To bee or not to bee? The bee extract propolis as a bioactive compound in the burden of lifestyle diseases

Background: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and long noncoding RNAs (lncRNAs), play significant regulatory roles in plant development and secondary metabolism and are involved in plant response to biotic and abiotic stresses. They have been intensively studied in model systems and crops for approximately two decades and massive amount of information have been obtained. However, for medicinal plants, ncRNAs, particularly their regulatory roles in bioactive compound biosynthesis, are just emerging as a hot research field. Objective: This review aims to summarize current knowledge on herbal ncRNAs and their regulatory roles in bioactive compound production. Results and Conclusion: So far, scientists have identified thousands of miRNA candidates from over 50 medicinal plant species and 11794 lncRNAs from Salvia miltiorrhiza, Panax ginseng, and Digitalis purpurea. Among them, more than 30 miRNAs and five lncRNAs have been predicted to regulate bioactive compound production. The regulation may achieve through various regulatory modules and pathways, such as the miR397-LAC module, the miR12112-PPO module, the miR156-SPL module, the miR828-MYB module, the miR858-MYB module, and other siRNA and lncRNA regulatory pathways. Further functional analysis of herbal ncRNAs will provide useful information for quality and quantity improvement of medicinal plants.

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An Overview of Nano formulated Nutraceuticals and its therapeutic approaches

Current Nutrition & Food Science ◽

10.2174/1573401316999200901120458 ◽

2020 ◽

Vol 16 ◽

Author(s):

Shaoli De ◽

Agraharam Gopikrishna ◽

Vedhantham Keerthana ◽

Agnishwar Girigoswami ◽

Koyeli Girigoswami

Keyword(s):

Diabetes Mellitus ◽

Food Habits ◽

Health Effect ◽

Antioxidant Properties ◽

Therapeutic Approaches ◽

Nutraceutical Compounds ◽

Current Review ◽

The People ◽

Lifestyle Diseases ◽

Herbal Formulations

Background: Economic development and vast changes in food habits have accelerated the consumption of junk foods which are the leading causes of several disorders that turns majority of the people to use various herbal formulations or drugs for preventing various lifestyle diseases. Nutraceuticals are the borderline apparatus between nutrients and drugs that provides supplementation of particular nutrient with favorable health effect. Objective: Various nutraceutical compounds like vitamins, spices, polyphenols, prebiotics and probiotics in the form of powders, tablets, capsules are currently marketed globally. Among them previous literatures have reported that polyphenols are the most promising compounds that have been proven to treat various chronic diseases like cancer, hypertension, diabetes mellitus (DM), osteoporosis, osteoarthritis, dyslipidemia, multiple sclerosis, congenital anomalies, Alzheimer’s disease, etc. It is warranted to discuss about the benefits of nanoformulations of nutraceuticals. Methods: We have searched PubMed using the keywords nutraceuticals, nanoformulations, therapeutic approaches, bionanotechnology, and therapeutics. The relevant papers and classical papers in this field were selected to write this review. Results and Discussion: The different classifications of nutraceuticals were elaborately described in this review. The comparison between the different categories of nutraceuticals with their nanoformulated forms was done explaining the benefits of nanoformulations regarding stability, bioavailability, enhanced antioxidant properties etc. A glimpse on the drawbacks of nanoformulations were also included. Conclusion: The current review highlights an overview of various nanoformulated nutraceuticals and its approach towards the treatment of multiple diseases.

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Different Carotenoid Enrichment in Two Climacteric Fruits after Post- Harvest UV-B Treatment

Current Bioactive Compounds ◽

10.2174/1573407214666180807114449 ◽

2020 ◽

Vol 16 (2) ◽

pp. 102-108

Author(s):

Carolina F. Assumpção ◽

Médelin M. da Silva ◽

Vanessa S. Hermes ◽

Annamaria Ranieri ◽

Ester A. Ferreira ◽

...

Keyword(s):

Bioactive Compound ◽

Ultraviolet B ◽

Low Flow ◽

Control Treatment ◽

Carotenoid Content ◽

Post Harvest ◽

Beneficial Effects ◽

Fruit Skin ◽

Compound Synthesis ◽

Viable Method

Background: Ultraviolet B (UV-B) radiation is a promising and environmentally friendly technique, which in a low flow rate, can induce bioactive compound synthesis. This work aimed at evaluating the effectiveness of post-harvest UV-B treatment in order to improve carotenoid content in climacteric fruits like persimmon and guava fruits. Methods: The fruits were harvested at commercial maturity and placed into climatic chambers equipped with UV-B lamps. For control treatment, the UV-B lamps were covered by a benzophenone film, known to block the radiation. This radiation was applied during 48 hours and fruits were sampled at 25, 30 and 48 hours of each treatment. HPLC analysis was performed to separate and identify carotenoid compounds from fruit skin after a saponification process. Results: Fruit from 30 hours treatment began to present a carotenoid accumulation since the majority of analyzed compounds exhibited its synthesis stimulated from this time on. In persimmon skin, it was observed that the maximum content was reached after 48 hours of UV-B treatment. Conclusion: These results suggest that this post-harvest UV-B treatment can be an innovative and a viable method to induce beneficial effects on guava and mainly on persimmon fruit.

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A Cytotoxic Natural Product from Patrinia villosa Juss

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520619666190416101014 ◽

2019 ◽

Vol 19 (11) ◽

pp. 1399-1404 ◽

Cited By ~ 1

Author(s):

Yangcheng Liu ◽

Wei Liu ◽

Changlan Chen ◽

Zheng Xiang ◽

Hongwei Liu

Keyword(s):

Cell Cycle ◽

Cell Lines ◽

Silica Gel ◽

Column Chromatography ◽

Bioactive Compound ◽

Antitumor Agent ◽

2D Nmr ◽

Preparative Hplc ◽

Dependent Manner ◽

2D Nmr Spectra

Background and Purpose:: Patrinia villosa Juss is an important Chinese herbal medicine widely used for thousands of years, but few reports on the ingredients of the herb have been presented. In this study, we aim to isolate the bioactive compound from the plant. Material and Methods:: The air-dried leaves of P. villosa (15kg) were extracted three times with 70% EtOH under reflux. The condensed extract was suspended in H2O and partitioned with light petroleum, dichloromethane and n-BuOH. The dichloromethane portion was then subjected to normal-phase silica gel column chromatography, ODS silica gel column chromatography and semi-preparative HPLC to yield compound 1. Cytotoxicities of 1 were assayed on HepG2, A549 and A2780 cell lines. The mechanism of apoptosis and cell cycle on A549 was confirmed subsequently. Results: A new impecylone (Impecylone A) was isolated from the leaves of Patrinia villosa Juss, and its structures were established using 1D, 2D-NMR spectra and HR-ESI-MS. Impecylone A could selectivity inhibit HepG2 and A549 cell lines. The compound could induce apoptosis of A549 and arrest the cell cycle at G2/M phase in a dose-dependent manner. Conclusion: Impecylone A is a novel compound from Patrinia villosa Juss and could be a potential antitumor agent especially in the cell lines of A549.

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Enhanced Anticancer Activity and Apoptosis Effect of Bioactive Compound Quercetin Extracted from Ocimum sanctum Leaves

Current Nanomedicine ◽

10.2174/2468187310999201117155414 ◽

2020 ◽

Vol 10 ◽

Author(s):

Amutha Santhanam ◽

Naveen Kumar Chandrasekharan ◽

Rajangam Ilangovan

Keyword(s):

Cell Cycle ◽

Anticancer Activity ◽

Cancer Cells ◽

Leaf Extract ◽

Nickel Nanoparticles ◽

Bioactive Compound ◽

Cell Cycle Analysis ◽

Ocimum Sanctum ◽

Sem Images ◽

Ft Ir

Background: The occurrence of Cancer results in cellular changes that causes the uncontrolled growth and division of cells. Apoptosis removes cells during development and eliminates the potentially cancerous cells. The bioactive compounds present in the herbal plant shows cytotoxic activity that result in apoptosis. The traditional herbal plants are used world-wide both in allopathy and other traditional ways. Objective: The main objective of this study is to extract the bioactive compound Quercetin from the medicinally significant plant Ocimum sanctum and also to develop nanomedicine as Qu-PEG-NiGs. Materials and Methods: Leaf extract of the medicinally significant plant Ocimum sanctum (O. sanctum) has been used for the synthesis of nickel nanoparticles (NiGs) and extraction of quercetin (Qu). The ethanolic extract of Ocimum sanctum is added to 1 mM Nickel Nitrate (Ni(NO3)2) and stirred for 3 hrs at RT and dried at 60°C for 3hrs and calcinated at 400°C for 2hrs and characterized using Uv-Vis Spectrophotometer, FT-IR, SEM, DLS and Zeta potential. The Quercetin is isolated from Ocimum sanctum leaf extract using the reflux condenser method. The bio-polymer is being PEG-coated over NiGs and Quercetin is loaded into it. The apoptosis activity using MCF-7 cells is performed with Qu-PEG-NiGs. The purity of Quercetin is characterized using HPLC. In order to analyse apoptosis efficiency, MTT assay, Reactive Oxygen Species (ROS), Cell cycle analysis has been performed. Results: The NiGs absorption spectrum gives a peak at 408nm. The FT-IR confirms the presence of particular functional groups shifting from the compound NiGs and then coated with PEG-Qu-NiGs. The SEM images show the size of NiGs ranging from 27.3 nm to 40.4 nm with varied morphology such as hexagonal and other irregular shapes. The presence of Quercetin extracted from the leaf powder is approximately 1.5 mg/g. The ROS results show the Qu-PEG-NiGs induced efficiency of the apoptosis, while the increased concentrations promote ROS and lead to activation of the apoptosis. The cell cycle analysis has shown the cytotoxic effect. Conclusion: PEG-coated nickel nanoparticles can be used as a promising chemotherapeutic agent against MCF7 breast cancer cells. It is the evidence to further studies for evaluating Qu-PEG-NiGs anticancer activity on different types of cancer cells.

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Yoga as an Innovative Solution for Financial Growth of Companies

Purushartha - A Journal of Management Ethics and Spirituality ◽

10.21844/pajmes.v11i1.14612 ◽

2018 ◽

Vol 11 (1) ◽

Author(s):

Ipseeta Satpathy ◽

B. Chandra Mohan Patnaik ◽

Chandrabhanu Das

Keyword(s):

Inventory Management ◽

Internal Control ◽

Positive Impact ◽

Cost Savings ◽

Well Being ◽

Primary Data ◽

Financial Health ◽

Antibiotic Drugs ◽

Lifestyle Diseases ◽

The Impact

The existence of Yoga dates back to more than ten thousand years around India and all nations. The Hindu Mythology considers the genesis of Yoga by incorporating Lord Shiva as Guru and Goddess Parvati as Shishya. Gradually with the development of civilization mankind assessed the benefits of this spiritual discipline and different leaders propagated the Yoga in different ways.In this era of 21st century Baba Ramdev propagated the yoga sutras with simple and effective techniques. The Pranayam and Suryanamaskar are the popular routines practiced by many followers of Baba Ramdev. Today Yoga is practiced as a way of Living to prevent Lifestyle diseases, combat stress and rejuvenate self. Yoga has gained immense popularity over the years with July 21st being celebrated as International Yoga Day. Corporate are also now introducing Yoga for employees as a means to relieve their stress and improve productivity. Long Hours of sitting, standing and excessive use of electronic gadgets puts pressure on bones, joints and responsible for Lifestyle diseases. Yoga is now increasingly used as a wellness solution replacing high cost antibiotic drugs. Employee well-being leads to Cost Savings in terms of personnel by reduced payment of Insurance and Medical Bills. The paper studies the Impact of Yoga to Financial benefits in MSME Organizations in Odisha in light of three different perspectives of Internal Control, Inventory management and Cash Flow. The primary data was collected from a sample of 155 high profile finance executives working in the MSME sector. Ranking Table and Regression Analysis Methodology was used to derive meaningful conclusions. The research takes initiative to transform the effectiveness of Yoga into improved financial health for the Organization. The observation from the study interprets a positive impact of Yoga on good financial health of Organization.

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Determinants of Co-creative Behaviour of Patients: A Case Study in Jammu

International Journal on Customer Relations ◽

10.21863/ijcr/2016.4.1.015 ◽

2016 ◽

Vol 4 (1) ◽

Cited By ~ 1

Author(s):

Jyoti Sharma ◽

Lata Raj ◽

Anil Gupta

Keyword(s):

Customer Value ◽

Research Area ◽

Point Of View ◽

Customer Participation ◽

Citizenship Behavior ◽

Future Research ◽

Creative Behavior ◽

Customer Profiling ◽

Customer Citizenship Behavior ◽

Lifestyle Diseases

The purpose of this study is to measure the existence of co-creation behavior between doctors and patients. The research also studies customer participation and customer citizenship behavior as the dimensions of co-creative behavior and tries to establish the relationship between co-creative behavior and satisfaction. This study uses Yi and Gong (2013) scale for collecting data regarding co-creation behavior and its dimensions which are customer participation (CP) and customer citizenship behavior (CCB). The data was collected from 204 patients who were suffering from various chronic/lifestyle diseases and getting their treatment from private clinics in Jammu city. The study uses 7-point Likert scale in the questionnaire ranging from 1 completely disagree through 7 completely agree, with a midpoint labeled 4 neither agree nor disagree. The analysis of paper reflects that co-creation behavior is prevalent among the patients and not only participation but the citizenship behavior also affects the co-creation behavior of patients. The study is conducted from patients point of view whereas doctors perspective should also be used in future research. The research area is restricted to Jammu city only. The research provides several implications-doctors can also use this scale for market segmentation and customer profiling for maximizing customer value co-creation behavior by gaining the useful information.

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Analyzing the Impact of Healthy Behavior on Weight Change with a Provable Mathematical Model (Preprint)

10.2196/preprints.25201 ◽

2020 ◽

Author(s):

Ayan Chatterjee ◽

Ram Bajpai ◽

Pankaj Khatiwada

Keyword(s):

Physical Activity ◽

Mathematical Model ◽

Health Behavior ◽

Weight Change ◽

Simulated Data ◽

Negative Behavior ◽

Healthy Behavior ◽

Healthy Habits ◽

Lifestyle Diseases ◽

The Impact

BACKGROUND Lifestyle diseases are the primary cause of death worldwide. The gradual growth of negative behavior in humans due to physical inactivity, unhealthy habit, and improper nutrition expedites lifestyle diseases. In this study, we develop a mathematical model to analyze the impact of regular physical activity, healthy habits, and a proper diet on weight change, targeting obesity as a case study. Followed by, we design an algorithm for the verification of the proposed mathematical model with simulated data of artificial participants. OBJECTIVE This study intends to analyze the effect of healthy behavior (physical activity, healthy habits, and proper dietary pattern) on weight change with a proposed mathematical model and its verification with an algorithm where personalized habits are designed to change dynamically based on the rule. METHODS We developed a weight-change mathematical model as a function of activity, habit, and nutrition with the first law of thermodynamics, basal metabolic rate (BMR), total daily energy expenditure (TDEE), and body-mass-index (BMI) to establish a relationship between health behavior and weight change. Followed by, we verified the model with simulated data. RESULTS The proposed provable mathematical model showed a strong relationship between health behavior and weight change. We verified the mathematical model with the proposed algorithm using simulated data following the necessary constraints. The adoption of BMR and TDEE calculation following Harris-Benedict’s equation has increased the model's accuracy under defined settings. CONCLUSIONS This study helped us understand the impact of healthy behavior on obesity and overweight with numeric implications and the importance of adopting a healthy lifestyle abstaining from negative behavior change.

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