Abstract
Due to the significance of drug delivery, the design of novel progressive nanomaterials for targeting drug delivery is a significant role in pharmacotherapy, as this method is supposed to reach a more exact target. One of the most distinguished materials by researchers is the poly ionic liquid (PIL), which have been used as anticancer drugs carriers and notably improve the antitumor effect and half-life. In this work, an efficient and stable nanocarrier containing silver nanoparticle, which were well distributed throughout the ionic liquid-based copolymer network (PILP-Ag), was reported for the drug delivery with antimicrobial effect. PILP was synthesized by radical silver nanoparticles was anchored into PIL voids by in-situ reduction, which enrich the adsorption capability of drug and antimicrobial effect of the nanocarrier. The synthesized nanomaterials were characterized by various techniques such as BET, TGA, SEM, TEM, AAS and FT-IR spectroscopy. The antibacterial activities of the silver-containing PIL against both S. aureus and E. coli were studied by determination of the minimum inhibitory concentration and Minimum Bactericidal Concentration.
Construction of Novel Polymerizable Ionic Liquid Microemulsions and the In Situ Synthesis of Poly(Ionic Liquid) Adsorbents