Inhaled Steroids Do Not Decrease Bone Mineral Density But Increase Risk of Fractures: Data from the GIUMO Study Group

2006 ◽  
Vol 9 (2) ◽  
pp. 154-158 ◽  
Author(s):  
M. Sosa ◽  
P. Saavedra ◽  
C. Valero ◽  
N. Guañabens ◽  
X. Nogués ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Study Group ◽  
Mineral Density ◽  
Inhaled Steroids ◽  
Increase Risk ◽  
Decrease Bone Mineral Density

scholarly journals P707 Anti-TNFα therapy has no effect on bone mineral density in younger patients with inflammatory bowel disease: A single-centre observational study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S572-S572
Author(s):  
R Filip ◽  
S Jarmakiewicz - Czaja ◽  
D Piątek ◽  
J Sztembis ◽  
A Pękala ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mean Value ◽  
Study Group ◽  
Mineral Density ◽  
Left Femur ◽  
Entire Study ◽  
Treatment Groups ◽  
T Score ◽  
Active Inflammation

Abstract Background Active inflammation negatively affects bone mineral density. Biological treatment, among others silences the excessive reaction of the immune system, which can also reduce the risk of osteoporosis. The aim of the study is to determine whether bone mineral density is higher in patients with biological therapy. Methods In total, 112 patients over 18 years of age with CD (Crohn’s Disease) or UC (Ulcerative colitis) were included in the study. The mean value age was 35 years. Patients who had received anti-TNFα therapy (biosimilar infliximab CT-P13 or adalimumab), and who underwent densitometric evaluation after two year treatment, were selected. Those who had never received anti-TNFα therapy were selected as controls. Information regarding age, sex, weight, duration of CD, use of glucocorticoids and bisphosphonates, and signs of disease activity at the time of densitometric measurement were collected. Bone mineral density was measured by dual-energy X-ray absorptiometry (DEXA) within femoral neck and lumbar spine. Results are reported as g/cm2 and presented either as Z-score or as a T-score. Results The study group has characterised a mean value BMI (Body Mass Index)—24. The group of patients with anti-TNFαα therapy showed an average T-score left femur −0.7744 (CD) and −0.4382 (UC), but without anti-TNFα therapy −0.6636 (CD) and −0.2208 (UC). The entire study group showed a mean value t-score left femur of −0.54286. There were no significant statistical differences between the examined groups and the effect of anti-TNFα therapy on BMI, T-score left femur, T-score L2–L4 Conclusion The results of the preliminary study assessing the effect of anti-TNFα therapy on bone mineral density among the two treatment groups (CD and UC) do not indicate significant differences after the introduction of such therapy

BMI and gender increase risk of sacral fractures after multilevel instrumented spinal fusion compared with bone mineral density and pelvic parameters

2019 ◽  
Vol 19 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Stephan N. Salzmann ◽  
Courtney Ortiz Miller ◽  
John A. Carrino ◽  
Jingyan Yang ◽  
Jennifer Shue ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Spinal Fusion ◽  
Bone Mineral ◽  
Mineral Density ◽  
Sacral Fractures ◽  
Pelvic Parameters ◽  
Increase Risk ◽  
And Gender

Cost-effectiveness of inhaled steroids in asthma: Impact of effect on bone mineral density

2006 ◽  
Vol 117 (2) ◽  
pp. 359-366 ◽  
Author(s):  
Anne L. Fuhlbrigge ◽  
Seung Jin Bae ◽  
Scott T. Weiss ◽  
Karen M. Kuntz ◽  
A. David Paltiel
Keyword(s):  
Bone Mineral Density ◽  
Cost Effectiveness ◽  
Bone Mineral ◽  
Mineral Density ◽  
Inhaled Steroids

Anti-tumor Necrosis Factor Therapy Increased Spine and Femoral Neck Bone Mineral Density of Patients with Active Ankylosing Spondylitis with Low Bone Mineral Density

2015 ◽  
Vol 42 (8) ◽  
pp. 1413-1417 ◽  
Author(s):  
Haibo Li ◽  
Qiuxia Li ◽  
Xi Chen ◽  
Chen Ji ◽  
Jieruo Gu
Keyword(s):  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Tumor Necrosis ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Mineral Density ◽  
Necrosis Factor

Objective.To evaluate the effect of anti-tumor necrosis factor (TNF) therapy on bone mineral density (BMD) in patients with active ankylosing spondylitis (AS) with low BMD.Methods.Eighty-nine patients with active AS with low BMD were randomly divided into either a study group or a control group. The study group received etanercept (50 mg/week) or adalimumab (40 mg/2 week) subcutaneously for 1 year. BMD of lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry, and bone turnover markers serum C telopeptide of type-I collagen (sCTX) and serum procollagen type-I N propeptide (PINP) were detected by ELISA at baseline and at end of study.Results.After 1 year, compared with baseline, there was a significant increase in spine and femoral neck BMD by a mean ± SD of 14.9% ± 15.6% (p < 0.0001) and 4.7% ± 7.9% (p < 0.0001) in the study group. In the control group, there was a significant decrease in spine and femoral neck BMD by a mean ± SD of −8.6% ± 9.7% (p < 0.0001) and −9.8% ± 11.5% (p < 0.0001). Compared with baseline, sCTX was significantly decreased in the study group (−40% at 1 yr, p < 0.0001), but bone-specific alkaline phosphatase and PINP increased (45.6%, p < 0.0001 and 30.8%, p < 0.0001, respectively).Conclusion.In patients with active AS with low BMD, the spine and femoral neck BMD increased after anti-TNF therapy for 1 year, and it was accompanied by a significant decrease in bone resorption markers and an increase in bone formation markers.

scholarly journals The impact of low-dose glucocorticoids on disease activity, bone mineral density, fragility fractures, and 10-year probability of fractures in patients with rheumatoid arthritis

2018 ◽  
Vol 66 (6) ◽  
pp. 1004-1007 ◽  
Author(s):  
Tien-Tsai Cheng ◽  
Han-Ming Lai ◽  
Shan-Fu Yu ◽  
Wen-Chan Chiu ◽  
Chung-Yuan Hsu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Disease Activity ◽  
Bone Mineral ◽  
Clinical Characteristics ◽  
Low Dose ◽  
Control Group ◽  
Study Group ◽  
Mineral Density ◽  
The Impact

This study aimed to investigate the effect of low-dose glucocorticoids (LDGs) on disease activity, bone density, and fractures in patients with rheumatoid arthritis (RA). This was an interim analysis of the RA Registry. Demographic data and clinical characteristics, including fracture risk assessment tool, were collected. 25(OH) Vitamin D, bone mineral density (BMD), and intact parathyroid hormone were measured at enrollment. The study group were those who took LDGs (2.5–7.5 mg/day prednisolone or equivalent dose), and the others were included as the control group. A total of 425 participants were enrolled, including 85 (20%) in the control group and 340 (80%) in the study group. The demographics and clinical characteristics were comparable between the two groups. Compared with the control group, the LDGs group had a significantly lower vertebral BMD (L 1–4) (g/cm2), (0.854 vs 0.896, p=0.046), significantly higher rate of previous fractures (103 (30.3%) vs 13 (15.3%), p=0.006), higher 10-year probability of major fractures (14 (15.5) vs 8 (8.6), p<0.0001), and higher 10-year probability of hip fractures (4.4 (8.4) vs 2 (3.9), p<0.0001). Disease activity appeared to be similar in the patients with RA regardless of whether or not they received LDG treatment. However, the patients with RA who received LDG treatment had a lower BMD at the spine (L1–4) and a higher rate of previous fractures that was associated with a significantly higher 10-year probability of fractures than those who did not receive LDG treatment.

Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study

2021 ◽  
Vol 34 (4) ◽  
pp. 441-447
Author(s):  
Ismail Solmaz ◽  
Mehmet Akif Ozdemir ◽  
Ekrem Unal ◽  
Ummuhan Abdurrezzak ◽  
Sebahattin Muhtaroglu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Acute Lymphoblastic Leukemia ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Lymphoblastic Leukemia ◽  
Vitamin K2 ◽  
Control Group ◽  
Study Group ◽  
Mineral Density

Abstract Objectives Current treatment protocols in acute lymphoblastic leukemia (ALL) are associated with high remission rates and long life expectancy, enhancing the importance of quality of life and prevention of treatment-related complications in patient care. As osteoporosis is a frequent complication in patients under chemotherapy, we investigated the effect of vitamin K2 (100 mcg menaquinone-7) and vitamin D3 (10 mcg calcitriol) on bone metabolism in children with ALL. Methods Twenty-nine consecutive patients recently diagnosed with B precursor ALL (B-ALL) and treated according to the Turkish Acute Lymphoblastic Leukemia Berlin Frankfurt Münster 2000 protocol were randomly assigned into study and control groups. The study group (n=15, M/F: 8/7, age 1–14.5 years, mean 6.5 years) received vitamin K2 and vitamin D3 with their chemotherapy, while the control group (n=14, M/F 9/5, age 2–17 years, mean 7.1 years) received chemotherapy only. Serum calcium, phosphorus, magnesium, alkaline phosphatase, bone-specific alkaline phosphatase, uncarboxylated osteocalcin (ucOC), tartrate resistant acid phosphatase 5b, carboxyl terminal procollagen propeptide (PICP), osteoprotegerin (OPG), and receptor activator nuclear kappa B ligand (RANKL) were measured and bone mineral density (BMD) was determined at baseline and first, second, third and sixth months. Results The study group had higher serum OPG/RANKL ratio and lower ucOC levels compared to the control group at the first month; PICP levels were higher in the study group at second and third months. Conclusions These results suggest an early beneficial effect of the combination of vitamin K2 and vitamin D3 on BMD in ALL patients especially during the period of intensive steroid therapy in the first months.

Effect of Inhaled Steroids on Bone Mineral Density: A Meta-Analysis

2003 ◽  
Vol 43 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Pramod Kumar Sharma ◽  
Samir Malhotra ◽  
Promila Pandhi ◽  
Narinder Kumar
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Mineral Density ◽  
Inhaled Steroids
Sign in / Sign up

Export Citation Format

Share Document