Mo1475 5-YEAR METABOLIC AND HEPATIC OUTCOMES FOLLOWING BARIATRIC SURGERY: RETROSPECTIVE OBSERVATIONAL COHORT ANALYSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-1416-S-1417
Author(s):  
Raad Haddad ◽  
Corey Lager ◽  
Abdelwahab Jalal Eldin ◽  
Mario Swaidan ◽  
Andrew Kraftson ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Cohort Analysis ◽  
Observational Cohort

scholarly journals Prevalence of Anti-Phospholipid Autoantibodies and Their Association with Respiratory SOFA Component in Patients with COVID-19 Pneumonia: A Prospective Cohort Analysis in Tunisia

2021 ◽  
Author(s):  
Amal ABOUDA ◽  
Yasmine BOUKHALFA ◽  
Wafa ANENE ◽  
Zied HAJJEJ ◽  
Ezzeddine GHAZOUANI ◽  
...  
Keyword(s):  
Critically Ill ◽  
Significant Positive Correlation ◽  
Cohort Analysis ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Respiratory Organ ◽  
Blood Samples ◽  
Observational Cohort ◽  
First Time ◽  
Independent Indicator

Abstract Purpose: The aim of our study was to evaluate the prevalence of aPLAs among Tunisian critically-ill covid19 and non-covid19 patients and to investigate the clinical significance of aPLAs by determining the SOFA score and their respiratory failure during their ICU stay. Methods: We conducted a prospective observational cohort study including critically ill COVID-19 patients and non-COVID-19 patients with pulmonary origin sepsis, admitted to the intensive care unit. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization in order to measure titers of anti-cardiolipin (aCL), anti-phosphatidylserine (aPS) by chemiluminescence immunoassay. Results: We enrolled 43 COVID-19 patients and 31 non COVID-19 with pulmonary origin sepsis. In-hospital mortality rate was significantly higher (p=0.026) in COVID-19 patients (79%). 58.8% of COVID-19 patients were aPLA positive; however, only 22.5% of the non-COVID-19 were positive for aPLA (p=0.002). A significant positive correlation existed between respiratory SOFA component at days 3, 5, 8 and 10 and anti-phospholipid antibodies concentrations. Conclusion: Based on our results, for the first time, anti-phospholipid antibodies may be used as an independent indicator of respiratory organ failure in critically ill patients, to stratify and assess the prognosis of pulmonary origin sepsis and COVID-19.

scholarly journals ANALYSIS OF ANTIBIOTICS USE IN PEDIATRIC PNEUMONIA PATIENTS AGED 3 MONTHS - 5 YEARS

2017 ◽  
Vol 52 (2) ◽  
pp. 108
Author(s):  
Dhita Evi Aryani ◽  
Didik Hasmono ◽  
Nun Zairina ◽  
Landia Setiawan
Keyword(s):  
Cohort Analysis ◽  
Qualitative Evaluation ◽  
Lung Parenchyma ◽  
Antibiotics Resistance ◽  
Pediatric Pneumonia ◽  
Antibiotics Use ◽  
Observational Cohort ◽  
Rational Use Of Antibiotics ◽  
Selection Of

Pneumonia is an infectious disease that causes acute inflammation of the lung parenchyma and compaction exudate in the lung tissue. In addition to causing significant morbidity and mortality, pneumonia is also difficult to diagnose, treatments are less precise and less taken seriously. Pneumonia caused the death of 14% of children under five in Indonesia, with a mortality rate of 83 children per day. The difficulty of diagnosis, the selection of a less appropriate antibiotics, side effects, differences in pharmacokinetics and pharmacodynamics of the drug in infants and antibiotics resistance is to be a problem in itself. Therefore it is necessary to study the analysis of the use of antibiotics in patients with pneumonia of children aged 3 months till 5 years. The aim of this research to analyze antibiotics therapy in patients with pneumonia of children aged 3 months till 5 years. Method: an observational cohort analysis was carried out in the Pediatrics Respirology Division Dr. Soetomo Hospital Surabaya. Data was collected from February to May 2014. Patients who met the inclusion criteria were observed prospectively and the quantity and quality of antibiotics usage assessed with Gyssens category. Result: from February to May 2014 period, prospectively, the antibiotics usage quantitative evaluation used DDD/patient days shows that ampicillin 34.39DDD/100 patient days. Qualitative evaluation using Gyssens category on 75 antibiotics therapy shows that 32% considered appropriate. So, this study showed that ampicillin is most widely and qualitative analysis, only 32% of rational use of antibiotics.

scholarly journals Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e034886 ◽  
Author(s):  
Daniel J Grint ◽  
Helen I McDonald ◽  
Jemma L Walker ◽  
Gayatri Amirthalingam ◽  
Nick Andrews ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Analysis ◽  
Care Staff ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Varicella Zoster ◽  
Related Disease ◽  
Observational Cohort ◽  
Primary Care Staff

ObjectivesTo investigate the safety of live attenuated varicella zoster vaccination when administered to immunosuppressed individuals.DesignProspective observational cohort study.SettingThe study used anonymised data from the Clinical Practice Research Datalink (CPRD), comprising a representative sample of routinely collected primary care data in England between 2013 and 2017 and and linked Hospital Episode Statistics data.Participants168 767 individuals age-eligible for varicella zoster vaccination registered at a general practice in England contributing data to CPRD.Main outcome measuresElectronic health records indicating immunosuppression, zoster vaccination, diagnoses of specific varicella-zoster virus (VZV)-related disease and non-specific rash/encephalitis compatible with VZV-related disease.ResultsBetween 1 September 2013 and 31 August 2017, a period of immunosuppression was identified for 9093/168 767 (5.4%; 95% CI: 5.3%–5.5%) individuals age-eligible for zoster vaccination. The overall rate of vaccination while immunosuppressed was 1742/5251 (33.2 per 100 adjusted person years at risk; 95% CI: 31.9%–34.5%). Follow-up of the 1742 individuals who were inadvertently vaccinated while immunosuppressed identified only two cases of VZV-related disease within 8 weeks of vaccination (0.1%; 95% CI: 0.01%–0.4%), both primary care diagnoses of ‘shingles’, neither with a related hospital admission.ConclusionsDespite evidence of inadvertent vaccination of immunosuppressed individuals with live zoster vaccination, there is a lack of evidence of severe consequences including hospitalisation. This should reassure primary care staff and encourage vaccination of mildly immunosuppressed individuals who do not meet current thresholds for contraindication. These findings support a review of the extent to which live zoster vaccination is contraindicated among the immunosuppressed.

scholarly journals Sex disparity in laparoscopic bariatric surgery outcomes: a matched-pair cohort analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pouria Mousapour ◽  
Erfan Tasdighi ◽  
Alireza Khalaj ◽  
Maryam Mahdavi ◽  
Majid Valizadeh ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Postoperative Complications ◽  
Cohort Analysis ◽  
Operation Time ◽  
Matched Pair ◽  
Laparoscopic Bariatric Surgery ◽  
Men And Women ◽  
Preoperative Body Mass Index ◽  
Surgery Outcomes

AbstractMen have been historically considered to be higher-risk patients for bariatric surgery compared to women, the perception of which is suggested to be a barrier to bariatric surgery in men. The purpose of this study is to conduct a matched-pair analysis to evaluate sex disparities in laparoscopic bariatric surgery outcomes. Data on patients who underwent laparoscopic bariatric surgery from March 2013 to 2017 was collected prospectively. Then, 707 men and 707 women pair-matched for age, preoperative body mass index (BMI) and the procedure type (i.e., sleeve gastrectomy, Roux-en-Y, or one-anastomosis gastric bypass) were compared in terms of weight loss, remission of obesity-related comorbidities, and postoperative complications classified according to the Clavien–Dindo classification. There was no difference between the two sexes regarding the operation time, bleeding during surgery and length of postoperative hospital stay. We observed similar total weight loss, BMI loss, and percentage of excess BMI loss at 12, 24, and 36 months postoperatively between men and women, with no difference in remission of diabetes mellitus, hypertension and dyslipidemia at 12 months. The rate of in-hospital, 30-day and late complications according to Clavien–Dindo classification grades was similar between men and women. Our matched-pair cohort analysis demonstrated that bariatric surgery results in comparable short- and mid-term efficacy in men and women, and is associated with similar rate and severity of postoperative complications between sexes. These findings suggest bariatric surgeons not to consider sex for patient selection in bariatric surgery.

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