An Overview of Nano formulated Nutraceuticals and its therapeutic approaches

2020 ◽  
Vol 16 ◽  
Author(s):  
Shaoli De ◽  
Agraharam Gopikrishna ◽  
Vedhantham Keerthana ◽  
Agnishwar Girigoswami ◽  
Koyeli Girigoswami
Keyword(s):  
Diabetes Mellitus ◽  
Food Habits ◽  
Health Effect ◽  
Antioxidant Properties ◽  
Therapeutic Approaches ◽  
Nutraceutical Compounds ◽  
Current Review ◽  
The People ◽  
Lifestyle Diseases ◽  
Herbal Formulations

Background: Economic development and vast changes in food habits have accelerated the consumption of junk foods which are the leading causes of several disorders that turns majority of the people to use various herbal formulations or drugs for preventing various lifestyle diseases. Nutraceuticals are the borderline apparatus between nutrients and drugs that provides supplementation of particular nutrient with favorable health effect. Objective: Various nutraceutical compounds like vitamins, spices, polyphenols, prebiotics and probiotics in the form of powders, tablets, capsules are currently marketed globally. Among them previous literatures have reported that polyphenols are the most promising compounds that have been proven to treat various chronic diseases like cancer, hypertension, diabetes mellitus (DM), osteoporosis, osteoarthritis, dyslipidemia, multiple sclerosis, congenital anomalies, Alzheimer’s disease, etc. It is warranted to discuss about the benefits of nanoformulations of nutraceuticals. Methods: We have searched PubMed using the keywords nutraceuticals, nanoformulations, therapeutic approaches, bionanotechnology, and therapeutics. The relevant papers and classical papers in this field were selected to write this review. Results and Discussion: The different classifications of nutraceuticals were elaborately described in this review. The comparison between the different categories of nutraceuticals with their nanoformulated forms was done explaining the benefits of nanoformulations regarding stability, bioavailability, enhanced antioxidant properties etc. A glimpse on the drawbacks of nanoformulations were also included. Conclusion: The current review highlights an overview of various nanoformulated nutraceuticals and its approach towards the treatment of multiple diseases.

scholarly journals Implications of Dietary Vegetables on Glycemic Control- A Mechanistic Review

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1130-1139
Author(s):  
Syed Sagheer Ahmed ◽  
Rupesh Kumar M ◽  
Rajesh Kowti ◽  
Ramesh B
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Transporter ◽  
Antioxidant Properties ◽  
Good Health ◽  
Diabetic Patients ◽  
Peroxisome Proliferator ◽  
Dietary Fibres ◽  
The People

The global prevalence of diabetes mellitus is increasing day by day. Despite using synthetic anti-diabetic agents, diabetic patients must modify their lifestyle, including routine diet. Vegetables are the adequate source of vitamins, dietary fibres, minerals and Phytoconstituents. Use of vegetables is growing among the people as a part of the diet. They, with their antioxidant properties, can maintain good health and reduce the risk of chronic diseases. Besides, they contain many dietary fibres that are anti-diabetic. The constituents present in these vegetables help to reduce blood glucose level through several mechanisms such as alpha-amylase and alpha-glucosidase enzyme inhibition, Dipeptidyl peptidase IV (DPP IV) inhibition, enhancing the expression of peroxisome proliferator activator receptor gamma (PPAR) γ and glucose transporter 4 (GLUT4). Therefore the people must consume such vegetables with the proper knowledge to control diabetes mellitus and its complications. Hence the present review focuses on summarizing in vitro and in vivo  anti-diabetic activity of most common dietary vegetables.

scholarly journals Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 323
Author(s):  
Subrat Kumar Bhattamisra ◽  
Hui Min Koh ◽  
Shin Yean Lim ◽  
Hira Choudhury ◽  
Manisha Pandey
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Complications ◽  
Inflammatory Markers ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Beneficial Effects ◽  
Ppar Γ ◽  
High Glucose Condition ◽  
Anti Inflammatory

Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against many disorders. This review appraises the key molecular pathways of catalpol against diabetes mellitus and its complications. Multiple search engines including Google Scholar, PubMed, and Science Direct were used to retrieve publications containing the keywords “Catalpol”, “Type 1 diabetes mellitus”, “Type 2 diabetes mellitus”, and “diabetic complications”. Catalpol promotes IRS-1/PI3K/AKT/GLUT2 activity and suppresses Phosphoenolpyruvate carboxykinase (PEPCK) and Glucose 6-phosphatase (G6Pase) expression in the liver. Catalpol induces myogenesis by increasing MyoD/MyoG/MHC expression and improves mitochondria function through the AMPK/PGC-1α/PPAR-γ and TFAM signaling in skeletal muscles. Catalpol downregulates the pro-inflammatory markers and upregulates the anti-inflammatory markers in adipose tissues. Catalpol exerts antioxidant properties through increasing superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gsh-px) activity in the pancreas and liver. Catalpol has been shown to have anti-oxidative, anti-inflammatory, anti-apoptosis, and anti-fibrosis properties that in turn bring beneficial effects in diabetic complications. Its nephroprotective effect is related to the modulation of the AGE/RAGE/NF-κB and TGF-β/smad2/3 pathways. Catalpol produces a neuroprotective effect by increasing the expression of protein Kinase-C (PKC) and Cav-1. Furthermore, catalpol exhibits a cardioprotective effect through the apelin/APJ and ROS/NF-κB/Neat1 pathway. Catalpol stimulates proliferation and differentiation of osteoblast cells in high glucose condition. Lastly, catalpol shows its potential in preventing neurodegeneration in the retina with NF-κB downregulation. Overall, catalpol exhibits numerous beneficial effects on diabetes mellitus and diabetic complications.

Potential therapeutic approaches in paraquat poisoning: a narrative review

2021 ◽  
Author(s):  
Amir Ghabousian ◽  
Saeed Safari ◽  
Niloufar Ansari
Keyword(s):  
Signaling Pathways ◽  
Cell Injury ◽  
Clinical Course ◽  
Medical Condition ◽  
Case Fatality ◽  
Therapeutic Approaches ◽  
Traditional Treatment ◽  
Current Review ◽  
Novel Therapeutic Strategies ◽  
Cell Signaling Pathways

Paraquat dichloride (PQ) poisoning is a relatively rare yet critical medical condition that has a high case fatality rate. Lung tissue is highly susceptible to PQ-induced injury, and respiratory failure is the leading cause of death in these patients. Unfortunately, there is a lack of an effective therapeutic approach to ameliorate outcomes. It is well-known that PQ interferes with a variety of cell signaling pathways and induces the generation of reactive oxygen species (ROS), which ultimately results in cell injury. The traditional treatment decisions have not been able to significantly change the clinical course of PQ poisoning. Moreover, novel therapeutic strategies for PQ poisoning have centered on the inhibition of PQ-induced signaling pathways. In the current review, we sought to provide a bird’s-eye view of the available therapeutic approaches in patients with PQ poisoning.

Newer therapeutic approaches towards the management of diabetes mellitus: an update

2019 ◽  
Author(s):  
Heng L. Lin ◽  
Fathin N. Mohamed Shukri ◽  
Eric S. Yih ◽  
Grace H. Sha ◽  
Grace S. Jing ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Therapeutic Approaches

scholarly journals Aortic stenosis and diabetes mellitus: An ominous combination

2019 ◽  
Vol 16 (4) ◽  
pp. 310-323 ◽  
Author(s):  
Marko Banovic ◽  
Lavanya Athithan ◽  
Gerry P McCann
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Aortic Stenosis ◽  
Therapeutic Approach ◽  
Severe Aortic Stenosis ◽  
Significant Morbidity ◽  
Therapeutic Approaches ◽  
The Relationship ◽  
Insight Into

Aortic stenosis and diabetes mellitus are both progressive diseases which, if left untreated, result in significant morbidity and mortality. There is evidence that the prevalence of diabetes is substantially increased in patients with aortic stenosis and those with diabetes have increased rates of progression from mild to severe aortic stenosis. There are good data supporting the hypothesis that aortic stenosis and diabetes mellitus are associated with diabetes mellitus being detrimental towards the quality of life and survival of patients. Thus, a thorough understanding of the pathogenesis of both of these disease processes and the relationship between them aids in designing appropriate preventive and therapeutic approaches. This review aims to give a comprehensive and up-to-date insight into the influence of diabetes mellitus on patients with degenerative aortic stenosis, as well as the prognosis and therapeutic approach to these patients.

scholarly journals Comparative Study on the Nutritional and Antioxidant Components of Fruit Parts of Citrullus lanatus

2020 ◽  
pp. 39-51
Author(s):  
Stanley Kanayochukwu Nnenne ◽  
Kingsley Ikechukwu Ubaoji ◽  
Uchechukwu Chibuzo Ogbodo ◽  
Victor Henry Azubuike Enemor ◽  
Adebayo Afees Oladejo
Keyword(s):  
Citrullus Lanatus ◽  
Antioxidant Properties ◽  
Reducing Power ◽  
Proximate Analysis ◽  
Nutritional Composition ◽  
The People ◽  
Dpph Scavenging Activity ◽  
Student’S T ◽  
Dpph Scavenging ◽  
Student’S T Test

Aim: Citrullus lanatus is a fruit widely consumed for its pulp though incompletely, as its other parts (seed and rind) are discarded and may possibly offer bioactive compounds involved in ameliorating certain disease conditions. Hence, this study aimed at comparatively investigating the nutritional composition and antioxidant properties of the seed, pulp and rind of C. lanatus so as to inform the inclusion of these different parts into the fare of the people. Methodology: Standard analytical methods of Association of Official Analytical Chemists were used to determine proximate, phytochemical, vitamin, mineral and antioxidant aspects of the fruit parts. The results were analyzed using Student’s t-test at .05. Results: The proximate analysis showed a high moisture value in the pulp (93.34 +/- .82) followed by the rind (77.11 +/- 3.44) and the seed (10.00 +/- .48). High crude protein and fiber contents were both noted in the seed followed by the rind and pulp. Mineral determinations revealed potassium to be abundant in the rind (452.31mg/kg) than the seed (305.7mg/kg) and the pulp (100.5mg/kg), followed by calcium occurring more in the rind (292.61mg/kg) than in the pulp (257.21mg/kg) and seed (227.45mg/kg) and then manganese being the least concentrated among the minerals. The investigated phytochemical principles revealed the highest concentration of cardiac glycosides in the seed (14.82 +/- .66) than the rind (1.95 +/- 0.80) and pulp (1.10 +/- 0.17), followed by saponins occurring most in the rind (12.05 +/- 3.91) than the seed (10.17 +/- 0.63) and pulp (.13 +/- .01). The seed had the highest DPPH scavenging activity followed by the rind and pulp respectively. The seed also showed a higher reducing power and lipid peroxidation capacities than the other fruit parts suggesting a potent property for antioxidant activity in the fruit parts of C. lanatus. Conclusion: The findings imply that both seed and rind of C. lanatus can be good sources of nutritional, phytochemical and antioxidant components in addition to the pulp which is commonly consumed and these may be implicated in management of certain diseases with further evidential research.

scholarly journals Health Education; The Comparison Between With Leaflet and Video Using Local Language In Improving Teenager’s Knowledge of Adverse Health Effect of Smoking

2020 ◽  
Vol 7 (1) ◽  
pp. 48-51
Author(s):  
Abdullah Abdullah ◽  
Andan Firmansyah ◽  
Asri Aprilia Rohman ◽  
Nurisriani Najamuddin ◽  
Rahmayanti Puang Kuma
Keyword(s):  
Health Education ◽  
Health Effects ◽  
Health Effect ◽  
Wilcoxon Test ◽  
Young Generation ◽  
Adverse Health Effect ◽  
Local Language ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
The People

Smoking is a usual activity that we always find in our society, although most of the people know the danger of it, the habit of smoking still can be found in a big amount in our society, especially in the teenage area, whose stand in the biggest amount of smoker in Indonesia in this present. Health education changes attitude of young generation through knowledge, which is influence by several elements, such as delivered information, manner or props used, and language. The purpose of this research was to identify the comparison of leaflets and videos using local language to improve knowledge of the adverse health effects of smoking in the teenager. This research used the Quasi Experiment design with Pretest and Posttest Two Group of 120 respondents. The questionnaire used to examine the knowledge of respondents. The result using the Wilcoxon test showed that leaflet and video with local language are equally effective to increase knowledge of respondents of the health effects of smoking(p= -0.000), mean score after intervention by using the local language leaflet is 1.98, and mean score by using local language video is 2.32. So, local video is more effective to improve the knowledge of teenagers about the danger of smoking than the use of local language leaflets.

scholarly journals Type 2 diabetes mellitus: time to change the concept

2013 ◽  
Vol 16 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Shmuel Levit ◽  
Yury Ivanovich Filippov ◽  
A S Gorelyshev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Heterogeneous Group ◽  
Therapy Goals ◽  
Current Review ◽  
The Common ◽  
Contemporary Approach

Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach. Current review discusses key pathogenic features of type 2 diabetes mellitus that determine therapy goals and options in management. We further enunciate and pathogenetically substantiate a new "gravicentric" concept for treatment of type 2 diabetes mellitus that differs in many ways from the common contemporary approach.

scholarly journals Perceptions on Diet and Dietary Modifications during Postpartum Period Aiming at Attenuating Progression of GDM to DM: A Qualitative Study of Mothers and Health Care Workers

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Thamudi D. Sundarapperuma ◽  
Champa J. Wijesinghe ◽  
Priyadarshika Hettiarachchi ◽  
Sudharshani Wasalathanthri
Keyword(s):  
Diabetes Mellitus ◽  
Health Care ◽  
Health Care Workers ◽  
Postpartum Period ◽  
Food Habits ◽  
Later Life ◽  
Dietary Recommendations ◽  
Financial Barriers ◽  
Care Workers ◽  
History Of

Background. Gestational diabetes mellitus (GDM) is a global concern. GDM mothers have a 7-fold relative risk of developing type 2 diabetes mellitus (T2DM) in their later life. User-friendly and culturally acceptable dietary interventions can minimize this risk. Therefore, this study aims at exploring the perceptions of GDM mothers and health care workers regarding factors that influence postpartum dietary practices aimed at attenuating the trajectory from GDM to DM. Methods. The study was conducted in selected MOH areas in three districts of Sri Lanka. Six focus group discussions were conducted with thirty mothers with a history of GDM and six in-depth interviews with six health care workers. The phenomenon of interest was to obtain inputs of two stakeholder groups on healthy food habits of GDM mothers during the postpartum period. Framework analysis was used to analyse the data. Data were coded using the analytical framework, abstracted from transcripts, and summarized verbatim in Microsoft Excel in a matrix comprised of one row per participant and one column per code. Finally, the matrix was reviewed intensely and themes were generated. Results. Overall, seven themes emerged from both cases: (1) myths and traditions specific to the postpartum period, (2) lack of motivation, (3) time pressure, (4) financial barriers, (5) negligence of mothers and families, (6) lack of awareness regarding GDM and its postpartum dietary recommendations, and (7) cultural barriers. Conclusions. This study provides an insight into the existing knowledge, common practices, and attitudes regarding food habits among postpartum mothers with a history of GDM. Since the postpartum period is unique, identifying barriers is crucial when introducing dietary modification protocols in order to prevent or attenuate the progression of GDM to T2DM in these mothers. The knowledge gained will be used to introduce feasible, scientifically sound, and culturally acceptable postpartum dietary recommendations for GDM mothers.

scholarly journals Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

Diabetologia ◽  
2020 ◽  
Vol 63 (10) ◽  
pp. 2205-2217 ◽  
Author(s):  
Ashton Faulkner ◽  
Anita Tamiato ◽  
William Cathery ◽  
Andrea Rampin ◽  
Carlo Maria Caravaggi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mitochondrial Function ◽  
Myogenic Differentiation ◽  
Tricarboxylic Acid Cycle ◽  
Antioxidant Properties ◽  
Vascular Complications ◽  
Redox Balance ◽  
Metabolic Enzyme ◽  
Antioxidant Systems ◽  
Limb Muscles

Abstract Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular patients with diabetes mellitus display elevated levels of oxidative stress causing a dysfunctional phenotype. Here, we investigated whether treatment with dimethyl-2-oxoglutarate (DM-2OG), a tricarboxylic acid cycle metabolite with antioxidant properties, can restore a healthy metabolic and functional phenotype. Methods MPs were isolated from limb muscles of diabetes patients with vascular disease (D-MPs) and from non-diabetic control participants (ND-MPs). Metabolic status was assessed in untreated and DM-2OG-treated (1 mmol/l) cells using an extracellular flux analyser and anion-exchange chromatography–mass spectrometry (IC-MS/MS). Redox status was measured using commercial kits and IC-MS/MS, with antioxidant and metabolic enzyme expression assessed by quantitative RT-PCR and western blotting. Myogenic differentiation and proliferation and pericyte–endothelial interaction were assessed as functional readouts. Results D-MPs showed mitochondrial dysfunction, suppressed glycolytic activity and reduced reactive oxygen species-buffering capacity, but no suppression of antioxidant systems when compared with ND-MP controls. DM-2OG supplementation improved redox balance and mitochondrial function, without affecting glycolysis or antioxidant systems. Nonetheless, this was not enough for treated D-MPs to regain the level of proliferation and myogenic differentiation of ND-MPs. Interestingly, DM-2OG exerted a positive effect on pericyte–endothelial cell interaction in the co-culture angiogenesis assay, independent of the diabetic status. Conclusions/interpretation These novel findings support the concept of using DM-2OG supplementation to improve pericyte redox balance and mitochondrial function, while concurrently allowing for enhanced pericyte–endothelial crosstalk. Such effects may help to prevent or slow down vasculopathy in skeletal muscles of people with diabetes.

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