Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway

2021 ◽  
pp. 112733
Author(s):  
Junlin Ge ◽  
Rili Hao ◽  
Xue Rong ◽  
Q. Ping Dou ◽  
Xintong Tan ◽  
...  
Keyword(s):  
Erk Pathway ◽  
Secoisolariciresinol Diglucoside ◽  
Kidney Toxicity ◽  
Liver And Kidney

scholarly journals PROTECTIVE EFFECTS OF ANTIOXIDANTS ON THE EXPERIMENTAL LIVER AND KIDNEY TOXICITY IN MICE

2008 ◽  
Vol 5 (3) ◽  
Author(s):  
Haluk Dülger ◽  
Ragıp Balahoroğlu ◽  
Hanefi Özbek ◽  
İrfan Bayram ◽  
Mehmet Ramazan Şekeroğlu
Keyword(s):  
Protective Effects ◽  
Kidney Toxicity ◽  
Liver And Kidney ◽  
Experimental Liver

scholarly journals Biochemical and Molecular Studies on the Role of Rosemary (Rosmarinus officinalis) Extract in Reducing Liver and Kidney Toxicity Due to Etoposide in Male Rats

2019 ◽  
pp. 1-11
Author(s):  
Majd Almakhatreh ◽  
Ezar Hafez ◽  
Ehab Tousson ◽  
Ahmed Masoud
Keyword(s):  
Dna Damage ◽  
Calcium Ions ◽  
Chloride Ions ◽  
Male Rats ◽  
Control Group ◽  
Potassium Ions ◽  
Sodium Ions ◽  
Total Proteins ◽  
Kidney Toxicity ◽  
Liver And Kidney

Aims: Etoposide (Vepesid) is chemotherapeutic drugs that inhibit topoisomerase II activity and long been used for treatment of human malignancies, where it is a semi-synthetic compound derived from the plant Podophyllum peltatum. The current study was designed to investigate the possible protective effect of rosemary extract against Etoposide -induced changes in liver and kidney functions, and DNA damage in rats. Materials and Methods: A total of 50 male Wistar albino rats were divided randomly into four groups (1st group was control; 2nd group was treated with rosemary, 3rd group was received etoposide, and 4th & 5th groups was co- and post treated groups respectively). Results: The administration of Etoposide revealed a significant increase in serum ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions, and DNA damage. In contrast; a significant decrease in albumen, total proteins, sodium ions, and calcium ions were when compared with control group. This increased in ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions, and DNA damage was reduced after administration of rosemary when co-treated with etoposide (G4), or post-treated after etoposide  (G5) for four weeks with lowest damage in G4. Also, this decreased in albumen, total proteins, sodium ions, and calcium ions was increased after administration of rosemary when co-treated with etoposide (G4), or post-treated after etoposide (G5) for four weeks with lowest damage in G4. Conclusion: It could be concluded that rosemary has a promising role and it worth to be considered as a natural substance for protective the liver and kidney toxicity induced by etoposide (Vepesid) chemotherapy.

scholarly journals The Evaluation of Toxicity Induced by Psoraleae Fructus in Rats Using Untargeted Metabonomic Method Based on UPLC-Q-TOF/MS

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanyan Xu ◽  
Yiwei Zhao ◽  
Jiabin Xie ◽  
Xue Sheng ◽  
Yubo Li ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Acid Metabolism ◽  
Safety Evaluation ◽  
Rat Plasma ◽  
Leguminous Plant ◽  
Control Group ◽  
Kidney Toxicity ◽  
Flight Mass Spectrometry ◽  
Liver And Kidney ◽  
Tof Ms

Psoraleae Fructus is the dry and mature fruit of leguminous plant Psoralea corylifolia L., with the activity of warming kidney and enhancing yang, warming spleen, and other effects. However, large doses can cause liver and kidney toxicity. Therefore, it is necessary to evaluate the toxicity of Psoraleae Fructus systematically. Although traditional biochemical indicators and pathological tests have been used to evaluate the safety of drug, these methods lack sensitivity and specificity, so a fast and sensitive analytical method is urgently needed. In this study, an ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) method was used to analyze the metabolic profiles of rat plasma. The changes of metabolites in plasma samples were detected by partial least squares-discriminant analysis (PLS-DA). Compared with the control group, after 7 days of administration, the pathological sections showed liver and kidney toxicity, and the metabolic trend was changed. Finally, 13 potential biomarkers related to the toxicity of Psoraleae Fructus were screened. The metabolic pathways involved were glycerol phospholipids metabolism, amino acid metabolism, energy metabolism, and so forth. The discovery of these biomarkers laid a foundation for better explaining the hepatotoxicity and nephrotoxicity of Psoraleae Fructus and provided a guarantee for its safety evaluation.

Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis

2017 ◽  
Vol 106 ◽  
pp. 455-465 ◽  
Author(s):  
Amina Maalej ◽  
Asma Mahmoudi ◽  
Zouhaier Bouallagui ◽  
Ines Fki ◽  
Rim Marrekchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phenolic Compounds ◽  
Kidney Toxicity ◽  
Liver And Kidney

scholarly journals Protective Role of Commiphora molmol Extract against Liver and Kidney Toxicity Induced by Carbon Tetrachloride in Mice

2016 ◽  
Vol 15 (1) ◽  
pp. 65 ◽  
Author(s):  
Abeer A. Alm-Eldeen ◽  
Sabry A. El-Naggar ◽  
Kamal F. El-Boray ◽  
Hassan A. Elgebaly ◽  
Ismail H. Osman
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Role ◽  
Kidney Toxicity ◽  
Liver And Kidney

scholarly journals Evaluation of the Ameliorative Effects of Spirulina in PropylthiouracilInduced Hyperlipidaemia, Liver and Kidney Toxicity in Rats

2020 ◽  
pp. 21-31
Author(s):  
Eman M. Ragheb ◽  
Buthaina M. Aljehany
Keyword(s):  
Body Weight ◽  
Antioxidant Activities ◽  
Body Weight Gain ◽  
Dry Weight ◽  
Protective Role ◽  
Lipid Peroxidation Product ◽  
Final Body Weight ◽  
Kidney Toxicity ◽  
Liver And Kidney ◽  
Peroxidation Product

Background: Propylthiouracil (PTU) is a drug widely used in the management of hyperthyroidism. The drug was observed to cause hepatitis and fulminant liver failure.Spirulinais documented to exhibit several therapeutic effectsincluding hepatoprotective, nephroprotective, and antioxidant activities. Objective: This study aimed to assess the nutritional value of Spirulina,and to examine its  ameliorative effects against PTU-induced hypothyroidism associated with hyperlipidemia, liver, and kidney toxicity in rats. Materials and Methods: This experiment was carried out on 50 rats (5 groups, n = 10). Hypothyroidism was induced in 40 ratsvia injecting 10 mg/kg/day PTUfor 6 weeks. Results: The results of this study showed that Spirulina contains 57.30 % of its dry weight proteins while it contains only 8.2% of its dry weight fats. It contains several minerals and vitamins (E and β-carotene).Spirulina increases the final body weight, food intake, and body weight gain % values compared to PTU rats. The Alga increased FT3 and FT4 levels, while decrease TSH level compared to PTU rats. Spirulina significantly decreased serum liver enzymes (ALT, AST, and ALP) and serum kidney function markers (creatinine and urea) compared to PTU rats. Besides, it reduced serum lipid profile markers (TC, TG, and LDL-C) and increased HDL-C. The Alga reduced the lipid peroxidation product and increased glutathione peroxidase concentrations. Conclusion: The results of this study confirmed the protective role of Spirulina versus PTU associated hypothyroidism, hyperlipidemia, hepatic, and nephrotoxicity. The antioxidant impact of Spirulina may elucidate its defensive effect against various PTU toxicities.

Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats

Planta Medica ◽  
2021 ◽  
Author(s):  
Dan Li ◽  
Yuanfeng Lyu ◽  
Jiajia Zhao ◽  
Xiaoyu Ji ◽  
Yufeng Zhang ◽  
...  
Keyword(s):  
Bolus Dose ◽  
Raw Material ◽  
Sprague Dawley ◽  
Multiple Dosing ◽  
Kidney Toxicity ◽  
Concentration Determination ◽  
Sprague Dawley Rats ◽  
Liver And Kidney

AbstractAlthough Polygoni Multiflori Radix (PMR) has been widely used as a tonic and an anti-aging remedy for centuries, the extensively reported hepatotoxicity and potential kidney toxicity hindered its safe use in clinical practice. To better understand its toxicokinetics, the current study was proposed, aiming to evaluate the biodistributions of the major PMR components including 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG), emodin, emodin-8-O-β-D-glucopyranoside (EMG) and physcion as well as their corresponding glucuronides following bolus and multiple oral administrations of PMR to rats. Male Sprague-Dawley rats received a bolus dose or 21 days of oral administrations of PMR concentrated granules at 4.12 g/kg (equivalent to 20.6 g/kg raw material). Fifteen minutes after bolus dose or the last dose on day 21, rats were sacrificed and the blood, liver, and kidney were collected for the concentration determination of both parent form and glucuronides of TSG, emodin, EMG, and physcion by HPLC-MS/MS. Among all the tested analytes, TSG, EMG, EMG glucuronides in liver and TSG, EMG, as well as all the glucuronides of these analytes in the kidney demonstrated the most significant accumulation after multiple doses. Moreover, the levels of the parent analytes were all significantly higher in liver and kidney in comparison to their plasma levels. Strong tissue binding of all four analytes and accumulation of TSG, EMG, and EMG glucuronides in the liver and TSG, EMG, as well as the glucuronides of all four analytes in the kidney after multiple dosing of PMR were considered to be associated with its toxicity.

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