Motor activity in depressed patients during therapeutic sleep deprivation

AbstractProblemBoth sleep and motor activity have a bidirectional relationship with depression. The existing literature on motor activity during therapeutic sleep deprivation in depressed patients is inconsistent and fragmentary. In the present study we measured motor activity continuously during 40 hours of sleep deprivation in depressed patients.MethodThirty-four inpatients suffering from a major depression (DSM-IV) underwent sleep deprivation with a continuous waking period of 40 hours. Motor activity of the patients was continuously recorded using an actigraph on the non-dominant wrist. The effect of sleep deprivation was assessed by the Hamilton Depression Scale (six-item version), thus separating the group into responders and non-responders to sleep deprivation.ResultsWe found no significant differences in motor activity between responders and non-responders on the day before sleep deprivation. During the night, responders to sleep deprivation exhibited a higher motor activity and less periods of rest. On the day after sleep deprivation, responders exhibited a higher activity, too.ConclusionsMotor activity levels differ between the two groups, thus giving more insight into possible mechanisms of action of the therapeutic sleep deprivation. We suggest that higher motor activity during the night prevents naps and leads to better response to sleep deprivation.

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Depression in women infected with HIV

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462006000100004 ◽

2006 ◽

Vol 28 (1) ◽

pp. 10-17 ◽

Cited By ~ 15

Author(s):

Valéria Antakly de Mello ◽

André Malbergier

Keyword(s):

Major Depression ◽

Hiv Infection ◽

Depressive Disorders ◽

Depression Scale ◽

Hamilton Depression Scale ◽

Asymptomatic Group ◽

Dsm Iv ◽

Women With Hiv ◽

Major Depressive Episodes ◽

Depressive Episodes

OBJETIVE:The number of women with HIV infection has been on the rise in recent years, making studies of the psychiatric aspects of this condition very important. The aim of this study was to evaluate the prevalence of major depression in women with HIV infection. METHOD: A total of 120 women were studied, 60 symptomatic (with AIDS symptoms) and 60 asymptomatic (without AIDS symptoms). Sociodemographic data were collected, and depressive disorders were identified. The instruments used to evaluate the depressive disorders were the SCID, DSM-IV, 17-item Hamilton depression scale, Hamilton depression scale for nonsomatic symptoms and the Beck depression scale. RESULTS: The prevalence of major depression was 25.8% and was higher in the symptomatic group than in the asymptomatic group (p = 0.002). CONCLUSIONS: The prevalence of major depressive episodes in women with HIV infection is high, and women with AIDS-related symptoms are more often depressed than are those who have never presented such symptoms.

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Distinct Changes in Global Brain Synchronization in Early-Onset vs. Late-Onset Parkinson Disease

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2020.604995 ◽

2020 ◽

Vol 12 ◽

Author(s):

Tianyu Wang ◽

Haiyan Liao ◽

Yuheng Zi ◽

Min Wang ◽

Zhenni Mao ◽

...

Keyword(s):

Late Onset ◽

Disease Onset ◽

Depression Scale ◽

Hamilton Depression Scale ◽

Global Synchronization ◽

Healthy Control ◽

The Right ◽

Global Brain ◽

Insight Into ◽

Left Insula

Early- and late-onset Parkinson’s disease (EOPD and LOPD, respectively) have different risk factors, clinical features, and disease course; however, the functional outcome of these differences have not been well characterized. This study investigated differences in global brain synchronization changes and their clinical significance in EOPD and LOPD patients. Patients with idiopathic PD including 25 EOPD and 24 LOPD patients, and age- and sex-matched healthy control (HC) subjects including 27 younger and 26 older controls (YCs and OCs, respectively) were enrolled. Voxel-based degree centrality (DC) was calculated as a measure of global synchronization and compared between PD patients and HC groups matched in terms of disease onset and severity. DC was decreased in bilateral Rolandic operculum and left insula and increased in the left superior frontal gyrus (SFG) and precuneus of EOPD patients compared to YCs. DC was decreased in the right putamen, mid-cingulate cortex, bilateral Rolandic operculum, and left insula and increased in the right cerebellum-crus1 of LOPD patients compared to OCs. Correlation analyses showed that DC in the right cerebellum-crus1 was inversely associated with the Hamilton Depression Scale (HDS) score in LOPD patients. Thus, EOPD and LOPD patients show distinct alterations in global synchronization relative to HCs. Furthermore, our results suggest that the left SFG and right cerebellum-crus1 play important roles in the compensation for corticostriatal–thalamocortical loop injury in EOPD and LOPD patients, whereas the cerebellum is a key hub in the neural mechanisms underlying LOPD with depression. These findings provide new insight into the clinical heterogeneity of the two PD subtypes.

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Demenz im Zusammenhang mit Diabetes und Familienanamnese Diabetes

Nervenheilkunde ◽

10.1055/s-0038-1627266 ◽

2008 ◽

Vol 27 (S 01) ◽

pp. S16-S17

Author(s):

E. Orso ◽

G. Hajak ◽

M. Stadlober-Degwerth ◽

H. Klünemann ◽

M. Zintl

Keyword(s):

Diabetes Mellitus ◽

Depression Scale ◽

Hamilton Depression Scale ◽

Körperliche Untersuchung ◽

Neuropsychologische Testung ◽

Icd 10 ◽

Dsm Iv ◽

Positive Familienanamnese

ZusammenfassungAnliegen: Untersuchung des Zusammenhangs zwischen Diabetes und positiver Familienanamnese Diabetes (jeweils Verwandte ersten und zweiten Grades) bei Demenzpatienten mit Krankheitsbeginn bis zum 70. Lebensjahr. Methode: Eigen- und Fremdanamnese, körperliche Untersuchung, neuropsychologische Testung mittels CERAD und Uhrentest. Beurteilungsskalen waren GDS, Hoehn-Yahr- Stadien, FBI, Hamilton-Depression-Scale. Einteilung der Demenzform anhand Hachinski-/Rosen-Scores, ICD-10-, DSM IV-, NINCDS-ADRDA-, NINDS-AIREN-, ADDTC-, Lund- Manchester-, Neary und McKeith-Kriterien. Zudem metabolisches Laborprofil und ApoE Genotypisierung. Kontrolle waren die kognitiv intakten Lebenspartner. Ergebnisse: Probandenanzahl war n = 213, davon waren n = 35 Kontrollen. Während nur 14,3% der Kontrollen an Diabetes litten, war der Anteil der Diabetiker in der Gruppe der Vaskulären Demenz (VD) mit 36,8% deutlich am höchsten. Der Anteil der Probanden mit vaskulärer Demenz und positiver Familienanamnese Diabetes war im Vergleich zur Kontrollgruppe um 7% erhöht. Schlussfolgerungen: Diabetes mellitus und eine positive Familienanamnese Diabetes mellitus korrelieren besonders stark mit der Entwicklung einer VD. Im Gegensatz zur Demenz vom Alzheimertyp (DAT) ergab sich kein Zusammenhang zwischen Apo ॉ4 und VD. Es besteht ebenfalls keine Beziehung zwischen Apo ॉ4 und Diabetes oder einer positiven Familienanamnese Diabetes.

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Characteristics and outcome of methadone maintenance treatment (MMT) patients with depression

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.1065 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S311-S312

Author(s):

E. Peles ◽

A. Sason ◽

E. Malik ◽

S. Schreiber ◽

M. Adelson

Keyword(s):

Suicide Attempts ◽

Methadone Maintenance ◽

Depression Scale ◽

Hamilton Depression Scale ◽

Depressed Patients ◽

Scale Scores ◽

First Year Retention ◽

Competing Interest ◽

Retention In Treatment ◽

One Year

IntroductionComorbidity of depression and opioid addiction is highly prevalent, but their outcome in MMT is not consistent.ObjectivesTo compare between depressed and non-depressed MMT patients.MethodsHamilton depression scale scores (taken during a psychiatric assessment) were studied among MMT patients on admission or during treatment (cutoff for depression > 18).ResultsA total of 498 MMT patients were studied. Depression proportion was 22.5%, and 23.2% among 263 who were studied on admission; the depressed vs. non-depressed on admission did not differ in female proportion (19.7% vs. 25.6%), age of admission (43.2 ± 10.4), opiate use onset (21.8 ± 6.3) and education years (9.5 ± 2.8), but had higher proportion of cocaine (55.7% vs. 35.1%, P = 0.005), and benzodiazepine abuse (73.8% vs. 58.4%, P = 0.04). Retention was high and similar (80.3 vs. 82.9% P = 0.7) and of those who stayed one year, cocaine and benzodiazepine were still higher among the depressed patients (cocaine: 43.8% vs. 23.2%, P = 0.03; BDZ: 61.2% vs. 40%, P = 0.01). Compared to the non-depressed, among all study group (n = 498) the depressed patients presented higher proportion of rape history (25% vs. 9.5%, P = 0.001), of suicide attempts (43.8% vs. 25%, P = 0.001) with only a trend of shorter cumulative retention in MMT of mean 9.4y (95% CI 7.8–10.7) vs. 11.5 (95% CI 10.5–12.5, P = 0.07).ConclusionDespite cocaine and benzodiazepine abuse on admission, depressed succeeded similarly to the non-depressed in the first year retention in treatment. Intervention is recommended since admission, as their long-term retention seems to be shorter, later on, and their ability to discontinue cocaine and benzodiazepine abuse is clearly hampered.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Effects of agomelatine and mirtazapine on sleep disturbances in major depressive disorder: evidence from polysomnographic and resting-state functional connectivity analyses

SLEEP ◽

10.1093/sleep/zsaa092 ◽

2020 ◽

Vol 43 (11) ◽

Author(s):

Wei-Feng Mi ◽

Serik Tabarak ◽

Li Wang ◽

Su-Zhen Zhang ◽

Xiao Lin ◽

...

Keyword(s):

Major Depressive Disorder ◽

Functional Connectivity ◽

Depressive Disorder ◽

Sleep Disturbances ◽

Rating Scale ◽

Sleep Onset ◽

Depression Scale ◽

Hamilton Depression Scale ◽

Major Depressive ◽

Depressed Patients

Abstract To investigate effects of agomelatine and mirtazapine on sleep disturbances in patients with major depressive disorder. A total of 30 depressed patients with sleep disturbances, 27 of which completed the study, took agomelatine or mirtazapine for 8 weeks. Subjective scales were administered, and polysomnography was performed at baseline and at the end of week 1 and 8. Functional magnetic resonance imaging was performed at baseline and at the end of week 8. Compared with baseline, scores on the Hamilton Depression Scale, Hamilton Anxiety Scale, Pittsburgh Sleep Quality Index, Sleep Dysfunction Rating Scale, and Insomnia Severity Index after 8 weeks of treatment significantly decreased in both groups, with no significant differences between groups, accompanied by significant increases in total sleep time, sleep efficiency, and rapid eye movement (REM) sleep and significant decrease in wake after sleep onset. Mirtazapine treatment increased N3 sleep at week 1 compared with agomelatine treatment, but this difference disappeared at week 8. The increases in the percentage and duration of N3 sleep were positively correlated with increases in connectivity between right dorsal lateral prefrontal cortex (dlPFC) and right precuneus and between left posterior cingulate cortex and right precuneus in both groups, respectively. Functional connectivity (FC) between right dlPFC and left precuneus in mirtazapine group was higher compared with agomelatine group after 8 weeks of treatment. These findings indicated that both agomelatine and mirtazapine improved sleep in depressed patients, and the effect of mirtazapine was greater than agomelatine with regard to rapidly increasing N3 sleep and gradually improving FC in the brain.

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Insight in bipolar disorder: a comparison between mania, depression and euthymia using the Insight Scale for Affective Disorders

Trends in Psychiatry and Psychotherapy ◽

10.1590/2237-6089-2015-0014 ◽

2015 ◽

Vol 37 (3) ◽

pp. 152-156 ◽

Cited By ~ 11

Author(s):

Rafael de Assis da Silva ◽

Daniel C. Mograbi ◽

Evelyn V. M. Camelo ◽

Jaqueline Bifano ◽

Mayra Wainstok ◽

...

Keyword(s):

Bipolar Disorder ◽

Clinical Management ◽

Affective Disorders ◽

Rating Scale ◽

Mood State ◽

Depression Scale ◽

Treatment Compliance ◽

Hamilton Depression Scale ◽

Young Mania ◽

Insight Into

Objective: To evaluate whether having general insight into bipolar disorder and its symptoms is affected by the mood state of the patient, using the Insight Scale for Affective Disorders, a hetero-application scale for people with mood disorders.Methods: Ninety-five patients with bipolar disorder were evaluated and divided into different groups according to the mood state presented during assessment (i.e., euthymia, mania and depression). Sociodemographic and clinical data (Hamilton Depression Scale, Young Mania Rating Scale, and Clinical Global Impressions Scale) were recorded. Insight was evaluated using the Insight Scale for Affective Disorders.Results: Patients with bipolar disorder in mania show less insight about their condition than patients in depression or euthymia, and less insight about their symptoms than patients with depression, with the exception of awareness of weight change.Conclusions: Loss of insight during mania may have important implications for treatment compliance and adherence and needs to be taken into account in the clinical management of people with bipolar disorder.

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Plasma nortriptyline and clinical response–a study using changing plasma levels

Psychological Medicine ◽

10.1017/s0033291700023163 ◽

1977 ◽

Vol 7 (1) ◽

pp. 87-91 ◽

Cited By ~ 13

Author(s):

Graham D. Burrows ◽

Kay P. Maguire ◽

Bruce A. Scoggins ◽

James Stevenson ◽

Brian Davies

Keyword(s):

Clinical Response ◽

Plasma Levels ◽

Depression Scale ◽

Hamilton Depression Scale ◽

The Third ◽

Depressed Patients ◽

Significant Relationships ◽

Severity Of Depression

SynopsisIn a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured by the Hamilton Depression Scale, showed no significant relationships. The implications of the study are discussed.

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Actigraphic recording of motor activity in depressed inpatients: a novel computational approach to prediction of clinical course and hospital discharge

Scientific Reports ◽

10.1038/s41598-020-74425-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Ignacio Peis ◽

Javier-David López-Moríñigo ◽

M. Mercedes Pérez-Rodríguez ◽

Maria-Luisa Barrigón ◽

Marta Ruiz-Gómez ◽

...

Keyword(s):

Motor Activity ◽

Hospital Discharge ◽

Process Model ◽

Inertial Sensors ◽

Clinical Course ◽

Psychiatric Inpatient ◽

Activity Levels ◽

Inpatient Ward ◽

Depressed Patients ◽

Hospital Discharge Date

Abstract Depressed patients present with motor activity abnormalities, which can be easily recorded using actigraphy. The extent to which actigraphically recorded motor activity may predict inpatient clinical course and hospital discharge remains unknown. Participants were recruited from the acute psychiatric inpatient ward at Hospital Rey Juan Carlos (Madrid, Spain). They wore miniature wrist wireless inertial sensors (actigraphs) throughout the admission. We modeled activity levels against the normalized length of admission—‘Progress Towards Discharge’ (PTD)—using a Hierarchical Generalized Linear Regression Model. The estimated date of hospital discharge based on early measures of motor activity and the actual hospital discharge date were compared by a Hierarchical Gaussian Process model. Twenty-three depressed patients (14 females, age: 50.17 ± 12.72 years) were recruited. Activity levels increased during the admission (mean slope of the linear function: 0.12 ± 0.13). For n = 18 inpatients (78.26%) hospitalised for at least 7 days, the mean error of Prediction of Hospital Discharge Date at day 7 was 0.231 ± 22.98 days (95% CI 14.222–14.684). These n = 18 patients were predicted to need, on average, 7 more days in hospital (for a total length of stay of 14 days) (PTD = 0.53). Motor activity increased during the admission in this sample of depressed patients and early patterns of actigraphically recorded activity allowed for accurate prediction of hospital discharge date.

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Diagnosis, phenomenology and treatment of poststroke depression

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462002000100011 ◽

2002 ◽

Vol 24 (1) ◽

pp. 44-49 ◽

Cited By ~ 1

Author(s):

Sergio E Starkstein ◽

Alicia Lischinsky

Keyword(s):

Daily Living ◽

Rating Scales ◽

Antidepressant Treatment ◽

Depression Scale ◽

Preliminary Evidence ◽

Depression Symptoms ◽

Hamilton Depression Scale ◽

Icd 10 ◽

Post Stroke Depression ◽

Dsm Iv

Diagnosing depression in stroke patients is a challenge in neuropsychiatry since depression symptoms may overlap neurological deficit signs. The best approach is to assess the presence of depressive symptoms using semi-structured or structured psychiatric interviews, such as the Present State Exam, the Structured Clinical Interview for DSM-IV or the Schedules for Clinical Assessment in Neuropsychiatry. The diagnosis of a depressive syndrome should be made according to standardized diagnostic criteria for mood disorders due to neurological disease such as in the DSM-IV or ICD-10. Depression rating scales such as the Hamilton Depression Scale and the Center for Epidemiologic Scales for Depression may be used to rate the depression severity and monitor the progression of antidepressant treatment. Most studies have reported the effectiveness of pharmacological treatment in patients with post-stroke depression, and there is preliminary evidence that the degree of impairment in activities of daily living (ADL) may improve as well.

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Plasma levels of neurotrophic factors are not associated with the severity of depression

Consortium Psychiatricum ◽

10.17816/cp110 ◽

2021 ◽

Vol 2 (4) ◽

pp. 13-22

Author(s):

Yana A. Zorkina ◽

Timur S. Syunyakov ◽

Olga V. Abramova ◽

Roman A. Yunes ◽

Aleksey V. Pavlichenko ◽

...

Keyword(s):

Neuropeptide Y ◽

Neurotrophic Factors ◽

Plasma Concentrations ◽

Depression Scale ◽

Epidemiological Studies ◽

Mental Illnesses ◽

Hamilton Depression Scale ◽

Depressed Patients ◽

Positive Correlations ◽

Study Participants

Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be useful as an objective diagnosis of the disease and predicting the severity of the pathology. We determined plasma concentrations of the monoamine neurotransmitters serotonin and dopamine, and neurotrophic factors involved in neurogenesis (BDNF, CDNF and neuropeptide Y) in depressed patients and healthy volunteers with the same socio-demographic parameters using enzyme immunoassay and mass spectrometry. All study participants were administered the Hamilton Depression Scale (HAMD), the Generalized Anxiety Disorder Questionnaire (GAD-7), and the Center for Epidemiological Studies (CES-D). The cumulative scores on the three scales examined were significantly higher in depressed patients than in controls. The concentration of serotonin, dopamine, BDNF, CDNF, and neuropeptide Y in plasma did not differ between the subject groups and was not associated with the scores on the scales. Positive correlations were found between the content of neuropeptide Y and serotonin, BDNF and CDNF in blood plasma. Thus, although these markers are related to the pathophysiology of depression, they do not correlate with the severity of symptomatology and possibly in plasma cannot reflect processes occurring in the brain.

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