Analysis of droplet size uniformity and selection of spray parameters based on the biological optimum particle size theory

2021 ◽  
pp. 112076
Author(s):  
Chongchong Chen ◽  
Shougen Li ◽  
Xiaoyi Wu ◽  
Yaxiong Wang ◽  
Feng Kang
Keyword(s):  
Particle Size ◽  
Droplet Size ◽  
Spray Parameters ◽  
Size Uniformity ◽  
Selection Of

Design of a spray dedusting system with variable particle size

2021 ◽  
pp. 1-12
Author(s):  
Guan Li ◽  
Biao Wang ◽  
Xiangli Bu ◽  
Di Wang ◽  
Jingkang He
Keyword(s):  
Particle Size ◽  
Control System ◽  
Droplet Size ◽  
Water Pressure ◽  
Size Control ◽  
Dust Removal ◽  
Experimental Conditions ◽  
Spray System ◽  
Size Uniformity ◽  
Spray Control

This paper proposes a spray control system with variable particle size to address the inaccuracy of droplet size control in the existing spray dedusting system. A PID control algorithm with stable air and water pressure is adopted to ensure droplet size uniformity. An experimental device of the droplet control system is built in the laboratory to verify the algorithm’s effectiveness. Experiments were conducted using PLC as the core controller to verify the influence of different types of nozzles on the droplet size under the same air pressure and water pressure through experiments. The results show: (1) the systems droplet size range is 8–200 μm, which meets the dust removal conditions of respirable dust and is suitable for dust removal. (2) When measured under identical experimental conditions, the droplet size decreases as the nozzle angle increases. It was shown that the spray system combined with various sprinklers can achieve full droplet size coverage and improve the efficiency of dust-fall. It provides a solution for the existing dust removal system to flexibly change the droplet size according to the dust size.

scholarly journals Development of nitazoxanide-loaded colon-targeted formulation for intestinal parasitic infections: centre composite design-based optimization and characterization

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Charu Bharti ◽  
Upendra Nagaich ◽  
Jaya Pandey ◽  
Suman Jain ◽  
Neha Jain
Keyword(s):  
Particle Size ◽  
Desirability Function ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Percentage Yield ◽  
Vitro Release ◽  
Selection Of

Abstract Background The current investigation is focused on the development and characterization of Eudragit S100 coated nitazoxanide-loaded microbeads as colon-targeted system utilizing central composite design (CCD) and desirability function. The study initiated with the selection of a BCS class II drug nitazoxanide and its preformulation screening with excipients, selection of polymer and identification of concentration for CCD, selection of optimized formulation based on desirability function, and in vitro release studies in simulated gastric and colonic media and stability studies. A two-factor, three-level CCD was employed with two independent variables, i.e. X1 (chitosan % w/v) and X2 (sodium tripolyphosphate % w/v), and three dependent variables, i.e. Y1 (particle size in micrometres), Y2 (percentage yield) and Y3 (percent entrapment efficiency), were chosen. Additionally, surface morphology, mucoadhesion and in vitro drug release studies were also conducted. Result Chitosan concentration showing maximum entrapment and optimum particle size was selected to formulate chitosan beads. The polynomial equation and model graphs obtained from the Design-Expert were utilized to examine the effect of independent variables on responses. The effect of formulation composition was found to be significant (p ˂ 0.05). Based on the desirability function, the optimized formulation was found to have 910.14 μm ± 1.03 particle size, 91.84% ± 0.64 percentage yield and 84.75% ± 0.38 entrapment efficiency with a desirability of 0.961. Furthermore, the formulations were characterized for in vitro drug release in simulated colonic media (2% rat caecal content) and have shown a sustained release of ∼ 92% up to 24 h as compared to in vitro release in simulated gastric fluid. Conclusion The possibility of formulation in enhancing percentage yield and entrapment efficiency of nitazoxanide and the utilization of CCD helps to effectively integrate nitazoxanide microbeads into a potential pharmaceutical dosage form for sustained release.

Porosity Control of Thermally Sprayed Ceramic Deposits

1998 ◽  
Author(s):  
P. Chraska ◽  
V. Brozek ◽  
B.J. Kolman ◽  
J. Ilavsky ◽  
K. Neufuss ◽  
...  
Keyword(s):  
Gas Permeability ◽  
Water Immersion ◽  
Thermal Spraying ◽  
Spray Parameters ◽  
Post Processing ◽  
Free Standing ◽  
Spray Process ◽  
Wide Range ◽  
Controlled Porosity ◽  
Selection Of

Abstract Porosity regulates the deposit's properties and therefore methods for its control are of a vital industrial importance. Thermal spraying can produce deposits in a wide range of porosities by selection of a spray process itself, by selection of spray parameters, feedstock size and chemistry, etc. Manufacturing of deposits with controlled porosity may be difficult if the selection of spray processes and materials is limited. Special methods of deposition or/and subsequent post processing may be therefore necessary. These methods are studied in the presented work. All spraying was done with the water-stabilized plasma (WSP®) system PAL 160. Thick deposits and free-standing parts were sprayed from alumina, zircon, metal Al and Ni powders and their combinations. Porosity was characterized by number of techniques such as gas permeability, water immersion, MIP, SEM and SANS. Mechanical properties were characterized by the Young's modulus. Special methods of deposition, such as spraying of mixtures of ceramics and metals were successfully used. Either sandwiched-structures with alternating layers of ceramics and metals were sprayed (for the sealing purpose) or mechanical mixtures of ceramic and metallic feedstock were sprayed. Several post-processing methods were used to change porosity volumes or other materials characteristics. To increase the porosity the metallic phases were subsequently removed by leaching or by annealing at temperatures above the melting point of metal. A number of sealing materials (organic and inorganic) were used to seal the pores by infiltration at ambient or higher pressures. The results show, that significant changes of porosity volume and, especially, of the gas permeability are possible. Another tested method was annealing/calcination of deposits, which resulted in an increase or decrease of porosity, depending on deposit's chemistry and annealing conditions. Results show that all used post processings are capable of significant changes of deposit microstructure and that they may be successfully applied in practice.

Formulation and Evaluation of Benidipine Nanosuspension

2021 ◽  
pp. 4111-4116
Author(s):  
Sejal Patel ◽  
Anita P. Patel
Keyword(s):  
Particle Size ◽  
Water Solubility ◽  
Polymer Concentration ◽  
Oral Route ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Scanning Calorimetry ◽  
23 Factorial Design ◽  
Selection Of

In the interest of administration of dosage form oral route is most desirable and preferred method. After oral administration to get maximum therapeutic effect, major challenge is their water solubility. Water insoluble drug indicate insufficient bioavailability as well dissolution resulting in fluctuating plasma level. Benidipine (BND) is poorly water soluble antihypertensive drug has lower bioavailability. To improve bioavailability of Benidipine HCL, BND nanosuspension was formulated using media milling technique. HPMC E5 was used to stabilize nanosuspension. The effect of different important process parameters e.g. selection of polymer concentration X1(1.25 mg), stirring time X2 (800 rpm), selection of zirconium beads size X3 (0.4mm) were investigated by 23 factorial design to accomplish desired particle size and saturation solubility. The optimized batch had 408 nm particle size Y1, and showed in-vitro dissolution Y2 95±0.26 % in 30 mins and Zeta potential was -19.6. Differential scanning calorimetry (DSC) and FT-IR analysis was done to confirm there was no interaction between drug and polymer.

Plasma Spraying of Self-Lubricating Cr2O3-CaF2 Coatings

1997 ◽  
Author(s):  
F. Vos ◽  
L. Delaey ◽  
M. De Bonte ◽  
L. Froyen
Keyword(s):  
Plasma Spraying ◽  
Matrix Material ◽  
Production Method ◽  
Atmospheric Plasma ◽  
Spray Parameters ◽  
The Matrix ◽  
Preparation Step ◽  
Plasma Sprayed ◽  
The Relationship ◽  
Selection Of

Abstract Results are presented of a project analysing the relationship between the production parameters of plasma sprayed self-lubricating Cr2O3-CaF2 coatings and their structural, wear and lubricating properties. The production method consists of a preparation step where a powder blend of the matrix material (Cr203) and solid lubricant (CaF2) is agglomerated, followed by atmospheric plasma spraying (APS) of the agglomerates. Selection of the most appropriate agglomeration and plasma spray parameters as well as the microstructure of the coatings will be discussed.

scholarly journals Modelling of Metallic Particle Binders for Increased Part Density in Binder Jet Printed Components

2019 ◽  
Author(s):  
Joseph Roberts ◽  
Peter Green ◽  
Kate Black ◽  
Christopher Sutcliffe
Keyword(s):  
Particle Size ◽  
Critical Radius ◽  
Detailed Knowledge ◽  
Particle Sizes ◽  
Powder Bed ◽  
Beneficial Effects ◽  
Drop Tests ◽  
Maximum Particle ◽  
Packing Efficiency ◽  
Selection Of

Binder jet printed components typically have low overall density in the green state and high shrinkage and deformation after heat treatment. It has previously been demonstrated that, by including nanoparticles of the same material in the binder, these properties can be improved as the nanoparticles can fill the interstices and pore throats between the bed particles. The beneficial effects from using these additive binder particles can be improved by maximising the binder particle size, enabling the space within the powder bed to be filled with a higher packing efficiency. The selection of maximum particle size for a binder requires detailed knowledge of the pores and pore throats between the powder bed particles. In this paper, a raindrop model is developed to determine the critical radius at which binder particles can pass between pores and penetrate the bed. The model is validated against helium pycnometry measurements and binder particle drop tests. It is found that the critical radius can be predicted, with acceptable accuracy, using a linear function of the mean and standard deviation of the particle radii. Percolation theory concepts have been employed in order to generalise the results for powder beds that have different mean particle sizes and size distributions. The results of this work can be employed to inform the selection of particle sizes required for binder formulations, to optimise density and reduce shrinkage in printed binder jet components.

Influence of the Particle Size Uniformity Degree on the Portland Cement Properties

2001 ◽  
Vol 206-213 ◽  
pp. 1883-1886
Author(s):  
Corina-Mihaela Ibris ◽  
Dorel Radu
Keyword(s):  
Particle Size ◽  
Portland Cement ◽  
Size Uniformity

Fading Activities of Herbicidal Droplets Amended with Emulsifiable Spray Adjuvants on Cucurbitaceous Leaves

2018 ◽  
Vol 61 (6) ◽  
pp. 1881-1888
Author(s):  
Jeng-Liang Lin ◽  
Heping Zhu
Keyword(s):  
Weed Control ◽  
Droplet Size ◽  
Spray Deposition ◽  
Herbicide Application ◽  
Spray Droplet ◽  
Coverage Area ◽  
Maximum Coverage ◽  
Fading Time ◽  
Selection Of ◽  
Spray Adjuvants

Abstract. Understanding reactions of surfactant-amended droplets on difficult-to-wet weed surfaces could help develop application strategies to increase herbicide efficacy. Behaviors of herbicidal droplets containing different emulsifiable anti-evaporation spray adjuvants were investigated by characterizing 250 and 450 µm herbicidal droplet dispersion and fading time on cucurbitaceous leaves placed inside a 20°C chamber at 30% and 60% relative humidity (RH). Droplet maximum coverage area increased with droplet size but not with RH, while droplet fading time increased with both droplet size and RH. Despite 450 µm droplets having greater maximum coverage area than 250 µm droplets, the larger droplets had higher fading rates and lower ratios of maximum coverage area to droplet volume. Droplet maximum coverage area and fading time on leaves were affected by adding spray adjuvants to the herbicide-only solution. The Uptake surfactant was more effective than the other two surfactants (AntiEvap+BS1000 and Enhance) in increasing droplet maximum coverage area and fading time. Compared to the herbicide-only solution, addition of Uptake surfactant to the herbicide solution could increase maximum coverage area by 68% and 52% for 250 and 450 µm droplets, respectively, but addition of AntiEvap+BS1000 or Enhance surfactants did not show significant increase. Similarly, addition of Uptake surfactant to the herbicide-only solution increased droplet fading times by 11.1% and 13.2% at 30% and 60% RH, respectively, for 250 µm droplets and by 34.7% and 2.8% at 30% and 60% RH, respectively, for 450 µm droplets. In contrast, addition of AntiEvap+BS1000 surfactant reduced fading time, and addition of Enhance surfactant did not significantly affect fading time. Therefore, appropriate selection of spray adjuvants for herbicide applications could significantly influence droplet deposit behaviors on cucurbitaceous leaves, leading to improved effectiveness of weed control. Keywords: Herbicide application, Spray deposition, Spray droplet, Surfactant, Weed control.

scholarly journals Spray Structure and Characteristics of a Pressure-Swirl Dust Suppression Nozzle Using a Phase Doppler Particle Analyze

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1127
Author(s):  
Junpeng Wang ◽  
Cuicui Xu ◽  
Gang Zhou ◽  
Yansong Zhang
Keyword(s):  
Particle Size ◽  
Velocity Distribution ◽  
Droplet Size ◽  
Three Dimensional ◽  
Calibration Data ◽  
Dust Suppression ◽  
Dust Fall ◽  
Spray Structure ◽  
Spray Field ◽  
Pressure Swirl

In order to understand the characteristics of the spray field of a dust suppression nozzle and provide a reference for dust nozzle selection according to dust characteristics, a three-dimensional phase Doppler particle analyzer (PDPA) spray measurement system is used to analyze the droplet size and velocity characteristics in a spray field, particularly the joint particle size–velocity distribution. According to the results, after the ejection of the jet from the nozzle, the droplets initially maintained some velocity; however, the distribution of particles with different sizes was not uniform. As the spray distance increased, the droplet velocity decreased significantly, and the particle size distribution changed very little. As the distance increased further, the large droplets separated into smaller droplets, and their velocity decreased rapidly. The distributions of the particle size and velocity of the droplets then became stable. Based on the particle size-velocity distribution characteristics, the spray structure of pressure-swirl nozzles can be divided into five regions, i.e., the mixing, expansion, stabilization, decay, and rarefied regions. The expansion, stabilization, and decay regions are the effective dust fall areas. In addition, the droplet size in the stabilization region is the most uniform, indicating that this region is the best dust fall region. The conclusions can provide abundant calibration data for spray dust fall nozzles.

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