Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children: A cross-sectional study in Taiwan

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

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Low insulin-like growth factor 1 is associated with low high-density lipoprotein cholesterol and metabolic syndrome in Chinese nondiabetic obese children and adolescents: a cross-sectional study

Lipids in Health and Disease ◽

10.1186/s12944-016-0275-7 ◽

2016 ◽

Vol 15 (1) ◽

Cited By ~ 6

Author(s):

Shuang Liang ◽

Yanyan Hu ◽

Caihong Liu ◽

Jianhong Qi ◽

Guimei Li

Keyword(s):

Metabolic Syndrome ◽

Growth Factor ◽

High Density Lipoprotein ◽

Children And Adolescents ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional

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Physical fitness and psychological health in overweight/obese children: A cross-sectional study from the ActiveBrains project

Journal of Science and Medicine in Sport ◽

10.1016/j.jsams.2017.09.019 ◽

2018 ◽

Vol 21 (2) ◽

pp. 179-184 ◽

Cited By ~ 22

Author(s):

M. Rodriguez-Ayllon ◽

C. Cadenas-Sanchez ◽

I. Esteban-Cornejo ◽

J.H. Migueles ◽

J. Mora-Gonzalez ◽

...

Keyword(s):

Physical Fitness ◽

Psychological Health ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional

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Chemokine (C-C motif) Ligand 2 is a potential biomarker of inflammation & physical fitness in obese children: a cross-sectional study

BMC Pediatrics ◽

10.1186/1471-2431-13-47 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 10

Author(s):

M Constantine Samaan ◽

Joyce Obeid ◽

Thanh Nguyen ◽

Lehana Thabane ◽

Brian W Timmons

Keyword(s):

Physical Fitness ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Potential Biomarker

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P0165HYPERTENSION IN OVERWEIGHT AND OBESE CHILDREN: IMPACT ASSESMENT OF ABPM PARAMETERS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0165 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Diletta Apuzzo ◽

Luigi Annicchiarico Petruzzelli ◽

Serena Ascione ◽

Adele Corcione ◽

Deianira Pedoto ◽

...

Keyword(s):

Cross Sectional Study ◽

Overweight And Obesity ◽

White Coat Hypertension ◽

Masked Hypertension ◽

Z Score ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Prevention Methods ◽

The Relationship

Abstract Background and Aims We describe the relationship between overweight and obesity and Hypertension on ABPM. Method We conducted a cross-sectional study using a database of patients aged 6-16 years, who had undergone 24h ABPM from December 2002 through December 2016. ABPM were performed using the validated device Spacelab 90217. Were evaluated the 24h MAP, daytime MAP, nocturnal MAP, systolic and diastolic load, MAP Systolic and Diastolic. Subjects were grouped by BMI Z-score into overweight (>1<2), obese (BMI Z-score >2<3) and severe obese (BMI Z-score >3). A total of 1016 patients were enrolled and recorded n.1210 ABPMs. Obese pts were 202 (19.8%); 126 M;76F;median age 10,2 y. Overweight childrens were 97 (11.9%);52 M;45F;median age 8,4y. Results Among overweight childrens (BMI Z-Score >1<2): 12 (12.3%) had hypertension, 22 (22.6%) pre-hypertension, 15 (15.4%) MH; non dipping pattern was recorded in 26 (52%). 48 were normotensive. Among obese childrens, 122 had hypertension (60.3%): 24 pts had Masked Hypertension (19.6%); 72 (59.0%) had severe ambulatory hypertension with BMI z-score >3 (mean 3.8) ,and in this category all pts were both systolic and diastolic non dipping. 32 (64%) obese with BMI z-score >2, <3 were non-dipping. Diastolic load was significantly higher (p>0,0001) in severe obese. 28 pts had ambulatory prehypertension (13.8%), 11 pts had White Coat Hypertension (4.9%).41 pts had normotension (20.2%). Conclusion The severity of ambulatory hypertension increased with increased BMI Z-score. The non-dipping status is associated, not only with higher BMI Z-score, but was present in overweight and obese with BMI z-score >2<3 also. ABPM is an effective tool that should become routine in all obese patient, but also in overweight childrens, which may lead to better treatments and prevention methods.

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Association between obesity and lipid profile in children 10--12 years of age

Paediatrica Indonesiana ◽

10.14238/pi48.5.2008.257-60 ◽

2016 ◽

Vol 48 (5) ◽

pp. 257

Author(s):

Ruqoyatul Himah ◽

Endy P. Prawirohartono ◽

Madarina Julia

Keyword(s):

Body Mass Index ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Sectional Study ◽

Obese Children ◽

Cross Sectional ◽

Age And Gender ◽

Prevalence Of Obesity ◽

And Gender

Background Worldwide prevalence of obesity in children hasbeen increasing. Together with dyslipidemia and hypertension,obesity is associated with higher risk of cardiovascular morbiditylater in life.Objective The aim of this study was to assess associationbetween obesity and occurrence of dyslipidemia in 10-12 yearsold children.Methods We performed a cross sectional study on 53 obese and53 non-obese children matched for age and gender in Yogyakarta.Obesity was defined as body mass index (BMI) at or above the95th percentile of the CDC 2000 reference. The levels of totalcholesterol, LDL-cholesterol, HDL-cholesterol and triglyceridewere measured. Dyslipidemia was defined as increased level oftotal cholesterol, LDL-cholesterol, triglyceride and decreasedlevel of HDL-cholesterol.Results Obese children had higher risk of increased level oftriglyseride, i.e. RR 2.6 (95% CI 1.6 to 4.4), P<O.OOl anddecreased level ofHDL-cholesterol, i.e. RR 17.8 (95%CI 14.0 to20.1), P=0.003. Overall, relative risk for dyslipidemia in obesechildren was 5.2 (95%CI 4.2 to 5.9), P=0.002, higher than innon-obese children.Conclusion Compared to non-obese children, obese children havehigher risk of dyslipidemia, particularly hypertriglyceridemia andhypo-HDL.

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Is There Difference of BMD between Non-Obese and Obese Children? - A Cross-Sectional Study in 194 Thai Children

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.08.10085 ◽

2020 ◽

Vol 103 (8) ◽

pp. 804-808

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Bone Markers ◽

Cross Sectional Study ◽

Skeletal Age ◽

Obese Group ◽

Sectional Study ◽

Obese Children ◽

Mineral Density ◽

Cross Sectional

Objective: To find the correlation between the presence of childhood obesity and bone mineral density (BMD). Materials and Methods: A cross-sectional study was conducted among children aged between 5 and 12 years old. After excluding children who had history of endocrinopathy, epilepsy, or cerebral palsy, all participants were divided into “obese group” (body mass index [BMI] at or above the 95 percentile of those with the same age and gender) and “control group” (BMI below the 95 percentile). Skeletal age, BMD, serum bone markers (osteocalcin and beta-crosslaps), and physical exercise were collected. Multivariate regression analysis was used for statistical analysis. Results: Ninety-six obese children and 98 controls were included in the present study. The average BMI was 28.5 kg/m² in obese group, and 16.6±1.9 kg/m² in controls (p<0.001). BMDs of the spine and hip area were significantly higher in obese group compared to controls (p=0.002 and <0.001, respectively). However, there was no significant difference of skeletal age or serum bone markers level between both groups (p>0.05 all). Exercise was shown to significantly correlated with hip and distal radius BMD (p<0.001 and 0.003, respectively). Conclusion: Obese children had significantly higher spine and hip BMD than non-obese children. Nevertheless, there were no differences between groups regarding skeletal age and bone markers. BMI and exercise activity might play an important role in higher BMD in children. Keywords: Bone mineral density, Children obesity

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