Does radiographic knee OA status impact age-related reduction of thigh muscle specific strength - data from the osteoarthritis initiative

AbstractOsteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, like knee OA. In a dynamic approach, telomere-qPCR was performed to evaluate the relative percentage of PBL telomere loss after a 6-year follow-up, in 281 subjects from the prospective osteoarthritis initiative (OAI) cohort. A radiological Kellgren-Lawrence (KL) grade ≥ 2 was indicative of knee OA. Individuals with knee OA at recruitment (n = 144) showed a higher PBL telomere loss after 6 years than those without knee OA at baseline (n = 137; p = 0.018). Moreover, individuals that developed knee OA during the follow-up (n = 39) exhibited a higher telomere loss compared to those that remained without OA (n = 98; p < 0.001). Logistic regression analysis showed that PBLs telomere loss was not significantly associated with knee OA at recruitment, but behaves as an independent risk factor associated with incidence after follow-up (OR: 1.043; p = 0.041), together with maximum KL grade (OR: 3.627; p = 0.011), body mass index-BMI (OR: 1.252; p < 0.001) and WOMAC-index (OR: 1.247; p = 0.021), at recruitment. The telomere decay in PBLs is faster in individuals with incident knee OA, possibly reflecting a systemic-global accelerated aging that enhances the cartilage degeneration.

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Gait Speed as a Predictor for Diabetes Incidence in People with or at Risk of Knee Osteoarthritis: A Longitudinal Analysis from the Osteoarthritis Initiative

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094414 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4414

Author(s):

Aqeel M. Alenazi ◽

Bader A. Alqahtani ◽

Vishal Vennu ◽

Mohammed M. Alshehri ◽

Ahmad D. Alanazi ◽

...

Keyword(s):

At Risk ◽

Gait Speed ◽

Area Under The Curve ◽

Incident Diabetes ◽

Future Research ◽

Cutoff Score ◽

Diabetes Incidence ◽

Knee Oa ◽

Osteoarthritis Initiative

Background: This study examined the association between baseline gait speed with incident diabetes mellitus (DM) among people with or at elevated risk for knee OA. Materials and Methods: Participants from the Osteoarthritis Initiative, aged 45 to 79 years, where included. Participants with or at risk of knee OA from baseline to the 96-month visit were included. Participants with self-reported DM at baseline were excluded. DM incidence was followed over the 4-time points. Gait speed was measured at baseline using a 20-m walk test. Generalized estimating equations with logistic regression were utilized for analyses. Receiver operator characteristic curves and area under the curve were used to determine the cutoff score for baseline speed. Results: Of the 4313 participants included in the analyses (58.7% females), 301 participants had a cumulative incidence of DM of 7.0% during follow-up. Decreased gait speed was a significant predictor of incident DM (RR 0.44, p = 0.018). The threshold for baseline gait speed that predicted incident DM was 1.32 m/s with an area under the curve of 0.59 (p < 0.001). Conclusions: Baseline gait speed could be an important screening tool for identifying people at risk of incident diabetes, and the determined cutoff value for gait speed should be examined in future research.

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One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status

Annals of the Rheumatic Diseases ◽

10.1136/ard.2008.089904 ◽

2008 ◽

Vol 68 (5) ◽

pp. 674-679 ◽

Cited By ~ 95

Author(s):

F Eckstein ◽

S Maschek ◽

W Wirth ◽

M Hudelmaier ◽

W Hitzl ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Body Mass ◽

Statistical Significance ◽

Weight Bearing ◽

Rate Of Change ◽

Cartilage Loss ◽

Knee Oa ◽

Symptomatic Knee ◽

Osteoarthritis Initiative

Objective:The Osteoarthritis Initiative (OAI) is a multicentre study targeted at identifying biomarkers for evaluating the progression and risk factors of symptomatic knee OA. Here cartilage loss using 3 Tesla (3 T) MRI is analysed over 1 year in a subset of the OAI, together with its association with various risk factors.Methods:An age- and gender-stratified subsample of the OAI progression subcohort (79 women and 77 men, mean (SD) age 60.9 (9.9) years, body mass index (BMI) 30.3 (4.7)) with both frequent symptoms and radiographic OA in at least one knee was studied. Coronal FLASHwe (fast low angle shot with water excitation) MRIs of the right knee were acquired at 3 T. Seven readers segmented tibial and femoral cartilages blinded to order of acquisition. Segmentations were quality controlled by one expert.Results:The reduction in mean cartilage thickness (ThC) was greater (p = 0.004) in the medial than in the lateral compartment, greater (p = 0.001) in the medial femur (−1.9%) than in the medial tibia (−0.5%) and greater (p = 0.011) in the lateral tibia (−0.7%) than in the lateral femur (0.1%). Multifactorial analysis of variance did not reveal significant differences in the rate of change in ThC by sex, BMI, symptoms and radiographic knee OA status. Knees with Kellgren–Lawrence grade 2 or 3 and with a BMI >30 tended to display greater changes.Conclusions:In this sample of the OAI progression subcohort, the greatest, but overall very modest, rate of cartilage loss was observed in the weight-bearing medial femoral condyle. Knees with radiographic OA in obese participants showed trends towards higher rates of change than those of other participants, but these trends did not reach statistical significance.

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THU0218 Diabetes Effects on Incidence of Radiographic Knee OA and Its Structural Progression: A Longitudinal Analysis of the Osteoarthritis Initiative Data: Table 1.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.2791 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 257.2-257

Author(s):

I. Shirinsky ◽

V. Shirinsky

Keyword(s):

Longitudinal Analysis ◽

Knee Oa ◽

Data Table ◽

Structural Progression ◽

Osteoarthritis Initiative

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Multidimensional prognostic index and the risk of fractures: an 8-year longitudinal cohort study in the Osteoarthritis Initiative

Archives of Osteoporosis ◽

10.1007/s11657-021-01015-3 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Nicola Veronese ◽

Lee Smith ◽

Ekaterini Zigoura ◽

Mario Barbagallo ◽

Ligia J. Dominguez ◽

...

Keyword(s):

Older People ◽

Fracture Risk ◽

Geriatric Assessment ◽

Comprehensive Geriatric Assessment ◽

Prognostic Index ◽

Knee Oa ◽

Increased Risk ◽

Cox's Regression ◽

Clinical Fractures ◽

Osteoarthritis Initiative

Abstract Summary In this longitudinal study, with a follow-up of 8 years, multidimensional prognostic index (MPI), a product of the comprehensive geriatric assessment, significantly predicted the onset of fractures in older people affected by knee osteoarthritis. Purpose Frailty may be associated with higher fracture risk, but limited research has been carried out using a multidimensional approach to frailty assessment and diagnosis. The present research aimed to investigate whether the MPI, based on comprehensive geriatric assessment (CGA), is associated with the risk of fractures in the Osteoarthritis Initiative (OAI) study. Methods Community-dwellers affected by knee OA or at high risk for this condition were followed-up for 8 years. A standardized CGA including information on functional, nutritional, mood, comorbidity, medication, quality of life, and co-habitation status was used to calculate the MPI. Fractures were diagnosed using self-reported information. Cox’s regression analysis was carried out and results are reported as hazard ratios (HRs), with their 95% confidence intervals (CIs), adjusted for potential confounders. Results The sample consisted of 4024 individuals (mean age 61.0 years, females = 59.0%). People with incident fractures had a significant higher MPI baseline value than those without (0.42 ± 0.18 vs. 0.40 ± 0.17). After adjusting for several potential confounders, people with an MPI over 0.66 (HR = 1.49; 95%CI: 1.11–2.00) experienced a higher risk of fractures. An increase in 0.10 point in MPI score corresponded to an increase in fracture risk of 4% (HR = 1.04; 95%CI: 1.008–1.07). Higher MPI values were also associated with a higher risk of non-vertebral clinical fractures. Conclusion Higher MPI values at baseline were associated with an increased risk of fractures, reinforcing the importance of CGA in predicting fractures in older people affected by knee OA.

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Osteoarthritis (OA): A Modern Disease of the Anthropocene Era

10.21203/rs.2.10480/v1 ◽

2019 ◽

Author(s):

Ali Mobasheri ◽

Marc C. Levesque

Keyword(s):

Roman Empire ◽

Environmental Factors ◽

Industrial Revolution ◽

Homo Sapiens ◽

Ancient Egypt ◽

Knee Oa ◽

Age Related ◽

Early Humans ◽

Independent Risk Factors ◽

Post Industrial

Abstract In this paper we discuss recent studies that have unravelled important roles for modern-day environmental factors in the pathogenesis of osteoarthritis (OA). OA is a relatively modern disease in terms of human evolution. While our ancestors have been around for about six million years, modern humans (Homo sapiens) only evolved about 200,000 years ago. Early humans did not live long enough to suffer from age-related musculoskeletal conditions such as OA and arthritic diseases are thought to have been extremely rare in early Natufians and Egyptians, but this is probably because of an underrepresentation of older adults in the skeletal records. Examination of Egyptian skeletal records from burial sites provides some evidence of arthritic diseases such as OA, but mainly in the mummified remains of pharaohs and high-ranking officials, viziers, priests and nobles. Examination of the skeletal records in Roman burial ground does reveal more evidence of arthritic diseases but the evidence is sketchy and we can only assume that arthritic diseases were more prevalent in the slave population in ancient Egypt and the Roman Empire. Recent studies indicate that independent risk factors for knee OA either arose or have become amplified in the post-industrial era, suggesting that the prevalence of OA has gradually increased since the industrial revolution. Alarmingly, the incidence of knee OA has doubled since the middle of the 20thcentury, suggesting that OA is a modern disease of the Anthropocene era and there may be unknown environmental factors that have led to its increased incidence since industrialization.

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Hand Joint Space Narrowing and Osteophytes Are Associated with Magnetic Resonance Imaging-defined Knee Cartilage Thickness and Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative

The Journal of Rheumatology ◽

10.3899/jrheum.110603 ◽

2011 ◽

Vol 39 (1) ◽

pp. 161-166 ◽

Cited By ~ 17

Author(s):

IDA K. HAUGEN ◽

SEBASTIAN COTOFANA ◽

MARTIN ENGLUND ◽

TORE K. KVIEN ◽

DONATUS DREHER ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Joint Space Narrowing ◽

Joint Space ◽

Cartilage Thickness ◽

Resonance Imaging ◽

Knee Cartilage ◽

Knee Oa ◽

Osteoarthritis Initiative ◽

Hand Radiographs

Objective.To evaluate whether features of radiographic hand osteoarthritis (OA) are associated with quantitative magnetic resonance imaging (MRI)-defined knee cartilage thickness, radiographic knee OA, and 1-year structural progression.Methods.A total of 765 participants in Osteoarthritis Initiative (OAI; 455 women, mean age 62.5 yrs, SD 9.4) obtained hand radiographs (at baseline), knee radiographs (baseline and Year 1), and knee MRI (baseline and Year 1). Hand radiographs were scored for presence of osteophytes and joint space narrowing (JSN). Knee radiographs were scored according to the Kellgren-Lawrence (KL) scale. Cartilage thickness in the medial and lateral femorotibial compartments was measured quantitatively from coronal FLASHwe images. We examined the cross-sectional and longitudinal associations between features of hand OA (total osteophyte and JSN scores) and knee cartilage thickness, 1-year knee cartilage thinning (above smallest detectable change), presence of knee OA (KL grade ≥ 3), and progression of knee OA (KL change ≥ 1) by linear and logistic regression. Both hand OA features were included in a multivariate model (if p ≤ 0.25) adjusted for age, sex, and body mass index (BMI).Results.Hand JSN was associated with reduced knee cartilage thickness (ß = −0.02, 95% CI −0.03, −0.01) in the medial femorotibial compartment, while hand osteophytes were associated with the presence of radiographic knee OA (OR 1.10, 95% CI 1.03–1.18; multivariate models) with both hand OA features as independent variables adjusted for age, sex, and BMI). Radiographic features of hand OA were not associated with 1-year cartilage thinning or radiographic knee OA progression.Conclusion.Our results support a systemic OA susceptibility and possibly different mechanisms for osteophyte formation and cartilage thinning.

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Thigh Muscle Specific‐Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index

Arthritis Care & Research ◽

10.1002/acr.23182 ◽

2017 ◽

Vol 69 (8) ◽

pp. 1266-1270 ◽

Cited By ~ 13

Author(s):

Adam G. Culvenor ◽

David T. Felson ◽

Jingbo Niu ◽

Wolfgang Wirth ◽

Martina Sattler ◽

...

Keyword(s):

Body Mass Index ◽

Knee Osteoarthritis ◽

Body Mass ◽

Thigh Muscle ◽

Specific Strength

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Association of Thigh Muscle Strength With Knee Symptoms and Radiographic Disease Stage of Osteoarthritis: Data From the Osteoarthritis Initiative

Arthritis Care & Research ◽

10.1002/acr.22317 ◽

2014 ◽

Vol 66 (9) ◽

pp. 1344-1353 ◽

Cited By ~ 37

Author(s):

Anja Ruhdorfer ◽

Wolfgang Wirth ◽

Wolfgang Hitzl ◽

Michael Nevitt ◽

Felix Eckstein ◽

...

Keyword(s):

Muscle Strength ◽

Disease Stage ◽

Thigh Muscle ◽

Radiographic Disease ◽

Osteoarthritis Initiative

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Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-204157 ◽

2014 ◽

Vol 74 (7) ◽

pp. 1353-1359 ◽

Cited By ~ 66

Author(s):

Hans Liebl ◽

Gabby Joseph ◽

Michael C Nevitt ◽

Nathan Singh ◽

Ursula Heilmeier ◽

...

Keyword(s):

Relaxation Time ◽

Knee Osteoarthritis ◽

Case Control ◽

T2 Relaxation Time ◽

T2 Relaxation ◽

Knee Oa ◽

Osteoarthritis Initiative ◽

Nested Case Control ◽

Radiographic Knee Osteoarthritis

ObjectiveTo evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).Materials and methodsWe performed a nested case–control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren–Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case–control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates.ResultsBaseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared with controls and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values, particularly in the patella, adjusted OR per 1 SD increase in T2 (3.37 (95% CI 1.72 to 6.62)), but also in the medial femur (1.90 (1.07 to 3.39)), lateral femur (2.17 (1.11 to 4.25)) and lateral tibia (2.23 (1.16 to 4.31)).ConclusionsThese findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

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