Neuronal correlates of appetite regulation in patients with schizophrenia: Is there a basis for future appetite dysfunction?

Abstract:BackgroundGiven the undesired metabolic side effects of atypical antipsychotic medication it is important to understand the neuronal basis related to processing of appetite regulation in patients affected by schizophrenia.Methods:Here we used functional magnetic resonance imaging (fMRI) to assess brain activity in response to food cues and neutral stimuli in twenty patients with schizophrenia and eleven healthy individuals. In addition to clinical and dietary habits assessments, we collected, in patients, measurements of fasting glucose, ghrelin, leptin, insulin, prolactin and lipids blood concentration and we correlated the cerebral activity with clinical and metabolic measures.Results:Both groups engaged a common neuronal network while processing food cues, which included the left insula, primary sensorimotor areas, and inferior temporal and parietal cortices. Cerebral responses to appetitive stimuli in thalamus, parahippocampus and middle frontal gyri were specific only to schizophrenic patients, with parahippocampal activity related to hunger state and increasing linearly over time. Antipsychotic medication dosage correlated positively with a cognitive measure reflecting food cravings, whereas the severity of the disease correlated negatively with a cognitive measure indicating dietary restraint in eating habits. These cognitive variables correlated, in turn, with parahippocampal and thalamic neuronal activities, respectively.Conclusions:We identified a specific neural substrate underlying cognitive processing of appetitive stimuli in schizophrenia, which may contribute to appetite dysfunction via perturbations in processing of homeostatic signals in relation to external stimuli. Our results also suggest that both antipsychotic medication and the disease severity per se could amplify these effects, via different mechanisms and neuronal networks.

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Skipping Breakfast Affects the Early Steps of Cognitive Processing

Journal of Psychophysiology ◽

10.1027/0269-8803/a000214 ◽

2019 ◽

Vol 33 (2) ◽

pp. 109-118

Author(s):

Andrés Antonio González-Garrido ◽

Jacobo José Brofman-Epelbaum ◽

Fabiola Reveca Gómez-Velázquez ◽

Sebastián Agustín Balart-Sánchez ◽

Julieta Ramos-Loyo

Keyword(s):

Working Memory ◽

Cognitive Processing ◽

Task Difficulty ◽

Brain Activity ◽

Reaction Times ◽

Brain Potentials ◽

Brain Functioning ◽

Attentional Processes ◽

Electrical Brain Activity ◽

Skipping Breakfast

Abstract. It has been generally accepted that skipping breakfast adversely affects cognition, mainly disturbing the attentional processes. However, the effects of short-term fasting upon brain functioning are still unclear. We aimed to evaluate the effect of skipping breakfast on cognitive processing by studying the electrical brain activity of young healthy individuals while performing several working memory tasks. Accordingly, the behavioral results and event-related brain potentials (ERPs) of 20 healthy university students (10 males) were obtained and compared through analysis of variances (ANOVAs), during the performance of three n-back working memory (WM) tasks in two morning sessions on both normal (after breakfast) and 12-hour fasting conditions. Significantly fewer correct responses were achieved during fasting, mainly affecting the higher WM load task. In addition, there were prolonged reaction times with increased task difficulty, regardless of breakfast intake. ERP showed a significant voltage decrement for N200 and P300 during fasting, while the amplitude of P200 notably increased. The results suggest skipping breakfast disturbs earlier cognitive processing steps, particularly attention allocation, early decoding in working memory, and stimulus evaluation, and this effect increases with task difficulty.

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Predictors of COVID-19-Related Perceived Improvements in Dietary Health: Results from a US Cross-Sectional Study

Nutrients ◽

10.3390/nu13062097 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2097

Author(s):

Kelly Cosgrove ◽

Christopher Wharton

Keyword(s):

Dietary Habits ◽

Eating Habits ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Lifestyle Changes ◽

Income Loss ◽

Cross Sectional ◽

Healthy Eating Habits ◽

Health Related ◽

Survey Responses

The COVID-19 pandemic resulted in substantial lifestyle changes. No US study has identified predictors of perceived dietary healthfulness changes during the pandemic period. This study included analyses of lifestyle and dietary healthfulness changes using 958 survey responses from US primary household food purchasers. Information was collected related to demographics, COVID-19-related household changes, and health-related habits before and during the pandemic. Binary logistic regression identified predictors of perceived increase in dietary healthfulness during the pandemic period. Overall, 59.8%, 16.4%, and 23.4% of participants reported that their eating habits likely changed, may have changed, and likely did not change, respectively. Of the participants whose dietary habits likely or may have changed, 64.1%, 16.8%, and 19% reported healthier, neither healthier nor less healthy, and less healthy eating habits, respectively. COVID-19-related income loss, more meals consumed with household members in front of the television, an increase in food advertisement exposure, increased perceived stress, and better perceived current health were significant predictors of a perceived increase in dietary healthfulness. Overall, dietary habits were perceived to become healthier during the pandemic. The predictors of perceived improvement in dietary healthfulness were surprising and indicate the need for further study of these factors in crisis and noncrisis situations.

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Patterns of Change in Dietary Habits and Physical Activity during Lockdown in Spain Due to the COVID-19 Pandemic

Nutrients ◽

10.3390/nu13020300 ◽

2021 ◽

Vol 13 (2) ◽

pp. 300

Author(s):

Carmen Pérez-Rodrigo ◽

Marta Gianzo Citores ◽

Gotzone Hervás Bárbara ◽

Fátima Ruiz-Litago ◽

Luis Casis Sáenz ◽

...

Keyword(s):

Physical Activity ◽

Dietary Habits ◽

Eating Habits ◽

Health Impact ◽

Sociodemographic Factors ◽

Cross Sectional Study ◽

Dietary Change ◽

Cross Sectional ◽

Supplement Use ◽

Active Cluster

Background: Lockdown due to COVID-19 influenced food habits and lifestyles with potential negative health impact. This study aims to identify patterns of change in eating habits and physical activity during COVID-19 lockdown in Spain and to identify associations with sociodemographic factors and usual habits. Methods: This cross-sectional study included 1155 adults recruited online to answer a 10-section questionnaire. The protocol assessed usual diet by means of a semi-quantitative food frequency questionnaire, usual physical activity (PA) and supplement use, dietary changes, sedentary time, PA, exposure to sunlight, sleep quality, and smoking during confinement. Patterns of dietary change were identified by factor analysis. Factor scores were included in cluster analysis together with change in PA. Results: Six patterns of dietary change were identified that together with PA changes during lockdown defined three clusters of lifestyle change: a cluster less active, a more active cluster, and a third cluster as active as usual. People who were usually less active were more likely to be classified in the cluster that increased physical activity in confinement. Scores of the Healthy Mediterranean-Style dietary pattern were higher in this group. Conclusions: Different patterns of change in lifestyles in confinement suggest the need to tailor support and advice to different population groups.

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Humans with obesity have disordered brain responses to food images during physiological hyperglycemia

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00335.2017 ◽

2018 ◽

Vol 314 (5) ◽

pp. E522-E529 ◽

Cited By ~ 9

Author(s):

Renata Belfort-DeAguiar ◽

Dongju Seo ◽

Cheryl Lacadie ◽

Sarita Naik ◽

Christian Schmidt ◽

...

Keyword(s):

Brain Activity ◽

Blood Oxygen Level Dependent ◽

Normal Weight ◽

Self Control ◽

Food Cues ◽

Brain Response ◽

Glucose Levels ◽

Hyperglycemic Clamp ◽

Brain Responses ◽

Food Images

Blood glucose levels influence brain regulation of food intake. This study assessed the effect of mild physiological hyperglycemia on brain response to food cues in individuals with obesity (OB) versus normal weight individuals (NW). Brain responses in 10 OB and 10 NW nondiabetic healthy adults [body mass index: 34 (3) vs. 23 (2) kg/m2, means (SD), P < 0.0001] were measured with functional MRI (blood oxygen level-dependent contrast) in combination with a two-step normoglycemic-hyperglycemic clamp. Participants were shown food and nonfood images during normoglycemia (~95 mg/dl) and hyperglycemia (~130 mg/dl). Plasma glucose levels were comparable in both groups during the two-step clamp ( P = not significant). Insulin and leptin levels were higher in the OB group compared with NW, whereas ghrelin levels were lower (all P < 0.05). During hyperglycemia, insula activity showed a group-by-glucose level effect. When compared with normoglycemia, hyperglycemia resulted in decreased activity in the hypothalamus and putamen in response to food images ( P < 0.001) in the NW group, whereas the OB group exhibited increased activity in insula, putamen, and anterior and dorsolateral prefrontal cortex (aPFC/dlPFC; P < 0.001). These data suggest that OB, compared with NW, appears to have disruption of brain responses to food cues during hyperglycemia, with reduced insula response in NW but increased insula response in OB, an area involved in food perception and interoception. In a post hoc analysis, brain activity in obesity appears to be associated with dysregulated motivation (striatum) and inappropriate self-control (aPFC/dlPFC) to food cues during hyperglycemia. Hyperstimulation for food and insensitivity to internal homeostatic signals may favor food consumption to possibly play a role in the pathogenesis of obesity.

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Nutrition Knowledge is Correlated with a Better Dietary Intake in Adolescent Soccer Players: A Cross-Sectional Study

Journal of Nutrition and Metabolism ◽

10.1155/2020/3519781 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Danilo C. Noronha ◽

Monique I. A. F. Santos ◽

Adrianny A. Santos ◽

Lizia G. A. Corrente ◽

Rúbia K. N. Fernandes ◽

...

Keyword(s):

Dietary Intake ◽

Nutrition Education ◽

Healthy Eating ◽

Dietary Habits ◽

Eating Habits ◽

Sodium Intake ◽

Cross Sectional Study ◽

Nutrition Knowledge ◽

Soccer Players ◽

Cross Sectional

Nutrition education is one of the factors that may help to promote behavior change and therefore may improve the dietary habits of adolescent soccer players. However, information about the relationship between nutrition knowledge (NK) and the dietary behavior of these athletes is scarce. The purpose of this study was to evaluate the eating habits of adolescent soccer players and analyse the correlations among dietary intake and NK. Seventy-three Brazilian adolescent soccer players (aged 14–19 years), from four professional clubs, underwent anthropometric evaluation and completed 3-day food records. Misreporting of energy intake was evaluated and the dietary intake data were energy-adjusted and compared with recommendations for athletes and dietary reference intakes. The athletes also answered a questionnaire about barriers for healthy eating and a nutrition knowledge test divided into three sections: Basic Nutrition Knowledge (BNK), Sports Nutrition Knowledge (SNK), and Food Pyramid Nutrition Knowledge (FPNK). The participants showed a low NK (54.6%) and an inadequate intake of fruits, vegetables, dairy, carbohydrates, and micronutrients. A positive correlation was found between the ingestion of phosphorus and FPNK as well as among calcium and both SNK and Total NK (p<0.05). Sodium intake was negatively correlated with all categories of the NK test (p<0.05). The adolescents reported that the principal barriers for adopting a healthy diet were the lack of willpower and a busy lifestyle. In this context, nutrition education is recommended and should also provide practicable healthy eating goals according to athletes´ lifestyle as well as target motivational barriers to increase adherence.

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Pattern of BMI and associated factors in residents of Hussainabad aged 15 years and above.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.04.3665 ◽

2020 ◽

Vol 27 (04) ◽

pp. 752-758

Author(s):

Aftab Nazir ◽

Rabia Arshad Usmani ◽

Muhammad Sarfraz ◽

Muhammad Zakria ◽

Muhammad Umar Ghafoor ◽

...

Keyword(s):

Physical Activity ◽

Associated Factors ◽

Dietary Habits ◽

Eating Habits ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Obese People ◽

Cross Sectional ◽

Risk Practices ◽

Sweet Foods

Objectives: To study the pattern of BMI and associated factors in residents of Hussainabad aged 15 years and above. Study Design: Cross-sectional study. Setting: Hussainabad, Faisalabad. Period: 15th April to 23th August 2017. Material & Methods: A sample of 410 was obtained. Participants were selected by convenience sampling. Data was collected by self-administered questionnaire. Results: Out of total 410 study participants, 250 (61%) were males and 160 (39%) were females. 258 (62.9%) participants were found having BMI in the range of overweight and obesity, 6 (1.4%) participants were underweight and the remaining 146 (36%) participants were having normal BMI range. Amongst 258 overweight/obese people, 83 (20.2%) people were overweight, 112 (27.3%) moderate obese, 30 (7.3%) severe obese and 33 (8.1%) very severe obese. Overall 175 (42.7%) people were suffering from obesity. 249 (60.7%) people were in habit of eating in between meals and 161 (39.3%) were not used to eating in between meals. 95 (23.1%) people eat four times a day and 55 (13.4%) people eat more than four times a day. Likeness and increased frequency of rice and meat [136 (33.2%) and (130 (31.7%)] was more than vegetables and pulses [(91 (22.2%) and (53 (12.9%)] respectively. 157 (38.3%) people were having nocturnal eating habits. 194 (47.3%) admitted of liking the sweets and sweet foods and 170 (41.5%) people admitted of eating more under stressful conditions. 130 (31.7%) participants don’t do any kind of physical activity. Conclusion: This study describes a high frequency of obesity among population of Hussainabad. Numerous health risk practices were identified including unhealthy dietary habits, eating sweet foods, increased meal frequency, snacking behavior and lack of physical activity.

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Parental Phone use during Mealtime with Toddlers and the Associations with Feeding Practices and Shared Family Meals: A Cross-sectional Study

10.21203/rs.3.rs-105794/v1 ◽

2020 ◽

Author(s):

Frøydis Nordgård Vik ◽

Erik Grasaas ◽

Maaike E. M. Polspoel ◽

Margrethe Røed ◽

Elisabet R. Hillesund ◽

...

Keyword(s):

Mobile Phone ◽

Emotional Regulation ◽

Dietary Habits ◽

Eating Habits ◽

Feeding Practices ◽

Cross Sectional Study ◽

Family Meals ◽

Cross Sectional ◽

Parental Feeding Practices ◽

Parental Feeding

Abstract BackgroundPositive parental feeding practices and a higher frequency of family meals are related to healthier child dietary habits. Parents play an essential role when it comes to the development of their child’s eating habits. However, parents are increasingly distracted by their mobile phone during mealtime. The aim of this study was to describe the feeding practices and daily shared family meals among parents who use and do not use mobile phone during mealtime, and further to explore the associations between the use of mobile phone during mealtime and feeding practices and daily shared family meals, respectively.Methods Cross-sectional data from the Food4toddler study were used to explore the association between mobile use during meals and parental feeding practices including family meals. In 2017/2018 parents of toddlers were recruited through social media to participate in the study. In total 298 out of 404 who volunteered to participate, filled in a baseline questionnaire, including questions from the comprehensive feeding practices questionnaire (CFPQ), questions of frequency of family meals and use of mobile phone during meals. ResultsHerein, 4 out of 10 parents reported various levels of phone use (meal distraction) during mealtimes. Parental phone use was associated with lower use of positive parental feeding practices like modelling (B= -1.05 (95% CI -1.69; -0.41)) and family food environment (B= -0.77 (95% CI -1.51; -0.03)), and more use of negative parental feeding practices like emotional regulation (B= 0.73 (95% CI 0.32; 1.14)) and the use of pressure to eat (B= 1.22 (95% CI 0.41; 2.03)). Furthermore, parental phone use was associated with a lower frequency of daily family breakfast (OR= 0.50 (95% CI 0.31; 0.82)) and dinner (OR= 0.57 (95% CI 0.35; 0.93)). ConclusionsMobile phone use is common among parents during mealtimes, and findings indicate that parental phone use is associated with less healthy feeding practices and shared family meals. These findings highlight the importance of making parents aware of potential impacts of meal distractions. Trial registration: ISRCTN92980420. Registered 13 September 2017. Retrospectively registered.

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Nutrition and Dietary Habits Associated with Risk of Colorectal Cancer in the Population of Omsk region: Case-Control Study

Epidemiology and Vaccinal Prevention ◽

10.31631/2073-3046-2019-18-1-67-73 ◽

2019 ◽

Vol 18 (1) ◽

pp. 67-73

Author(s):

N. G. Shirlina ◽

V. L. Stasenko ◽

D. V. Turchaninov ◽

I. A. Sohoshko

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Food Habits ◽

Dietary Habits ◽

Eating Habits ◽

Case Control ◽

Red Meat ◽

Biological Factor ◽

Individual Risk ◽

Malignant Neoplasms

Relevance.Nutrition is the most important biological factor on which the functioning of the human body depends. The link between the development of colorectal cancer and nutrition and eating habits is well known: excessive consumption of red meat, fats, alcohol, lack of dietary fiber, obesity. Objective: To assess the prevalence and significance of factors related to nutrition and food habits in the development of colorectal cancer (CRC) in the population of the Omsk region.Materials and methods.An epidemiological analytical study (case-control) was conducted, in which 609 people took part - residents of the Omsk Region aged 30 to 85 years (average age 51.2 years; 95% CI 48.1 – 54.3). The study examined 23 factors characterizing the diet and eating habits of study participants.Result and discussion.Of the 23 risk factors for CRC associated with nutrition and food habits, only six confirmed their importance to the residents of the Omsk region: a body mass index of more than 25, alcohol consumption more than twice a month with a predominance of strong, the frequency of red meat consumed more than 10 times a month, the amount of fresh fruit consumed is less than 100 grams at a time, the preference for fatty foods.Findings.The implementation of preventive measures, taking into account the prevalence of risk factors for CRC, including factors related to nutrition and eating habits, reduces the population and individual risk of this pathology in the population of the region, as well as health losses due to malignant neoplasms of the colon and colon.

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Nutritional Behaviors, Vitamin Supplementation and Physical Activity among Polish Adults during the COVID-19 Pandemic

Nutrients ◽

10.3390/nu14020331 ◽

2022 ◽

Vol 14 (2) ◽

pp. 331

Author(s):

Bogna Gryszczyńska ◽

Magdalena Budzyń ◽

Joanna Grupińska ◽

Magdalena Paulina Kasprzak ◽

Agnieszka Gryszczyńska

Keyword(s):

Physical Activity ◽

Body Mass ◽

Dietary Habits ◽

Eating Habits ◽

Working Women ◽

Lifestyle Changes ◽

The Self ◽

Vitamin Supplementation ◽

Anonymous Questionnaire ◽

Gender Groups

The COVID-19 pandemic and its consequences, including social isolation, movement restrictions and work instability have altered many people’s nutritional behaviors and daily lifestyle. The aim of the study was to evaluate the influence of the COVID-19 pandemic on selected eating habits, physical activity and daily lifestyle changes of Polish adults (n = 145). The self-designed and anonymous questionnaire was available online from the 1 May 2021 to the 15 May 2021. In general, 60% of respondents declared that the COVID-19 pandemic did not affect their dietary habits, whereas 26% of surveyed individuals answered in the affirmative. The effect of the COVID-19 pandemic on changing dietary habits was differentiated by age (Pearson’s χ2 = 12.604; p = 0.0134). The number of meals consumed by respondents per day differed across gender groups (Pearson’s χ2 = 9.653; df = 4; p = 0.0466). An increase in body weight during the COVID-19 pandemic was reported by 43% of women and 7.6% of surveyed men. Additionally, hybrid working women declared most often an increase in body mass independent of age, education level and living place. Moreover, the majority of respondents who reported the effect of the pandemic on changing dietary habits also declared more frequent sweets consumption. The study revealed that respondents who stated more frequent sweets consumption during the COVID-19 pandemic were more likely associated with an increase in body mass (OR = 6.75, 95% CI, 6.75–91.25). No increase in the consumption of vitamin D, C and Mg supplements and pickled products was found.

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Gut microbiome dysbiosis in anorexia nervosa

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0014.8601 ◽

2021 ◽

Vol 75 ◽

pp. 283-291

Author(s):

Agata Janczy ◽

Magdalena Landowska ◽

Zdzisław Kochan

Keyword(s):

Anorexia Nervosa ◽

Gut Microbiota ◽

Body Mass ◽

Intestinal Microbiota ◽

Gut Microbiome ◽

Dietary Habits ◽

Eating Habits ◽

Current Knowledge ◽

Functional Gastrointestinal Disorders

Anorexia nervosa (AN) is described as an eating disorder, which is characterized by malnutrition, a fear of gaining body mass, and a disturbed self-body image. This disease is dependent on biological, psychological and socio-cultural factors. Among the various biological factors, the importance of intestinal microbiota has recently attracted much attention. Identification of the gut microbiota dysbiosis in patients with AN has opened new and promising research directions. Recent observations focus in particular on the association between intestinal microorganisms and the occurrence of functional gastrointestinal disorders associated with anorexia, anxiety and depression, as well as the regulation of eating habits. The composition of the gut microbiota differs between patients with AN and individuals with normal body mass. This is due to the incorrect diet of patients; on the other hand, there is growing interest in the role of intestinal microbiota in the pathogenesis of AN, its changes through re-nutrition practices, and in particular the modulation of intestinal microbiological composition by means of nutritional interventions or the use of preand probiotics as standard supplements therapy of eating disorders. There is a need for further research about the microbiome - intestine - brain axis. Furthermore, consequences of changes in dietary habits as part of AN treatment are also unknown. However, better knowledge about the relationship between the gut microbiome and the brain can help improve the treatment of this disorder. This review aims to present the current knowledge about the potential role of intestinal microbiota in the pathogenesis, course and treatment of AN.

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