The surface of the Moon, as well as the surface of an airless body of the solar system, is subject to constant bombardment of micrometeorites, the effects of solar radiation, solar wind, and other space factors. As a result of the impact of high-speed micrometeorites for billions of years, the silicate base of the lunar surface is crushed, turning into particles with an approximately power-law-sized distribution. Given the explosive nature of the occurrence, these particles are characterized by an extremely irregular shape with pointed edges, either droplets close to spheres or conglomerates sintered at high temperatures. The plasma of the solar wind and the solar radiation, especially its ultraviolet part of the spectrum, when interacting with the upper layer of regolith causes a charge of the regolith upper layer and creates a near-surface double layer and an electric field. In this field, regolith particles of micron and submicron sizes can break away from the surface and levitate above the surface. Such dynamic processes lead to the transfer of dust particles over the surface of the Moon, as well as to the scattering of sunlight on these particles. Glows above the lunar surface of this nature were observed by television systems of American and Soviet landers in the early stages of lunar exploration. The American astronauts who landed on the lunar surface during the Apollo program experienced the aggressive properties of lunar dust. The results of the Apollo missions showed that dust particles are one of the main causes of danger to humans, spacecraft systems, and activities on the lunar surface. Based on the results of late 20th- and early 21st-century lunar research, as well as the proposed models, the article discusses the formation of the lunar regolith and the near-surface exosphere of the Moon under the influence of external factors in outer space. Relevant considerations include the causes and conditions of dust particle dynamics, the consequences of these processes as well as possible threats to humans, engineering systems during the implementation of planned research programs, and the exploration of the Moon. Also of relevance are models of the formation of a plasma-dust exosphere, the dynamics of dust particles in the near-surface region, and dust clouds at a distance of several tens of kilometers from the Moon’s surface, based on the available experimental data. The main unresolved problems associated with the dynamics of the dust component of lunar regolith are given, and methods for solving problematic issues are discussed. The Moon research programs of leading space agencies and their role in the study of Moon dust, its dynamics, human impact, and its activities in the implementation of promising programs for the study and exploration of the Moon are examined.