scholarly journals Biological tribology properties of the modified polyether ether ketone composite materials

2020 ◽  
Vol 59 (1) ◽  
pp. 399-405
Author(s):  
Li Ning ◽  
Chen Deqiang ◽  
Gao Xiyan ◽  
Lu Lirong ◽  
Chen Weizeng
Keyword(s):  
Tribological Properties ◽  
Blood Compatibility ◽  
Biological Properties ◽  
Nano Particles ◽  
Orthopaedic Implant ◽  
In Vivo Experiments ◽  
Polyether Ether Ketone ◽  
Medical Materials ◽  
Ether Ketone

AbstractModification of poly-ether-ether-ketone (PEEK) to adapt to the biological properties of materials is currently the key point in the research of medical materials. The tribological properties and biocompatibility of the PEEK composites modified by carbon fiber (CF), potassium titanate whisker(PTW) and nano-particles were discussed in this paper. The results show the modified PEEK composites by a certain length to diameter ratio of CF show the best using effect in vivo experiments in good blood compatibility, which is suitable for orthopaedic implant materials. A large number of experiments show that the PEEK composites would be modified with a certain ratio of CF (about 30%wt.), whisker (about 15%wt.) and HA (about 5%wt.) particle with better biological tribological properties, more important value in medical research.

scholarly journals Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy

2021 ◽  
Author(s):  
Raphaelle Delattre ◽  
Jeremy Seurat ◽  
Feyrouz Haddad ◽  
Thu-Thuy Nguyen ◽  
Baptiste Gaborieau ◽  
...  
Keyword(s):  
Phage Therapy ◽  
Biological Properties ◽  
General Strategy ◽  
In Vivo Experiments ◽  
Bacterial Dynamics ◽  
Optimal Dosing ◽  
Dosing Regimens ◽  
The Impact

The clinical (re)development of phage therapy to treat antibiotic resistant infections requires grasping specific biological properties of bacteriophages (phages) as antibacterial. However, identification of optimal dosing regimens is hampered by the poor understanding of phage-bacteria interactions in vivo. Here we developed a general strategy coupling in vitro and in vivo experiments with a mathematical model to characterize the interplay between phage and bacterial dynamics during pneumonia induced by a pathogenic strain of Escherichia coli. The model estimates some key parameters for phage therapeutic efficacy, in particular the impact of dose and route of administration on phage dynamics and the synergism of phage and the innate immune response on the bacterial clearance rate. Simulations predict a low impact of the intrinsic phage characteristics in agreement with the current semi-empirical choices of phages for compassionate treatments. Model-based approaches will foster the deployment of future phage therapy clinical trials.

scholarly journals Peri-implant cartilage and bone histological changes following treatment of focal osteochondral defects in the femoral head with polyether ether ketone implants versus cobalt chromium molybdenum alloy implants: assessment in a goat model

2020 ◽  
Author(s):  
Zhiguo Yuan ◽  
Wei Zhang ◽  
Xiangchao Meng ◽  
Jue Zhang ◽  
Teng TengLong ◽  
...  
Keyword(s):  
Femoral Head ◽  
Osteochondral Defect ◽  
Osteochondral Defects ◽  
Cobalt Chromium ◽  
Cocrmo Alloy ◽  
Polyether Ether Ketone ◽  
Histological Score ◽  
Ether Ketone ◽  
Cobalt Chromium Molybdenum

Abstract Objective: This study aimed to quantitatively investigate the peri-implant histology of applying defect-size polyether ether ketone (PEEK) implant for the treatment of localized osteochondral defects in the femoral head and compared it with cobalt chromium molybdenum (CoCrMo) alloy implant.Methods: A femoral head osteochondral defect model was created in the left hips of goats (n=12). Defects were randomly treated by immediate placement of a PEEK (n=6) or CoCrMo implant (n=6). The un-operated right hip joints served as a control. Goats were sacrificed at 12 weeks. Periprosthetic cartilage quality was semi-quantitatively analyzed macroscopically and microscopically. Implant osseointegration was measured by micro-CT and histomorphometry.Results: The modified macroscopic articular evaluation score in the PEEK group was lower than that in the CoCrMo group (p<0.05), and the histological score of the periprosthetic and acetabular cartilage in the PEEK group was lower than that in the CoCrMo group (P<0.05). The mean bone-implant contact for PEEK implants was comparable with that for CoCrMo alloy implants at 12 weeks.Conclusions: A PEEK implant for the treatment of local osteochondral defect in the femoral head demonstrated effective fixation and superior in vivo cartilage protection compared with an identical CoCrMo alloy implant.

Effects of potassium titanate whisker and glass fiber on tribological and mechanical properties of PTFE/PEEK blend

2017 ◽  
Vol 30 (6) ◽  
pp. 752-764 ◽  
Author(s):  
Xue Teng ◽  
Lefei Wen ◽  
Yunxia Lv ◽  
Wenge Tang ◽  
Xiaogang Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Thermal Stability ◽  
Friction Coefficient ◽  
Wear Rate ◽  
Glass Fiber ◽  
Tribological Properties ◽  
Reinforcing Effect ◽  
Potassium Titanate ◽  
Polyether Ether Ketone ◽  
Ether Ketone

Two series of 10% polytetrafluoroethylene (PTFE)/polyether ether ketone (PEEK) composites reinforced with potassium titanate whisker (PTW/PTFE/PEEK) and chopped glass fiber (GF/PTFE/PEEK) were prepared and characterized. We investigated the effects of the additives on thermal stability, tribological properties, mechanical properties, and rheological behavior. The results illustrated that the mechanical properties of 10% PTFE/PEEK blend can be dramatically improved by incorporating either PTW or GF; however, the reinforcing effect of GF was found to be superior. It was found that 1% additive resulted in blends with the best tribological properties. Compared to the unmodified blend, the friction coefficient and wear rate of the 1% PTW blend decreased by 7.2% and 21%, respectively, while the corresponding values of 1% GF blend decreased by 0.66% and 51%, respectively.

scholarly journals Clitoria ternatea - Shifting Paradigms: From Laboratory to Industry

2021 ◽  
pp. 18-26
Author(s):  
C. B. Ranaweera ◽  
A. K. Chandana
Keyword(s):  
Folk Medicine ◽  
Biological Properties ◽  
Biologically Active ◽  
Potential Health ◽  
Clitoria Ternatea ◽  
In Vivo Experiments ◽  
Industrial Level ◽  
New Treatments

Clitoria ternatea commonly known as Butterfly pea is a standard Ayurvedic medicinal plant used in many parts of south Asian countries. Traditional medicinal plants are a great alternative to find new treatments and for the development of novel antimicrobials to combat many diseases. In Ayurveda and traditional and folk medicine in several countries, decoction and extracts made from C. ternatea are recommended to be used for various medical treatments. C. ternatea extracts claimed to possess antibacterial, antiviral, and antifungal properties, which had been supported and validated by many in vitro and in vivo experiments. However, biologically active compound/s isolation and development novel compounds still remain in its infancy. Despite its enormous potential health benefits, only a single commercial product managed to reach industrial level production. C. ternatea cyclotide studies are also limited despite the fact that it the fastest known natural ligase discovered to date. These cyclotides are rapid peptide ligators and has been the focus of many recent studies on peptide ligation and cyclization for biotechnological applications. In this mini summary we have tried to point out innate unique biological properties of C. ternatea and suggested few future studies, more specifically on C. ternatea cyclotides development against bacterial heat shock proteins (Hsp 100) for novel antimicrobial discovery and development.

Effects of UV irradiation time on the molecular structure of typical engineering plastics and tribological properties under heavy load

2022 ◽  
pp. 095400832110665
Author(s):  
Lian Liu ◽  
Haitao Duan ◽  
Wen Zhan ◽  
Shengpeng Zhan ◽  
Dan Jia ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Wear Rate ◽  
Uv Irradiation ◽  
Tribological Properties ◽  
Irradiation Time ◽  
Heavy Load ◽  
Polyether Ether Ketone ◽  
Engineering Plastics ◽  
Ether Ketone ◽  
Heavy Loads

Exposing engineering plastics to UV irradiation can easily destroy the original molecular structure of the materials and consequently affect their tribological properties. This study investigated the effects of UV irradiation on the molecular structure of typical engineering plastics, such as polytetrafluoroethylene (PTFE) and polyether ether ketone (PEEK), and on their tribological properties under heavy loads (20 MPa). The surface morphology results showed that the appearance of PEEK changed significantly under UV irradiation. However, the change in PTFE was negligible. Under micromorphology, the processing lines of the two materials gradually became lighter with increasing UV irradiation time. The resulting infrared spectra showed that the molecular chains of both materials were broken, and new functional groups were formed under UV irradiation. Tribology testing demonstrated that with prolonged UV irradiation, the average PTFE coefficient of friction remained relatively stable, whereas that of PEEK was approximately 0.55. As the UV irradiation time increased, the wear rate of PTFE increased significantly, whereas that of PEEK showed no significant change.

The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant

2018 ◽  
Vol 18 (7) ◽  
pp. 1231-1240 ◽  
Author(s):  
William Robert Walsh ◽  
Matthew H. Pelletier ◽  
Chris Christou ◽  
Jiawei He ◽  
Frank Vizesi ◽  
...  
Keyword(s):  
Polyether Ether Ketone ◽  
Ether Ketone

scholarly journals Convergent synthesis of diversified reversible network leads to liquid metal-containing conductive hydrogel adhesives

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yong Xu ◽  
Rebecca Rothe ◽  
Dagmar Voigt ◽  
Sandra Hauser ◽  
Meiying Cui ◽  
...  
Keyword(s):  
Liquid Metal ◽  
Polymer Networks ◽  
Biological Properties ◽  
Self Healing ◽  
Convergent Synthesis ◽  
Chemical Structures ◽  
In Vivo Experiments ◽  
Macromolecular System

AbstractMany features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed of many different covalent and non-covalent chemical bonds. Whereas a reductionism approach would have the limitation to fully recapitulate various biological properties with simple chemical structures, mimicking such sophisticated networks by incorporating many different functional groups in a macromolecular system is synthetically challenging. Herein, we propose a strategy of convergent synthesis of complex polymer networks to produce biomimetic electroconductive liquid metal hydrogels. Four precursors could be individually synthesized in one to two reaction steps and characterized, then assembled to form hydrogel adhesives. The convergent synthesis allows us to combine materials of different natures to generate matrices with high adhesive strength, enhanced electroconductivity, good cytocompatibility in vitro and high biocompatibility in vivo. The reversible networks exhibit self-healing and shear-thinning properties, thus allowing for 3D printing and minimally invasive injection for in vivo experiments.

scholarly journals Evaluation of the Grafting Efficacy of Active Biomolecules of Phosphatidylcholine and Type I Collagen on Polyether Ether Ketone: In Vitro and In Vivo

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2081
Author(s):  
Jian-Chih Chen ◽  
Chih-Hua Chen ◽  
Kai-Chi Chang ◽  
Shih-Ming Liu ◽  
Chia-Ling Ko ◽  
...  
Keyword(s):  
Type I Collagen ◽  
3D Structure ◽  
Orthopedic Implants ◽  
Type I ◽  
Polyether Ether Ketone ◽  
Hydrophilic Nature ◽  
Potential Alternative ◽  
Ether Ketone

Biomolecule grafting on polyether ether ketone (PEEK) was used to improve cell affinity caused by surface inertness. This study demonstrated the sequence-polished (P) and sulfonated (SA) PEEK modification to make a 3D structure, active biomolecule graftings through PEEK silylation (SA/SI) and then processed with phosphatidylcholine (with silylation of SA/SI/PC; without SA/PC) and type I collagen (COL I, with silylation of SA/SI/C; without SA/C). Different modified PEEKs were implanted for 4, 8, and 12 weeks for histology. Sulfonated PEEK of SA showed the surface roughness was significantly increased; after the silylation of SA/SI, the hydrophilic nature was remarkably improved. The biomolecules were effectively grafted through silylation, and the cells showed improved attachment after 1 h. Furthermore, the SA/SI/PC group showed good in vitro mineralization. The new bone tissues were integrated into the 3D porous structures of SA/SI/PC and SA/SI/C in vivo making PEEK a potential alternative to metals in orthopedic implants.

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