
Xiangguo Che ◽  
Soung-Hoon Lee ◽  
...  
Keyword(s):  
Bone Mass ◽  
Fat Mass ◽  
Ppar Γ ◽  
Phospholipase D1 ◽  
Signaling Axis

Increased fat mass may be protective of bone mass in young male cancer survivors

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S189-S190
Author(s):  
J.S. Walsh ◽  
R. Eastell ◽  
R.E. Coleman ◽  
J.A. Snowden ◽  
S.M. Shalet ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cancer Survivors ◽  
Fat Mass ◽  
Young Male

scholarly journals Acute fat loss does not affect bone mass

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie K. Lagerquist ◽  
Karin L. Gustafsson ◽  
Petra Henning ◽  
Helen Farman ◽  
Jianyao Wu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Bone Mass ◽  
Fat Mass ◽  
Tissue Loss ◽  
Obese Mice ◽  
Long Term Effects ◽  
High Bone Mass ◽  
Age Related ◽  
Total Fat ◽  
Old Mice

AbstractObesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity.

scholarly journals Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice

2020 ◽  
Vol 150 (6) ◽  
pp. 1370-1378 ◽  
Author(s):  
Jay J Cao ◽  
Brian R Gregoire ◽  
Kim G Michelsen ◽  
Matthew J Picklo Sr
Keyword(s):  
Bone Mass ◽  
Linolenic Acid ◽  
Fat Mass ◽  
Bone Structure ◽  
Structural Parameters ◽  
Tartrate Resistant Acid Phosphatase ◽  
Low Grade ◽  
Obese Mice ◽  
Treatment Groups ◽  
Serum Trap

ABSTRACT Background Linoleic acid (LA; 18:2n–6) has been considered to promote low-grade chronic inflammation and adiposity. Studies show adiposity and inflammation are inversely associated with bone mass. Objectives This study tested the hypothesis that decreasing the dietary ratio of LA to α-linolenic acid (ALA, 18:3n–3), while keeping ALA constant, mitigates high-fat diet (HF)-induced adiposity and bone loss. Methods Male C57BL/6 mice at 6 wk old were assigned to 4 treatment groups and fed 1 of the following diets ad libitum for 6 mo: a normal-fat diet (NF; 3.85 kcal/g and 10% energy as fat) with the ratio of the PUFAs LA to ALA at 6; or HFs (4.73 kcal/g and 45% energy as fat) with the ratio of LA to ALA at 10:1, 7:1, or 4:1, respectively. ALA content in the diets was kept the same for all groups at 1% energy. Bone structure, body composition, bone-related cytokines in serum, and gene expression in bone were measured. Data were analyzed using 1-factor ANOVA. Results Compared with those fed the NF, mice fed the HFs had 19.6% higher fat mass (P < 0.01) and 13.5% higher concentration of serum tartrate-resistant acid phosphatase (TRAP) (P < 0.05), a bone resorption cytokine. Mice fed the HFs had 19.5% and 12.2% lower tibial and second lumbar vertebral bone mass, respectively (P < 0.01). Decreasing the dietary ratio of LA to ALA from 10 to 4 did not affect body mass, fat mass, serum TRAP and TNF-α, or any bone structural parameters. Conclusions These data indicate that decreasing the dietary ratio of LA to ALA from 10 to 4 by simply reducing LA intake does not prevent adiposity or improve bone structure in obese mice.

scholarly journals Adiposity, Insulin Resistance, and Bone Mass in Children and Adolescents

2018 ◽  
Vol 104 (3) ◽  
pp. 892-899 ◽  
Author(s):  
Joseph M Kindler ◽  
Andrea J Lobene ◽  
Kara A Vogel ◽  
Berdine R Martin ◽  
Linda D McCabe ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Insulin Resistance ◽  
Waist Circumference ◽  
Bone Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Total Body ◽  
The Relationship

Abstract Context Insulin resistance is an adverse health outcome that accompanies obesity. Fat mass is negatively associated with the bone mass after adjustment for confounders. Insulin resistance might be an intermediary in this relationship. Objective To determine whether insulin resistance is an intermediary in the relationship between adiposity and bone mass in adolescents. Design Cross-sectional secondary analysis of baseline data from a previous randomized trial. Setting University research facility. Participants A total of 240 adolescents (68% female), aged 7 to 15 years. Main Outcome Measures Using dual energy x-ray absorptiometry, bone mineral content (BMC), areal bone mineral density, lean mass, and fat mass were measured. Skeletal sites of interest included the total body and lumbar spine (LS). Waist circumference was measured using an anthropometric tape measure. Insulin and glucose were measured in fasting sera, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Path analysis was performed to determine whether the relationship between adiposity and bone was mediated through insulin resistance. Results Fat mass (r = 0.467; P < 0.001) and waist circumference (r = 0.487; P < 0.001) correlated positively with HOMA-IR. Controlling for race, sex, maturation, lean mass, and height, fat mass, waist circumference, and HOMA-IR were negatively associated with LS BMC and total body areal bone mineral density (P < 0.05 for all). Additionally, path models for fat mass (95% CI, −5.893 to −0.956) and waist circumference (95% CI, −15.473 to −2.124) showed a negative relationship with LS BMC via HOMA-IR. Conclusions These results support an intermediary role of insulin resistance in the relationship between adiposity and LS bone mass.

scholarly journals Fat Mass Exerts a Greater Effect on Cortical Bone Mass in Girls than Boys

2010 ◽  
Vol 95 (2) ◽  
pp. 699-706 ◽  
Author(s):  
Adrian Sayers ◽  
Jonathan H. Tobias
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Fat Mass ◽  
Quantitative Computed Tomography ◽  
Positive Association ◽  
Mineral Density ◽  
Cortical Bone Mineral Density ◽  
Cortical Bone Mass

Abstract Context: It is unclear whether fat mass (FM) and lean mass (LM) differ in the way they influence cortical bone development in boys and girls. Objective: The aim of the study was to investigate the contributions of total body FM and LM to parameters related to cortical bone mass and geometry. Design/Setting: We conducted a longitudinal birth cohort study, the Avon Longitudinal Study of Parents and Children. Participants: A total of 4005 boys and girls (mean age, 15.5 yr) participated in the study. Outcome Measures: We measured cortical bone mass, cortical bone mineral content (BMCC), cortical bone mineral density, periosteal circumference (PC), and endosteal circumference by tibial peripheral quantitative computed tomography. Results: LM had a similar positive association with BMCC in boys and girls [regression coefficients with 95% confidence interval (CI); P for gender interactions: boys/girls, 0.952 (0.908, 0.997); P = 0.85]. However, the mechanisms by which LM influenced bone mass differed according to gender because LM was positively associated with PC more strongly in girls [boys, 0.579 (0.522, 0.635); girls, 0.799 (0.722, 0.875); P < 0.0001], but was only associated with cortical bone mineral density in boys [boys, 0.443 (0.382, 0.505); girls, 0.014 (−0.070, 0.097); P < 0.0001]. There was a stronger positive association between FM and BMCC in girls [boys, 0.227 (0.185, 0.269); girls, 0.355 (0.319, 0.392); P < 0.0001]. This reflected both a greater positive association of FM with PC in girls [boys, 0.213 (0.174, 0.253); girls, 0.312 (0.278, 0.347); P = 0.0002], and a stronger negative association with endosteal circumferencePC [boys, −0.059 (−0.096, 0.021); girls, −0.181 (−0.215, −0.146); P < 0.0001]. Conclusions: Whereas LM stimulates the accrual of cortical bone mass to a similar extent in boys and girls, FM is a stronger stimulus for accrual of cortical bone mass in girls, reflecting a greater tendency in females for FM to stimulate periosteal growth and suppress endosteal expansion.

Fat mass is positively associated with bone mass in relatively thin adolescents: Data from the Kitakata Kids Health Study

Bone ◽  
2014 ◽  
Vol 64 ◽  
pp. 298-302 ◽  
Author(s):  
Katsuyasu Kouda ◽  
Yuki Fujita ◽  
Yuho Sato ◽  
Kumiko Ohara ◽  
Harunobu Nakamura ◽  
...  
Keyword(s):  
Bone Mass ◽  
Fat Mass ◽  
Health Study

scholarly journals Bone mass in Chinese premenarcheal girls: the roles of body composition, calcium intake and physical activity

2004 ◽  
Vol 92 (6) ◽  
pp. 985-993 ◽  
Author(s):  
Kun Zhu ◽  
Xueqin Du ◽  
Heather Greenfield ◽  
Qian Zhang ◽  
Guansheng Ma ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Bone Age ◽  
Dietary Intakes ◽  
Food Record ◽  
Total Body ◽  
Proximal Forearm ◽  
Body Bone

The association of growth and anthropometric characteristics and lifestyle factors with bone mass and second metacarpal radiogrammetry parameters was evaluated in 373 healthy Chinese premenarcheal girls aged 9–11 years. Bone mineral content (BMC) and density (BMD) and bone area (BA) of distal forearm, proximal forearm and total body, bone mineral-free lean (BMFL) mass and fat mass were measured by dual-energy X-ray absorptiometry. Metacarpal bone periosteal and medullary diameters were measured. Dietary intakes were assessed by 7d food record and physical activity (PA) by questionnaire. BMFL and fat mass together explained 6·3 and 51·6% of the variation in total body BMC and BMD, respectively. BMFL mass contributed to a substantial proportion of the variation in forearm BMC and BMD and periosteal diameter (10·4–41·0%). The corresponding BA explained 14·8–80·4% of the variation in BMC. Other minor but significant predictors of total body bone mass were Ca intake, height, age and PA score (BMD only), and of forearm bone mass were PA score, bone age, height and fat mass. Nevertheless, after adjusting for bone and body size and for age or bone age, subjects with Ca intake above the median (417mg/d) had 1·8% greater total body BMC (P<0·001), and subjects with PA scores above the median had 2·4–2·5% greater distal and proximal forearm BMC (P<0·05) than those below. Vitamin D intake negatively associated with medullary diameter (partialR21·7%). The results indicate that premenarcheal girls should be encouraged to optimise nutrition and Ca intake and exercise regularly to achieve maximum peak bone mass.

scholarly journals Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-γ

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kehinde Samuel Olaniyi ◽  
Morounkeji Nicole Owolabi ◽  
Chukwubueze Lucky Atuma ◽  
Toluwani Bosede Agunbiade ◽  
Bolanle Yemisi Alabi
Keyword(s):  
Body Weight ◽  
Fat Mass ◽  
Visceral Fat ◽  
Wistar Rats ◽  
Pyruvate Dehydrogenase Kinase ◽  
Peroxisome Proliferator ◽  
Elevated Plasma ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ppar Γ ◽  
Glutamyl Transferase

AbstractWe investigated the hypothesis that acetate ameliorates brain-adipose metabolic dysfunction (BAMED) in high fat diet (HFD)-induced obesity, possibly by modulation of peroxisome proliferator-activated receptor-γ (PPAR-γ). Ten-week-old male Wistar rats were randomly assigned into four groups (n = 6/group): Control, acetate and obese with or without acetate groups received vehicle (distilled water; po), acetate (200 mg/kg, po) and 40% HFD with or without acetate respectively. The treatments lasted for 12 weeks. Obese animals showed increase in body weight, visceral fat mass, insulin and triglyceride-glucose index and a reduction in insulin sensitivity. In addition, obese animals also showed increase in plasma/hypothalamic and adipose pyruvate dehydrogenase kinase-4, lactate-pyruvate ratio, malondialdehyde, γ-glutamyl transferase, and a decrease in glucose-6-phosphate dehydrogenase, glutathione, nitric oxide and PPAR-γ. HFD also elevated plasma/hypothalamic lipid and decreased adipose lipid profile, increased hypothalamic and adipose tumor necrosis factor-α, interleukin-6 and histone deacetylase (HDAC), and elevated plasma/adipose leptin. These alterations were reversed by concomitant administration of acetate. The present results demonstrate that obesity is characterized by BAMED, which is accompanied by altered HDAC/PPAR-γ. The results in addition suggest that acetate, an HDAC inhibitor rescues BAMED with consequent normalization of body weight and visceral fat mass by modulation of PPAR-γ and suppression of oxidative stress.

Effect of growth hormone administration and treadmill exercise on the body composition of rats

1994 ◽  
Vol 77 (1) ◽  
pp. 23-29 ◽  
Author(s):  
J. K. Yeh ◽  
J. F. Aloia ◽  
M. Chen ◽  
S. Sprintz
Keyword(s):  
Growth Hormone ◽  
Bone Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Treadmill Exercise ◽  
The Body ◽  
Fat Free Mass ◽  
Body Fat Mass ◽  
Growth Hormone Administration ◽  
Hormone Administration

The aim of this study was to compare the effects of growth hormone administration and treadmill exercise on bone mass, body fat mass, and fat-free mass. Forty female rats aged 14 mo were divided into control, ovine growth hormone administration (0.5 mg.kg-1.day-1; GH), treadmill exercise (17 m/min, 60 min/day; EX), and EX + GH groups. Noninvasive total body electrical conductivity and dual X-ray absorptiometry techniques were used to assess the body fat content, fat-free mass, and tibial and L4 vertebral bone mineral content of each experimental animal at weeks 0, 9, and 16. The age-related increase in body fat mass was suppressed in the GH group, and the fat-free mass and L4 bone mass were higher in the GH group than in the control group. Conversely, in the EX group there was no gain in body fat mass and no significant change in fat-free mass or vertebral bone mass. The tibial bone mass increased in both the GH and EX groups; however, the time response to the two interventions appeared to differ. In the EX + GH group there was no further enhancement of the anabolic effect on the tibial bone mass. The effect of growth hormone administration on body fat content and bone mass is distinct from that of treadmill exercise.

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