Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface

2004 ◽  
Vol 190 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Kevin J. Whittlesey ◽  
Lonnie D. Shea
Keyword(s):  
Small Molecule ◽  
Delivery Systems ◽  
Small Molecule Drugs

scholarly journals Extracellular Vesicles as Natural Nanosized Delivery Systems for Small-Molecule Drugs and Genetic Material: Steps towards the Future Nanomedicines

2015 ◽  
Vol 18 (3) ◽  
pp. 396 ◽  
Author(s):  
Mustafa Kotmakçı ◽  
Vildan Bozok Çetintaş
Keyword(s):  
Extracellular Vesicles ◽  
Small Molecule ◽  
Protein Delivery ◽  
Drug Loading ◽  
Genetic Material ◽  
Delivery Systems ◽  
Small Molecule Drugs ◽  
The Common ◽  
Therapeutic Protocols ◽  
Targeting Ability

A new platform for drug, gene and peptide-protein delivery is emerging, under the common name of “extracellular vesicles”. Extracellular vesicles (EVs) are 30-1000 nm-sized cell-derived, liposome-like vesicles. Current research on EVs as nano-delivery systems for small-molecule drugs and genetic material, reveal that these tiny, biologically-derived vesicles carry a great potential to boost the efficacy of many therapeutic protocols. Several features of EVs; from efficacy to safety, from passive to active targeting ability, the opportunity to be biologically or chemically labelled, and most importantly, their eobiotic origin make them promising candidate for development of the next generation personalized nanomedicines. The aim of this article is to provide a view on the current research in which EVs are used as drug/genetic material delivery systems. Their application areas, drug loading and targeting strategies, and biodistribution properties are discussed.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Self-assembling peptide-based nanodrug delivery systems

2019 ◽  
Vol 7 (12) ◽  
pp. 4888-4911 ◽  
Author(s):  
Qian Wang ◽  
Nan Jiang ◽  
Bo Fu ◽  
Fan Huang ◽  
Jianfeng Liu
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Delivery Systems ◽  
Present Review ◽  
Peptide Conjugates ◽  
Nanodrug Delivery ◽  
Self Assembling ◽  
Small Molecule Drugs ◽  
Delivery Strategies

The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.

Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs

2020 ◽  
Vol 263 ◽  
pp. 127235 ◽  
Author(s):  
Zahra Nazemi ◽  
Mohammad Sadegh Nourbakhsh ◽  
Sahar Kiani ◽  
Hamed Daemi ◽  
Mohammad Kazemi Ashtiani ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Small Molecule ◽  
Electrostatic Interactions ◽  
Delivery Systems ◽  
Small Molecule Drugs

scholarly journals Drug Transport across the Blood–Brain Barrier

2012 ◽  
Vol 32 (11) ◽  
pp. 1959-1972 ◽  
Author(s):  
William M Pardridge
Keyword(s):  
Blood Brain Barrier ◽  
Small Molecule ◽  
Drug Transport ◽  
Delivery Systems ◽  
Brain Barrier ◽  
Large Molecule ◽  
Transport Systems ◽  
Small Molecule Drugs ◽  
Blood Brain ◽  
The Brain

The blood–brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This property arises from the epithelial-like tight junctions within the brain capillary endothelium. The BBB is anatomically and functionally distinct from the blood–cerebrospinal fluid barrier at the choroid plexus. Certain small molecule drugs may cross the BBB via lipid-mediated free diffusion, providing the drug has a molecular weight <400 Da and forms <8 hydrogen bonds. These chemical properties are lacking in the majority of small molecule drugs, and all large molecule drugs. Nevertheless, drugs can be reengineered for BBB transport, based on the knowledge of the endogenous transport systems within the BBB. Small molecule drugs can be synthesized that access carrier-mediated transport (CMT) systems within the BBB. Large molecule drugs can be reengineered with molecular Trojan horse delivery systems to access receptor-mediated transport (RMT) systems within the BBB. Peptide and antisense radiopharmaceuticals are made brain-penetrating with the combined use of RMT-based delivery systems and avidin–biotin technology. Knowledge on the endogenous CMT and RMT systems expressed at the BBB enable new solutions to the problem of BBB drug transport.

scholarly journals Advances in Nanomaterials Used in Co-Delivery of siRNA and Small Molecule Drugs for Cancer Treatment

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2467
Author(s):  
Shei Li Chung ◽  
Maxine Swee-Li Yee ◽  
Ling-Wei Hii ◽  
Wei-Meng Lim ◽  
Mui Yen Ho ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Small Molecule ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Cancer Treatments ◽  
Small Molecule Drugs ◽  
Emerging Issues ◽  
Properties Of Materials ◽  
Interfering Rna ◽  
Novel Delivery Systems

Recent advancements in nanotechnology have improved our understanding of cancer treatment and allowed the opportunity to develop novel delivery systems for cancer therapy. The biological complexities of cancer and tumour micro-environments have been shown to be highly challenging when treated with a single therapeutic approach. Current co-delivery systems which involve delivering small molecule drugs and short-interfering RNA (siRNA) have demonstrated the potential of effective suppression of tumour growth. It is worth noting that a considerable number of studies have demonstrated the synergistic effect of co-delivery systems combining siRNA and small molecule drugs, with promising results when compared to single-drug approaches. This review focuses on the recent advances in co-delivery of siRNA and small molecule drugs. The co-delivery systems are categorized based on the material classes of drug carriers. We discuss the critical properties of materials that enable co-delivery of two distinct anti-tumour agents with different properties. Key examples of co-delivery of drug/siRNA from the recent literature are highlighted and discussed. We summarize the current and emerging issues in this rapidly changing field of research in biomaterials for cancer treatments.

scholarly journals Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 136
Author(s):  
Masahiko Terauchi ◽  
Atsushi Tamura ◽  
Yoshinori Arisaka ◽  
Hiroki Masuda ◽  
Tetsuya Yoda ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Formation ◽  
Small Molecule ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Inclusion Complexation ◽  
Dental Tissue ◽  
Polyelectrolyte Complexes ◽  
Small Molecule Drugs

Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. Additionally, small-molecule drugs that promote bone formation have been identified and tested as new regenerative treatment. However, treatments need to progress to realize successful regeneration of oral functions. In this review, we describe recent progress in development of regenerative treatment of oral tissues. In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. CDs can encapsulate hydrophobic small-molecule drugs into their cavities, resulting in inclusion complexes. The inclusion complexation of osteoinductive small-molecule drugs improves solubility of the drugs in aqueous solutions and increases in vitro osteogenic differentiation efficiency. Additionally, various anionic polymers such as heparin and its mimetic polymers have been developed to improve stability and bioactivity of growth factors. These polymers protect growth factors from deactivation and degradation by complex formation through electrostatic interaction, leading to potentiation of bone formation ability. These approaches using an inclusion complex and polyelectrolyte complexes have great potential in the regeneration of oral tissues.

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