Obesity as the 21st Century’s Major Disease: The Role of Probiotics and Prebiotics in Prevention and Treatment

2021 ◽  
pp. 101115
Author(s):  
Michał Włodarczyk ◽  
Katarzyna Śliżewska
2018 ◽  
Vol 18 (7) ◽  
pp. 985-992 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Ertan Kucuksayan ◽  
Rana Cagla Akduman ◽  
Tomris Ozben

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal

AbstractThere are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.


Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1460
Author(s):  
Kalliopi Karatzi ◽  
Yannis Manios

Type 2 diabetes (T2DM) and hypertension are major health problems, with an undisputed growth burden in the past decades [...]


Author(s):  
Dorota Ochijewicz ◽  
Mariusz Tomaniak ◽  
Grzegorz Opolski ◽  
Janusz Kochman

AbstractCardiovascular disease remains the leading cause of death and morbidity worldwide. Inflammation plays an important role in the development of atherosclerosis and is associated with adverse clinical outcomes in patients after percutaneous coronary interventions. Data on stent elements that lead to excessive inflammatory response, proper identification of high–risk patients, prevention and treatment targeting residual inflammatory risk are limited. This review aims to present the role of inflammation in the context of evolving stent technologies and appraise the potential imaging modalities in detection of inflammatory response and anti-inflammatory therapies.


Maturitas ◽  
1997 ◽  
Vol 28 (1) ◽  
pp. 95
Author(s):  
J.L. Stock ◽  
L. Amantea ◽  
J.H. Overdorf ◽  
A.D. Samar ◽  
F.L. Pickens

2010 ◽  
Vol 151 (19) ◽  
pp. 763-773 ◽  
Author(s):  
Andrea Balázs

A túlsúly és az elhízás bizonyítottan a jövő egyik legjelentősebb egészségügyi problémája. A fejlett országokban a túlsúlyos és elhízott emberek aránya ötévente megduplázódik. Egy európai vizsgálat adatai szerint minden második felnőtt túlsúlyos, és a becslések szerint 2000 és 2030 között az elhízottak száma megduplázódhat. Ahogy növekszik világszerte az elhízottak és a cukorbetegek száma, úgy nő az érdeklődés a természetes alapú készítmények iránt. Az elhízás terápiájában több száz gyógynövény ismert, de a forgalmazott és alkalmazott teakeverékeket szájhagyomány vagy más információforrás alapján alkalmazzák. A nagyszámú növény botanikailag rendkívül sokféle, számos rendszertani egységből kerül ki, így az sem meglepő, hogy a hatóanyagok kémiailag szintén sokfélék. A különböző hatóanyagok más-más hatásmechanizmuson keresztül fejtik ki hatásukat. Az elhízás, a diabetes kezelésére engedélyezett növényi gyógyszerkészítmény még nincs forgalomban, így a lakosság vagy engedély nélküli, vagy ismeretlen minőségű, vagy más célra engedélyezett termékeket fogyaszt. Ez a helyzet sok országra jellemző, ami visszaélésekre ad lehetőséget, valamint a betegek számára sem ad kellő biztonságot a gyógynövények alkalmazásában.


3 Biotech ◽  
2021 ◽  
Vol 11 (5) ◽  
Author(s):  
Zunaira Iqbal ◽  
Shahzaib Ahmed ◽  
Natasha Tabassum ◽  
Riya Bhattacharya ◽  
Debajyoti Bose

2018 ◽  
Vol 122 ◽  
pp. 92-97 ◽  
Author(s):  
Giorgio Bogani ◽  
Umberto Leone Roberti Maggiore ◽  
Mauro Signorelli ◽  
Fabio Martinelli ◽  
Antonino Ditto ◽  
...  

1984 ◽  
Vol 29 (2) ◽  
pp. 132-134 ◽  
Author(s):  
L.B. Raschka

Most violence connected with sleep disorder is assumed to be related to sleep walking. It is less well known that other sleep disorders can also give rise to violence. The role of narcolepsy in car accidents is mentioned. Sleep drunkenness can lead to confusion resulting in violent behaviour especially on forced awakening. This condition is associated to sleep apnea. Primary or central sleep apnea is caused by disorders of the brain stem affecting the respiratory center. Secondary or upper airway sleep apnea can be caused by virtually any condition that results in cessation of the airflow due to occlusion of the upper airway. The author describes one patient who engaged in assaultive behaviour on forced awakening following earlier alcohol consumption. The pathomechanism of violent behaviour generated by a combination of sleep apnea and respiratory pathology is described. The differential diagnosis, prevention and treatment is outlined. The use of polysomnography in diagnosis and the potentially dangerous effects of drugs with respiratory depressing effects is highlighted.


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