scholarly journals Antidiabetic Activity of Durian (Durio Zibethinus Murr.) and Rambutan (Nephelium Lappaceum L.) Fruit Peels in Alloxan Diabetic Rats

2015 ◽  
Vol 3 ◽  
pp. 255-261 ◽  
Author(s):  
Muhtadi ◽  
Alfiani Urilia Primarianti ◽  
Tanti Azizah Sujono
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Durio Zibethinus ◽  
Nephelium Lappaceum

Antidiabetic Activity of Pistia strateotes L.Aqueous Extract in Alloxan-induced Diabetic Rats

2019 ◽  
Vol 3 (3) ◽  
pp. 91-94
Author(s):  
Mudassir Lawal ◽  
◽  
Abdulaziz Suleiman ◽  
Nasiruddin Matazu ◽  
Fatima Dawud ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Activity

Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

2020 ◽  
Vol 16 (1) ◽  
pp. 33-41
Author(s):  
Mohini C. Upadhye ◽  
Uday Deokate ◽  
Rohini Pujari ◽  
Vishnu Thakare
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Oral Glucose ◽  
Ficus Glomerata

Background: Ficus glomerata (F. glomerata) Linn. Family Moraceace is a large tree found all over India including outer Himalayan ranges, Punjab, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and also as a common plant in South India. It is planted around the home and temples. It is cultivated throughout the year, distributed in evergreen forests and moist localities. Objective: The Ethanolic Extract of roots of F. Glomerata (EEFG) belonging to the family Moraceace, was investigated for its antidiabetic activity using alloxan induced diabetic rats. Methods: Thirty rats were divided into 5 groups having 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. A dose of 100mg/kg and 200 mg/kg body weight of EEFG was administered to alloxan induced diabetic rats. The administration of the extract was lasted for 11 days. Effectiveness of the extract on glucose, cholesterol, triglycerides, and high density lipoprotein and protein concentrations was analyzed. Results: Significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride of the diabetic rats was observed after treatment with ethanolic extract. After subjecting to oral glucose tolerance test EEFG also showed significant improvement in glucose tolerance. Conclusion: F. glomerata root ethanolic extract showed that it possesses antidiabetic effect and can be found useful for the management of diabetes mellitus.

scholarly journals Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats

2011 ◽  
Vol 3 (2) ◽  
pp. 242 ◽  
Author(s):  
BK Mehta ◽  
DC Jain ◽  
Himanshu Misra ◽  
Manish Soni ◽  
Narendra Silawat ◽  
...  
Keyword(s):  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Antidiabetic Activity

scholarly journals Alcoholic Stem Extract ofCoscinium fenestratumRegulates Carbohydrate Metabolism and Improves Antioxidant Status in Streptozotocin–Nicotinamide Induced Diabetic Rats

2005 ◽  
Vol 2 (3) ◽  
pp. 375-381 ◽  
Author(s):  
I. R. Punitha ◽  
K. Rajendran ◽  
Arun Shirwaikar ◽  
Annie Shirwaikar
Keyword(s):  
Carbohydrate Metabolism ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Glutathione Synthetase ◽  
Alcoholic Extract ◽  
Enzymatic Antioxidants ◽  
Stem Extract ◽  
Gluconeogenic Enzyme ◽  
Glucose 6 Phosphate Dehydrogenase

Alcoholic extract of the stems ofCoscinium fenestratum, a medicinal plant indigenous to India and Sri Lanka used in ayurveda and siddha medicine for treating diabetes, was studied for its carbohydrate metabolism effect and antioxidant status in streptozotocin–nicotinamide induced type 2 diabetic rats. Oral administration ofC. fenestratumstem extract in graded doses caused a significant increase in enzymatic antioxidants such as catalase, superoxide dismutase, glutathione synthetase, peroxidase, and glutathione peroxidase and in the nonenzymatic antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of alcoholic extract on glycolytic enzymes such as glucose-6-phosphate dehydrogenase, lactate dehydrogenase and hexokinase showed a significant increase in their levels, whereas a significant decrease was observed in the levels of gluconeogenic enzyme, glucose-6-phosphatase and alanine aminotransferase in treated diabetic rats. Serum creatinine and urea levels also declined significantly. This investigation demonstrates significant antidiabetic activity ofC. fenestratum.

scholarly journals Antidiabetic and anti-obesity acylated flavonol diglucoside from Ammannia baccifera L. subsp. aegyptiaca (Willd.) Koehne Waste

2020 ◽  
Author(s):  
Noha Swilam ◽  
Mahmoud Nawwar ◽  
Rasha Radwan ◽  
Eman Mostafa
Keyword(s):  
Binding Free Energy ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Insulin Level ◽  
Diabetic Rats ◽  
High Serum ◽  
Antidiabetic Activity ◽  
Active Site Residues ◽  
Sod Activity ◽  
Aerial Parts

Abstract Chemical investigation of the aerial parts of Ammania aegyptiaca ethanol extract (AEEE) revealed significant high concentrations of polyphenols and flavonoids content with notable antioxidant activity in DPPH, ORAC, and reducing power assay. New acylated diglucoside flavonol myricetin 3-O-β-4­C1-(6"-O-galloyl glucopyranoside) 7-O-β-4C1-glucopyranoside (MGGG) was isolated from aerial parts of AEEE along with four additional known phenolics, not characterized previously from AEEE. Moreover, powerful inhibitory effects of MGGG, AEEE, and all isolates against α-amylase, pancreatic lipase and β-glucosidase, were assessed. In addition, flexible molecular docking was used to reveal the inhibition towards digestive enzymes and confirmed that the MGGG interacted strongly with the active site residues of these enzymes with the highest binding free energy against β-glucosidase (DG=-8.98 kcal/mol) compared to the commercial drug Acarbose, thus justifying its dual management of diabetes and obesity. In streptozotocin (STZ) induced diabetic rats, AEEE significantly decreased high serum glucose, α-amylase activity, liver and kidney function markers and increased insulin level. Moreover, it improved lipid profile due to diabetes with increased SOD activity and inhibited of TBARS formation. Consequently, AEEE and MGGG are found useful in controlling the secondary complications associated with type 2 diabetes mellitus. Histopathological studies proved the decrease in the pancreas damage and agreed with the biochemical findings. These results provide evidence that AEEE and MGGG have potent antidiabetic activity, which warrants additional investigations.

scholarly journals REHABILITASI HUTAN DAN LAHAN BERDASARKAN KEARIFAN LOKAL SUKU MOILE DAN SUKU MEYAH DI KABUPATEN MANOKWARI PROVINSI PAPUA BARAT (Rehabilitation of Forest and Land Based On Local Knowledge of Moile and the Meyah in Manokwari Regency West Papua Province)

2017 ◽  
Vol 24 (3) ◽  
pp. 141
Author(s):  
Mervin Arison Asmuruf ◽  
Ris Hadi Purwanto ◽  
Lies Rahayu Wijayanti Faida
Keyword(s):  
Local Knowledge ◽  
Local Community ◽  
Economic Value ◽  
Combination Method ◽  
Snowball Sampling ◽  
Durio Zibethinus ◽  
Aquilaria Malaccensis ◽  
Nephelium Lappaceum ◽  
West Papua ◽  
Papua Barat

ABSTRAKKajian Rehabilitasi Hutan dan Lahan (RHL) di Kabupaten Manokwari Provinsi Papua Barat telah dilakukan dengan berdasarkan kearifan lokal Suku Moile dan Suku Meyah. Penelitian ini bertujuan untuk mengetahui jenis–jenis tanaman lokal, indentifikasi kearifan lokal masyarakat Suku Moile dan Suku Meyah dan merumuskan strategi RHL berdasarkan kearifan lokal masyarakat. Penelitian ini dilakukan di Kampung Sub Sai Distrik Warmare dan Kampung Lebau Distrik Manokwari Utara Kabupaten Manokwari Provinsi Papua Barat. Teknik pengambilan data adalah pendekatan metode kombinasi data primer dan sekunder yang diperoleh melalui observasi lapangan, wawancara dengan teknik Snowball sampling dan penelusuran dokumen. Metode deskriptif dengan analisis Miles dan Huberman digunakan untuk mengidentifikasi kearifan lokal Suku Moile dan Suku Meyah. Hasil penelitian menunjukkan bahwa jenis-jenis tanaman lokal yang berpotensi digunakan dalam kegiatan RHL di Kabupaten Manokwari adalah: tanaman yang mempunyai kualitas kayu pertukangan yang baik dan memiliki nilai ekonomis tinggi, seperti: kayu besi (Intsia bijuga), kayu susu (Astonia sp), kayu matoa (Pometia sp).  Di samping tanaman yang buah dan kulitnya bernilai ekonomi tinggi sehingga dapat menambah penghasilan masyarakat, seperti: buah merah (Pandanus conoideus), Gaharu (Aquilaria malaccensis), Mangga (Manggifera indica), Rambutan (Nephelium lappaceum), Durian (Durio Zibethinus). Masyarakat Arfak pada kawasan ini memiliki nilai dan kearifan budaya Igya Ser Hanjob yang artinya berdiri menjaga batas. Kawasan hutan yang dimanfaatkan terbagi atas 4 (empat) bagian yakni Susti, Bahamti, Nimahamti dan Tumti, dengan fokus kegiatan RHL seharusnya dilakukan di Susti dan Nimahamti yang berfungsi sebagai kawasan penyangga.ABSTRACTStudy of the Forest and Land Rehabilitation (FLR) in Manokwari Regency West Papua Province have been done based on local knowledge of Moile and the Meyah. This research aims to know the type of local plants, identification the local wisdom of a tribal society Moile and Tribe Meyah and formulate the FLR strategy based on the wisdom of the local community. The study is done in sub sai vilagge warmare district and lebau vilagge manokwari the northern district manokwari counties provincial west papua. Techniques used in the data is the approach combination method through observation field, interviews with snowball sampling techniques and the tracing documents. Descriptive method with an analysis Miles and Huberman used to identify local knowledge of Moile and Meyah. The results showed that the local-crop potentially used FLR in the district Manokwari intsia bijuga asltonia sp, pometia .sp, where its have good quality for use as timber carpentry having high as well as economic value and Pandanus conoideus, Aquilaria malaccensis, Manggifera indica, Nephelium lappaceum, Durio Zibethinus which fruit and the skin can be utilized to add community incomes. The community arfak in this area has a value and culture igya wisdom similar hanjob which means keeping the limit stood, forest areas being utilized divided over 4 (four) : susti, bahamti, nimahamti and tumti , where RHL activities should be undertaken in susti and nimahamti because it can function as buffer area

scholarly journals IN VITRO ANTIOXIDANT AND IN VIVO ANTIDIABETIC ACTIVITY OF TWO POTENTIAL PROBIOTIC ENTEROCOCCUS SPP. ON ALLOXAN-INDUCED DIABETIC RATS

2021 ◽  
pp. 94-98
Author(s):  
KAMNI RAJPUT ◽  
RAMESH CHANDRA DUBEY
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Bacterial Cells ◽  
Bacterial Strains ◽  
Animal Group ◽  
Enterococcus Spp

Objective: In vitro antioxidant activity, in vivo antidiabetic property and intestinal attachment by two potential probiotic bacterial strains, namely, Enterococcus faecium and Enterococcus hirae were studied using albino rats. Methods: Antioxidant the activity was assessed using 2,2-Diphenyl-1-picrylhydrazyl radicals scavenging assay. Alloxan was administered intraperitoneally to induce diabetic conditions in experimental rats. Animals were treated with oral administration of Enterococcus spp., such as E. faecium, and E. hirae isolated from goat and sheep milk. The control animal group received normal saline for the same days. Glibenclamide drug was used as a positive control against probiotic bacterial cells. Results: However, administration of probiotic bacterial strains E. faecium and E. hirae, in albino rats significantly (p<0.05) at varying doses lowered blood glucose levels in diabetic rats as compared to the diabetic control group. Both the species of Enterococcus increased the bodyweight of experimental rats. However, E. faecium was the best antidiabetic strain having the antioxidant activities also in comparison to E. hirae. The attachment of probiotic bacterial cells E. faecium on the rat’s intestine wall against pathogens was examined. Furthermore, E. faecium showed its aggregation with pathogens by attachment of the intestines of albino rats. This showed that both the bacterial strains exhibited in vivo antidiabetic effect. Conclusion: The results of this study showed that probiotic bacteria possess antioxidant, antidiabetic activities, and attachment of intestine.

Sign in / Sign up

Export Citation Format

Share Document