Diverse effects on vaccine-specific serum IgG titres and memory B cells upon methotrexate and anti-TNF-α therapy in children with rheumatic diseases: A cross-sectional study

Vaccine ◽  
2016 ◽  
Vol 34 (10) ◽  
pp. 1304-1311 ◽  
Author(s):  
Hanna M. Ingelman-Sundberg ◽  
Åsa Laestadius ◽  
Cecilia Chrapkowska ◽  
Karina Mördrup ◽  
Bo Magnusson ◽  
...  
Keyword(s):  
B Cells ◽  
Rheumatic Diseases ◽  
Cross Sectional Study ◽  
Memory B Cells ◽  
Sectional Study ◽  
Cross Sectional ◽  
Specific Serum ◽  
Serum Igg ◽  
Tnf Α

scholarly journals A Cross-Sectional Study of Bitter-Taste Receptor Genotypes, Oral Health, and Markers of Oral Inflammation

Oral ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 122-138
Author(s):  
Kiranjit Kaur ◽  
Alexandria Turner ◽  
Patrice Jones ◽  
Dean Sculley ◽  
Martin Veysey ◽  
...  
Keyword(s):  
Oral Health ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Bitter Taste Receptor ◽  
Cross Sectional ◽  
Tnf Α ◽  
Oral Inflammation ◽  
Major Allele

(1) Background: The aetiology of oral disease is multifactorial, involving genetic and environmental factors, including dietary ones. Bitter taste genetics may be related to oral health through dietary modulation or non-gustatory roles, including modulation of inflammation. Investigations of bitter taste and oral health associations to date have been restricted to specific polymorphisms, limited outcomes (caries), and age-groups (children), and links to inflammation remain to be elucidated. (2) Methods: A cross-sectional study (n = 65) investigated the correlations between bitter taste genotypes, oral health outcomes, and oral inflammation markers. Oral examinations were conducted, including saliva testing with evaluation of flow rate, pH, and buffering and antioxidant capacity (FRAP) and IL-1β, TNF-α, IL-6 levels. DNA was collected via buccal swabs and used to evaluate the presence of multiple bitter-taste receptor gene polymorphisms. (3) Results: The major allele for TAS2R4-rs2233998, TAS2R5-rs2227264, TAS2R50-rs1376251, and TAS2R9-rs3741845 was associated with a higher mean of unstimulated salivary flow rate, FRAP, TNF-α, IL-1β, and likelihood of filled teeth. Presence of the major allele for TAS2R4-rs2234001 and TAS2R9-rs3741845 was associated with lower means FRAP, TNF-α, IL-1β, DMFT index, and likelihood of missing teeth. (4) Conclusions: These findings suggest relationships between bitter-taste genotypes, oral health outcomes, and inflammatory markers. These findings justify the need for further studies that could help identify risk groups and develop novel agents for maintaining oral health.

scholarly journals The Effect of Obesity and Other Factors towards On the Increased Risk of Rheumatism in Indonesia (Analysis of IFLS 2014)

2021 ◽  
Vol 12 (1) ◽  
pp. 77-87
Author(s):  
Nuraini Nuraini ◽  
Amrina Rosyada
Keyword(s):  
Rheumatic Disease ◽  
Rheumatic Diseases ◽  
Cross Sectional Study ◽  
Sample Survey ◽  
Healthy Lifestyles ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Gender Education ◽  
Complex Sample

The number of people with rheumatism worldwide has reached 355 million, and this is estimated by 2025, suggesting that more than 25% will experience paralysis. This study aims to determine obesity and other factors related to the increased risk of rheumatic diseases in Indonesia, the method used was data analysis using a complex sample survey. It used 2014 IFLS data and a cross sectional study design, as well as a multistage random sampling with a total of 29,106 respondents, and the results showed that the prevalence of rheumatic disease in Indonesia was 5.2% in 2014. The most dominant and unmodifiable variable that influenced incidence was gender (PR=1.686; 95% CI=1.488-1.910). Meanwhile, obesity is the most dominant and modifying variable that influences the incidence of rheumatic disease (PR=1.630; 95% CI=1.433-1.855). Factors that are simultaneously related to the increased risk of rheumatic diseases include age, gender, education, physical activity, protein consumption, obesity, and accident history. Considering the results, patients need to eat healthy and low purine foods, as well as implementing other healthy lifestyles such as appropriate, adequate, and regular physical activities in order to reduce the risk of rheumatism.

scholarly journals P.0493 COVID-19 related perceived stress in patients with rheumatic diseases: an Italian cross-sectional study

2021 ◽  
Vol 53 ◽  
pp. S363-S364
Author(s):  
C. Posio ◽  
F. Ingegnoli ◽  
M. Buoli ◽  
R. Di Taranto ◽  
E. Cumbo ◽  
...  
Keyword(s):  
Perceived Stress ◽  
Rheumatic Diseases ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Adverse events of six COVID-19 vaccines in patients with autoimmune rheumatic diseases: a cross-sectional study

2021 ◽  
Author(s):  
Jorge Antonio Esquivel-Valerio ◽  
Cassandra Michele Skinner-Taylor ◽  
Ilse Andrea Moreno-Arquieta ◽  
Jesus Alberto Cardenas-de la Garza ◽  
Gisela Garcia-Arellano ◽  
...  
Keyword(s):  
Adverse Events ◽  
Rheumatic Diseases ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Autoimmune Rheumatic Diseases

scholarly journals Social determinants and other aspects associated with rheumatic diseases in the Brazilian population: a cross-sectional study based on the National Health Survey (PNS2013).

2020 ◽  
Author(s):  
Clécio Gabriel Souza ◽  
Marcelo Cardoso Souza ◽  
Hugo Jario Silva ◽  
Sanderson Assis ◽  
Diego Sousa Dantas
Keyword(s):  
Physical Activity ◽  
Rheumatic Diseases ◽  
Social Factors ◽  
Cross Sectional Study ◽  
National Health Survey ◽  
Brazilian Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Social

Abstract Background: Rheumatic diseases are increasingly present in the world population, represented by chronic joint and musculoskeletal pain. Among them, osteoarthritis (OA) is the most prevalent. It is considered the third most prevalent chronic non-communicable disease in the Brazilian population, being responsible for a high rate of physical disability and reduced quality of life. Little has been discussed about the social factors associated with this health condition. This study aimed to analyze the social factors associated with arthritis in the Brazilian population.Methods: This is a cross-sectional study based on data from the 2013 National Health Survey in Brazil with arthritis as its main outcome. Sex, age, body weight, usual activities, physical activity, self-perceived health and diagnosis of depression were analyzed as independent variables. Descriptive and inferential statistics were used. Poisson multiple regression was performed, and the prevalence ratio (PR) and confidence interval (CI) of 95% were calculated using a significance level of 5% (p≤0.05).Results: A total of 60,202 individuals of both sexes took part in this study and the rheumatic diseases or arthrtitis prevalence was 6.4%. The individual factors associated with a higher prevalence of arthritis were female (PR = 2.09; CI = 1.95-2.25), age over 35 years (PR = 2.88; CI = 2.57-3.24) and excess body weight (PR = 1.61; CI = 1.25-2.07). The presence of rhemautic diseases showed an association with lower performance of usual activities (PR = 1.61; CI = 1.50-1.73) and self-perceived health as very poor (PR = 3.96; CI = 3.31-4.72). In addition, it was associated with a higher prevalence of mental illnesses such as depression (PR = 1.77; CI = 1.64-1.90).Conclusion: Social and modifiable factors which are associated with a higher prevalence of arthritis can be controlled through incentive measures such as social participation and physical activity.

scholarly journals Proportions of B-cell subsets are altered in incomplete systemic lupus erythematosus and correlate with interferon score and IgG levels

Rheumatology ◽  
2020 ◽  
Vol 59 (9) ◽  
pp. 2616-2624
Author(s):  
Svenja Henning ◽  
Wietske M Lambers ◽  
Berber Doornbos-van der Meer ◽  
Wayel H Abdulahad ◽  
Frans G M Kroese ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Lupus Erythematosus ◽  
Cell Subset ◽  
Cross Sectional Study ◽  
Type I ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
B Cell Subsets

Abstract Objectives Incomplete SLE (iSLE) patients display symptoms typical for SLE but have insufficient criteria to fulfil the diagnosis. Biomarkers are needed to identify iSLE patients that will progress to SLE. IFN type I activation, B-cell-activating factor (BAFF) and B-cell subset distortions play an important role in the pathogenesis of SLE. The aim of this cross-sectional study was to investigate whether B-cell subsets are altered in iSLE patients, and whether these alterations correlate with IFN scores and BAFF levels. Methods iSLE patients (n = 34), SLE patients (n = 41) with quiescent disease (SLEDAI ≤4) and healthy controls (n = 22) were included. Proportions of B-cell subsets were measured with flow cytometry, IFN scores with RT-PCR and BAFF levels with ELISA. Results Proportions of age-associated B-cells were elevated in iSLE patients compared with healthy controls and correlated with IgG levels. In iSLE patients, IFN scores and BAFF levels were significantly increased compared with healthy controls. Also, IFN scores correlated with proportions of switched memory B-cells, plasma cells and IgG levels, and correlated negatively with complement levels in iSLE patients. Conclusion In this cross-sectional study, distortions in B-cell subsets were observed in iSLE patients and were correlated with IFN scores and IgG levels. Since these factors play an important role in the pathogenesis of SLE, iSLE patients with these distortions, high IFN scores, and high levels of IgG and BAFF may be at risk for progression to SLE.

scholarly journals Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

2017 ◽  
Vol 135 (6) ◽  
pp. 535-540 ◽  
Author(s):  
Rayana Taques Posselt ◽  
Vinícius Nicolelli Coelho ◽  
Danieli Cristina Pigozzo ◽  
Marcela Idalia Guerrer ◽  
Marília da Cruz Fagundes ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Cross Sectional Study ◽  
Thyroid Autoantibodies ◽  
Sectional Study ◽  
Cross Sectional ◽  
Autoimmune Rheumatic Diseases

scholarly journals Correlation between Circulating Levels of Pro-Inflammatory Cytokines TNF-alpha and Vascular Calcification Inhibitor Matrix Gla Protein in Obese Men

2010 ◽  
Vol 2 (3) ◽  
pp. 126
Author(s):  
Trilis Yulianti ◽  
Mansyur Arif ◽  
Andi Wijaya
Keyword(s):  
Vascular Calcification ◽  
Inflammatory Cytokines ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Matrix Gla Protein ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tnf Α ◽  
Circulating Levels ◽  
Pro Inflammatory Cytokines

BACKGROUND: Adult obesity is rapidly increasing in the world including Indonesia. Tumor necrosis factor α (TNF-α) was chronically elevated in obese adipose tissue. TNF-α, a pleiotropic cytokine and also a regulator of bone formation, may might represent an important link between obesity and vascular calcification. Elegant genetic studies in mice and human have highlighted the important roles for Matrix Gla Protein (MGP) as an inhibitor of vascular calcification. The aim of this study was to examine the correlation between circulating levels of pro-inflammatory cytokines TNF-α and vascular calcification inhibitor MGP in obese men.METHODS: This was an observational cross-sectional study including 40 central obese men (waist circumference ≥90 cm) aged 31-60 years old. Serum MGP and serum TNF-α concentrations were quantified by ELISA principle. Fasting plasma glucose was assessed using hexokinase methods, triglyceride by GPO-PAP methods, and creatinine by Jaffe methods. All assays were performed according to the manufacture instruction. Statistical analysis was performed with SPSS for windows ver 16. Univariate analysis were performed to analyze mean, maximum, minimum value and SD. Pearson correlation statistic were performed to determine the correlation between variables. Significance value were define as alpha level = 0.05 based on two-tailed tests.RESULTS: The cross-sectional study (n=40) showed that the advancing age was correlated with plasma TNF-α concentration (r=0.348; p=0.028). The mean concentration of TNF-α and MGP were 8.323 and 8.368, respectively. We found a significant negative correlation between TNF-α with MGP (r=-0.425; p=0.006) and a significant correlation between TNF-α and triglyceride (r=0.375; p=0.017).CONCLUSIONS: Circulating level of TNF-α was inversely correlated with MGP concentration in obese men. This finding suggested that high level TNF-α leads to low MGP concentration obese men, hence, limits inhibitory capacity in vascular calcification.KEYWORDS: hypertension, obesity, vascular calcification, MGP, TNF-α

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