scholarly journals The role of sea ports in end-to-end maritime transport chain emissions

Energy Policy ◽  
2014 ◽  
Vol 64 ◽  
pp. 337-348 ◽  
Author(s):  
David Gibbs ◽  
Patrick Rigot-Muller ◽  
John Mangan ◽  
Chandra Lalwani
Keyword(s):  
Maritime Transport ◽  
Transport Chain ◽  
Sea Ports ◽  
End To End

scholarly journals The Role of Selected Wavelengths of Light in the Activity of Photosystem II in Gloeobacter violaceus

2021 ◽  
Vol 22 (8) ◽  
pp. 4021
Author(s):  
Monika Kula-Maximenko ◽  
Kamil Jan Zieliński ◽  
Ireneusz Ślesak
Keyword(s):  
Photosystem Ii ◽  
Spectral Composition ◽  
Photosynthetic Electron Transport ◽  
Metabolic Energy ◽  
Light Conditions ◽  
Gloeobacter Violaceus ◽  
Transport Chain ◽  
Cyanobacterial Culture ◽  
Photosynthetic Antennas

Gloeobacter violaceus is a cyanobacteria species with a lack of thylakoids, while photosynthetic antennas, i.e., phycobilisomes (PBSs), photosystem II (PSII), and I (PSI), are located in the cytoplasmic membrane. We verified the hypothesis that blue–red (BR) light supplemented with a far-red (FR), ultraviolet A (UVA), and green (G) light can affect the photosynthetic electron transport chain in PSII and explain the differences in the growth of the G. violaceus culture. The cyanobacteria were cultured under different light conditions. The largest increase in G. violaceus biomass was observed only under BR + FR and BR + G light. Moreover, the shape of the G. violaceus cells was modified by the spectrum with the addition of G light. Furthermore, it was found that both the spectral composition of light and age of the cyanobacterial culture affect the different content of phycobiliproteins in the photosynthetic antennas (PBS). Most likely, in cells grown under light conditions with the addition of FR and G light, the average antenna size increased due to the inactivation of some reaction centers in PSII. Moreover, the role of PSI and gloeorhodopsin as supplementary sources of metabolic energy in the G. violaceus growth is discussed.

scholarly journals Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors

2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Yi-Ta Hsieh ◽  
Hsi-Feng Tu ◽  
Muh-Hwa Yang ◽  
Yi-Fen Chen ◽  
Xiang-Yun Lan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Tongue Cancer ◽  
Aerobic Glycolysis ◽  
Lactate Production ◽  
Cellular Level ◽  
Metabolic Reprogramming ◽  
Transport Chain ◽  
Genetically Manipulated ◽  
The Impact

AbstractMitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis is controversial. Current study aims to define TFAM mediated regulations in head and neck cancer (HNC). Multifaceted analyses in HNC cells genetically manipulated for TFAM were performed. Clinical associations of TFAM and mtDNA encoded Electron Transport Chain (ETC) genes in regulating HNC tumourigenesis were also examined in HNC specimens. At cellular level, TFAM silencing led to an enhanced cell growth, motility and chemoresistance whereas enforced TFAM expression significantly reversed these phenotypic changes. These TFAM mediated cellular changes resulted from (1) metabolic reprogramming by directing metabolism towards aerobic glycolysis, based on the detection of less respiratory capacity in accompany with greater lactate production; and/or (2) enhanced ERK1/2-Akt-mTORC-S6 signalling activity in response to TFAM induced mtDNA perturbance. Clinical impacts of TFAM and mtDNA were further defined in carcinogen-induced mouse tongue cancer and clinical human HNC tissues; as the results showed that TFAM and mtDNA expression were significantly dropped in tumour compared with their normal counterparts and negatively correlated with disease progression. Collectively, our data uncovered a tumour-suppressing role of TFAM and mtDNA in determining HNC oncogenicity and potentially paved the way for development of TFAM/mtDNA based scheme for HNC diagnosis.

scholarly journals Cross-cutting technologies in education

2021 ◽  
Vol 10 (47) ◽  
pp. 27-34
Author(s):  
Olga I. Vaganova ◽  
Julia M. Tsarapkina ◽  
Marina R. Zheltukhina ◽  
Elena G. Knyazeva ◽  
Julia S. Krasilnikova
Keyword(s):  
Vocational Education ◽  
Significant Role ◽  
Professional Training ◽  
Educational Process ◽  
Promising Direction ◽  
Professional Activities ◽  
Article Analysis ◽  
End To End ◽  
Senior Students

Purpose of the article: analysis of the experience of implementing end-to-end technologies in vocational education. Methodology: the article presents a study aimed at identifying the role of end-to-end technologies in the professional training of students. For this, a survey was conducted among students on the use of end-to-end technologies in the educational process in three age categories (junior, middle, senior). Students had to assess the importance of end-to-end technologies for the implementation of the educational process on a scale from 1 to 4. Results: Students note the significant role of end-to-end technologies in professional activities. This is a promising direction for the development of vocational education.

Sterilization Modality Selection: Role of Sterility Assurance Subject Matter Expert

2021 ◽  
Vol 55 (s3) ◽  
pp. 67-77
Author(s):  
Jami McLaren ◽  
Joyce M. Hansen ◽  
Vu Le
Keyword(s):  
Supply Chain ◽  
Subject Matter ◽  
Selection Process ◽  
Collaborative Partnerships ◽  
Supply Chain Logistics ◽  
End To End ◽  
Negative Impacts ◽  
Assurance Process ◽  
Selection Of

Abstract Selection of a sterilization modality for a medical device is a critical decision that requires sterility assurance subject matter experts (SME)s to work collaboratively with various company functions. The sterility assurance SME is responsible and accountable for the sterilization modality decision for a product. The modality selection process starts with the sterility assurance SME partnering with research and development to ensure that the sterilization modality allows the device to deliver its intended function in patient care. After the sterilization modality is selected, the sterility assurance SME needs to work with other partners, including quality, supply chain/logistics, operations, and regulatory, to ensure that the selected sterilization modality is appropriately integrated into the end-to-end process. Collaborative partnerships between sterility assurance experts and key partners regarding sterilization modality selection reduce the potential for negative impacts within the end-to-end sterility assurance process, including impacts on product functionality, increased regulatory approval timelines, and inefficiencies and risks throughout the supply chain. This article describes aspects of a comprehensive approach to sterilization modality selection, including critical information necessary to address each of the key considerations.

Real World Applications

2016 ◽  
pp. 113-132
Author(s):  
Ibibia K. Dabipi ◽  
Judy A. Perkins ◽  
Tierney Moore
Keyword(s):  
Supply Chain ◽  
Supply Chain Management ◽  
Real World ◽  
Chain Structure ◽  
Total Asset ◽  
Chain Management ◽  
Real World Applications ◽  
End To End ◽  
Supply Chain Structure

Over the years the supply chain industry has been transforming to improve the end-to-end (production to delivery) process. Supply chain management (SCM) allows various industries to oversee and better handle how their product is manufactured and delivered. It allows them to track and identify the location of the product and to be more efficient in delivery. Integrating total asset visibility (TAV) technology into the supply chain structure can provide excellent visibility of a product. This kind of visibility complemented with various packaging schemes can assist in accommodating optimization strategies for visualizing the movement of a product throughout the entire supply chain pipeline. The chapter will define SCM, discuss TAV, review how transportation as well as optimization impacts SCM and TAV, and examine the role of packaging in the context of SCM and TAV.

Dissociation of FAD from the NAD(P)H-Nitrate Reductase Complex from Ankistrodesmus braunii and Role of Flavin in Catalysis

1982 ◽  
Vol 37 (1-2) ◽  
pp. 24-30 ◽  
Author(s):  
Miguel A. De la Rosa ◽  
Antonio J. Márquez ◽  
José M. Vega
Keyword(s):  
Nitrate Reductase ◽  
Reductase Activity ◽  
Prosthetic Group ◽  
Original Activity ◽  
Enzyme Preparations ◽  
Fluorescence Studies ◽  
Transport Chain ◽  
Sulphydryl Groups ◽  
Nadh Cytochrome

Ankistrodesmus braunii NAD(P)H-nitrate reductase is a complex hemoflavomolybdoprotein composed by eight similar subunits. The flavin prosthetic group, identified as FAD, is essential for the NAD(P)H-dependent activities of the complex, and is located before the heme chromo- phore in the enzyme electron transport chain from reduced pyridine nucleotides to nitrate. Fluorescence studies indicate that nitrate reductase can dissociate about 80% of its FAD by incubation at room temperature, the flavin dissociation being followed by a parallel decrease of NADH-nitrate reductase activity. Dissociation of FAD from the protein is easily increased by dilution or prolonged dialysis of the enzyme preparations. However, exogenous FAD specifically prevents the dissociation of enzyme-bound flavin, and protects the NAD(P)H-dependent activities. The Km for FAD, as a protector of NADH-cytochrome c reductase activity, is 4 nᴍ. In addition, dithioerythritol also prevents the flavin dissociation, and therefore the presence of free sulphydryl groups in the FAD-domain is suggested. FAD-depleted nitrate reductase, obtained by several methods, is unable to recover its original activity when incubated in the presence of FAD alone or with thiols.

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