Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks

Abstract In this study, juvenile Manchurian trout, Brachymystax lenok (initial weight: 6.43 ± 0.02 g, mean ± SE) were received for nine weeks with five types of diets prepared by gradually replacing the proportion of fish oil (FO) with linseed oil (LO) from 0% (LO0) to 25% (LO25), 50% (LO50), 75% (LO75), and 100% (LO100). The eicosapentaenoic (EPA) and docosahexaenoic (DHA) composition decreased with increasing inclusion level of LO (P < 0.05). With increasing LO inclusion level, triglyceride (TAG) content of serum increased significantly, however, there was a decrease in high-density lipoprotein cholesterol (HDL) (P < 0.05). LO substitution of FO up-regulated the gene expression level of lipid metabolism-related genes Fatty Acid Desaturases 6 (FAD6), Acetyl-Coa Carboxylase (ACCα), Sterol Regulatory Element Binding Protein 1 (SREBP-1), and Sterol O- Acyl Transferase 2 (SOAT2), and down-regulated the gene expression level of Peroxisome Proliferator-Activated Receptor a (PPARα) (P < 0.05). The SOD activities of both serum and liver in LO100 were significantly lower than in LO25 (P < 0.05). The CAT activity of the liver in LO100 was significantly lower than in LO0 and LO25 (P < 0.05). This study indicates that the Manchurian trout may have the ability to synthesize LC-PUFAs from ALA, and an appropriate LO in substitution of FO (<75%) could improve both the lipid metabolism and the oxidation resistance.

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Effects of oxidized fish oil intake on tissue lipid metabolism and fatty acid composition of channel catfish (Ictalurus punctatus)

Aquaculture Research ◽

10.1111/are.12138 ◽

2013 ◽

pp. n/a-n/a ◽

Cited By ~ 6

Author(s):

Guifang Dong ◽

Xiaoming Zhu ◽

Hongxiang Ren ◽

Boyao Nie ◽

Lu Chen ◽

...

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Lipid Metabolism ◽

Fish Oil ◽

Acid Composition ◽

Ictalurus Punctatus ◽

Channel Catfish ◽

Tissue Lipid ◽

Oxidized Fish Oil

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The changes in growth performance and lipid metabolism of pigs with yellow fat induced by high dietary fish oil

Canadian Journal of Animal Science ◽

10.1139/cjas-2019-0094 ◽

2020 ◽

Vol 100 (1) ◽

pp. 154-164

Author(s):

Qiuping Guo ◽

Fengna Li ◽

Chaoyue Wen ◽

Lingyu Zhang ◽

Yehui Duan ◽

...

Keyword(s):

Fatty Acid ◽

Lipid Metabolism ◽

Fish Oil ◽

Growth Performance ◽

Polyunsaturated Fatty Acid ◽

Fatty Acid Synthase ◽

Basal Diet ◽

Final Body Weight ◽

Fresh Fish ◽

High Fish

The aim of this study was to investigate the alteration in growth performance and lipid metabolism during the development of yellow fat in pigs. A total of 30 pigs (9.23 ± 0.21 kg) were assigned to three treatments: (1) low fish oil (LFO), basal diet + 2% fresh fish oil; (2) high fish oil (HFO), basal diet + 8% fresh fish oil; and (3) oxidized fish oil (OFO), basal diet + 8% OFO (peroxide value = 250 meqO2 kg−1). Pigs fed HFO and OFO diets showed yellow staining of fat and decreased growth performance, including average daily gain, average daily feed intake, and final body weight (P < 0.01). The oxidized lipid markers malondialdehyde, yellowness b* of backfat, perirenal fat, and abdominal fat were markedly increased in the pigs fed with HFO and OFO (P < 0.05). Furthermore, following HFO feeding, pigs showed significant decreases in n-6 polyunsaturated fatty acid, n-6/n-3 polyunsaturated fatty acid ratio and mRNA expression levels of CCAAT-/enhancer-binding protein alpha, fatty acid synthase, lipoprotein lipase, and hormone-sensitive lipase in backfat (P < 0.01). Overall, pigs with yellow-fat trait showed decreased growth performance and altered lipid metabolism by the high fish oil feeding.

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OR-004 Changes in serum indexes of obese adolescents induced by closed weight loss summer camp

Exercise Biochemistry Review ◽

10.14428/ebr.v1i2.8633 ◽

2018 ◽

Vol 1 (2) ◽

Author(s):

Chunyan Li ◽

Caifeng Mao ◽

Lei Xu ◽

Feihu Feng

Keyword(s):

Weight Loss ◽

Fatty Acid ◽

Lipid Metabolism ◽

Oxidative Damage ◽

Antioxidant Capacity ◽

Summer Camp ◽

The Body ◽

Inflammatory Factors ◽

Obese Adolescents ◽

Inflammatory State

Objective A series of experiments were conducted to explore the changes of some serum indexes in obese adolescents induced by closed weight loss summer camp. Methods The 12 to 18 year old obese adolescents (BMI ≥ 28), who volunteered to participate in the Haoqian summer camp, were selected for 4 weeks of closed summer camp. The main activities of the summer camp included compound exercise (aerobic exercise + resistance exercise, 3 times / day, 6 days / week), Dietary intervention, fun activities and health knowledge lectures. In order to explore the changes of serum indexes of obese adolescents, glycolipid metabolism index, fatty acid components, inflammatory factors and oxidative stress markers were analyzed before and after 4 weeks. Results (1) The 4 week weight loss summer camp had no significant effect on blood sugar, but it can obviously reduce the level of serum total cholesterol, triglyceride and low density lipoprotein cholesterol, and significantly improve the abnormal lipid metabolism. (2) The level of serum total saturated fatty acid (P < 0.05), total monounsaturated fatty acid (P < 0.01) and total polyunsaturated fatty acid (P < 0.05) in obese adolescents were decreased significantly in the 4 week weight loss summer camp. (3) The 4 week weight loss summer camp significantly reduced serum inflammatory factors IL-6 and TN F- alpha in obese adolescents, increased the level of adiponectin per body fat mass (P < 0.05), and relieved the inflammatory state of the body. (4) After 4 weeks weight loss summer camp, the serum total antioxidant capacity T-AOC, antioxidant enzyme catalase CAT, superoxide dismutase SOD and glutathione peroxidase GPx activity in obese adolescents were significantly enhanced (P < 0.05); oxidative damage markers 8-iso-PGF2α, 8-OHdG, and MDA levels were not significantly changed (P > 0.05), while protein oxidation product protein carbohydrate PC content decreased significantly (P < 0.05). Conclusions 4 weeks weight loss summer camp can significantly alleviate the body's lipid metabolism abnormalities, change the serum fatty acid components, reduce the body's inflammatory state, enhance the body's antioxidant capacity, and reduce the body's oxidative damage.

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