A method to generate a pipe model to compensate for low congestion level of 3D geometry available at the early stage of detailed design

AbstractResearch funded projects are often concerned with the development of proof-of-concept products. Consequently, activities related to verification and validation testing (VVT) are often not considered in depth, even though various design iterations are carried out to refine an idea. Furthermore, the introduction of additive manufacturing (AM) has facilitated, in particular, the development of bespoke medical products. End bespoke products, which will be used by relevant stakeholders (e.g. patients and clinicians) are fabricated with the same manufacturing technologies used during prototyping. As a result, the detailed design stage of products fabricated by AM is much shorter. Therefore, to improve the market-readiness of bespoke medical devices, testing must be integrated within the development from an early stage, allowing better planning of resources. To address these issues, in this paper, a comprehensive VVT framework is proposed for research projects, which lack a VVT infrastructure. The framework builds up on previous studies and methods utilised in industry to enable project key experts to capture risks as early as the concept design stage.

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Multi-Scale Numerical Model for Groundwater flow Simulation of a Karst Tunnel in Kunming,China

10.5194/egusphere-egu2020-15112 ◽

2020 ◽

Author(s):

Mo Xu ◽

Jihong Qi ◽

Yige Tang ◽

Xiao Li ◽

JIan Guo

Keyword(s):

Groundwater Flow ◽

Water Level ◽

Large Scale ◽

Early Stage ◽

Water Discharge ◽

Scale Model ◽

Small Scale ◽

Tunnel Construction ◽

Multi Scale ◽

Pipe Model

Due to the inhomogeneity of the carbonate rocks and discreteness of the karst water, delineation of the groundwater flow within karst area remains a challenging task as yet. Based on KunCheng tunnel of a water diversion project in KunMing, multi-scale groundwater flow models were set upto simulate the groundwater flow. Large scale model was used to obtain the boundary conditions and hydrogeological parameters, which were then assigned to the small scale model.The small scale model was generalized as an equivalent continuous medium, and two karst pipelines are established &#160;by module River. After then, &#160;the multi-scale numerical modelswere used to simulate the &#160;groundwater seepage field and predict the recovery of groundwater after tunnel construction. The main results and conclusions are as follows.(1)Black karst pipeline and white karst pipeline systems share one recharge source but have two independent discharge systems. The recharge source is the exposed karst rock in the northeast part of study area. Obstructed by aluminum clay rock of P1d, groundwater discharge is divided into two parts during the runoff process.(2)During the tunnel construction process, the water level at the exit of White karst pipeline reduced 9m in pipe model B1 while reduced 10m in the solution fissure model B2, both two models suggest that the tunnel construction will cause the drainage of White karst pipeline exit. The water level at the exit of black karst pipeline reduced 1m in pipe model B1 while reduced 4m in the solution fissure model B2.(3)In model B1, total water discharge during tunnel construction is 69876m3/d, in model B2 , the total water discharge is 95817 m3/d &#160;and &#160;is much larger than model B1 due to the quick groundwater transporting and exchange in karst pipeline..(4)After the tunnel construction, exits of two pipelines and observation well see the water level recovery because of the formation sealing . The recovery trend is relatively rapid in the early stage, and slow in the later stage. It takes 8.5 years and 10 years for the exits of black and white pipelines and observation wells to reach the original water level, respectively. During the recovery process, groundwater exchange form was changing from pipe supplying aquifer to aquifer supplying pipe, which made model B2 recovered faster than model B1 in early stage, and vice versa.Using large scale model combining with secondary scale model, and the module River to generalize karst pipeline can reflect the flow dynamic characteristics of karst pipeline effectively.

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Learning abstract models for system design

Artificial intelligence for engineering design analysis and manufacturing ◽

10.1017/s0890060400001475 ◽

1996 ◽

Vol 10 (2) ◽

pp. 167-169

Author(s):

Sudhakar Y. Reddy

Keyword(s):

Machine Learning ◽

Early Stage ◽

Simulation Models ◽

Preliminary Design ◽

Engineering Systems ◽

Design Decisions ◽

Detailed Design ◽

Stage Design ◽

Detailed Simulation ◽

Early Stage Design

AbstractThough simulation models are extensively used for detailed design analysis, they find limited role in preliminary design decisions. We have developed a machine learning based approach to enable detailed simulation models to be harvested for supporting early-stage design of engineering systems.

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Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141226 ◽

1995 ◽

Vol 53 ◽

pp. 970-971

Author(s):

L. Vacca-Galloway ◽

Y.Q. Zhang ◽

P. Bose ◽

S.H. Zhang

Keyword(s):

Spinal Cord ◽

Early Stage ◽

Cervical Spinal Cord ◽

Wild Type Mouse ◽

Reflex Response ◽

Mouse Strains ◽

Behavioral Tests ◽

Wobbler Mouse ◽

Stage 4 ◽

Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

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Automated high-resolution microscopy: the approaches so far

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100125312 ◽

1987 ◽

Vol 45 ◽

pp. 58-61

Author(s):

W. O. Saxton

Keyword(s):

High Resolution ◽

Early Stage ◽

Automatic Recording ◽

Microprocessor Control ◽

Alternative Systems ◽

Electron Image ◽

Complete Automation ◽

Analysis System ◽

High Resolution Microscopy

Recent commercial microscopes with internal microprocessor control of all major functions have already demonstrated some of the benefits anticipated from such systems, such as continuous magnification, rotation-free diffraction and magnification, automatic recording of mutually registered focal series, and fewer control knobs. Complete automation of the focusing, stigmating and alignment of a high resolution microscope, allowing focal series to be recorded at preselected focus values as well, is still imminent rather than accomplished, however; some kind of image pick-up and analysis system, fed with the electron image via a TV camera, is clearly essential for this, but several alternative systems and algorithms are still being explored. This paper reviews the options critically in turn, and stresses the need to consider alignment and focusing at an early stage, and not merely as an optional extension to a basic proposal.

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Direct observation of Fe-Al-Zn ternary intermetallic compound and its transformation during the early stage of hot-dip galvanizing

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100151416 ◽

1993 ◽

Vol 51 ◽

pp. 1116-1117

Author(s):

C. S. Lin ◽

W. A. Chiou ◽

M. Meshii

Keyword(s):

Intermetallic Compound ◽

Reaction Rate ◽

Diffusion Rate ◽

Early Stage ◽

Zinc Bath ◽

Steel Sheets ◽

Direct Observations ◽

Solid Iron ◽

Iron And Zinc ◽

Ternary Intermetallic Compound

The galvannealed steel sheets have received ever increased attention because of their excellent post-painting corrosion resistance and good weldability. However, its powdering and flaking tendency during press forming processes strongly impairs its performance. In order to optimize the properties of galvanneal coatings, it is critical to control the reaction rate between solid iron and molten zinc.In commercial galvannealing line, aluminum is added to zinc bath to retard the diffusion rate between iron and zinc by the formation of a thin layer of Al intermetallic compound on the surface of steel at initial hot-dip galvanizing. However, the form of this compound and its transformation are still speculated. In this paper, we report the direct observations of this compound and its transformation.The specimens were prepared in a hot-dip simulator in which the steel was galvanized in the zinc bath containing 0.14 wt% of Al at a temperature of 480 °C for 5 seconds and was quenched by liquid nitrogen.

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Anisotropy of interfacial defects in the initial stage of MOVPE GaAs growth On Si

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100176095 ◽

1990 ◽

Vol 48 (4) ◽

pp. 592-593

Author(s):

C. Vannuffel ◽

C. Schiller ◽

J. P. Chevalier

Keyword(s):

Early Stage ◽

Threading Dislocations ◽

Mbe Growth ◽

Detailed Mechanism ◽

Si Substrates ◽

Initial Stage ◽

Interfacial Defects ◽

Interfacial Dislocations ◽

Step Growth ◽

Essential Problem

Recently, interest has focused on the epitaxy of GaAs on Si as a promising material for electronic applications, potentially for integration of optoelectronic devices on silicon wafers. The essential problem concerns the 4% misfit between the two materials, and this must be accommodated by a network of interfacial dislocations with the lowest number of threading dislocations. It is thus important to understand the detailed mechanism of the formation of this network, in order to eventually reduce the dislocation density at the top of the layers.MOVPE growth is carried out on slightly misoriented, (3.5°) from (001) towards , Si substrates. Here we report on the effect of this misorientation on the interfacial defects, at a very early stage of growth. Only the first stage, of the well-known two step growth process, is thus considered. Previously, we showed that full substrate coverage occured for GaAs thicknesses of 5 nm in contrast to MBE growth, where substantially greater thicknesses are required.

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