scholarly journals High effective proteinaceous α-amylase inhibitors from grains and control release

LWT ◽  
2022 ◽  
pp. 113098
Author(s):  
Li Li ◽  
Qilei Fan ◽  
Wei Zhao
Keyword(s):  
Control Release ◽  
And Control ◽  
Amylase Inhibitors

Characteristics, phase behavior and control release for copolymer–liposome with both pH and temperature sensitivities

2012 ◽  
Vol 395 ◽  
pp. 225-232 ◽  
Author(s):  
Wenting Zhou ◽  
Xueqin An ◽  
Junzhi Wang ◽  
Weiguo Shen ◽  
Zhiyun Chen ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Control Release ◽  
And Control

scholarly journals Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

2020 ◽  
Vol 21 (16) ◽  
pp. 5832
Author(s):  
Agata Kowalczyk ◽  
Artur Kasprzak ◽  
Magdalena Poplawska ◽  
Monika Ruzycka ◽  
Ireneusz P. Grudzinski ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Drugs ◽  
Antitumor Effect ◽  
Control Release ◽  
Controlled Drug Release ◽  
Release Mechanism ◽  
Cytotoxicity Studies ◽  
Branched Polyethylenimine ◽  
And Control ◽  
A549 Lung

This work presents a new look at the application of cyclodextrins (CD) as a drug nanocarrier. Two different cyclodextrins (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). Here, we demonstrated that the combination of αCD and βCD enabled to load and control release of two anticancer drugs: doxorubicin (DOX) and beta-lapachone (beta-LP) (DOX in β-CD and beta-LP into α-CD) via host-guest inclusion. The PEI-βCD(DOX)-αCD-FA nanoconjugate was used to transport anticancer drugs into A549 lung cancer cells for estimation the cytotoxic and antitumor effect of this nanoconjugate. The presence of FA molecules should facilitate the penetration of studied nanoconjugate into the cell. Whereas, the non-cellular experiments proved that the drugs are released from the carrier mainly in the pH 4.0. The release mechanism is found to be anomalous in all studied cases.

scholarly journals Recent Developments in Delivery of MicroRNAs Utilizing Nanosystems for Metabolic Syndrome Therapy

2021 ◽  
Vol 22 (15) ◽  
pp. 7855
Author(s):  
Tong Li ◽  
Liye Zhu ◽  
Longjiao Zhu ◽  
Pengjie Wang ◽  
Wentao Xu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Therapeutic Potential ◽  
Control Release ◽  
Delivery Systems ◽  
Comprehensive Overview ◽  
Inflammatory Conditions ◽  
Increased Risk ◽  
Recent Developments ◽  
Target Effect ◽  
And Control

Metabolic syndrome (MetS) is a set of complex, chronic inflammatory conditions that are characterized by central obesity and associated with an increased risk of cardiovascular diseases. In recent years, microRNAs (miRNAs) have become an important type of endocrine factors, which play crucial roles in maintaining energy balance and metabolic homeostasis. However, its unfavorable properties such as easy degradation in blood and off-target effect are still a barrier for clinical application. Nanosystem based delivery possess strong protection, high bioavailability and control release rate, which is beneficial for success of gene therapy. This review first describes the current progress and advances on miRNAs associated with MetS, then provides a summary of the therapeutic potential and targets of miRNAs in metabolic organs. Next, it discusses recent advances in the functionalized development of classic delivery systems (exosomes, liposomes and polymers), including their structures, properties, functions and applications. Furthermore, this work briefly discusses the intelligent strategies used in emerging novel delivery systems (selenium nanoparticles, DNA origami, microneedles and magnetosomes). Finally, challenges and future directions in this field are discussed provide a comprehensive overview of the future development of targeted miRNAs delivery for MetS treatment. With these contributions, it is expected to address and accelerate the development of effective NA delivery systems for the treatment of MetS.

scholarly journals Niosomes as Nano-carrier Based Targeted Drug Delivery System

2021 ◽  
Vol 11 (4-S) ◽  
pp. 166-170
Author(s):  
Chanchal Joy ◽  
Smitha K. Nair ◽  
K Krishna Kumar ◽  
B Dineshkumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Control Release ◽  
Cell Tissue ◽  
Potential Applications ◽  
Targeted Drug ◽  
And Control ◽  
Targeted Drug Delivery System

Niosomes are considered as novel nano-carrier in the drug delivery systems. These are much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted and control release of medication. The drug is entrapped into lipid core so that it prevents the drug from leaching. Here the drug will be targeted only to the desired cell/tissue and not to the non-targeted cells. By giving this formulation we can thereby reduce the dose of the drug and toxicity. This review article mainly emphasizes on the potential applications of niosomes in targeted drug delivery system. Keywords: niosomes, nanocarriers, targeted drug delivery.

Silk fibroin nanoparticles for cellular uptake and control release

2010 ◽  
Vol 388 (1-2) ◽  
pp. 242-250 ◽  
Author(s):  
Joydip Kundu ◽  
Yong-Il Chung ◽  
Young Ha Kim ◽  
Giyoong Tae ◽  
S.C. Kundu
Keyword(s):  
Silk Fibroin ◽  
Cellular Uptake ◽  
Control Release ◽  
Silk Fibroin Nanoparticles ◽  
And Control

scholarly journals Synthesis of Pro Drug Polyester and Control Release

2017 ◽  
Vol 20 (1) ◽  
pp. 1-6
Author(s):  
Abeer Abd Alrazaak M. ◽  
Keyword(s):  
Control Release ◽  
And Control

scholarly journals A systematic review of encapsulation and control release technology in food application

2021 ◽  
pp. 292-296
Author(s):  
Awulachew Melaku Tafese
Keyword(s):  
Systematic Review ◽  
Functional Food ◽  
Review Paper ◽  
Control Release ◽  
Food Preservation ◽  
Factory Workers ◽  
Food Ingredients ◽  
Food Industries ◽  
And Control ◽  
Selection Of

This review paper is aims to give a brief description of encapsulation and control release technology in food preservation. Besides the material give potential information for those who interested for future development perspectives of the sector and also create awareness potentially for readers, traders, Students, factory workers, technologist and related stakeholder. the selection of encapsulating materials depends on the types, origins, and properties of these food ingredients. It is being increasingly popular in pharmaceutical, nutraceutical and functional food industries as a highly effective method that performs various functions; the major being prolonging the shelf-life of the active, masking the undesirable flavour, colour and taste and controlling the release of bioactive.

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