Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review

2018 ◽  
Vol 183 ◽  
pp. 91-101 ◽  
Author(s):  
Yue Yu ◽  
Mingyue Shen ◽  
Qianqian Song ◽  
Jianhua Xie
Keyword(s):  
Natural Resources ◽  
Biological Activities ◽  
Pharmaceutical Applications

scholarly journals Medicinal Plants and Its Pharmacological Values

2021 ◽  
Author(s):  
Smita G. Bhat
Keyword(s):  
Medicinal Plants ◽  
Natural Resources ◽  
Bioactive Compounds ◽  
Biological Diversity ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Natural Sources ◽  
Plant Parts ◽  
New Drug ◽  
Important Chemical

Plants have been used as a source of medicine for the treatment of different diseases from thousands of years ago. There is numerous evidences are available for use of plants as a medicine in the treatment of diseases in Indian, Egyptian, Chinese, Greek and Roman system of medicine. Pharmacognosy is the study of medicines derived from natural sources, mainly from plants which may further lead to development of new drug. The exploration, extraction and screening of biological diversity such as herbs, spices, microbes and other natural resources is the worldwide activity in recent years. Phytochemicals are the naturally available bioactive compounds which are derived from different plant parts and are primarily responsible for biological activities. The most important chemical compounds which are present in the plants are alkaloids, phenols, saponins, carbohydrates, terpenoids, steroids, flavonoids and tannins etc.

scholarly journals Synthesis of Chlorinated 3,5 Diaryl 2 Pyrazrolines

2021 ◽  
pp. 476-479
Author(s):  
Pratiksha S. Rathod ◽  
Shilpa G. Chavan
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Heterocyclic Compounds ◽  
Mass Spectra ◽  
Biological Activities ◽  
Research Activity ◽  
Biological Screening ◽  
Pharmaceutical Applications

Pyrazolines are important nitrogen containing 5-membered heterocyclic compounds. Various, pyrazoline derivatives have been found to possess considerable biological and pharmaceutical applications as activities, which stimulated the research activity in this field. The chlorinated 3,5-diary-l-2-pyrazolines has been synthesized by reaction of appropriately substituted chloro chalcones and mono-substituted hydrazine’s have been synthesized. These compounds were characterized using IR, 1H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore, biological screening of novel compounds has been also done.

scholarly journals The Natural Products and Pharmacological Biodiversity of Brown Algae from the Genus Dictyopteris

2021 ◽  
Vol 66 (1) ◽  
Author(s):  
Mohammed I. Rushdi ◽  
Iman A. M. Abdel- Rahman ◽  
Hani Saber ◽  
Eman Zekry Attia ◽  
Usama Ramadan Abdelmohsen
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Brown Algae ◽  
Biological Activities ◽  
Biological Properties ◽  
Sulfur Compounds ◽  
Chemical Feature ◽  
Pharmaceutical Applications

Abstract. Genus Dictyopteris is an important genus among marine seaweeds and is excessively distributed and known by its ocean smell due to its secondary metabolites including C11-hydrocarbons and sulfur compounds. This chemical feature is responsible for its interesting biological properties. This review detected the literature from 1959 to 2021 on the genus Dictyopteris and revealed the secondary metabolites, together with biological activities of the genus Dictyopteris to create the base for additional studies on its clinical and pharmaceutical applications.   Resumen. El género Dictyopteris es un género importante entre las algas marinas y está excesivamente distribuido y conocido por su olor a océano debido a sus metabolitos secundarios que incluyen hidrocarburos C11 y compuestos de azufre. Esta característica química es responsable de sus interesantes propiedades biológicas. Esta revisión detectó la literatura de 1959 a 2021 sobre el género Dictyopteris y reveló los metabolitos secundarios, junto con las actividades biológicas del género Dictyopteris, para crear la base para estudios adicionales sobre sus aplicaciones clínicas y farmacéuticas.

scholarly journals Algae Bioactive Constituents and Possible Role During COVID-19 Pandemic (A review)

2021 ◽  
Vol 30 (2) ◽  
pp. 16-22
Author(s):  
Sayed Rashad ◽  
Ghadir El-Chaghaby
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Bioactive Constituents ◽  
Algae Biomass ◽  
Synthetic Drugs ◽  
Pharmaceutical Applications ◽  
Active Chemical ◽  
Wide Range ◽  
Algal Products

Nowadays, the use of natural bio-products in pharmaceuticals is gaining popularity as safe alternatives to chemicals and synthetic drugs. Algal products are offering a pure, healthy and sustainable choice for pharmaceutical applications. Algae are photosynthetic microorganisms that can survive in different environmental conditions. Algae have many outstanding properties that make them excellent candidate for use in therapeutics. Algae grow in fresh and marine waters and produce in their cells a wide range of biologically active chemical compounds. These bioactive compounds are offering a great source of highly economic bio-products. The present review discusses the phytochemical and bioactive compounds present in algae biomass and their potent biological activities. The review focuses on the use of alga in therapy and their pharmaceutical applications with special reference to the possible preventive and therapeutic role of algae against COVID-19.

scholarly journals Characterisation and Bioactivity Analysis of Peridinin-Chlorophyll a-Protein (PCP) Isolated from Symbiodinium tridacnidorum CS-73

2021 ◽  
Vol 9 (12) ◽  
pp. 1387
Author(s):  
Kanoknate M. Supasri ◽  
Manoj Kumar ◽  
Anna Segečová ◽  
Janice I. McCauley ◽  
Andrei Herdean ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chlorophyll A ◽  
Rna Binding ◽  
Biological Activities ◽  
Metastatic Breast ◽  
Spectroscopic Properties ◽  
Breast Adenocarcinoma ◽  
Pharmaceutical Applications ◽  
Anti Cancer ◽  
Anti Inflammation

Peridinin-Chlorophyll a-Proteins (PCP) are the major light harvesting proteins in photosynthetic dinoflagellates. PCP shows great variation in protein length, pigment ratio, sequence, and spectroscopic properties. PCP conjugates (PerCP) are widely used as fluorescent probes for cellular and tissue analysis in the biomedical field. PCP consists of a peridinin carotenoid; thereby, it can potentially be used as a bioactive compound in pharmaceutical applications. However, the biological activities of PCP are yet to be explored. In this study, we extracted, purified, and partially characterised the PCP from Symbiodinium tridacnidorum (CS-73) and explored its antioxidant, anti-cancer and anti-inflammation bioactivities. The PCP was purified using an ÄKTA™ PURE system and predicted to be of 17.3 kDa molecular weight (confirmed as a single band on SDS-PAGE) with an isoelectric point (pI) 5.6. LC-MS/MS and bioinformatic analysis of purified PCP digested with trypsin indicated it was 164 amino acids long with >90% sequence similarity to PCP of SymA3.s6014_g3 (belonging to clade A of Symbiodinium sp.) confirmed with 59 peptide combinations matched across its protein sequence. The spectroscopic properties of purified PCP showed a slight shift in absorption and emission spectra to previously documented analysis in Symbiodinium species possibly due to variation in amino acid sequences that interact with chl a and peridinin. Purified PCP consisted of a 19-amino-acid-long signal peptide at its N terminal and nine helixes in its secondary structure, with several protein binding sites and no DNA/RNA binding site. Furthermore, purified PCP exhibited antioxidant and in vitro anti-inflammation bioactivities, and anti-cancer activities against human metastatic breast adenocarcinoma (MDA-MB-231) and human colorectal (HTC-15) cancer cell lines. Together, all these findings present PCP as a promising candidate for continued investigations for pharmaceutical applications to cure chronic diseases, apart from its existing application as a fluorescent-probe.

A Comprehensive Review on Therapeutic Potentials of Natural Cyclic Peptides

2022 ◽  
Vol 18 ◽  
Author(s):  
Renu Saharan ◽  
Suresh Kumar ◽  
Sukhbir Lal Khokra ◽  
Sunil Singh ◽  
Abhishek Tiwari ◽  
...  
Keyword(s):  
Natural Resources ◽  
Cyclic Peptides ◽  
Higher Plants ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Ring Structure ◽  
Amide Bond ◽  
Microtubule Inhibitor ◽  
Natural Sources ◽  
Marine Habitats

Abstract: Cyclic peptides have emerged as a promising class of organic compounds that possess polypeptide chains with a cyclic ring structure. There is a circular sequence of bonds in which the ring structure is formed via linkage between one end of the peptide bond and the other end with an amide bond or any other chemically stable bonds like ether, thioether, lactone, and disulfide. Generally, the cyclic peptides are isolated from natural resources like invertebrate animals, micro-organisms of marine habitats, and higher plants. These cyclic peptides possess unique structures with diverse pharmacological activities. Now a day, cyclic peptides possess superior therapeutic value due to several reasons such as greater resistance to enzymatic degradation (in vivo) and higher bio-availability. Some of these cyclic peptides are rich in leucine, proline while some have other amino acids as their major constituents. Numerous novel cyclic peptides isolated from natural sources are successfully developed as bioactive products. Recently, cyclic peptides derived from natural resources have attracted attention for exploring their numerous beneficial effects. Moreover, it is reported that natural cyclic peptides exhibit various therapeutic activities like an anthelmintic, ACE inhibitor, anti-tumor, microtubule inhibitor, anti-fungal, anti-malarial, and platelet aggregation inhibiting activity. In this review, various cyclic peptides are reported with structures and biological activities that are isolated from various natural sources. The natural cyclic peptides possess a wide spectrum of biological activities and can become a drug of the future for replacing the existing drugs which develop resistance

Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles

2020 ◽  
Vol 20 (1) ◽  
pp. 66-87 ◽  
Author(s):  
Mariangela Marrelli ◽  
Giancarlo Statti ◽  
Filomena Conforti
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Point Of View ◽  
Herbal Remedies ◽  
Complex Spectrum ◽  
Metabolic Profiles ◽  
Pharmaceutical Applications ◽  
The World ◽  
Hypericum Species

: Plants from the genus Hypericum, one genus of the Hypericaceae family, have attracted a lot of attention for their potential pharmaceutical applications. Most of the studies in the literature focus on H. perforatum L. (common St. John's wort), whose complex spectrum of bioactive compounds makes this species one of the top herbal remedies and supplements in the world. It is also important to compare the studies on other Hypericum species, both from the phytochemical and biological point of view. The aim of this review was to provide an update of most recent studies about biological investigations of plants belonging to Hypericum genus. The metabolic profiles of Hypericum spp. were also discussed in order to present a spectrum of secondary metabolites not previously identified in this genus.

Development, validation, and application of UPLC-PDA method for anthocyanins profiling in Vaccinium L. berries

2021 ◽  
pp. 1-17
Author(s):  
Gabriele Vilkickyte ◽  
Vida Motiekaityte ◽  
Rimanta Vainoriene ◽  
Mindaugas Liaudanskas ◽  
Lina Raudone
Keyword(s):  
Genetic Diversity ◽  
Daily Life ◽  
Biological Activities ◽  
Vaccinium Macrocarpon ◽  
Variation Analysis ◽  
Key Factors ◽  
Complex Profile ◽  
Pharmaceutical Applications ◽  
Content Variation ◽  
Vaccinium Myrtillus L

BACKGROUND: Anthocyanins are one of the key factors contributing to the quality and biological activities in various berries. Particular attention was devoted to Vaccinium L. berries, because of being commonly consumed in daily life and providing a large potential for the development of new pharmaceutical applications. OBJECTIVE: The present work aimed at establishing a novel UPLC-PDA method for profiling anthocyanins in berries and evaluating their distribution in cultivated lingonberries. METHODS: The method was developed and validated using bilberries (Vaccinium myrtillus L.), cranberries (Vaccinium macrocarpon Ait.), and lingonberries (Vaccinium vitis-idaea L.) matrices. Anthocyanins content variation was analyzed among 7 different cultivars and 1 infraspecific taxon of lingonberries. RESULTS: The proposed method ensured the separation of 20 compounds, including major and minor anthocyanins and their aglycones, in bilberries, 15 in cranberries, and 9 in lingonberries, during 12 min analysis. Bilberry matrix was distinguished by the most complex profile and the presence of delphinidin and petunidin, which were not identified either in cranberries or lingonberries. Cranberry anthocyanins consisted mainly of the 3-galactosides of cyanidin and peonidin, whereas lingonberry anthocyanins included cyanidin and its glycosides with just traces of other anthocyanins. Obtained anthocyanins fingerprinting results have guidance function in practice and demonstrate valuable chemophenetic information for studied Vaccinium berries. All determined method validation values were considered to be acceptable. Variation analysis of anthocyanins levels among cultivated lingonberries suggested genetic diversity and because of the highest anthocyanins content—the superiority of Russian cultivars (‘Kostromička’ and ‘Rubin’). To the best of our knowledge, this is the first comprehensive report on the anthocyanins of certain lingonberry cultivars. CONCLUSIONS: This study resulted in the rapid, simple, and validated method, which was shown to be applicable and convenient for routine analysis and authentication of Vaccinium berry samples.

scholarly journals Advances in the Chemical and Biological Characterization of Amaryllidaceae Alkaloids and Natural Analogues Isolated in the Last Decade

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5621
Author(s):  
Marco Masi ◽  
Roberta Di Lecce ◽  
Alessio Cimmino ◽  
Antonio Evidente
Keyword(s):  
Biological Activities ◽  
Cultivated Plants ◽  
Biological Characterization ◽  
Scientific Publications ◽  
Amaryllidaceae Alkaloids ◽  
Chemical Structures ◽  
Pharmaceutical Applications ◽  
Natural Analogues

Amaryllidaceae are bulbous wild and cultivated plants well known for their beautiful flowers and pharmaceutical applications, essentially due to the alkaloids and flavonoids content. Hundreds of alkaloids have been isolated until now and several scientific publications reported their sources, chemical structures, and biological activities. During the last decade, some unstudied Amaryllidaceae plants were the object of in-depth investigations to isolate and chemically and biologically characterize new and already known alkaloids as well as some analogues. This review describes the isolation and chemical and biological characterization of the Amaryllidaceae alkaloids, and their analogues obtained in the last decade, focusing the discussion on the new ones.

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