scholarly journals LB796 Protective Effect of the Aqueous Extract of Polypodium leucotomos (Fernblock®) on Skin Cells against Blue Light Emitted from Digital Devices

2021 ◽  
Vol 141 (9) ◽  
pp. B21
Author(s):  
A. Rodríguez Luna ◽  
M. Portillo-Esnaola ◽  
M. Mataix ◽  
S. Lorrio ◽  
M. Villalba ◽  
...  
Keyword(s):  
Protective Effect ◽  
Blue Light ◽  
Aqueous Extract ◽  
Digital Devices ◽  
Skin Cells ◽  
Polypodium Leucotomos

scholarly journals The Aqueous Extract of Polypodium leucotomos (Fernblock®) Regulates Opsin 3 and Prevents Photooxidation of Melanin Precursors on Skin Cells Exposed to Blue Light Emitted from Digital Devices

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 400
Author(s):  
Mikel Portillo ◽  
Manuel Mataix ◽  
Miguel Alonso-Juarranz ◽  
Silvia Lorrio ◽  
María Villalba ◽  
...  
Keyword(s):  
Blue Light ◽  
Aqueous Extract ◽  
Human Fibroblasts ◽  
Sun Exposure ◽  
Mitogen Activated Protein Kinase ◽  
Mitochondrial Morphology ◽  
Beneficial Effects ◽  
Digital Devices ◽  
Mitogen Activated Protein ◽  
Polypodium Leucotomos

The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of an aqueous extract of Polypodium leucotomos (Fernblock®) is known. Our aim was to investigate the action mechanism of Fernblock® against pigmentation induced by blue light from digital devices. Human fibroblasts (HDF) and murine melanocytes (B16-F10) were exposed to artificial blue light (a 400–500 nm LED lamp). Cell viability, mitochondrial morphology, and the expression of the mitogen-activated protein kinase (MAPK) p38, known markers involved in the melanogenesis pathway, were evaluated. The activation of Opsin-3, a membrane protein sensitive to blue light that triggers the activation of the enzyme tyrosinase responsible for melanogenesis in melanocytes, was also analyzed. Our results demonstrated that pretreatment with Fernblock® prevents cell death, alteration of mitochondrial morphology, and phosphorylation of p38 in HDF exposed to blue light. In addition, Fernblock® significantly reduced the activation of Opsin-3 in melanocytes and the photo-oxidation of melanin, preventing its photodegradation. In sum, Fernblock® exerts beneficial effects against the detrimental impact of blue light from digital devices and could prevent early photoaging, while maintaining skin homeostasis.

Blue light-induced retinal damage: a brief review and a proposal for examining the hypothetical causal link between person digital device use and retinal injury

2021 ◽  
Vol 1 (3) ◽  
pp. 129-134
Author(s):  
Michael R. Kozlowski
Keyword(s):  
Blue Light ◽  
Additional Data ◽  
Light Exposure ◽  
High Energy ◽  
Causal Link ◽  
Retinal Damage ◽  
Digital Devices ◽  
Retinal Injury ◽  
Device Use ◽  
Harmful Effects

Background: There is growing concern that the increased use of personal digital devices, which emit a high proportion of their light in the blue wavelengths, may have harmful effects on the retina. Extensive historical as well as current research demonstrates that exposure to high energy visible light (blue light) can damage the retina under certain circumstances. There are, however, no studies that directly address whether blue light at the intensities emitted by digital devices can potentially cause such harm. The present review aimed to examine whether blue light exposure from computers, tablets, and cell phones can, when used habitually over a prolonged period of time, be harmful to the retinal. Methods: A search of the literature on blue light-induced retinal damage was performed using a number of scientific search engines, including BioOne Complete™, Google Scholar™, Paperity™, PubMed™, and ScienceOpen™. Studies most significant for addressing the question of possible harmful effects of blue light emitted by personal digital devices were selected from this search and reviewed. Results: The data from the selected studies were summarized and their limitations in addressing the question of whether the blue light from personal digital devices is capable of producing retinal damage were addressed. Based on these limitations, a practical experimental protocol for collecting the additional data needed was proposed. Data from pilot experiments are presented that indicate the practicality of this approach. Conclusions: The currently available data on the effects of blue light on the retina are not sufficient to refute the hypothesis that the use of personal digital devices could, over a lifetime, produce retinal damage. Additional studies, such as those proposed in this article, are needed to resolve this issue.

scholarly journals Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats

2018 ◽  
Vol 19 (12) ◽  
pp. 4016 ◽  
Author(s):  
Valéria da Silva ◽  
Aurigena de Araújo ◽  
Daline Araújo ◽  
Maíra Lima ◽  
Roseane Vasconcelos ◽  
...  
Keyword(s):  
Protective Effect ◽  
Aqueous Extract ◽  
Intestinal Inflammation ◽  
Activity Index ◽  
Immunohistochemical Analysis ◽  
Histological Evaluation ◽  
Myeloperoxidase Activity ◽  
Down Regulation ◽  
Anti Inflammatory ◽  
Ipomoea Asarifolia

Inflammatory bowel disease is triggered by an uncontrolled immune response associated with genetic, environmental, and intestinal microbiota imbalance. Ipomoea asarifolia (IA), popularly known as “salsa” or “brave salsa”, belongs to the Convolvulaceae family. The aim of this approach was to study the preventive effect of IA aqueous extract in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rats. Rats pretreated with IA extract or sulfasalazine (SSZ) received intracolonic instillation of DNBS in 50% ethanol (v/v). IA extract presented a protective effect against intestinal inflammation, with improvement in the disease activity index and macroscopic damage. IA or SSZ significantly reduced myeloperoxidase activity, and also down-regulation of the gene expression of JNK1, NF-κβ-p65, STAT3, and decreased levels of TNFα, IL-1β, and increased IL-10, associated with a significant improvement of oxidative stress, in addition to a reduction in MDA and an increase of glutathione in colonic tissue. The protective effect of the extract was also confirmed in histological evaluation, showing preservation of the colonic cytoarchitecture. Immunohistochemical analysis revealed down-regulation of NF-κβ-p65, iNOS, IL-17, and up-regulation of SOCs-1 and MUC-2. IA extract presents antioxidant and anti-inflammatory intestinal properties, and proved to be a potential application for preventing damage induced by DNBS.

Blue light disrupts the circadian rhythm and create damage in skin cells

2019 ◽  
Vol 41 (6) ◽  
pp. 558-562 ◽  
Author(s):  
K. Dong ◽  
E. C. Goyarts ◽  
E. Pelle ◽  
J. Trivero ◽  
N. Pernodet
Keyword(s):  
Circadian Rhythm ◽  
Blue Light ◽  
Skin Cells

scholarly journals Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE®) on Skin Cells against Blue Light Emitted from Digital Devices

2020 ◽  
Vol 21 (3) ◽  
pp. 988 ◽  
Author(s):  
Silvia Lorrio ◽  
Azahara Rodríguez-Luna ◽  
Pablo Delgado-Wicke ◽  
Marta Mascaraque ◽  
María Gallego ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Blue Light ◽  
Aqueous Extract ◽  
Electronic Devices ◽  
High Energy ◽  
Dermal Fibroblasts ◽  
Light Irradiation ◽  
Deschampsia Antarctica ◽  
Pathway Activation

Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices. This, together with recent observations reporting that blue light—also known as high-energy visible light—can exert cytotoxic effects associated with oxidative stress and promote hyperpigmentation, has sparked interest in blue light and its potential harmful effects on skin. The photoprotective properties of new extracts of different botanicals with antioxidant activity are therefore being studied. Deschampsia antarctica (Edafence®, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. In this regard, we studied the protective capacity of EDA against the deleterious effects of artificial blue light irradiation in human dermal fibroblasts (HDF) and melanocytes. We analyzed the impact of EDA on viability, cell morphology, oxidative stress, melanogenic signaling pathway activation and hyperpigmentation in HDF and melanocytes subjected to artificial blue light irradiation. Our results show that EDA protects against cell damage caused by artificial blue light, decreasing oxidative stress, melanogenic signaling pathway activation and hyperpigmentation caused by blue light irradiation. All these findings suggest that EDA might help prevent skin damage produced by artificial blue light exposure from screen of electronic devices.

scholarly journals Protective Effect of Astaxanthin on Blue Light Light-Emitting Diode-Induced Retinal Cell Damage via Free Radical Scavenging and Activation of PI3K/Akt/Nrf2 Pathway in 661W Cell Model

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 387 ◽  
Author(s):  
Chao-Wen Lin ◽  
Chung-May Yang ◽  
Chang-Hao Yang
Keyword(s):  
Antioxidant Enzymes ◽  
Free Radical ◽  
Protective Effect ◽  
Blue Light ◽  
Nuclear Translocation ◽  
Light Exposure ◽  
Cell Damage ◽  
Radical Scavenging ◽  
Photoreceptor Cells ◽  
Light Emitting

Light-emitting diodes (LEDs) are widely used and energy-efficient light sources in modern life that emit higher levels of short-wavelength blue light. Excessive blue light exposure may damage the photoreceptor cells in our eyes. Astaxanthin, a xanthophyll that is abundantly available in seafood, is a potent free radical scavenger and anti-inflammatory agent. We used a 661W photoreceptor cell line to investigate the protective effect of astaxanthin on blue light LED-induced retinal injury. The cells were treated with various concentrations of astaxanthin and then exposed to blue light LED. Our results showed that pretreatment with astaxanthin inhibited blue light LED-induced cell apoptosis and prevented cell death. Moreover, the protective effect was concentration dependent. Astaxanthin suppressed the production of reactive oxygen species and oxidative stress biomarkers and diminished mitochondrial damage induced by blue light exposure. Western blot analysis confirmed that astaxanthin activated the PI3K/Akt pathway, induced the nuclear translocation of Nrf2, and increased the expression of phase II antioxidant enzymes. The expression of antioxidant enzymes and the suppression of apoptosis-related proteins eventually protected the 661W cells against blue light LED-induced cell damage. Thus, our results demonstrated that astaxanthin exerted a dose-dependent protective effect on photoreceptor cells against damage mediated by blue light LED exposure.

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